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Fusion gene ID: 4315 |
FusionGeneSummary for BOP1_CPSF1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: BOP1_CPSF1 | Fusion gene ID: 4315 | Hgene | Tgene | Gene symbol | BOP1 | CPSF1 | Gene ID | 23246 | 29894 |
Gene name | block of proliferation 1 | cleavage and polyadenylation specific factor 1 | |
Synonyms | - | CPSF160|HSU37012|P/cl.18 | |
Cytomap | 8q24.3 | 8q24.3 | |
Type of gene | protein-coding | protein-coding | |
Description | ribosome biogenesis protein BOP1 | cleavage and polyadenylation specificity factor subunit 1CPSF 160 kDa subunitcleavage and polyadenylation specific factor 1, 160kDacleavage and polyadenylation specificity factor 160 kDa subunitpolyadenylation specificity factor | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q14137 | Q10570 | |
Ensembl transtripts involved in fusion gene | ENST00000307404, ENST00000529231, ENST00000525016, | ENST00000349769, ENST00000531727, | |
Fusion gene scores | * DoF score | 6 X 4 X 6=144 | 4 X 4 X 4=64 |
# samples | 6 | 4 | |
** MAII score | log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: BOP1 [Title/Abstract] AND CPSF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | STAD | TCGA-BR-8373-01A | BOP1 | chr8 | 145500212 | - | CPSF1 | chr8 | 145620570 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000307404 | ENST00000349769 | BOP1 | chr8 | 145500212 | - | CPSF1 | chr8 | 145620570 | - |
5CDS-intron | ENST00000307404 | ENST00000531727 | BOP1 | chr8 | 145500212 | - | CPSF1 | chr8 | 145620570 | - |
Frame-shift | ENST00000529231 | ENST00000349769 | BOP1 | chr8 | 145500212 | - | CPSF1 | chr8 | 145620570 | - |
5CDS-intron | ENST00000529231 | ENST00000531727 | BOP1 | chr8 | 145500212 | - | CPSF1 | chr8 | 145620570 | - |
intron-3CDS | ENST00000525016 | ENST00000349769 | BOP1 | chr8 | 145500212 | - | CPSF1 | chr8 | 145620570 | - |
intron-intron | ENST00000525016 | ENST00000531727 | BOP1 | chr8 | 145500212 | - | CPSF1 | chr8 | 145620570 | - |
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FusionProtFeatures for BOP1_CPSF1 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
BOP1 | CPSF1 |
Component of the PeBoW complex, which is required formaturation of 28S and 5.8S ribosomal RNAs and formation of the 60Sribosome. {ECO:0000255|HAMAP-Rule:MF_03027,ECO:0000269|PubMed:17353269, ECO:0000269|PubMed:24120868}. | Component of the cleavage and polyadenylationspecificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence andinteracting with poly(A) polymerase and other factors to bringabout cleavage and poly(A) addition. This subunit is involved inthe RNA recognition step of the polyadenylation reaction.{ECO:0000269|PubMed:14749727}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >BOP1 | chr8:145500212 | chr8:145620570 | ENST00000307404 | - | 3 | 16 | 265_427 | 130 | 747 | Region | Sufficient for nucleolar localization |
Hgene | >BOP1 | chr8:145500212 | chr8:145620570 | ENST00000307404 | - | 3 | 16 | 411_450 | 130 | 747 | Repeat | Note=WD 1 |
Hgene | >BOP1 | chr8:145500212 | chr8:145620570 | ENST00000307404 | - | 3 | 16 | 452_492 | 130 | 747 | Repeat | Note=WD 2 |
Hgene | >BOP1 | chr8:145500212 | chr8:145620570 | ENST00000307404 | - | 3 | 16 | 532_576 | 130 | 747 | Repeat | Note=WD 3 |
Hgene | >BOP1 | chr8:145500212 | chr8:145620570 | ENST00000307404 | - | 3 | 16 | 577_615 | 130 | 747 | Repeat | Note=WD 4 |
Hgene | >BOP1 | chr8:145500212 | chr8:145620570 | ENST00000307404 | - | 3 | 16 | 618_657 | 130 | 747 | Repeat | Note=WD 5 |
Hgene | >BOP1 | chr8:145500212 | chr8:145620570 | ENST00000307404 | - | 3 | 16 | 661_700 | 130 | 747 | Repeat | Note=WD 6 |
Hgene | >BOP1 | chr8:145500212 | chr8:145620570 | ENST00000307404 | - | 3 | 16 | 716_746 | 130 | 747 | Repeat | Note=WD 7 |
Tgene | CPSF1 | chr8:145500212 | chr8:145620570 | ENST00000349769 | - | 26 | 38 | 893_908 | 1032 | 1444 | Motif | Nuclear localization signal |
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FusionGeneSequence for BOP1_CPSF1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_BOP1_ENST00000307404_chr8_145500212_-_CPSF1_ENST00000349769_chr8_145620570_-_542aa MAGSRGAGRTAAPSVRPEKRRSEPELEPEPEPEPPLLCTSPLSHSTGSDSGVSDSEESVFSGLEDSGSDSSEDDDEGDEEGEDGALDDEG HSGIKKTTEEQVQASTPCPRTEMASARIGDEYAEDSSDEEVYAVATSTNTPCARIPRMTGEEKEFETIERDERYIHPQQEAFSIQLISPV SWEAIPNARIELQEWEHVTCMKTVSLRSEETVSGLKGYVAAGTCLMQGEEVTCRGRILIMDVIEVVPEPGQPLTKNKFKVLYEKEQKGPV TALCHCNGHLVSAIGQKIFLWSLRASELTGMAFIDTQLYIHQMISVKNFILAADVMKSISLLRYQEESKTLSLVSRDAKPLEVYSVDFMV DNAQLGFLVSDRDRNLMVYMYLPEAKESFGGMRLLRRADFHVGAHVNTFWRTPCRGATEGLSKKSVVWENKHITWFATLDGGIGLLLPMQ EKTYRRLLMLQNALTTMLPHHAGLNPRAFRMLHVDRRTLQNAVRNVLDGELLNRYLYLSTMERSELAKKIGTTPDIILDDLLETDRVTAH |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_BOP1_ENST00000307404_chr8_145500212_-_CPSF1_ENST00000349769_chr8_145620570_-_1626nt ATGGCGGGTTCGCGGGGTGCGGGGCGCACGGCGGCGCCGAGCGTGCGGCCGGAGAAGCGGCGGTCTGAGCCCGAACTGGAGCCTGAGCCC GAGCCGGAGCCCCCCCTCCTCTGCACCTCTCCTCTCAGCCACAGCACCGGCAGCGATTCTGGCGTCTCCGACAGCGAGGAGAGTGTGTTC TCAGGCCTGGAAGATTCCGGCAGTGACAGCAGTGAGGATGATGACGAAGGCGACGAGGAGGGAGAGGACGGAGCCCTTGATGACGAGGGC CACAGTGGGATTAAAAAGACCACTGAGGAGCAGGTGCAGGCCAGCACTCCTTGCCCGAGGACAGAGATGGCGAGCGCCCGGATTGGGGAT GAGTATGCGGAGGACAGCTCTGATGAGGAGGTGTATGCTGTGGCCACCAGCACCAACACGCCGTGTGCCCGCATCCCACGCATGACTGGC GAGGAGAAGGAGTTTGAGACCATCGAGAGAGATGAGCGGTACATCCACCCCCAGCAGGAGGCCTTCTCCATCCAGCTCATCTCCCCGGTC AGCTGGGAGGCTATTCCCAATGCCAGGATCGAGCTGCAGGAGTGGGAGCATGTGACCTGCATGAAGACAGTGTCTCTGCGCAGTGAGGAG ACCGTGTCGGGCCTCAAAGGCTACGTGGCCGCCGGGACCTGCCTCATGCAGGGGGAGGAGGTCACGTGCCGAGGGCGGATCTTGATCATG GATGTGATTGAGGTGGTGCCCGAGCCTGGCCAGCCCTTGACCAAGAACAAGTTCAAAGTCCTTTACGAGAAGGAGCAGAAGGGGCCCGTG ACCGCCCTGTGCCACTGCAATGGCCACCTGGTGTCGGCCATCGGCCAGAAGATTTTCCTGTGGAGCCTGCGGGCCAGCGAGCTGACGGGC ATGGCCTTCATCGACACGCAGCTCTACATACACCAGATGATCAGCGTCAAGAACTTCATCCTGGCAGCCGACGTCATGAAGAGCATTTCG CTGCTGCGCTACCAGGAGGAAAGCAAGACGCTGAGCCTGGTGTCGCGGGATGCCAAGCCCCTGGAGGTGTACAGCGTGGACTTCATGGTG GACAATGCCCAGCTGGGTTTTCTGGTGTCTGACCGCGACCGCAACCTCATGGTGTACATGTACCTGCCCGAAGCCAAGGAGAGTTTCGGG GGCATGCGCCTGCTGCGTCGGGCAGACTTCCACGTGGGTGCCCACGTGAACACGTTCTGGAGGACCCCGTGCCGGGGGGCCACTGAAGGG CTCAGCAAAAAGTCGGTCGTGTGGGAGAATAAGCACATCACGTGGTTTGCCACCCTGGACGGCGGCATCGGGCTGCTGCTGCCCATGCAG GAGAAGACCTACCGGCGGCTGCTGATGCTGCAGAACGCGCTGACCACCATGCTGCCACACCACGCCGGCCTCAACCCCCGCGCCTTCCGG ATGCTGCACGTGGACCGCCGCACCCTCCAGAATGCCGTGCGCAACGTGCTGGATGGGGAGCTGCTCAACCGCTACCTGTACCTGAGCACC ATGGAGCGCAGCGAGCTAGCCAAGAAGATCGGCACCACACCAGACATAATCCTGGACGACTTGCTGGAGACGGACCGCGTCACCGCCCAC |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_BOP1_ENST00000307404_chr8_145500212_-_CPSF1_ENST00000349769_chr8_145620570_-_1739nt GTGCGGGTGGCGGCCGGCGCGCGGTGGGGCATGGCGGGTTCGCGGGGTGCGGGGCGCACGGCGGCGCCGAGCGTGCGGCCGGAGAAGCGG CGGTCTGAGCCCGAACTGGAGCCTGAGCCCGAGCCGGAGCCCCCCCTCCTCTGCACCTCTCCTCTCAGCCACAGCACCGGCAGCGATTCT GGCGTCTCCGACAGCGAGGAGAGTGTGTTCTCAGGCCTGGAAGATTCCGGCAGTGACAGCAGTGAGGATGATGACGAAGGCGACGAGGAG GGAGAGGACGGAGCCCTTGATGACGAGGGCCACAGTGGGATTAAAAAGACCACTGAGGAGCAGGTGCAGGCCAGCACTCCTTGCCCGAGG ACAGAGATGGCGAGCGCCCGGATTGGGGATGAGTATGCGGAGGACAGCTCTGATGAGGAGGTGTATGCTGTGGCCACCAGCACCAACACG CCGTGTGCCCGCATCCCACGCATGACTGGCGAGGAGAAGGAGTTTGAGACCATCGAGAGAGATGAGCGGTACATCCACCCCCAGCAGGAG GCCTTCTCCATCCAGCTCATCTCCCCGGTCAGCTGGGAGGCTATTCCCAATGCCAGGATCGAGCTGCAGGAGTGGGAGCATGTGACCTGC ATGAAGACAGTGTCTCTGCGCAGTGAGGAGACCGTGTCGGGCCTCAAAGGCTACGTGGCCGCCGGGACCTGCCTCATGCAGGGGGAGGAG GTCACGTGCCGAGGGCGGATCTTGATCATGGATGTGATTGAGGTGGTGCCCGAGCCTGGCCAGCCCTTGACCAAGAACAAGTTCAAAGTC CTTTACGAGAAGGAGCAGAAGGGGCCCGTGACCGCCCTGTGCCACTGCAATGGCCACCTGGTGTCGGCCATCGGCCAGAAGATTTTCCTG TGGAGCCTGCGGGCCAGCGAGCTGACGGGCATGGCCTTCATCGACACGCAGCTCTACATACACCAGATGATCAGCGTCAAGAACTTCATC CTGGCAGCCGACGTCATGAAGAGCATTTCGCTGCTGCGCTACCAGGAGGAAAGCAAGACGCTGAGCCTGGTGTCGCGGGATGCCAAGCCC CTGGAGGTGTACAGCGTGGACTTCATGGTGGACAATGCCCAGCTGGGTTTTCTGGTGTCTGACCGCGACCGCAACCTCATGGTGTACATG TACCTGCCCGAAGCCAAGGAGAGTTTCGGGGGCATGCGCCTGCTGCGTCGGGCAGACTTCCACGTGGGTGCCCACGTGAACACGTTCTGG AGGACCCCGTGCCGGGGGGCCACTGAAGGGCTCAGCAAAAAGTCGGTCGTGTGGGAGAATAAGCACATCACGTGGTTTGCCACCCTGGAC GGCGGCATCGGGCTGCTGCTGCCCATGCAGGAGAAGACCTACCGGCGGCTGCTGATGCTGCAGAACGCGCTGACCACCATGCTGCCACAC CACGCCGGCCTCAACCCCCGCGCCTTCCGGATGCTGCACGTGGACCGCCGCACCCTCCAGAATGCCGTGCGCAACGTGCTGGATGGGGAG CTGCTCAACCGCTACCTGTACCTGAGCACCATGGAGCGCAGCGAGCTAGCCAAGAAGATCGGCACCACACCAGACATAATCCTGGACGAC TTGCTGGAGACGGACCGCGTCACCGCCCACTTCTAGCCCCGTGGATGCCGTCACCACCAGCACACGGAACTACCTCCCACCCCCTTTTTG |
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FusionGenePPI for BOP1_CPSF1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
BOP1 | ARRB1, ARRB2, WDR48, MYBBP1A, KLF10, SIRT7, CUL3, CAND1, WDR12, PES1, NOP58, FBL, NOP2, NOP56, RPS7, NHP2L1, ACIN1, RPL30, GNL3, BOP1, C18orf25, GARS, GORASP2, GTF2A1, TSNAX, ME1, SNX5, UGDH, FBXW11, CUL7, OBSL1, RNF2, CASQ2, NTRK1, IFI16, BTRC, MDN1, DDX27, HIP1R, WDR74, BUB3, MYH9, OTULIN, RPL7L1, NDUFAF3, ACAP1, SYT10, CHAMP1, WDR55, WDR46, FMR1NB, PRR11, TRIM25 | CPSF1 | PRRC2A, CSTF2, COPS5, COPS2, CDC73, GLIS2, TBP, TAF7, TAF12, TAF5, CSTF3, PAPOLA, CSTF2T, SMARCAD1, SIRT7, CUL3, COPS6, POLR2A, CPSF2, CPSF3, FIP1L1, WDR33, RNPC3, GTF3C3, MED8, NPM1, TUT1, HMOX1, IL7R, HDAC6, ICK, CLK2, TARDBP, NEDD4, WWOX, RPA3, RPA2, RPA1, LGR4, STAU1, RBBP6, REL, MOV10, NXF1, CUL7, OBSL1, EZH2, EED, NTRK1, CHD3, CPSF4, PPP1CB, RANGAP1, SYMPK, GPS1, KIF21B, CEP170P1, SNW1, FBXW7, SSU72 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BOP1_CPSF1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for BOP1_CPSF1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | BOP1 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Tgene | CPSF1 | C0038356 | Stomach Neoplasms | 1 | CTD_human |