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Fusion gene ID: 43252 |
FusionGeneSummary for ZNF384_SDR16C5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNF384_SDR16C5 | Fusion gene ID: 43252 | Hgene | Tgene | Gene symbol | ZNF384 | SDR16C5 | Gene ID | 171017 | 195814 |
| Gene name | zinc finger protein 384 | short chain dehydrogenase/reductase family 16C member 5 | |
| Synonyms | CAGH1|CAGH1A|CIZ|ERDA2|NMP4|NP|TNRC1 | EPHD-2|RDH#2|RDH-E2|RDHE2|retSDR2 | |
| Cytomap | 12p13.31 | 8q12.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein 384CAG repeat protein 1Cas-interacting zinc finger proteinexpanded repeat domain, CAG/CTG 2nuclear matrix transcription factor 4trinucleotide repeat-containing gene 1 protein | epidermal retinol dehydrogenase 2epidermal retinal dehydrogenase 2retinal short chain dehydrogenase reductaseretinal short-chain dehydrogenase reductase 2 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8TF68 | Q8N3Y7 | |
| Ensembl transtripts involved in fusion gene | ENST00000396795, ENST00000319770, ENST00000396801, ENST00000361959, ENST00000355772, ENST00000396799, | ENST00000396721, ENST00000303749, ENST00000522671, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 1 X 1 X 1=1 |
| # samples | 3 | 1 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: ZNF384 [Title/Abstract] AND SDR16C5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SDR16C5 | GO:0031065 | positive regulation of histone deacetylation | 16691198 |
| Tgene | SDR16C5 | GO:0035067 | negative regulation of histone acetylation | 16691198 |
| Tgene | SDR16C5 | GO:0042572 | retinol metabolic process | 18926804|19102727 |
| Tgene | SDR16C5 | GO:0042574 | retinal metabolic process | 18926804|19102727 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE464107 | ZNF384 | chr12 | 6776259 | + | SDR16C5 | chr8 | 57213284 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000396795 | ENST00000396721 | ZNF384 | chr12 | 6776259 | + | SDR16C5 | chr8 | 57213284 | + |
| intron-intron | ENST00000396795 | ENST00000303749 | ZNF384 | chr12 | 6776259 | + | SDR16C5 | chr8 | 57213284 | + |
| intron-intron | ENST00000396795 | ENST00000522671 | ZNF384 | chr12 | 6776259 | + | SDR16C5 | chr8 | 57213284 | + |
| intron-3UTR | ENST00000319770 | ENST00000396721 | ZNF384 | chr12 | 6776259 | + | SDR16C5 | chr8 | 57213284 | + |
| intron-intron | ENST00000319770 | ENST00000303749 | ZNF384 | chr12 | 6776259 | + | SDR16C5 | chr8 | 57213284 | + |
| intron-intron | ENST00000319770 | ENST00000522671 | ZNF384 | chr12 | 6776259 | + | SDR16C5 | chr8 | 57213284 | + |
| intron-3UTR | ENST00000396801 | ENST00000396721 | ZNF384 | chr12 | 6776259 | + | SDR16C5 | chr8 | 57213284 | + |
| intron-intron | ENST00000396801 | ENST00000303749 | ZNF384 | chr12 | 6776259 | + | SDR16C5 | chr8 | 57213284 | + |
| intron-intron | ENST00000396801 | ENST00000522671 | ZNF384 | chr12 | 6776259 | + | SDR16C5 | chr8 | 57213284 | + |
| intron-3UTR | ENST00000361959 | ENST00000396721 | ZNF384 | chr12 | 6776259 | + | SDR16C5 | chr8 | 57213284 | + |
| intron-intron | ENST00000361959 | ENST00000303749 | ZNF384 | chr12 | 6776259 | + | SDR16C5 | chr8 | 57213284 | + |
| intron-intron | ENST00000361959 | ENST00000522671 | ZNF384 | chr12 | 6776259 | + | SDR16C5 | chr8 | 57213284 | + |
| intron-3UTR | ENST00000355772 | ENST00000396721 | ZNF384 | chr12 | 6776259 | + | SDR16C5 | chr8 | 57213284 | + |
| intron-intron | ENST00000355772 | ENST00000303749 | ZNF384 | chr12 | 6776259 | + | SDR16C5 | chr8 | 57213284 | + |
| intron-intron | ENST00000355772 | ENST00000522671 | ZNF384 | chr12 | 6776259 | + | SDR16C5 | chr8 | 57213284 | + |
| intron-3UTR | ENST00000396799 | ENST00000396721 | ZNF384 | chr12 | 6776259 | + | SDR16C5 | chr8 | 57213284 | + |
| intron-intron | ENST00000396799 | ENST00000303749 | ZNF384 | chr12 | 6776259 | + | SDR16C5 | chr8 | 57213284 | + |
| intron-intron | ENST00000396799 | ENST00000522671 | ZNF384 | chr12 | 6776259 | + | SDR16C5 | chr8 | 57213284 | + |
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FusionProtFeatures for ZNF384_SDR16C5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZNF384 | SDR16C5 |
| Transcription factor that binds the consensus DNAsequence [GC]AAAAA. Seems to bind and regulate the promoters ofMMP1, MMP3, MMP7 and COL1A1 (By similarity). {ECO:0000250}. | Oxidoreductase with strong preference for NAD. Active inboth the oxidative and reductive directions. Oxidizes all-trans-retinol in all-trans-retinaldehyde. No activity was detected with11-cis-retinol or 11-cis-retinaldehyde as substrates with eitherNAD(+)/NADH or NADP(+)/NADPH. {ECO:0000269|PubMed:18926804}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF384_SDR16C5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZNF384_SDR16C5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF384_SDR16C5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF384_SDR16C5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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