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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43145

FusionGeneSummary for ZNF266_SMARCA4

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF266_SMARCA4
Fusion gene ID: 43145
HgeneTgene
Gene symbol

ZNF266

SMARCA4

Gene ID

10781

6597

Gene namezinc finger protein 266SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SynonymsHZF1BAF190|BAF190A|BRG1|CSS4|MRD16|RTPS2|SNF2|SNF2L4|SNF2LB|SWI2|hSNF2b
Cytomap

19p13.2

19p13.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 266zinc finger protein 1zinc finger protein HZF1transcription activator BRG1ATP-dependent helicase SMARCA4BRG1-associated factor 190ABRM/SWI2-related gene 1SNF2-betaSNF2-like 4brahma protein-like 1global transcription activator homologous sequencehomeotic gene regulatormitotic growth and trans
Modification date2018052320180523
UniProtAcc

Q14584

P51532

Ensembl transtripts involved in fusion geneENST00000361151, ENST00000361451, 
ENST00000588933, ENST00000588221, 
ENST00000592904, ENST00000590306, 
ENST00000592292, ENST00000588013, 
ENST00000358026, ENST00000344626, 
ENST00000429416, ENST00000541122, 
ENST00000589677, ENST00000444061, 
ENST00000590574, ENST00000413806, 
ENST00000450717, ENST00000538456, 
Fusion gene scores* DoF score4 X 5 X 3=6012 X 14 X 8=1344
# samples 415
** MAII scorelog2(4/60*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(15/1344*10)=-3.16349873228288
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF266 [Title/Abstract] AND SMARCA4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSMARCA4

GO:0006337

nucleosome disassembly

8895581

TgeneSMARCA4

GO:0006338

chromatin remodeling

10943845|11726552

TgeneSMARCA4

GO:0045892

negative regulation of transcription, DNA-templated

12065415

TgeneSMARCA4

GO:0045944

positive regulation of transcription by RNA polymerase II

15774904|17938176

TgeneSMARCA4

GO:0051091

positive regulation of DNA binding transcription factor activity

11950834|17938176

TgeneSMARCA4

GO:1902661

positive regulation of glucose mediated signaling pathway

22368283


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLGGTCGA-TM-A7CF-01AZNF266chr19

9544741

-SMARCA4chr19

11130267

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000361151ENST00000358026ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000361151ENST00000344626ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000361151ENST00000429416ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000361151ENST00000541122ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000361151ENST00000589677ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000361151ENST00000444061ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000361151ENST00000590574ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000361151ENST00000413806ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000361151ENST00000450717ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-intronENST00000361151ENST00000538456ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000361451ENST00000358026ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000361451ENST00000344626ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000361451ENST00000429416ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000361451ENST00000541122ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000361451ENST00000589677ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000361451ENST00000444061ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000361451ENST00000590574ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000361451ENST00000413806ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000361451ENST00000450717ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-intronENST00000361451ENST00000538456ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
5UTR-3CDSENST00000588933ENST00000358026ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
5UTR-3CDSENST00000588933ENST00000344626ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
5UTR-3CDSENST00000588933ENST00000429416ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
5UTR-3CDSENST00000588933ENST00000541122ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
5UTR-3CDSENST00000588933ENST00000589677ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
5UTR-3CDSENST00000588933ENST00000444061ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
5UTR-3CDSENST00000588933ENST00000590574ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
5UTR-3CDSENST00000588933ENST00000413806ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
5UTR-3CDSENST00000588933ENST00000450717ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
5UTR-intronENST00000588933ENST00000538456ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000588221ENST00000358026ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000588221ENST00000344626ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000588221ENST00000429416ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000588221ENST00000541122ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000588221ENST00000589677ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000588221ENST00000444061ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000588221ENST00000590574ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000588221ENST00000413806ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000588221ENST00000450717ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-intronENST00000588221ENST00000538456ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000592904ENST00000358026ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000592904ENST00000344626ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000592904ENST00000429416ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000592904ENST00000541122ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000592904ENST00000589677ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000592904ENST00000444061ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000592904ENST00000590574ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000592904ENST00000413806ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000592904ENST00000450717ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-intronENST00000592904ENST00000538456ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000590306ENST00000358026ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000590306ENST00000344626ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000590306ENST00000429416ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000590306ENST00000541122ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000590306ENST00000589677ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000590306ENST00000444061ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000590306ENST00000590574ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000590306ENST00000413806ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000590306ENST00000450717ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-intronENST00000590306ENST00000538456ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000592292ENST00000358026ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000592292ENST00000344626ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000592292ENST00000429416ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000592292ENST00000541122ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000592292ENST00000589677ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000592292ENST00000444061ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000592292ENST00000590574ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000592292ENST00000413806ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000592292ENST00000450717ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-intronENST00000592292ENST00000538456ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000588013ENST00000358026ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000588013ENST00000344626ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000588013ENST00000429416ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000588013ENST00000541122ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000588013ENST00000589677ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000588013ENST00000444061ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000588013ENST00000590574ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000588013ENST00000413806ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-3CDSENST00000588013ENST00000450717ZNF266chr19

9544741

-SMARCA4chr19

11130267

+
intron-intronENST00000588013ENST00000538456ZNF266chr19

9544741

-SMARCA4chr19

11130267

+

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FusionProtFeatures for ZNF266_SMARCA4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF266

Q14584

SMARCA4

P51532

May be involved in transcriptional regulation. Involved in transcriptional activation and repression ofselect genes by chromatin remodeling (alteration of DNA-nucleosometopology). Component of SWI/SNF chromatin remodeling complexesthat carry out key enzymatic activities, changing chromatinstructure by altering DNA-histone contacts within a nucleosome inan ATP-dependent manner. Component of the CREST-BRG1 complex, amultiprotein complex that regulates promoter activation byorchestrating the calcium-dependent release of a repressor complexand the recruitment of an activator complex. In resting neurons,transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex.Upon calcium influx, RB1 is dephosphorylated by calcineurin, whichleads to release of the repressor complex. At the same time, thereis increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation.The CREST-BRG1 complex also binds to the NR2B promoter, andactivity-dependent induction of NR2B expression involves therelease of HDAC1 and recruitment of CREBBP. Belongs to the neuralprogenitors-specific chromatin remodeling complex (npBAF complex)and the neuron-specific chromatin remodeling complex (nBAFcomplex). During neural development, a switch from astem/progenitor to a postmitotic chromatin remodeling mechanismoccurs as neurons exit the cell cycle and become committed totheir adult state. The transition from proliferating neuralstem/progenitor cells to postmitotic neurons requires a switch insubunit composition of the npBAF and nBAF complexes. As neuralprogenitors exit mitosis and differentiate into neurons, npBAFcomplexes which contain ACTL6A/BAF53A and PHF10/BAF45A, areexchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45Bor DPF3/BAF45C subunits in neuron-specific complexes (nBAF). ThenpBAF complex is essential for the self-renewal/proliferativecapacity of the multipotent neural stem cells. The nBAF complexalong with CREST plays a role regulating the activity of genesessential for dendrite growth. SMARCA4/BAF190A may promote neuralstem cell self-renewal/proliferation by enhancing Notch-dependentproliferative signals, while concurrently making the neural stemcell insensitive to SHH-dependent differentiating cues (Bysimilarity). Acts as a corepressor of ZEB1 to regulate E-cadherintranscription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1. Binds via DLX1 to enhancerslocated in the intergenic region between DLX5 and DLX6 and thisbinding is stabilized by the long non-coding RNA (lncRNA) Evf2 (Bysimilarity). Binds to RNA in a promiscuous manner (By similarity).Binding to RNAs including lncRNA Evf2 leads to inhibition ofSMARCA4 ATPase and chromatin remodeling activities (Bysimilarity). {ECO:0000250|UniProtKB:Q3TKT4,ECO:0000269|PubMed:19571879, ECO:0000269|PubMed:20418909,ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF266_SMARCA4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF266_SMARCA4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF266SPRY2, CDC37, KRTAP5-9, MDFI, CEP70, TRIM41, KRT40, KRTAP10-7, KRTAP10-3, RANGRFSMARCA4ESR1, FANCA, ARID1B, RELB, MYC, BRCA1, CTNNB1, NR3C1, SMARCD1, SMARCB1, POLR2A, SMARCC1, SIN3A, HDAC2, RBBP4, KLF1, GATA1, SP1, CCNE1, TP53, HSF1, PHB, RB1, AHR, STAT2, ARID1A, SMARCC2, SMARCE1, ACTL6A, STK11, CBX5, MED17, HSP90B1, NCOR2, NCOR1, ACTB, CREBBP, NCOA1, ING1, PABPN1, AR, ZMYND8, TAF10, PMS2, MYOD1, SMARCA2, JUNB, LMNB1, SRF, MYOCD, CDKN2A, SS18L1, HDAC1, HDAC3, CDYL, ADD1, NR4A2, MCPH1, REST, DDX5, H2AFX, NFE2L2, BCL7C, BRD7, PAX6, CREB1, HSF4, CEBPA, CDX2, MYOG, MYEF2, ATF3, PRMT5, SMARCD2, SIN3B, CHD4, BRWD1, HNRNPC, STAT1, USF1, IRF1, RCOR1, CIITA, ZMIZ2, GMNN, NEUROG2, NEUROD1, NF1, PBX1, NR1H2, RXRA, HIF1A, STAT3, NONO, SMAD2, SMAD3, CARM1, ADNP, STAT5A, CEBPB, PML, MKL1, DPF2, NPM1, KPNA2, BCL7A, ZEB1, HDAC9, TOPBP1, TRIM28, RUNX1, WDR77, HIST1H3A, BCL6, CHD7, PBRM1, ARID2, MARK4, BRD4, WHSC1L1, SMARCAD1, MBD3, KLF4, CDK19, CDK8, MED6, SIRT7, ANGPTL4, ACTC1, SETD7, DPF3, PHF10, DPF1, CHFR, KDM6A, TBX5, SMARCD3, NR2C1, CUL3, COPS5, CAND1, HIST1H4F, HIST2H3C, HIST2H2BE, CHMP5, IKZF1, RBL1, RBL2, RPS6KA5, BAZ1B, TOP2B, CPSF2, SMARCA1, CAD, NOTCH1, RBPJ, MAML1, EPAS1, PPARG, MPP6, FBXO6, WWOX, OBSL1, EED, RNF2, BMI1, SS18, HSPB1, NTRK1, BYSL, EP400, HMGB1, MDC1, MYO18A, PELO, BCL7B, GTF3C3, NOP56, POLR3A, POLR3C, POLR3F, SMC3, UPF1, SCARNA22, MDM2, HIST1H3E, CAT, KPNA1, RAB5C, REEP5, VAPA, PARD6A, NEIL3, ATL2, PAPD5, GLI1, NFATC1, FOXE1, FOXO1, CDC5L, NFATC2, CHEK1, NCL, SPTA1, TRIM25, YAP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF266_SMARCA4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF266_SMARCA4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSMARCA4C0262584Carcinoma, Small Cell4CTD_human
TgeneSMARCA4C0919267ovarian neoplasm4CTD_human
TgeneSMARCA4C0006413Burkitt Lymphoma1CTD_human
TgeneSMARCA4C0036920Sezary Syndrome1CTD_human
TgeneSMARCA4C0039981Thoracic Neoplasms1CTD_human
TgeneSMARCA4C0149925Small cell carcinoma of lung1CTD_human
TgeneSMARCA4C0265338Coffin-Siris syndrome1CTD_human;ORPHANET
TgeneSMARCA4C1261473Sarcoma1CTD_human
TgeneSMARCA4C3553249MENTAL RETARDATION, AUTOSOMAL DOMINANT 161UNIPROT