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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43154

FusionGeneSummary for ZNF275_ZNF275

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF275_ZNF275
Fusion gene ID: 43154
HgeneTgene
Gene symbol

ZNF275

ZNF275

Gene ID

10838

10838

Gene namezinc finger protein 275zinc finger protein 275
Synonyms--
Cytomap

Xq28

Xq28

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 275zinc finger protein 275
Modification date2018051920180519
UniProtAcc

Q9NSD4

Q9NSD4

Ensembl transtripts involved in fusion geneENST00000370251, ENST00000421401, 
ENST00000440091, ENST00000370249, 
ENST00000438239, 
ENST00000370251, 
ENST00000421401, ENST00000440091, 
ENST00000370249, ENST00000438239, 
Fusion gene scores* DoF score1 X 1 X 1=11 X 1 X 1=1
# samples 11
** MAII scorelog2(1/1*10)=3.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: ZNF275 [Title/Abstract] AND ZNF275 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA132881ZNF275chrX

152617332

-ZNF275chrX

152617460

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000370251ENST00000370251ZNF275chrX

152617332

-ZNF275chrX

152617460

+
3UTR-3UTRENST00000370251ENST00000421401ZNF275chrX

152617332

-ZNF275chrX

152617460

+
3UTR-3UTRENST00000370251ENST00000440091ZNF275chrX

152617332

-ZNF275chrX

152617460

+
3UTR-intronENST00000370251ENST00000370249ZNF275chrX

152617332

-ZNF275chrX

152617460

+
3UTR-intronENST00000370251ENST00000438239ZNF275chrX

152617332

-ZNF275chrX

152617460

+
3UTR-3UTRENST00000421401ENST00000370251ZNF275chrX

152617332

-ZNF275chrX

152617460

+
3UTR-3UTRENST00000421401ENST00000421401ZNF275chrX

152617332

-ZNF275chrX

152617460

+
3UTR-3UTRENST00000421401ENST00000440091ZNF275chrX

152617332

-ZNF275chrX

152617460

+
3UTR-intronENST00000421401ENST00000370249ZNF275chrX

152617332

-ZNF275chrX

152617460

+
3UTR-intronENST00000421401ENST00000438239ZNF275chrX

152617332

-ZNF275chrX

152617460

+
3UTR-3UTRENST00000440091ENST00000370251ZNF275chrX

152617332

-ZNF275chrX

152617460

+
3UTR-3UTRENST00000440091ENST00000421401ZNF275chrX

152617332

-ZNF275chrX

152617460

+
3UTR-3UTRENST00000440091ENST00000440091ZNF275chrX

152617332

-ZNF275chrX

152617460

+
3UTR-intronENST00000440091ENST00000370249ZNF275chrX

152617332

-ZNF275chrX

152617460

+
3UTR-intronENST00000440091ENST00000438239ZNF275chrX

152617332

-ZNF275chrX

152617460

+
intron-3UTRENST00000370249ENST00000370251ZNF275chrX

152617332

-ZNF275chrX

152617460

+
intron-3UTRENST00000370249ENST00000421401ZNF275chrX

152617332

-ZNF275chrX

152617460

+
intron-3UTRENST00000370249ENST00000440091ZNF275chrX

152617332

-ZNF275chrX

152617460

+
intron-intronENST00000370249ENST00000370249ZNF275chrX

152617332

-ZNF275chrX

152617460

+
intron-intronENST00000370249ENST00000438239ZNF275chrX

152617332

-ZNF275chrX

152617460

+
intron-3UTRENST00000438239ENST00000370251ZNF275chrX

152617332

-ZNF275chrX

152617460

+
intron-3UTRENST00000438239ENST00000421401ZNF275chrX

152617332

-ZNF275chrX

152617460

+
intron-3UTRENST00000438239ENST00000440091ZNF275chrX

152617332

-ZNF275chrX

152617460

+
intron-intronENST00000438239ENST00000370249ZNF275chrX

152617332

-ZNF275chrX

152617460

+
intron-intronENST00000438239ENST00000438239ZNF275chrX

152617332

-ZNF275chrX

152617460

+

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FusionProtFeatures for ZNF275_ZNF275


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF275

Q9NSD4

ZNF275

Q9NSD4

May be involved in transcriptional regulation. May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF275_ZNF275


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF275_ZNF275


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF275_ZNF275


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF275_ZNF275


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource