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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43166

FusionGeneSummary for ZNF280D_RNF111

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF280D_RNF111
Fusion gene ID: 43166
HgeneTgene
Gene symbol

ZNF280D

RNF111

Gene ID

54816

54778

Gene namezinc finger protein 280Dring finger protein 111
SynonymsSUHW4|ZNF634ARK|hRNF111
Cytomap

15q21.3

15q22.1-q22.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 280Dsuppressor of hairy wing homolog 4zinc finger protein 634E3 ubiquitin-protein ligase ArkadiaArkadiaRING-type E3 ubiquitin transferase Arkadia
Modification date2018052320180523
UniProtAcc

Q6N043

Q6ZNA4

Ensembl transtripts involved in fusion geneENST00000559237, ENST00000267807, 
ENST00000559000, ENST00000396245, 
ENST00000558320, ENST00000561122, 
ENST00000348370, ENST00000434298, 
ENST00000559209, ENST00000557998, 
ENST00000561186, ENST00000560080, 
Fusion gene scores* DoF score3 X 3 X 3=277 X 6 X 5=210
# samples 37
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF280D [Title/Abstract] AND RNF111 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-EW-A423-01AZNF280Dchr15

56935150

-RNF111chr15

59384736

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000559237ENST00000348370ZNF280Dchr15

56935150

-RNF111chr15

59384736

+
Frame-shiftENST00000559237ENST00000434298ZNF280Dchr15

56935150

-RNF111chr15

59384736

+
Frame-shiftENST00000559237ENST00000559209ZNF280Dchr15

56935150

-RNF111chr15

59384736

+
Frame-shiftENST00000559237ENST00000557998ZNF280Dchr15

56935150

-RNF111chr15

59384736

+
Frame-shiftENST00000559237ENST00000561186ZNF280Dchr15

56935150

-RNF111chr15

59384736

+
5CDS-intronENST00000559237ENST00000560080ZNF280Dchr15

56935150

-RNF111chr15

59384736

+
Frame-shiftENST00000267807ENST00000348370ZNF280Dchr15

56935150

-RNF111chr15

59384736

+
Frame-shiftENST00000267807ENST00000434298ZNF280Dchr15

56935150

-RNF111chr15

59384736

+
Frame-shiftENST00000267807ENST00000559209ZNF280Dchr15

56935150

-RNF111chr15

59384736

+
Frame-shiftENST00000267807ENST00000557998ZNF280Dchr15

56935150

-RNF111chr15

59384736

+
Frame-shiftENST00000267807ENST00000561186ZNF280Dchr15

56935150

-RNF111chr15

59384736

+
5CDS-intronENST00000267807ENST00000560080ZNF280Dchr15

56935150

-RNF111chr15

59384736

+
intron-3CDSENST00000559000ENST00000348370ZNF280Dchr15

56935150

-RNF111chr15

59384736

+
intron-3CDSENST00000559000ENST00000434298ZNF280Dchr15

56935150

-RNF111chr15

59384736

+
intron-3CDSENST00000559000ENST00000559209ZNF280Dchr15

56935150

-RNF111chr15

59384736

+
intron-3CDSENST00000559000ENST00000557998ZNF280Dchr15

56935150

-RNF111chr15

59384736

+
intron-3CDSENST00000559000ENST00000561186ZNF280Dchr15

56935150

-RNF111chr15

59384736

+
intron-intronENST00000559000ENST00000560080ZNF280Dchr15

56935150

-RNF111chr15

59384736

+
intron-3CDSENST00000396245ENST00000348370ZNF280Dchr15

56935150

-RNF111chr15

59384736

+
intron-3CDSENST00000396245ENST00000434298ZNF280Dchr15

56935150

-RNF111chr15

59384736

+
intron-3CDSENST00000396245ENST00000559209ZNF280Dchr15

56935150

-RNF111chr15

59384736

+
intron-3CDSENST00000396245ENST00000557998ZNF280Dchr15

56935150

-RNF111chr15

59384736

+
intron-3CDSENST00000396245ENST00000561186ZNF280Dchr15

56935150

-RNF111chr15

59384736

+
intron-intronENST00000396245ENST00000560080ZNF280Dchr15

56935150

-RNF111chr15

59384736

+
intron-3CDSENST00000558320ENST00000348370ZNF280Dchr15

56935150

-RNF111chr15

59384736

+
intron-3CDSENST00000558320ENST00000434298ZNF280Dchr15

56935150

-RNF111chr15

59384736

+
intron-3CDSENST00000558320ENST00000559209ZNF280Dchr15

56935150

-RNF111chr15

59384736

+
intron-3CDSENST00000558320ENST00000557998ZNF280Dchr15

56935150

-RNF111chr15

59384736

+
intron-3CDSENST00000558320ENST00000561186ZNF280Dchr15

56935150

-RNF111chr15

59384736

+
intron-intronENST00000558320ENST00000560080ZNF280Dchr15

56935150

-RNF111chr15

59384736

+
intron-3CDSENST00000561122ENST00000348370ZNF280Dchr15

56935150

-RNF111chr15

59384736

+
intron-3CDSENST00000561122ENST00000434298ZNF280Dchr15

56935150

-RNF111chr15

59384736

+
intron-3CDSENST00000561122ENST00000559209ZNF280Dchr15

56935150

-RNF111chr15

59384736

+
intron-3CDSENST00000561122ENST00000557998ZNF280Dchr15

56935150

-RNF111chr15

59384736

+
intron-3CDSENST00000561122ENST00000561186ZNF280Dchr15

56935150

-RNF111chr15

59384736

+
intron-intronENST00000561122ENST00000560080ZNF280Dchr15

56935150

-RNF111chr15

59384736

+

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FusionProtFeatures for ZNF280D_RNF111


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF280D

Q6N043

RNF111

Q6ZNA4


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF280D_RNF111


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF280D_RNF111


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF280DCBX3, BRCA1, CBX5, CBX1RNF111SMAD3, SMAD6, SMAD7, SKIL, SMAD2, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E3, UBE2G2, UBE2W, UBE2I, UBE2M, UBE2V1, UBE2K, UBE2E2, UBE2Q2, TSG101, CREB1, SKI, RB1CC1, SUMO2, SUMO1, FHL2, RNF111, HSP90AA1, SMURF2, PML, UBE2N, XPC, DTX3L, TRIM21, ANAPC11, LRSAM1, MARCH7, PHF7, TRIM8, TRAF5, CSNK2A2, CTBP1, MVP, ACTN3, CSNK2A1, KRTAP5-9, EDARADD, LCE4A, SUMO3, NR4A1, AXIN2, UBC, ESRP2, ESRP1, SETD7, FAM189B, UBXN7, TPX2, DCUN1D5, TTC9C, SUGP1, CGGBP1, RBM27, GNAQ, ADD3, C21orf59, SPAST


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF280D_RNF111


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF280D_RNF111


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource