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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43183

FusionGeneSummary for ZNF292_GRM4

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF292_GRM4
Fusion gene ID: 43183
HgeneTgene
Gene symbol

ZNF292

GRM4

Gene ID

23036

2914

Gene namezinc finger protein 292glutamate metabotropic receptor 4
SynonymsNbla00365|ZFP292|ZN-16|Zn-15|bA393I2.3GPRC1D|MGLUR4|mGlu4
Cytomap

6q14.3

6p21.31

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 29216 zinc-finger domain proteinputative protein product of Nbla00365metabotropic glutamate receptor 4glutamate receptor, metabotropic 4
Modification date2018051920180523
UniProtAcc

O60281

Q14833

Ensembl transtripts involved in fusion geneENST00000369577, ENST00000339907, 
ENST00000392985, ENST00000369578, 
ENST00000538487, ENST00000374181, 
ENST00000374177, ENST00000544773, 
ENST00000545715, ENST00000535756, 
ENST00000609222, ENST00000455714, 
Fusion gene scores* DoF score11 X 2 X 7=1545 X 5 X 4=100
# samples 126
** MAII scorelog2(12/154*10)=-0.359895945086383
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF292 [Title/Abstract] AND GRM4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGRM4

GO:0000187

activation of MAPK activity

15102938


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-TM-A7CF-01AZNF292chr6

87865477

+GRM4chr6

34101636

-
TCGARVLGGTCGA-TM-A7CF-02AZNF292chr6

87865477

+GRM4chr6

34101636

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000369577ENST00000538487ZNF292chr6

87865477

+GRM4chr6

34101636

-
5CDS-intronENST00000369577ENST00000374181ZNF292chr6

87865477

+GRM4chr6

34101636

-
5CDS-intronENST00000369577ENST00000374177ZNF292chr6

87865477

+GRM4chr6

34101636

-
5CDS-intronENST00000369577ENST00000544773ZNF292chr6

87865477

+GRM4chr6

34101636

-
5CDS-intronENST00000369577ENST00000545715ZNF292chr6

87865477

+GRM4chr6

34101636

-
5CDS-intronENST00000369577ENST00000535756ZNF292chr6

87865477

+GRM4chr6

34101636

-
5CDS-intronENST00000369577ENST00000609222ZNF292chr6

87865477

+GRM4chr6

34101636

-
5CDS-intronENST00000369577ENST00000455714ZNF292chr6

87865477

+GRM4chr6

34101636

-
5CDS-5UTRENST00000339907ENST00000538487ZNF292chr6

87865477

+GRM4chr6

34101636

-
5CDS-intronENST00000339907ENST00000374181ZNF292chr6

87865477

+GRM4chr6

34101636

-
5CDS-intronENST00000339907ENST00000374177ZNF292chr6

87865477

+GRM4chr6

34101636

-
5CDS-intronENST00000339907ENST00000544773ZNF292chr6

87865477

+GRM4chr6

34101636

-
5CDS-intronENST00000339907ENST00000545715ZNF292chr6

87865477

+GRM4chr6

34101636

-
5CDS-intronENST00000339907ENST00000535756ZNF292chr6

87865477

+GRM4chr6

34101636

-
5CDS-intronENST00000339907ENST00000609222ZNF292chr6

87865477

+GRM4chr6

34101636

-
5CDS-intronENST00000339907ENST00000455714ZNF292chr6

87865477

+GRM4chr6

34101636

-
5CDS-5UTRENST00000392985ENST00000538487ZNF292chr6

87865477

+GRM4chr6

34101636

-
5CDS-intronENST00000392985ENST00000374181ZNF292chr6

87865477

+GRM4chr6

34101636

-
5CDS-intronENST00000392985ENST00000374177ZNF292chr6

87865477

+GRM4chr6

34101636

-
5CDS-intronENST00000392985ENST00000544773ZNF292chr6

87865477

+GRM4chr6

34101636

-
5CDS-intronENST00000392985ENST00000545715ZNF292chr6

87865477

+GRM4chr6

34101636

-
5CDS-intronENST00000392985ENST00000535756ZNF292chr6

87865477

+GRM4chr6

34101636

-
5CDS-intronENST00000392985ENST00000609222ZNF292chr6

87865477

+GRM4chr6

34101636

-
5CDS-intronENST00000392985ENST00000455714ZNF292chr6

87865477

+GRM4chr6

34101636

-
3UTR-5UTRENST00000369578ENST00000538487ZNF292chr6

87865477

+GRM4chr6

34101636

-
3UTR-intronENST00000369578ENST00000374181ZNF292chr6

87865477

+GRM4chr6

34101636

-
3UTR-intronENST00000369578ENST00000374177ZNF292chr6

87865477

+GRM4chr6

34101636

-
3UTR-intronENST00000369578ENST00000544773ZNF292chr6

87865477

+GRM4chr6

34101636

-
3UTR-intronENST00000369578ENST00000545715ZNF292chr6

87865477

+GRM4chr6

34101636

-
3UTR-intronENST00000369578ENST00000535756ZNF292chr6

87865477

+GRM4chr6

34101636

-
3UTR-intronENST00000369578ENST00000609222ZNF292chr6

87865477

+GRM4chr6

34101636

-
3UTR-intronENST00000369578ENST00000455714ZNF292chr6

87865477

+GRM4chr6

34101636

-

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FusionProtFeatures for ZNF292_GRM4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF292

O60281

GRM4

Q14833

May be involved in transcriptional regulation. G-protein coupled receptor for glutamate. Ligand bindingcauses a conformation change that triggers signaling via guaninenucleotide-binding proteins (G proteins) and modulates theactivity of down-stream effectors. Signaling inhibits adenylatecyclase activity. {ECO:0000269|PubMed:7617140,ECO:0000269|PubMed:8738157, ECO:0000269|PubMed:9473604}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF292_GRM4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF292_GRM4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF292ALB, SLAMF1, P4HB, YEATS4, NEDD1GRM4EGFR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF292_GRM4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneGRM4Q14833DB00142Glutamic AcidMetabotropic glutamate receptor 4small moleculeapproved|nutraceutical

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RelatedDiseases for ZNF292_GRM4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneZNF292C0009404Colorectal Neoplasms1CTD_human
TgeneGRM4C0036341Schizophrenia3PSYGENET
TgeneGRM4C0005586Bipolar Disorder2PSYGENET
TgeneGRM4C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneGRM4C0014556Epilepsy, Temporal Lobe1CTD_human
TgeneGRM4C0027746Nerve Degeneration1CTD_human
TgeneGRM4C0029463Osteosarcoma1CTD_human