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Fusion gene ID: 43239 |
FusionGeneSummary for ZNF345_TRIM21 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNF345_TRIM21 | Fusion gene ID: 43239 | Hgene | Tgene | Gene symbol | ZNF345 | TRIM21 | Gene ID | 25850 | 6737 |
| Gene name | zinc finger protein 345 | tripartite motif containing 21 | |
| Synonyms | HZF10 | RNF81|RO52|Ro/SSA|SSA|SSA1 | |
| Cytomap | 19q13.12 | 11p15.4 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein 345zinc finger protein HZF10 | E3 ubiquitin-protein ligase TRIM2152 kDa Ro protein52 kDa ribonucleoprotein autoantigen Ro/SS-ARING finger protein 81RING-type E3 ubiquitin transferase TRIM21SS-ASicca syndrome antigen ASjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoanti | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q14585 | P19474 | |
| Ensembl transtripts involved in fusion gene | ENST00000589046, ENST00000420450, ENST00000526123, ENST00000432005, ENST00000529555, | ENST00000254436, ENST00000543625, | |
| Fusion gene scores | * DoF score | 5 X 3 X 3=45 | 2 X 1 X 2=4 |
| # samples | 4 | 2 | |
| ** MAII score | log2(4/45*10)=-0.169925001442312 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: ZNF345 [Title/Abstract] AND TRIM21 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | TRIM21 | GO:0000209 | protein polyubiquitination | 16297862 |
| Tgene | TRIM21 | GO:0006513 | protein monoubiquitination | 16297862|19675099 |
| Tgene | TRIM21 | GO:0016567 | protein ubiquitination | 16472766|16880511|18845142 |
| Tgene | TRIM21 | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 19675099 |
| Tgene | TRIM21 | GO:0032897 | negative regulation of viral transcription | 18248090 |
| Tgene | TRIM21 | GO:0034341 | response to interferon-gamma | 26347139 |
| Tgene | TRIM21 | GO:0045087 | innate immune response | 18248090 |
| Tgene | TRIM21 | GO:0051091 | positive regulation of DNA binding transcription factor activity | 23077300 |
| Tgene | TRIM21 | GO:0051865 | protein autoubiquitination | 16880511 |
| Tgene | TRIM21 | GO:0070206 | protein trimerization | 17156811 |
| Tgene | TRIM21 | GO:1902187 | negative regulation of viral release from host cell | 18248090 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-EW-A1PB-01A | ZNF345 | chr19 | 37383887 | + | TRIM21 | chr11 | 4411688 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000589046 | ENST00000254436 | ZNF345 | chr19 | 37383887 | + | TRIM21 | chr11 | 4411688 | - |
| intron-5UTR | ENST00000589046 | ENST00000543625 | ZNF345 | chr19 | 37383887 | + | TRIM21 | chr11 | 4411688 | - |
| intron-5UTR | ENST00000420450 | ENST00000254436 | ZNF345 | chr19 | 37383887 | + | TRIM21 | chr11 | 4411688 | - |
| intron-5UTR | ENST00000420450 | ENST00000543625 | ZNF345 | chr19 | 37383887 | + | TRIM21 | chr11 | 4411688 | - |
| 5CDS-5UTR | ENST00000526123 | ENST00000254436 | ZNF345 | chr19 | 37383887 | + | TRIM21 | chr11 | 4411688 | - |
| 5CDS-5UTR | ENST00000526123 | ENST00000543625 | ZNF345 | chr19 | 37383887 | + | TRIM21 | chr11 | 4411688 | - |
| 3UTR-5UTR | ENST00000432005 | ENST00000254436 | ZNF345 | chr19 | 37383887 | + | TRIM21 | chr11 | 4411688 | - |
| 3UTR-5UTR | ENST00000432005 | ENST00000543625 | ZNF345 | chr19 | 37383887 | + | TRIM21 | chr11 | 4411688 | - |
| intron-5UTR | ENST00000529555 | ENST00000254436 | ZNF345 | chr19 | 37383887 | + | TRIM21 | chr11 | 4411688 | - |
| intron-5UTR | ENST00000529555 | ENST00000543625 | ZNF345 | chr19 | 37383887 | + | TRIM21 | chr11 | 4411688 | - |
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FusionProtFeatures for ZNF345_TRIM21 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZNF345 | TRIM21 |
| May be involved in transcriptional regulation. | E3 ubiquitin-protein ligase whose activity is dependenton E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms aubiquitin ligase complex in cooperation with the E2 UBE2D2 that isused not only for the ubiquitination of USP4 and IKBKB but alsofor its self-ubiquitination. Component of cullin-RING-based SCF(SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexessuch as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation bythe proteasome. Monoubiquitinates IKBKB that will negativelyregulates Tax-induced NF-kappa-B signaling. Negatively regulatesIFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediatedproteasomal degradation of IgG1 heavy chain, which is linked tothe VCP-mediated ER-associated degradation (ERAD) pathway.Promotes IRF8 ubiquitination, which enhanced the ability of IRF8to stimulate cytokine genes transcription in macrophages. Plays arole in the regulation of the cell cycle progression. Enhances thedecapping activity of DCP2. Exists as a ribonucleoprotein particlepresent in all mammalian cells studied and composed of a singlepolypeptide and one of four small RNA molecules. At least twoisoforms are present in nucleated and red blood cells, and tissuespecific differences in RO/SSA proteins have been identified. Thecommon feature of these proteins is their ability to bind HYRNAs.2. Involved in the regulation of innate immunity and theinflammatory response in response to IFNG/IFN-gamma. Organizesautophagic machinery by serving as a platform for the assembly ofULK1, Beclin 1/BECN1 and ATG8 family members and recognizesspecific autophagy targets, thus coordinating target recognitionwith assembly of the autophagic apparatus and initiation ofautophagy. Acts as an autophagy receptor for the degradation ofIRF3, hence attenuating type I interferon (IFN)-dependent immuneresponses (PubMed:26347139). {ECO:0000269|PubMed:16297862,ECO:0000269|PubMed:16316627, ECO:0000269|PubMed:16472766,ECO:0000269|PubMed:16880511, ECO:0000269|PubMed:18022694,ECO:0000269|PubMed:18361920, ECO:0000269|PubMed:18641315,ECO:0000269|PubMed:18845142, ECO:0000269|PubMed:19675099,ECO:0000269|PubMed:26347139}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF345_TRIM21 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZNF345_TRIM21 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ZNF345 | TRIM21 | NIF3L1, TRIM21, NCOA1, NCOA3, USP4, IRF8, USP19, SKP2, CUL1, SKP1, FBXW11, CDKN1B, APC, HDAC1, IRF3, FADD, AGO3, AGO4, IKBKB, HLA-DRB1, SQSTM1, YWHAG, YWHAZ, IRF7, ERG, DAXX, CASP8AP2, CDK2, ZFPM1, CD52, FCGR2A, TROVE2, IGHG1, TRIM5, DCP2, CBL, UBE2D1, UBE2H, UBE2D2, UBE2L3, UBE2C, CDC34, USP2, USP15, VCP, MYC, ROR1, IQCB1, UBC, NOS2, PAN2, NPM1, TRIM39, RNF111, DZIP3, TRIM27, RBCK1, MNAT1, TRIM8, FBXO6, HAUS2, UBE2I, GRAP, TXN2, IGHV4-31, IRF5, HIST1H3E, PFKFB2, ULK1, BECN1, MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1, GABARAPL2, GAN, PRMT5, IFI35, NMI, NF2, CDC5L, CALR, DPPA4, NANOG, GMPS, RC3H1, BAG6, CRBN, FAIM2, CYLD, G3BP1, DCAF4L2, HDAC6 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF345_TRIM21 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF345_TRIM21 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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