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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43234

FusionGeneSummary for ZNF343_PRPSAP2

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF343_PRPSAP2
Fusion gene ID: 43234
HgeneTgene
Gene symbol

ZNF343

PRPSAP2

Gene ID

79175

5636

Gene namezinc finger protein 343phosphoribosyl pyrophosphate synthetase associated protein 2
SynonymsdJ734P14.5PAP41
Cytomap

20p13

17p11.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 343phosphoribosyl pyrophosphate synthase-associated protein 241 kDa phosphoribosypyrophosphate synthetase-associated proteinPRPP synthase-associated protein 2
Modification date2018052320180523
UniProtAcc

Q6P1L6

O60256

Ensembl transtripts involved in fusion geneENST00000358413, ENST00000278772, 
ENST00000381253, 
ENST00000419071, 
ENST00000268835, ENST00000536323, 
ENST00000542013, ENST00000575337, 
Fusion gene scores* DoF score3 X 3 X 3=273 X 3 X 3=27
# samples 33
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZNF343 [Title/Abstract] AND PRPSAP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-97-A4LX-01AZNF343chr20

2489527

-PRPSAP2chr17

18827227

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000358413ENST00000419071ZNF343chr20

2489527

-PRPSAP2chr17

18827227

+
intron-3CDSENST00000358413ENST00000268835ZNF343chr20

2489527

-PRPSAP2chr17

18827227

+
intron-3CDSENST00000358413ENST00000536323ZNF343chr20

2489527

-PRPSAP2chr17

18827227

+
intron-3CDSENST00000358413ENST00000542013ZNF343chr20

2489527

-PRPSAP2chr17

18827227

+
intron-intronENST00000358413ENST00000575337ZNF343chr20

2489527

-PRPSAP2chr17

18827227

+
5UTR-3CDSENST00000278772ENST00000419071ZNF343chr20

2489527

-PRPSAP2chr17

18827227

+
5UTR-3CDSENST00000278772ENST00000268835ZNF343chr20

2489527

-PRPSAP2chr17

18827227

+
5UTR-3CDSENST00000278772ENST00000536323ZNF343chr20

2489527

-PRPSAP2chr17

18827227

+
5UTR-3CDSENST00000278772ENST00000542013ZNF343chr20

2489527

-PRPSAP2chr17

18827227

+
5UTR-intronENST00000278772ENST00000575337ZNF343chr20

2489527

-PRPSAP2chr17

18827227

+
5UTR-3CDSENST00000381253ENST00000419071ZNF343chr20

2489527

-PRPSAP2chr17

18827227

+
5UTR-3CDSENST00000381253ENST00000268835ZNF343chr20

2489527

-PRPSAP2chr17

18827227

+
5UTR-3CDSENST00000381253ENST00000536323ZNF343chr20

2489527

-PRPSAP2chr17

18827227

+
5UTR-3CDSENST00000381253ENST00000542013ZNF343chr20

2489527

-PRPSAP2chr17

18827227

+
5UTR-intronENST00000381253ENST00000575337ZNF343chr20

2489527

-PRPSAP2chr17

18827227

+

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FusionProtFeatures for ZNF343_PRPSAP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF343

Q6P1L6

PRPSAP2

O60256

May be involved in transcriptional regulation. Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF343_PRPSAP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF343_PRPSAP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF343APP, UBQLN1, MOV10PRPSAP2COPS5, DCUN1D1, APP, YWHAE, IQGAP1, ELP2, LRRC47, PSMD10, SNRPB2, CBL, MAST3, PRPS2, PRPS1, PRPSAP1, WHSC1, MTRF1L, NTRK1, UBXN1, IVNS1ABP, LZTR1, GALNT16, PRPS1L1, CCNB1, FNTB, NAPG, PRKAR1B, DOCK7, VTI1B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF343_PRPSAP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF343_PRPSAP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource