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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 43195

FusionGeneSummary for ZNF318_CD2AP

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF318_CD2AP
Fusion gene ID: 43195
HgeneTgene
Gene symbol

ZNF318

CD2AP

Gene ID

24149

23607

Gene namezinc finger protein 318CD2 associated protein
SynonymsHRIHFB2436|TZF|ZFP318CMS
Cytomap

6p21.1

6p12.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 318endocrine regulatorendocrine regulatory proteintesticular zinc fingerCD2-associated proteinCas ligand with multiple Src homology 3 (SH3) domainsadapter protein CMScas ligand with multiple SH3 domains
Modification date2018051920180522
UniProtAcc

Q5VUA4

Q9Y5K6

Ensembl transtripts involved in fusion geneENST00000607252, ENST00000318149, 
ENST00000361428, 
ENST00000359314, 
ENST00000486693, 
Fusion gene scores* DoF score6 X 5 X 5=1507 X 7 X 5=245
# samples 77
** MAII scorelog2(7/150*10)=-1.09953567355091
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/245*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF318 [Title/Abstract] AND CD2AP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A3LU-01AZNF318chr6

43336705

-CD2APchr6

47548600

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000607252ENST00000359314ZNF318chr6

43336705

-CD2APchr6

47548600

+
intron-intronENST00000607252ENST00000486693ZNF318chr6

43336705

-CD2APchr6

47548600

+
In-frameENST00000318149ENST00000359314ZNF318chr6

43336705

-CD2APchr6

47548600

+
5CDS-intronENST00000318149ENST00000486693ZNF318chr6

43336705

-CD2APchr6

47548600

+
In-frameENST00000361428ENST00000359314ZNF318chr6

43336705

-CD2APchr6

47548600

+
5CDS-intronENST00000361428ENST00000486693ZNF318chr6

43336705

-CD2APchr6

47548600

+

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FusionProtFeatures for ZNF318_CD2AP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF318

Q5VUA4

CD2AP

Q9Y5K6

Isoform 2: Acts as a transcriptional corepressor for AR-mediated transactivation function. May act as a transcriptionalregulator during spermatogenesis and, in particular, duringmeiotic division. {ECO:0000250|UniProtKB:Q99PP2}. Isoform 1: Acts as a transcriptional coactivator for AR-mediated transactivation function. May act as a transcriptionalregulator during spermatogenesis and, in particular, duringmeiotic division. {ECO:0000250|UniProtKB:Q99PP2}. Seems to act as an adapter protein between membraneproteins and the actin cytoskeleton (PubMed:10339567). Incollaboration with CBLC, modulates the rate of RET turnover andmay act as regulatory checkpoint that limits the potency of GDNFon neuronal survival. Controls CBLC function, converting it froman inhibitor to a promoter of RET degradation (By similarity). Mayplay a role in receptor clustering and cytoskeletal polarity inthe junction between T-cell and antigen-presenting cell (Bysimilarity). May anchor the podocyte slit diaphragm to the actincytoskeleton in renal glomerolus. Also required for cytokinesis(PubMed:15800069). Plays a role in epithelial cell junctionsformation (PubMed:22891260). {ECO:0000250|UniProtKB:F1LRS8,ECO:0000250|UniProtKB:Q9JLQ0, ECO:0000269|PubMed:10339567,ECO:0000269|PubMed:15800069, ECO:0000269|PubMed:22891260}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF318_CD2AP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ZNF318_ENST00000318149_chr6_43336705_-_CD2AP_ENST00000359314_chr6_47548600_+_437aa
MYRSSARSSVSSHRPKDDGGGGPRSGRSSGSSSGPARRSSPPPPPSGSSSRTPARRPRSPSGHRGRRASPSPPRGRRVSPSPPRARRGSP
SPPRGRRLFPPGPAGFRGSSRGESRADTARDGRGDHPGDSGSRKPKKPPPPAKAPAPKPELIAAEKKTFSLKPEEKDEKSTLEQKPSKPA
APQVPPKKPTPPTKASNLLRSSGTVYPKRPEKPVPPPPPIAKINGEVSSISSKFETEPVSKLKLDSEQLPLRPKSVDFDSLTVRTSKETD
VVNFDDIASSENLLHLTANRPKMPGRRLPGRFNGGHSPTHSPEKILKLPKEEDSANLKPSELKKDTCYSPKPSVYLSTPSSASKANTTAF

>In-frame_ZNF318_ENST00000361428_chr6_43336705_-_CD2AP_ENST00000359314_chr6_47548600_+_437aa
MYRSSARSSVSSHRPKDDGGGGPRSGRSSGSSSGPARRSSPPPPPSGSSSRTPARRPRSPSGHRGRRASPSPPRGRRVSPSPPRARRGSP
SPPRGRRLFPPGPAGFRGSSRGESRADTARDGRGDHPGDSGSRKPKKPPPPAKAPAPKPELIAAEKKTFSLKPEEKDEKSTLEQKPSKPA
APQVPPKKPTPPTKASNLLRSSGTVYPKRPEKPVPPPPPIAKINGEVSSISSKFETEPVSKLKLDSEQLPLRPKSVDFDSLTVRTSKETD
VVNFDDIASSENLLHLTANRPKMPGRRLPGRFNGGHSPTHSPEKILKLPKEEDSANLKPSELKKDTCYSPKPSVYLSTPSSASKANTTAF


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ZNF318_ENST00000318149_chr6_43336705_-_CD2AP_ENST00000359314_chr6_47548600_+_1311nt
ATGTACCGCAGCAGCGCTCGCTCCTCCGTCTCTTCCCACCGGCCTAAAGACGACGGCGGGGGCGGCCCGCGCAGCGGCCGCAGCTCTGGC
TCCTCCTCAGGCCCGGCTCGCCGCAGCTCACCGCCGCCTCCGCCCTCCGGCTCCTCGTCGCGGACCCCGGCTCGCCGACCCCGCTCGCCC
TCAGGGCACCGCGGCCGCCGGGCCTCGCCGTCCCCGCCACGGGGTCGTCGCGTCTCCCCGTCCCCGCCTCGGGCCCGTCGCGGCTCCCCG
TCGCCACCGCGGGGCCGACGACTCTTCCCGCCGGGCCCGGCCGGCTTCAGAGGCAGCAGCCGGGGGGAGTCCCGCGCCGACTATGCCCGG
GACGGCCGCGGAGACCATCCAGGCGACAGCGGCAGCCGGAAACCAAAGAAACCACCACCTCCTGCTAAGGCTCCAGCTCCAAAGCCTGAA
CTGATAGCTGCAGAGAAGAAATATTTTTCTTTAAAGCCTGAAGAAAAGGATGAAAAATCAACACTGGAACAGAAACCTTCTAAACCAGCA
GCTCCACAAGTCCCACCCAAGAAACCTACTCCACCTACCAAAGCCAGTAATTTACTGAGATCTTCTGGAACAGTGTACCCAAAGCGACCT
GAAAAACCAGTTCCTCCACCACCTCCTATAGCCAAGATTAATGGGGAAGTTTCTAGCATTTCATCAAAATTTGAAACTGAGCCAGTATCA
AAACTAAAGCTAGATTCTGAACAGCTGCCCCTTAGACCAAAATCAGTAGACTTTGATTCACTTACAGTAAGGACCTCCAAAGAAACAGAT
GTTGTAAATTTTGATGACATAGCTTCCTCAGAAAACTTGCTTCATCTCACTGCAAATAGACCAAAGATGCCTGGAAGAAGGTTGCCGGGC
CGTTTCAATGGTGGACATTCTCCAACTCACAGCCCCGAAAAAATCTTGAAGTTACCAAAAGAAGAAGACAGTGCCAACCTGAAGCCATCT
GAATTAAAAAAAGATACATGCTACTCTCCAAAGCCATCTGTGTACCTTTCAACACCTTCCAGTGCTTCTAAAGCAAATACAACTGCTTTC
CTGACTCCATTAGAAATCAAAGCTAAAGTGGAAACAGATGATGTGAAAAAAAATTCCCTGGATGAACTTAGAGCCCAGATTATTGAATTG
TTGTGCATTGTAGAAGCACTGAAAAAGGATCACGGGAAAGAACTGGAAAAACTGCGAAAAGATTTGGAAGAAGAGAAGACAATGAGAAGT

>In-frame_ZNF318_ENST00000361428_chr6_43336705_-_CD2AP_ENST00000359314_chr6_47548600_+_1311nt
ATGTACCGCAGCAGCGCTCGCTCCTCCGTCTCTTCCCACCGGCCTAAAGACGACGGCGGGGGCGGCCCGCGCAGCGGCCGCAGCTCTGGC
TCCTCCTCAGGCCCGGCTCGCCGCAGCTCACCGCCGCCTCCGCCCTCCGGCTCCTCGTCGCGGACCCCGGCTCGCCGACCCCGCTCGCCC
TCAGGGCACCGCGGCCGCCGGGCCTCGCCGTCCCCGCCACGGGGTCGTCGCGTCTCCCCGTCCCCGCCTCGGGCCCGTCGCGGCTCCCCG
TCGCCACCGCGGGGCCGACGACTCTTCCCGCCGGGCCCGGCCGGCTTCAGAGGCAGCAGCCGGGGGGAGTCCCGCGCCGACTATGCCCGG
GACGGCCGCGGAGACCATCCAGGCGACAGCGGCAGCCGGAAACCAAAGAAACCACCACCTCCTGCTAAGGCTCCAGCTCCAAAGCCTGAA
CTGATAGCTGCAGAGAAGAAATATTTTTCTTTAAAGCCTGAAGAAAAGGATGAAAAATCAACACTGGAACAGAAACCTTCTAAACCAGCA
GCTCCACAAGTCCCACCCAAGAAACCTACTCCACCTACCAAAGCCAGTAATTTACTGAGATCTTCTGGAACAGTGTACCCAAAGCGACCT
GAAAAACCAGTTCCTCCACCACCTCCTATAGCCAAGATTAATGGGGAAGTTTCTAGCATTTCATCAAAATTTGAAACTGAGCCAGTATCA
AAACTAAAGCTAGATTCTGAACAGCTGCCCCTTAGACCAAAATCAGTAGACTTTGATTCACTTACAGTAAGGACCTCCAAAGAAACAGAT
GTTGTAAATTTTGATGACATAGCTTCCTCAGAAAACTTGCTTCATCTCACTGCAAATAGACCAAAGATGCCTGGAAGAAGGTTGCCGGGC
CGTTTCAATGGTGGACATTCTCCAACTCACAGCCCCGAAAAAATCTTGAAGTTACCAAAAGAAGAAGACAGTGCCAACCTGAAGCCATCT
GAATTAAAAAAAGATACATGCTACTCTCCAAAGCCATCTGTGTACCTTTCAACACCTTCCAGTGCTTCTAAAGCAAATACAACTGCTTTC
CTGACTCCATTAGAAATCAAAGCTAAAGTGGAAACAGATGATGTGAAAAAAAATTCCCTGGATGAACTTAGAGCCCAGATTATTGAATTG
TTGTGCATTGTAGAAGCACTGAAAAAGGATCACGGGAAAGAACTGGAAAAACTGCGAAAAGATTTGGAAGAAGAGAAGACAATGAGAAGT


* Fusion transcript sequences (Full-length transcript).
>In-frame_ZNF318_ENST00000318149_chr6_43336705_-_CD2AP_ENST00000359314_chr6_47548600_+_4425nt
CTGCGGCGGCGCGCTCCGAGCCTGCGTCTAGGGCGCCCCCGGGTCAGAGCTGTCGCCGTGGCCGCCGCTGCAAGAACCATGTACCGCAGC
AGCGCTCGCTCCTCCGTCTCTTCCCACCGGCCTAAAGACGACGGCGGGGGCGGCCCGCGCAGCGGCCGCAGCTCTGGCTCCTCCTCAGGC
CCGGCTCGCCGCAGCTCACCGCCGCCTCCGCCCTCCGGCTCCTCGTCGCGGACCCCGGCTCGCCGACCCCGCTCGCCCTCAGGGCACCGC
GGCCGCCGGGCCTCGCCGTCCCCGCCACGGGGTCGTCGCGTCTCCCCGTCCCCGCCTCGGGCCCGTCGCGGCTCCCCGTCGCCACCGCGG
GGCCGACGACTCTTCCCGCCGGGCCCGGCCGGCTTCAGAGGCAGCAGCCGGGGGGAGTCCCGCGCCGACTATGCCCGGGACGGCCGCGGA
GACCATCCAGGCGACAGCGGCAGCCGGAAACCAAAGAAACCACCACCTCCTGCTAAGGCTCCAGCTCCAAAGCCTGAACTGATAGCTGCA
GAGAAGAAATATTTTTCTTTAAAGCCTGAAGAAAAGGATGAAAAATCAACACTGGAACAGAAACCTTCTAAACCAGCAGCTCCACAAGTC
CCACCCAAGAAACCTACTCCACCTACCAAAGCCAGTAATTTACTGAGATCTTCTGGAACAGTGTACCCAAAGCGACCTGAAAAACCAGTT
CCTCCACCACCTCCTATAGCCAAGATTAATGGGGAAGTTTCTAGCATTTCATCAAAATTTGAAACTGAGCCAGTATCAAAACTAAAGCTA
GATTCTGAACAGCTGCCCCTTAGACCAAAATCAGTAGACTTTGATTCACTTACAGTAAGGACCTCCAAAGAAACAGATGTTGTAAATTTT
GATGACATAGCTTCCTCAGAAAACTTGCTTCATCTCACTGCAAATAGACCAAAGATGCCTGGAAGAAGGTTGCCGGGCCGTTTCAATGGT
GGACATTCTCCAACTCACAGCCCCGAAAAAATCTTGAAGTTACCAAAAGAAGAAGACAGTGCCAACCTGAAGCCATCTGAATTAAAAAAA
GATACATGCTACTCTCCAAAGCCATCTGTGTACCTTTCAACACCTTCCAGTGCTTCTAAAGCAAATACAACTGCTTTCCTGACTCCATTA
GAAATCAAAGCTAAAGTGGAAACAGATGATGTGAAAAAAAATTCCCTGGATGAACTTAGAGCCCAGATTATTGAATTGTTGTGCATTGTA
GAAGCACTGAAAAAGGATCACGGGAAAGAACTGGAAAAACTGCGAAAAGATTTGGAAGAAGAGAAGACAATGAGAAGTAATCTAGAGATG
GAAATAGAGAAGCTGAAAAAAGCTGTCCTGTCTTCTTGAGTGGTGTGGACCTGGTGTTCATAATGTTCCAGGGATTCAGAAGCAACGCTA
TGAACTTCAGCTGACTTGTTACTTAAAAATTGTGAATTCTGTTGTTGTGATAAATATGAGCAAATGAAGTGTAATATCTATAGAAAAGTA
GAGTGAGGGTGAATTTATATATATATTTTGTTTTGCCAATATGAAGAAAAAGAGGCCTTATTTCTTAACTGTGCTGGGATTGCAAACACT
TTTTAAAAAATTGTTTGCTTGAAAATACTACTGAATATAAATAAGAATGTGCACAGTAGTTTTTTTATTGAAACTTGTATTATTTTTAAA
GAGATCTATACTATAAATATGGTGATATATTTACAAGTAATCTGTTAAGATATACTATTTGAGAGGGACAGATTAGCCTTTTAGTAACTA
TAGTCACTACTTTTTCCATAATGCATAAGGGATATAAACTCTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATATAT
ATATATATATTTTTACTTTTATCCTCTTACCGAAGGTTACACTGTTGTGCCTGTTTGTCTGCAATGCTGTTTATATTTTGGGTGATGAAA
TAGGAGTTTCCTAGCTATATAAACCAGATTACTCACCCATGCATATAGTAAGAACTAATGAATAATCAAAATAATTTCATCAACTTTTAG
AATATTTTATGTTGCTTGCACTATAGGAGTCATAAAAGGAACTTAGTTAAAATATGTTGGATTGTTAAACATTTGGGGAAATATGAACTG
TATTTTAAATTTGTTAGGTCTGAAGAATCTAAAACTGTTAATTTAACCCTTAACTTGTGCCTAGAAACTACAGCACATATAAAATATGTA
AACACCAGCCTGTTGCTGTACTTTTCTGCTTATTTTACAGCCTCAAATATTTCTCATTATCTTGTCACTTAGTTCTTCATGTTTCTCCTT
CTGACTTTTAATAATGGTAATAGGAAAACAAAACCCAAAGCTTTTCAGAACTTCAGTGTGAGGTTTCCTATTTTGACAAGTTAACTTGTA
AATACTCAGGTTTTACGATGTATAATTTACCTAATAGACCAAACTAACTCATGGAGATATTTTGAACTATTATTTAGGTACAAACTTTAT
AAAGAATGTTAGTATGTCATAAAATATAACATTACAGCTTATTTAAAACCAAATATAGTTGAACATATTTAAAATACATTTTCACAGAAT
GGATGAATTAGTTGTTTCTTCAGAGTTACTTATGAACAGTTGAATGCTTTAAAATGTTCTGTCTGTAGGTAACATCTAAAACACAAGTGG
GTTTATTTAAATTTTTAAAATTTGAAATTTTTTATTTGCAAAAAATTGTTTTATGCTTTATTATATCGCAAATGAGTGTCAGATTTTTGA
GTACCAATGATCATGCTTCCATTTTTTTTAGTTTTAAACCACCAAACCAATATTTTTCCTTTAAATTTTAATCTTATAATATAGAAATCT
TATGTAAATGAAATTTTGTCATGTTTCAAATAAAGAGAACTGAAGTAGAAAATAGAAATGCCAGTAAACAACATAATGTTTAATTTACAA
CTTACATTAGGGGTTTGGGGGAATGCTAATTATATATTGAGAATATACATTAGAACTCTTCAAAATGGGCTCTTCTAATGAGGTCACTAC
TGAACAAAATTGTTCCCTCTTCTGTTAAATAGAATAGGTTTAAATGACTAGTCAAATGAATTATTTTCTTCTTGTTAAATAAATTAAATC
TTACTTTCTTTTAATGACCAACCTTAGGTAAAACAAAAATATTGTAATCCTAGAAATTATCCTCCAGCTTTCTCACCTGAAAATCTATTG
AAGTGATCCCTGGTCATCCTAATAATGGGATGAGGGAAGTTTCCAGCAGATTTCAGGCTGTTCTTAAAGTTTTTGTTGGTCATTTTCTCA
ATAGTACATGAAATCAAGATGCTTATGAGCATGGAAATGTATTTAAAGTTTTTGCTTGTGTCCTCCTCAGTCAGAATAGAAAAGTAACTG
AAATACTTTTACCTTTCTGTCCTTGATAAAATAGTAAAGAAAACCAAACAAACCCAGGCCTGATGGGAAAAATGATTCCTTTATTCTAGC
AACTTACTTTCTGTTGGTATGGGAAATGTTATTAATTTCTATTACTAAAGTTCATATCACAAAATGATATTTAATAATAACCTTGGGGTA
AATCATGAATTTTTTTTCTACGTGTGAGTATAAAAGACAAAAGTTGAACAGCATGGAATCTCATTGCCAAATTATTAGTGAATGTATAGT
TCAGGTATTCTTTGAGACACACAGTATCATTAATTTCTGAATTGTATTTCAGTGTTATTTTTTGTTTGTGACCACTAAGCTTCTGTCTTA
ATACAAAGCTGTTACCTTCTACAGAATTTAAGTCTGAAGATGTAAAGAGAGAACAGGCCTTGTGTAACAGAAGATACTCTTTTTTATGCT
CCTTACTGTGATCACAGAAAAATTAAAAATCCAAGTGCTCTCTAGATTTGTTGATAAACATTTTATGCTTGCATTTAAACTTGAAATGTA
TGAGCAGAATGAGACAATCAGTTAAATCAGAAATGAGAAGTATTATAATGTAAAGGCCTTGTTTTGCTGTAGCAATAAAATGACCAAGTG
CAATGACTTGATTTAATAAAATCATATTTTAAAAGTTGCTGCTATGAATATTTTTGGCTATAAAATTTTACCCTGACTTGCTTTCAATAA
CTGTTACGTAATGCAGTTGATGTTGTAACCTAACATTCCAAAAAAAAAATTGAGAGGGGGAATCTCAAAATAGTATATACTTCACTAACT
TGTTTACAGGTGCTGTATTTAAAAGCATGCTTCTCTCTCAAAAAGAAAAATTAAAGGATTTTATTGCCAGTCGTGTCAGTCTTTATTGGT
TATTTTTTGTTAACTTTAGCATTTGTGTATTTCAGAGTATGATGAAAATTATATTACTTCAATTTCCAAATACAAGAATAAATAGTAAAC

>In-frame_ZNF318_ENST00000361428_chr6_43336705_-_CD2AP_ENST00000359314_chr6_47548600_+_4425nt
CTGCGGCGGCGCGCTCCGAGCCTGCGTCTAGGGCGCCCCCGGGTCAGAGCTGTCGCCGTGGCCGCCGCTGCAAGAACCATGTACCGCAGC
AGCGCTCGCTCCTCCGTCTCTTCCCACCGGCCTAAAGACGACGGCGGGGGCGGCCCGCGCAGCGGCCGCAGCTCTGGCTCCTCCTCAGGC
CCGGCTCGCCGCAGCTCACCGCCGCCTCCGCCCTCCGGCTCCTCGTCGCGGACCCCGGCTCGCCGACCCCGCTCGCCCTCAGGGCACCGC
GGCCGCCGGGCCTCGCCGTCCCCGCCACGGGGTCGTCGCGTCTCCCCGTCCCCGCCTCGGGCCCGTCGCGGCTCCCCGTCGCCACCGCGG
GGCCGACGACTCTTCCCGCCGGGCCCGGCCGGCTTCAGAGGCAGCAGCCGGGGGGAGTCCCGCGCCGACTATGCCCGGGACGGCCGCGGA
GACCATCCAGGCGACAGCGGCAGCCGGAAACCAAAGAAACCACCACCTCCTGCTAAGGCTCCAGCTCCAAAGCCTGAACTGATAGCTGCA
GAGAAGAAATATTTTTCTTTAAAGCCTGAAGAAAAGGATGAAAAATCAACACTGGAACAGAAACCTTCTAAACCAGCAGCTCCACAAGTC
CCACCCAAGAAACCTACTCCACCTACCAAAGCCAGTAATTTACTGAGATCTTCTGGAACAGTGTACCCAAAGCGACCTGAAAAACCAGTT
CCTCCACCACCTCCTATAGCCAAGATTAATGGGGAAGTTTCTAGCATTTCATCAAAATTTGAAACTGAGCCAGTATCAAAACTAAAGCTA
GATTCTGAACAGCTGCCCCTTAGACCAAAATCAGTAGACTTTGATTCACTTACAGTAAGGACCTCCAAAGAAACAGATGTTGTAAATTTT
GATGACATAGCTTCCTCAGAAAACTTGCTTCATCTCACTGCAAATAGACCAAAGATGCCTGGAAGAAGGTTGCCGGGCCGTTTCAATGGT
GGACATTCTCCAACTCACAGCCCCGAAAAAATCTTGAAGTTACCAAAAGAAGAAGACAGTGCCAACCTGAAGCCATCTGAATTAAAAAAA
GATACATGCTACTCTCCAAAGCCATCTGTGTACCTTTCAACACCTTCCAGTGCTTCTAAAGCAAATACAACTGCTTTCCTGACTCCATTA
GAAATCAAAGCTAAAGTGGAAACAGATGATGTGAAAAAAAATTCCCTGGATGAACTTAGAGCCCAGATTATTGAATTGTTGTGCATTGTA
GAAGCACTGAAAAAGGATCACGGGAAAGAACTGGAAAAACTGCGAAAAGATTTGGAAGAAGAGAAGACAATGAGAAGTAATCTAGAGATG
GAAATAGAGAAGCTGAAAAAAGCTGTCCTGTCTTCTTGAGTGGTGTGGACCTGGTGTTCATAATGTTCCAGGGATTCAGAAGCAACGCTA
TGAACTTCAGCTGACTTGTTACTTAAAAATTGTGAATTCTGTTGTTGTGATAAATATGAGCAAATGAAGTGTAATATCTATAGAAAAGTA
GAGTGAGGGTGAATTTATATATATATTTTGTTTTGCCAATATGAAGAAAAAGAGGCCTTATTTCTTAACTGTGCTGGGATTGCAAACACT
TTTTAAAAAATTGTTTGCTTGAAAATACTACTGAATATAAATAAGAATGTGCACAGTAGTTTTTTTATTGAAACTTGTATTATTTTTAAA
GAGATCTATACTATAAATATGGTGATATATTTACAAGTAATCTGTTAAGATATACTATTTGAGAGGGACAGATTAGCCTTTTAGTAACTA
TAGTCACTACTTTTTCCATAATGCATAAGGGATATAAACTCTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATATAT
ATATATATATTTTTACTTTTATCCTCTTACCGAAGGTTACACTGTTGTGCCTGTTTGTCTGCAATGCTGTTTATATTTTGGGTGATGAAA
TAGGAGTTTCCTAGCTATATAAACCAGATTACTCACCCATGCATATAGTAAGAACTAATGAATAATCAAAATAATTTCATCAACTTTTAG
AATATTTTATGTTGCTTGCACTATAGGAGTCATAAAAGGAACTTAGTTAAAATATGTTGGATTGTTAAACATTTGGGGAAATATGAACTG
TATTTTAAATTTGTTAGGTCTGAAGAATCTAAAACTGTTAATTTAACCCTTAACTTGTGCCTAGAAACTACAGCACATATAAAATATGTA
AACACCAGCCTGTTGCTGTACTTTTCTGCTTATTTTACAGCCTCAAATATTTCTCATTATCTTGTCACTTAGTTCTTCATGTTTCTCCTT
CTGACTTTTAATAATGGTAATAGGAAAACAAAACCCAAAGCTTTTCAGAACTTCAGTGTGAGGTTTCCTATTTTGACAAGTTAACTTGTA
AATACTCAGGTTTTACGATGTATAATTTACCTAATAGACCAAACTAACTCATGGAGATATTTTGAACTATTATTTAGGTACAAACTTTAT
AAAGAATGTTAGTATGTCATAAAATATAACATTACAGCTTATTTAAAACCAAATATAGTTGAACATATTTAAAATACATTTTCACAGAAT
GGATGAATTAGTTGTTTCTTCAGAGTTACTTATGAACAGTTGAATGCTTTAAAATGTTCTGTCTGTAGGTAACATCTAAAACACAAGTGG
GTTTATTTAAATTTTTAAAATTTGAAATTTTTTATTTGCAAAAAATTGTTTTATGCTTTATTATATCGCAAATGAGTGTCAGATTTTTGA
GTACCAATGATCATGCTTCCATTTTTTTTAGTTTTAAACCACCAAACCAATATTTTTCCTTTAAATTTTAATCTTATAATATAGAAATCT
TATGTAAATGAAATTTTGTCATGTTTCAAATAAAGAGAACTGAAGTAGAAAATAGAAATGCCAGTAAACAACATAATGTTTAATTTACAA
CTTACATTAGGGGTTTGGGGGAATGCTAATTATATATTGAGAATATACATTAGAACTCTTCAAAATGGGCTCTTCTAATGAGGTCACTAC
TGAACAAAATTGTTCCCTCTTCTGTTAAATAGAATAGGTTTAAATGACTAGTCAAATGAATTATTTTCTTCTTGTTAAATAAATTAAATC
TTACTTTCTTTTAATGACCAACCTTAGGTAAAACAAAAATATTGTAATCCTAGAAATTATCCTCCAGCTTTCTCACCTGAAAATCTATTG
AAGTGATCCCTGGTCATCCTAATAATGGGATGAGGGAAGTTTCCAGCAGATTTCAGGCTGTTCTTAAAGTTTTTGTTGGTCATTTTCTCA
ATAGTACATGAAATCAAGATGCTTATGAGCATGGAAATGTATTTAAAGTTTTTGCTTGTGTCCTCCTCAGTCAGAATAGAAAAGTAACTG
AAATACTTTTACCTTTCTGTCCTTGATAAAATAGTAAAGAAAACCAAACAAACCCAGGCCTGATGGGAAAAATGATTCCTTTATTCTAGC
AACTTACTTTCTGTTGGTATGGGAAATGTTATTAATTTCTATTACTAAAGTTCATATCACAAAATGATATTTAATAATAACCTTGGGGTA
AATCATGAATTTTTTTTCTACGTGTGAGTATAAAAGACAAAAGTTGAACAGCATGGAATCTCATTGCCAAATTATTAGTGAATGTATAGT
TCAGGTATTCTTTGAGACACACAGTATCATTAATTTCTGAATTGTATTTCAGTGTTATTTTTTGTTTGTGACCACTAAGCTTCTGTCTTA
ATACAAAGCTGTTACCTTCTACAGAATTTAAGTCTGAAGATGTAAAGAGAGAACAGGCCTTGTGTAACAGAAGATACTCTTTTTTATGCT
CCTTACTGTGATCACAGAAAAATTAAAAATCCAAGTGCTCTCTAGATTTGTTGATAAACATTTTATGCTTGCATTTAAACTTGAAATGTA
TGAGCAGAATGAGACAATCAGTTAAATCAGAAATGAGAAGTATTATAATGTAAAGGCCTTGTTTTGCTGTAGCAATAAAATGACCAAGTG
CAATGACTTGATTTAATAAAATCATATTTTAAAAGTTGCTGCTATGAATATTTTTGGCTATAAAATTTTACCCTGACTTGCTTTCAATAA
CTGTTACGTAATGCAGTTGATGTTGTAACCTAACATTCCAAAAAAAAAATTGAGAGGGGGAATCTCAAAATAGTATATACTTCACTAACT
TGTTTACAGGTGCTGTATTTAAAAGCATGCTTCTCTCTCAAAAAGAAAAATTAAAGGATTTTATTGCCAGTCGTGTCAGTCTTTATTGGT
TATTTTTTGTTAACTTTAGCATTTGTGTATTTCAGAGTATGATGAAAATTATATTACTTCAATTTCCAAATACAAGAATAAATAGTAAAC


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FusionGenePPI for ZNF318_CD2AP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF318AR, HDAC2, SIRT7, ISG15, PPP1CC, MMS19, MDM2, CCDC8, FBL, CARD8, FAM160B2, PNMA1, LIPH, MIER2, ZBTB46, B9D2, RPGRIP1L, DYNLT1, AP4M1, SGTB, MCM2, SIRT6, CDC16, NCAPH2, IL17RA, C6orf141, BAG4, CCBL1, CELA1, APOBEC3D, PRPF39, ASB3, P4HA3, CPNE2, AP1G2, CORO6CD2APRAB4A, CBL, CD2, CAPZA1, CD2AP, NPHS2, BCAR1, MVB12A, SH3KBP1, NPHS1, NR4A1, NR2C2, HBP1, HOXC11, KHDRBS1, BLNK, TRA, PDCD6IP, ACTC1, CBLB, CTTN, EGFR, SH3GL2, DNM2, TSG101, INPP5D, CAPZB, CBLC, ARHGAP17, CAPZA2, MORF4L1P2, SH3BP1, GRB2, NRAS, VCAM1, ITGA4, LMNA, PTGES3, UBC, GZMB, LOX, ARHGEF10, BRCC3, CCDC6, ELP2, SPAG9, HNRNPR, HUWE1, MTA2, NR3C1, IKBKAP, KIAA0196, KIAA1033, LARP7, NOLC1, NRBP1, RABEP2, TSC22D1, USP34, WDHD1, FRS3, UBE2I, SLC25A41, STAP1, TAS2R7, ASNS, CSTF2, DPH5, GALE, IMPDH2, MSN, NPLOC4, PFDN2, PPA2, PRDX6, SCPEP1, SEC24C, SEC24D, TTC27, UFD1L, ZYX, NIT1, MED4, RPGRIP1L, KIF23, ATP6AP2, RACGAP1, KIF15, NF2, CDH1, TCP10L, ARHGAP44, MRPL12, DACH2, SETX, UBE2A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF318_CD2AP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF318_CD2AP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCD2APC0002395Alzheimer's Disease2CTD_human