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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4315

FusionGeneSummary for BOP1_CPSF1

check button Fusion gene summary
Fusion gene informationFusion gene name: BOP1_CPSF1
Fusion gene ID: 4315
HgeneTgene
Gene symbol

BOP1

CPSF1

Gene ID

23246

29894

Gene nameblock of proliferation 1cleavage and polyadenylation specific factor 1
Synonyms-CPSF160|HSU37012|P/cl.18
Cytomap

8q24.3

8q24.3

Type of geneprotein-codingprotein-coding
Descriptionribosome biogenesis protein BOP1cleavage and polyadenylation specificity factor subunit 1CPSF 160 kDa subunitcleavage and polyadenylation specific factor 1, 160kDacleavage and polyadenylation specificity factor 160 kDa subunitpolyadenylation specificity factor
Modification date2018052320180523
UniProtAcc

Q14137

Q10570

Ensembl transtripts involved in fusion geneENST00000307404, ENST00000529231, 
ENST00000525016, 
ENST00000349769, 
ENST00000531727, 
Fusion gene scores* DoF score6 X 4 X 6=1444 X 4 X 4=64
# samples 64
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BOP1 [Title/Abstract] AND CPSF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-BR-8373-01ABOP1chr8

145500212

-CPSF1chr8

145620570

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000307404ENST00000349769BOP1chr8

145500212

-CPSF1chr8

145620570

-
5CDS-intronENST00000307404ENST00000531727BOP1chr8

145500212

-CPSF1chr8

145620570

-
Frame-shiftENST00000529231ENST00000349769BOP1chr8

145500212

-CPSF1chr8

145620570

-
5CDS-intronENST00000529231ENST00000531727BOP1chr8

145500212

-CPSF1chr8

145620570

-
intron-3CDSENST00000525016ENST00000349769BOP1chr8

145500212

-CPSF1chr8

145620570

-
intron-intronENST00000525016ENST00000531727BOP1chr8

145500212

-CPSF1chr8

145620570

-

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FusionProtFeatures for BOP1_CPSF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BOP1

Q14137

CPSF1

Q10570

Component of the PeBoW complex, which is required formaturation of 28S and 5.8S ribosomal RNAs and formation of the 60Sribosome. {ECO:0000255|HAMAP-Rule:MF_03027,ECO:0000269|PubMed:17353269, ECO:0000269|PubMed:24120868}. Component of the cleavage and polyadenylationspecificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence andinteracting with poly(A) polymerase and other factors to bringabout cleavage and poly(A) addition. This subunit is involved inthe RNA recognition step of the polyadenylation reaction.{ECO:0000269|PubMed:14749727}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBOP1chr8:145500212chr8:145620570ENST00000307404-316265_427130747RegionSufficient for nucleolar localization
HgeneBOP1chr8:145500212chr8:145620570ENST00000307404-316411_450130747RepeatNote=WD 1
HgeneBOP1chr8:145500212chr8:145620570ENST00000307404-316452_492130747RepeatNote=WD 2
HgeneBOP1chr8:145500212chr8:145620570ENST00000307404-316532_576130747RepeatNote=WD 3
HgeneBOP1chr8:145500212chr8:145620570ENST00000307404-316577_615130747RepeatNote=WD 4
HgeneBOP1chr8:145500212chr8:145620570ENST00000307404-316618_657130747RepeatNote=WD 5
HgeneBOP1chr8:145500212chr8:145620570ENST00000307404-316661_700130747RepeatNote=WD 6
HgeneBOP1chr8:145500212chr8:145620570ENST00000307404-316716_746130747RepeatNote=WD 7
TgeneCPSF1chr8:145500212chr8:145620570ENST00000349769-2638893_90810321444MotifNuclear localization signal


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FusionGeneSequence for BOP1_CPSF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_BOP1_ENST00000307404_chr8_145500212_-_CPSF1_ENST00000349769_chr8_145620570_-_542aa
MAGSRGAGRTAAPSVRPEKRRSEPELEPEPEPEPPLLCTSPLSHSTGSDSGVSDSEESVFSGLEDSGSDSSEDDDEGDEEGEDGALDDEG
HSGIKKTTEEQVQASTPCPRTEMASARIGDEYAEDSSDEEVYAVATSTNTPCARIPRMTGEEKEFETIERDERYIHPQQEAFSIQLISPV
SWEAIPNARIELQEWEHVTCMKTVSLRSEETVSGLKGYVAAGTCLMQGEEVTCRGRILIMDVIEVVPEPGQPLTKNKFKVLYEKEQKGPV
TALCHCNGHLVSAIGQKIFLWSLRASELTGMAFIDTQLYIHQMISVKNFILAADVMKSISLLRYQEESKTLSLVSRDAKPLEVYSVDFMV
DNAQLGFLVSDRDRNLMVYMYLPEAKESFGGMRLLRRADFHVGAHVNTFWRTPCRGATEGLSKKSVVWENKHITWFATLDGGIGLLLPMQ
EKTYRRLLMLQNALTTMLPHHAGLNPRAFRMLHVDRRTLQNAVRNVLDGELLNRYLYLSTMERSELAKKIGTTPDIILDDLLETDRVTAH


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_BOP1_ENST00000307404_chr8_145500212_-_CPSF1_ENST00000349769_chr8_145620570_-_1626nt
ATGGCGGGTTCGCGGGGTGCGGGGCGCACGGCGGCGCCGAGCGTGCGGCCGGAGAAGCGGCGGTCTGAGCCCGAACTGGAGCCTGAGCCC
GAGCCGGAGCCCCCCCTCCTCTGCACCTCTCCTCTCAGCCACAGCACCGGCAGCGATTCTGGCGTCTCCGACAGCGAGGAGAGTGTGTTC
TCAGGCCTGGAAGATTCCGGCAGTGACAGCAGTGAGGATGATGACGAAGGCGACGAGGAGGGAGAGGACGGAGCCCTTGATGACGAGGGC
CACAGTGGGATTAAAAAGACCACTGAGGAGCAGGTGCAGGCCAGCACTCCTTGCCCGAGGACAGAGATGGCGAGCGCCCGGATTGGGGAT
GAGTATGCGGAGGACAGCTCTGATGAGGAGGTGTATGCTGTGGCCACCAGCACCAACACGCCGTGTGCCCGCATCCCACGCATGACTGGC
GAGGAGAAGGAGTTTGAGACCATCGAGAGAGATGAGCGGTACATCCACCCCCAGCAGGAGGCCTTCTCCATCCAGCTCATCTCCCCGGTC
AGCTGGGAGGCTATTCCCAATGCCAGGATCGAGCTGCAGGAGTGGGAGCATGTGACCTGCATGAAGACAGTGTCTCTGCGCAGTGAGGAG
ACCGTGTCGGGCCTCAAAGGCTACGTGGCCGCCGGGACCTGCCTCATGCAGGGGGAGGAGGTCACGTGCCGAGGGCGGATCTTGATCATG
GATGTGATTGAGGTGGTGCCCGAGCCTGGCCAGCCCTTGACCAAGAACAAGTTCAAAGTCCTTTACGAGAAGGAGCAGAAGGGGCCCGTG
ACCGCCCTGTGCCACTGCAATGGCCACCTGGTGTCGGCCATCGGCCAGAAGATTTTCCTGTGGAGCCTGCGGGCCAGCGAGCTGACGGGC
ATGGCCTTCATCGACACGCAGCTCTACATACACCAGATGATCAGCGTCAAGAACTTCATCCTGGCAGCCGACGTCATGAAGAGCATTTCG
CTGCTGCGCTACCAGGAGGAAAGCAAGACGCTGAGCCTGGTGTCGCGGGATGCCAAGCCCCTGGAGGTGTACAGCGTGGACTTCATGGTG
GACAATGCCCAGCTGGGTTTTCTGGTGTCTGACCGCGACCGCAACCTCATGGTGTACATGTACCTGCCCGAAGCCAAGGAGAGTTTCGGG
GGCATGCGCCTGCTGCGTCGGGCAGACTTCCACGTGGGTGCCCACGTGAACACGTTCTGGAGGACCCCGTGCCGGGGGGCCACTGAAGGG
CTCAGCAAAAAGTCGGTCGTGTGGGAGAATAAGCACATCACGTGGTTTGCCACCCTGGACGGCGGCATCGGGCTGCTGCTGCCCATGCAG
GAGAAGACCTACCGGCGGCTGCTGATGCTGCAGAACGCGCTGACCACCATGCTGCCACACCACGCCGGCCTCAACCCCCGCGCCTTCCGG
ATGCTGCACGTGGACCGCCGCACCCTCCAGAATGCCGTGCGCAACGTGCTGGATGGGGAGCTGCTCAACCGCTACCTGTACCTGAGCACC
ATGGAGCGCAGCGAGCTAGCCAAGAAGATCGGCACCACACCAGACATAATCCTGGACGACTTGCTGGAGACGGACCGCGTCACCGCCCAC


* Fusion transcript sequences (Full-length transcript).
>In-frame_BOP1_ENST00000307404_chr8_145500212_-_CPSF1_ENST00000349769_chr8_145620570_-_1739nt
GTGCGGGTGGCGGCCGGCGCGCGGTGGGGCATGGCGGGTTCGCGGGGTGCGGGGCGCACGGCGGCGCCGAGCGTGCGGCCGGAGAAGCGG
CGGTCTGAGCCCGAACTGGAGCCTGAGCCCGAGCCGGAGCCCCCCCTCCTCTGCACCTCTCCTCTCAGCCACAGCACCGGCAGCGATTCT
GGCGTCTCCGACAGCGAGGAGAGTGTGTTCTCAGGCCTGGAAGATTCCGGCAGTGACAGCAGTGAGGATGATGACGAAGGCGACGAGGAG
GGAGAGGACGGAGCCCTTGATGACGAGGGCCACAGTGGGATTAAAAAGACCACTGAGGAGCAGGTGCAGGCCAGCACTCCTTGCCCGAGG
ACAGAGATGGCGAGCGCCCGGATTGGGGATGAGTATGCGGAGGACAGCTCTGATGAGGAGGTGTATGCTGTGGCCACCAGCACCAACACG
CCGTGTGCCCGCATCCCACGCATGACTGGCGAGGAGAAGGAGTTTGAGACCATCGAGAGAGATGAGCGGTACATCCACCCCCAGCAGGAG
GCCTTCTCCATCCAGCTCATCTCCCCGGTCAGCTGGGAGGCTATTCCCAATGCCAGGATCGAGCTGCAGGAGTGGGAGCATGTGACCTGC
ATGAAGACAGTGTCTCTGCGCAGTGAGGAGACCGTGTCGGGCCTCAAAGGCTACGTGGCCGCCGGGACCTGCCTCATGCAGGGGGAGGAG
GTCACGTGCCGAGGGCGGATCTTGATCATGGATGTGATTGAGGTGGTGCCCGAGCCTGGCCAGCCCTTGACCAAGAACAAGTTCAAAGTC
CTTTACGAGAAGGAGCAGAAGGGGCCCGTGACCGCCCTGTGCCACTGCAATGGCCACCTGGTGTCGGCCATCGGCCAGAAGATTTTCCTG
TGGAGCCTGCGGGCCAGCGAGCTGACGGGCATGGCCTTCATCGACACGCAGCTCTACATACACCAGATGATCAGCGTCAAGAACTTCATC
CTGGCAGCCGACGTCATGAAGAGCATTTCGCTGCTGCGCTACCAGGAGGAAAGCAAGACGCTGAGCCTGGTGTCGCGGGATGCCAAGCCC
CTGGAGGTGTACAGCGTGGACTTCATGGTGGACAATGCCCAGCTGGGTTTTCTGGTGTCTGACCGCGACCGCAACCTCATGGTGTACATG
TACCTGCCCGAAGCCAAGGAGAGTTTCGGGGGCATGCGCCTGCTGCGTCGGGCAGACTTCCACGTGGGTGCCCACGTGAACACGTTCTGG
AGGACCCCGTGCCGGGGGGCCACTGAAGGGCTCAGCAAAAAGTCGGTCGTGTGGGAGAATAAGCACATCACGTGGTTTGCCACCCTGGAC
GGCGGCATCGGGCTGCTGCTGCCCATGCAGGAGAAGACCTACCGGCGGCTGCTGATGCTGCAGAACGCGCTGACCACCATGCTGCCACAC
CACGCCGGCCTCAACCCCCGCGCCTTCCGGATGCTGCACGTGGACCGCCGCACCCTCCAGAATGCCGTGCGCAACGTGCTGGATGGGGAG
CTGCTCAACCGCTACCTGTACCTGAGCACCATGGAGCGCAGCGAGCTAGCCAAGAAGATCGGCACCACACCAGACATAATCCTGGACGAC
TTGCTGGAGACGGACCGCGTCACCGCCCACTTCTAGCCCCGTGGATGCCGTCACCACCAGCACACGGAACTACCTCCCACCCCCTTTTTG


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FusionGenePPI for BOP1_CPSF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
BOP1ARRB1, ARRB2, WDR48, MYBBP1A, KLF10, SIRT7, CUL3, CAND1, WDR12, PES1, NOP58, FBL, NOP2, NOP56, RPS7, NHP2L1, ACIN1, RPL30, GNL3, BOP1, C18orf25, GARS, GORASP2, GTF2A1, TSNAX, ME1, SNX5, UGDH, FBXW11, CUL7, OBSL1, RNF2, CASQ2, NTRK1, IFI16, BTRC, MDN1, DDX27, HIP1R, WDR74, BUB3, MYH9, OTULIN, RPL7L1, NDUFAF3, ACAP1, SYT10, CHAMP1, WDR55, WDR46, FMR1NB, PRR11, TRIM25CPSF1PRRC2A, CSTF2, COPS5, COPS2, CDC73, GLIS2, TBP, TAF7, TAF12, TAF5, CSTF3, PAPOLA, CSTF2T, SMARCAD1, SIRT7, CUL3, COPS6, POLR2A, CPSF2, CPSF3, FIP1L1, WDR33, RNPC3, GTF3C3, MED8, NPM1, TUT1, HMOX1, IL7R, HDAC6, ICK, CLK2, TARDBP, NEDD4, WWOX, RPA3, RPA2, RPA1, LGR4, STAU1, RBBP6, REL, MOV10, NXF1, CUL7, OBSL1, EZH2, EED, NTRK1, CHD3, CPSF4, PPP1CB, RANGAP1, SYMPK, GPS1, KIF21B, CEP170P1, SNW1, FBXW7, SSU72


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BOP1_CPSF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BOP1_CPSF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBOP1C0038356Stomach Neoplasms1CTD_human
TgeneCPSF1C0038356Stomach Neoplasms1CTD_human