FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 43172

FusionGeneSummary for ZNF283_DPRX

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF283_DPRX
Fusion gene ID: 43172
HgeneTgene
Gene symbol

ZNF283

DPRX

Gene ID

284349

503834

Gene namezinc finger protein 283divergent-paired related homeobox
SynonymsHZF19|HZF41-
Cytomap

19q13.31

19q13.42

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 283zinc finger protein 41zinc finger protein HZF19divergent paired-related homeobox
Modification date2018052220180403
UniProtAcc

Q8N7M2

A6NFQ7

Ensembl transtripts involved in fusion geneENST00000324461, ENST00000588797, 
ENST00000586976, ENST00000590950, 
ENST00000593268, ENST00000593164, 
ENST00000310738, 
ENST00000376650, 
Fusion gene scores* DoF score3 X 3 X 3=273 X 2 X 3=18
# samples 33
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZNF283 [Title/Abstract] AND DPRX [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTranscription factor involved fusion gene, inframe and retained DNA-binding domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-D3-A3CC-06AZNF283chr19

44341331

+DPRXchr19

54137785

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000324461ENST00000376650ZNF283chr19

44341331

+DPRXchr19

54137785

+
intron-3CDSENST00000588797ENST00000376650ZNF283chr19

44341331

+DPRXchr19

54137785

+
3UTR-3CDSENST00000586976ENST00000376650ZNF283chr19

44341331

+DPRXchr19

54137785

+
intron-3CDSENST00000590950ENST00000376650ZNF283chr19

44341331

+DPRXchr19

54137785

+
intron-3CDSENST00000593268ENST00000376650ZNF283chr19

44341331

+DPRXchr19

54137785

+
Frame-shiftENST00000593164ENST00000376650ZNF283chr19

44341331

+DPRXchr19

54137785

+
Frame-shiftENST00000310738ENST00000376650ZNF283chr19

44341331

+DPRXchr19

54137785

+

Top

FusionProtFeatures for ZNF283_DPRX


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF283

Q8N7M2

DPRX

A6NFQ7

May be involved in transcriptional regulation. Putative transcription factor. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDPRXchr19:44341331chr19:54137785ENST00000376650+0316_759192DNA bindingHomeobox

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF283chr19:44341331chr19:54137785ENST00000324461+6773_152112680DomainKRAB
HgeneZNF283chr19:44341331chr19:54137785ENST00000324461+67205_227112680Zinc fingerC2H2-type 1
HgeneZNF283chr19:44341331chr19:54137785ENST00000324461+67233_255112680Zinc fingerC2H2-type 2
HgeneZNF283chr19:44341331chr19:54137785ENST00000324461+67261_283112680Zinc fingerC2H2-type 3
HgeneZNF283chr19:44341331chr19:54137785ENST00000324461+67289_311112680Zinc fingerC2H2-type 4
HgeneZNF283chr19:44341331chr19:54137785ENST00000324461+67317_339112680Zinc fingerC2H2-type 5
HgeneZNF283chr19:44341331chr19:54137785ENST00000324461+67345_367112680Zinc fingerC2H2-type 6
HgeneZNF283chr19:44341331chr19:54137785ENST00000324461+67373_395112680Zinc fingerC2H2-type 7
HgeneZNF283chr19:44341331chr19:54137785ENST00000324461+67401_423112680Zinc fingerC2H2-type 8
HgeneZNF283chr19:44341331chr19:54137785ENST00000324461+67429_451112680Zinc fingerC2H2-type 9
HgeneZNF283chr19:44341331chr19:54137785ENST00000324461+67457_479112680Zinc fingerC2H2-type 10
HgeneZNF283chr19:44341331chr19:54137785ENST00000324461+67485_507112680Zinc fingerC2H2-type 11
HgeneZNF283chr19:44341331chr19:54137785ENST00000324461+67513_535112680Zinc fingerC2H2-type 12
HgeneZNF283chr19:44341331chr19:54137785ENST00000324461+67541_563112680Zinc fingerC2H2-type 13
HgeneZNF283chr19:44341331chr19:54137785ENST00000324461+67569_591112680Zinc fingerC2H2-type 14
HgeneZNF283chr19:44341331chr19:54137785ENST00000324461+67597_619112680Zinc fingerC2H2-type 15


Top

FusionGeneSequence for ZNF283_DPRX


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ZNF283_ENST00000324461_chr19_44341331_+_DPRX_ENST00000376650_chr19_54137785_+_295aa
MESRSVAQAGVQWCDLGSLQAPPPGFTLFSCLSLLSSWDYSSGFSGFCASPIEESHGALISSCNSRTMTDGLVTFRDVAIDFSQEEWECL
DPAQRDLYVDVMLENYSNLVSLGKDQMHSHRKRTMFTKKQLEDLNILFNENPYPNPSLQKEMASKIDIHPTVLQVWFKNHRAKLKKAKCK
HIHQKQETPQPPIPEGGVSTSVGLRNADTLPRLPNAAHPIGLVYTGHRVPSFQLILYPNLKVPANDFIGHRIVHFGCCRDPNIYCLYPIL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ZNF283_ENST00000324461_chr19_44341331_+_DPRX_ENST00000376650_chr19_54137785_+_885nt
ATGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGCGATCTTGGCTCACTGCAAGCTCCGCCTCCTGGGTTCACGCTATTCTCC
TGCCTCAGCCTCCTGAGTAGCTGGGACTACAGTTCTGGCTTTTCTGGATTCTGTGCTTCACCAATAGAGGAATCCCATGGAGCATTAATT
AGTTCTTGCAATTCCAGAACCATGACTGATGGGTTGGTGACATTCAGGGATGTGGCCATCGACTTCTCTCAGGAGGAGTGGGAATGCCTG
GACCCTGCTCAGAGGGACTTGTACGTGGATGTAATGTTGGAGAACTATAGTAACTTGGTGTCACTGGGCAAGGACCAGATGCATTCACAC
AGGAAACGAACCATGTTCACTAAGAAGCAACTGGAAGATCTGAACATCTTGTTCAATGAGAACCCATACCCAAACCCCAGCCTTCAGAAA
GAAATGGCCTCGAAAATAGACATACACCCAACAGTACTGCAGGTCTGGTTCAAGAATCACAGAGCAAAACTCAAGAAAGCGAAATGCAAG
CATATTCATCAAAAACAAGAAACTCCACAACCGCCAATACCAGAGGGTGGGGTCTCCACCAGTGTCGGCCTGAGAAATGCAGACACACTA
CCCAGATTGCCCAACGCTGCTCACCCGATCGGCCTGGTGTACACGGGTCATCGAGTCCCCTCATTCCAGCTCATCCTGTACCCCAACCTC
AAGGTCCCTGCAAATGACTTCATTGGCCACAGAATAGTCCATTTTGGCTGCTGCCGAGATCCTAATATATACTGCCTCTACCCCATTTTG


* Fusion transcript sequences (Full-length transcript).
>In-frame_ZNF283_ENST00000324461_chr19_44341331_+_DPRX_ENST00000376650_chr19_54137785_+_1203nt
CTTTTAGGGGCGGGGCGAGCTTGCCTGCCAGAAGCTCCTCTCCCAGCCTGCGAGCATTTCCAGGCTCTTGTTTCCCATCAGCCTCTGGGT
CCAAACTAACCACAGGTCTCTGGGTCCTTTTCCGGTGTCCTTAAGGTTCTTGGACTCTGCATGTGCTGCCAGGTTGCCAGATTTCTAAGA
AGGAGTTTGAAGAGGAGAAAAGGATTTTTGCATGTTTAGAAATCAAGGTTCAGGAGAATCTTGACAGTGAATGTGTCTCATTACATTGAA
TAACAGCTACAGGATGTTCGAGAGCTGATGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGCGATCTTGGCTCACTGCAAGCT
CCGCCTCCTGGGTTCACGCTATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGTTCTGGCTTTTCTGGATTCTGTGCTTCACCA
ATAGAGGAATCCCATGGAGCATTAATTAGTTCTTGCAATTCCAGAACCATGACTGATGGGTTGGTGACATTCAGGGATGTGGCCATCGAC
TTCTCTCAGGAGGAGTGGGAATGCCTGGACCCTGCTCAGAGGGACTTGTACGTGGATGTAATGTTGGAGAACTATAGTAACTTGGTGTCA
CTGGGCAAGGACCAGATGCATTCACACAGGAAACGAACCATGTTCACTAAGAAGCAACTGGAAGATCTGAACATCTTGTTCAATGAGAAC
CCATACCCAAACCCCAGCCTTCAGAAAGAAATGGCCTCGAAAATAGACATACACCCAACAGTACTGCAGGTCTGGTTCAAGAATCACAGA
GCAAAACTCAAGAAAGCGAAATGCAAGCATATTCATCAAAAACAAGAAACTCCACAACCGCCAATACCAGAGGGTGGGGTCTCCACCAGT
GTCGGCCTGAGAAATGCAGACACACTACCCAGATTGCCCAACGCTGCTCACCCGATCGGCCTGGTGTACACGGGTCATCGAGTCCCCTCA
TTCCAGCTCATCCTGTACCCCAACCTCAAGGTCCCTGCAAATGACTTCATTGGCCACAGAATAGTCCATTTTGGCTGCTGCCGAGATCCT
AATATATACTGCCTCTACCCCATTTTGGAATCCCAAGTTTGCGCTCCAAGCTTCCATTCTGGCTCTCCTGCCTGTTCATCTAACCAAAGT


Top

FusionGenePPI for ZNF283_DPRX


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF283DPRX


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ZNF283_DPRX


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ZNF283_DPRX


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource