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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43212

FusionGeneSummary for ZNF329_EPG5

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF329_EPG5
Fusion gene ID: 43212
HgeneTgene
Gene symbol

ZNF329

EPG5

Gene ID

79673

57724

Gene namezinc finger protein 329ectopic P-granules autophagy protein 5 homolog
Synonyms-HEEW1|KIAA1632|VICIS
Cytomap

19q13.43

18q12.3-q21.1

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 329ectopic P granules protein 5 homolog
Modification date2018052320180523
UniProtAcc

Q86UD4

Q9HCE0

Ensembl transtripts involved in fusion geneENST00000598312, ENST00000358067, 
ENST00000282041, ENST00000585906, 
Fusion gene scores* DoF score3 X 3 X 3=273 X 3 X 3=27
# samples 33
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZNF329 [Title/Abstract] AND EPG5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLGGTCGA-E1-A7YL-01AZNF329chr19

58662119

-EPG5chr18

43532609

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000598312ENST00000282041ZNF329chr19

58662119

-EPG5chr18

43532609

-
5UTR-intronENST00000598312ENST00000585906ZNF329chr19

58662119

-EPG5chr18

43532609

-
intron-3CDSENST00000358067ENST00000282041ZNF329chr19

58662119

-EPG5chr18

43532609

-
intron-intronENST00000358067ENST00000585906ZNF329chr19

58662119

-EPG5chr18

43532609

-

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FusionProtFeatures for ZNF329_EPG5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF329

Q86UD4

EPG5

Q9HCE0

May be involved in transcriptional regulation. Involved in autophagy. May play a role in a late step ofautophagy, such as clearance of autophagosomal cargo.{ECO:0000269|PubMed:20550938, ECO:0000269|PubMed:23222957}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF329_EPG5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF329_EPG5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF329SMAD3, MEOX2, TRIM37, OPTN, MTUS2, CEP70, TRIM41, KRT40, KRTAP10-7, KRTAP10-1, KRTAP10-5EPG5TP53


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF329_EPG5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF329_EPG5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneEPG5C0021051Immunologic Deficiency Syndromes1CTD_human
TgeneEPG5C0162835Hypopigmentation disorder1CTD_human
TgeneEPG5C0878544Cardiomyopathies1CTD_human
TgeneEPG5C1855772Absent corpus callosum cataract immunodeficiency1CTD_human;ORPHANET;UNIPROT