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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43140

FusionGeneSummary for ZNF263_ZNF263

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF263_ZNF263
Fusion gene ID: 43140
HgeneTgene
Gene symbol

ZNF263

ZNF263

Gene ID

10127

10127

Gene namezinc finger protein 263zinc finger protein 263
SynonymsFPM315|ZKSCAN12|ZSCAN44FPM315|ZKSCAN12|ZSCAN44
Cytomap

16p13.3

16p13.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 263zinc finger protein FPM315zinc finger protein with KRAB and SCAN domains 12zinc finger protein 263zinc finger protein FPM315zinc finger protein with KRAB and SCAN domains 12
Modification date2018052320180523
UniProtAcc

O14978

O14978

Ensembl transtripts involved in fusion geneENST00000573951, ENST00000538765, 
ENST00000219069, ENST00000573578, 
ENST00000574253, 		ENST00000573951, 
ENST00000538765, ENST00000219069, 
ENST00000573578, ENST00000574253, 
Fusion gene scores* DoF score3 X 4 X 3=362 X 3 X 1=6
# samples 43
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/6*10)=2.32192809488736
Context

PubMed: ZNF263 [Title/Abstract] AND ZNF263 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZNF263

GO:0000122

negative regulation of transcription by RNA polymerase II

19887448

TgeneZNF263

GO:0000122

negative regulation of transcription by RNA polymerase II

19887448


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA243879ZNF263chr16

3340998

-ZNF263chr16

3341169

+
ChiTaRS3.1BF588566ZNF263chr16

3340370

-ZNF263chr16

3341233

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000573951ENST00000573951ZNF263chr16

3340998

-ZNF263chr16

3341169

+
intron-intronENST00000573951ENST00000538765ZNF263chr16

3340998

-ZNF263chr16

3341169

+
intron-3UTRENST00000573951ENST00000219069ZNF263chr16

3340998

-ZNF263chr16

3341169

+
intron-intronENST00000573951ENST00000573578ZNF263chr16

3340998

-ZNF263chr16

3341169

+
intron-intronENST00000573951ENST00000574253ZNF263chr16

3340998

-ZNF263chr16

3341169

+
3UTR-intronENST00000538765ENST00000573951ZNF263chr16

3340998

-ZNF263chr16

3341169

+
3UTR-intronENST00000538765ENST00000538765ZNF263chr16

3340998

-ZNF263chr16

3341169

+
3UTR-3UTRENST00000538765ENST00000219069ZNF263chr16

3340998

-ZNF263chr16

3341169

+
3UTR-intronENST00000538765ENST00000573578ZNF263chr16

3340998

-ZNF263chr16

3341169

+
3UTR-intronENST00000538765ENST00000574253ZNF263chr16

3340998

-ZNF263chr16

3341169

+
3UTR-intronENST00000219069ENST00000573951ZNF263chr16

3340998

-ZNF263chr16

3341169

+
3UTR-intronENST00000219069ENST00000538765ZNF263chr16

3340998

-ZNF263chr16

3341169

+
3UTR-3UTRENST00000219069ENST00000219069ZNF263chr16

3340998

-ZNF263chr16

3341169

+
3UTR-intronENST00000219069ENST00000573578ZNF263chr16

3340998

-ZNF263chr16

3341169

+
3UTR-intronENST00000219069ENST00000574253ZNF263chr16

3340998

-ZNF263chr16

3341169

+
intron-intronENST00000573578ENST00000573951ZNF263chr16

3340998

-ZNF263chr16

3341169

+
intron-intronENST00000573578ENST00000538765ZNF263chr16

3340998

-ZNF263chr16

3341169

+
intron-3UTRENST00000573578ENST00000219069ZNF263chr16

3340998

-ZNF263chr16

3341169

+
intron-intronENST00000573578ENST00000573578ZNF263chr16

3340998

-ZNF263chr16

3341169

+
intron-intronENST00000573578ENST00000574253ZNF263chr16

3340998

-ZNF263chr16

3341169

+
intron-intronENST00000574253ENST00000573951ZNF263chr16

3340998

-ZNF263chr16

3341169

+
intron-intronENST00000574253ENST00000538765ZNF263chr16

3340998

-ZNF263chr16

3341169

+
intron-3UTRENST00000574253ENST00000219069ZNF263chr16

3340998

-ZNF263chr16

3341169

+
intron-intronENST00000574253ENST00000573578ZNF263chr16

3340998

-ZNF263chr16

3341169

+
intron-intronENST00000574253ENST00000574253ZNF263chr16

3340998

-ZNF263chr16

3341169

+
intron-intronENST00000573951ENST00000573951ZNF263chr16

3340370

-ZNF263chr16

3341233

-
intron-intronENST00000573951ENST00000538765ZNF263chr16

3340370

-ZNF263chr16

3341233

-
intron-3UTRENST00000573951ENST00000219069ZNF263chr16

3340370

-ZNF263chr16

3341233

-
intron-intronENST00000573951ENST00000573578ZNF263chr16

3340370

-ZNF263chr16

3341233

-
intron-intronENST00000573951ENST00000574253ZNF263chr16

3340370

-ZNF263chr16

3341233

-
5CDS-intronENST00000538765ENST00000573951ZNF263chr16

3340370

-ZNF263chr16

3341233

-
5CDS-intronENST00000538765ENST00000538765ZNF263chr16

3340370

-ZNF263chr16

3341233

-
5CDS-3UTRENST00000538765ENST00000219069ZNF263chr16

3340370

-ZNF263chr16

3341233

-
5CDS-intronENST00000538765ENST00000573578ZNF263chr16

3340370

-ZNF263chr16

3341233

-
5CDS-intronENST00000538765ENST00000574253ZNF263chr16

3340370

-ZNF263chr16

3341233

-
5CDS-intronENST00000219069ENST00000573951ZNF263chr16

3340370

-ZNF263chr16

3341233

-
5CDS-intronENST00000219069ENST00000538765ZNF263chr16

3340370

-ZNF263chr16

3341233

-
5CDS-3UTRENST00000219069ENST00000219069ZNF263chr16

3340370

-ZNF263chr16

3341233

-
5CDS-intronENST00000219069ENST00000573578ZNF263chr16

3340370

-ZNF263chr16

3341233

-
5CDS-intronENST00000219069ENST00000574253ZNF263chr16

3340370

-ZNF263chr16

3341233

-
intron-intronENST00000573578ENST00000573951ZNF263chr16

3340370

-ZNF263chr16

3341233

-
intron-intronENST00000573578ENST00000538765ZNF263chr16

3340370

-ZNF263chr16

3341233

-
intron-3UTRENST00000573578ENST00000219069ZNF263chr16

3340370

-ZNF263chr16

3341233

-
intron-intronENST00000573578ENST00000573578ZNF263chr16

3340370

-ZNF263chr16

3341233

-
intron-intronENST00000573578ENST00000574253ZNF263chr16

3340370

-ZNF263chr16

3341233

-
intron-intronENST00000574253ENST00000573951ZNF263chr16

3340370

-ZNF263chr16

3341233

-
intron-intronENST00000574253ENST00000538765ZNF263chr16

3340370

-ZNF263chr16

3341233

-
intron-3UTRENST00000574253ENST00000219069ZNF263chr16

3340370

-ZNF263chr16

3341233

-
intron-intronENST00000574253ENST00000573578ZNF263chr16

3340370

-ZNF263chr16

3341233

-
intron-intronENST00000574253ENST00000574253ZNF263chr16

3340370

-ZNF263chr16

3341233

-

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FusionProtFeatures for ZNF263_ZNF263


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF263

O14978

ZNF263

O14978

Might play an important role in basic cellular processesas a transcriptional repressor. Might play an important role in basic cellular processesas a transcriptional repressor.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF263_ZNF263


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF263_ZNF263


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF263_ZNF263


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF263_ZNF263


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource