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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43118

FusionGeneSummary for ZNF248_FAM107B

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF248_FAM107B
Fusion gene ID: 43118
HgeneTgene
Gene symbol

ZNF248

FAM107B

Gene ID

57209

83641

Gene namezinc finger protein 248family with sequence similarity 107 member B
SynonymsbA162G10.3C10orf45|HITS
Cytomap

10p11.21

10p13

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 248KRAB protein domainKruppel-type zinc finger proteinbA162G10.3 (zinc finger protein)protein FAM107BFAM107B/CDNF fusionheat shock-inducible tumor small protein
Modification date2018052320180519
UniProtAcc

Q8NDW4

Q9H098

Ensembl transtripts involved in fusion geneENST00000395867, ENST00000374648, 
ENST00000357328, ENST00000494133, 
ENST00000181796, ENST00000378470, 
ENST00000468747, ENST00000378467, 
ENST00000378465, ENST00000378458, 
ENST00000478076, ENST00000378462, 
ENST00000496330, ENST00000479731, 
ENST00000471815, 
Fusion gene scores* DoF score3 X 3 X 2=189 X 7 X 6=378
# samples 39
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(9/378*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF248 [Title/Abstract] AND FAM107B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-DK-A1A6-01AZNF248chr10

38120160

-FAM107Bchr10

14595386

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000395867ENST00000181796ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
intron-intronENST00000395867ENST00000378470ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
intron-intronENST00000395867ENST00000468747ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
intron-5UTRENST00000395867ENST00000378467ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
intron-intronENST00000395867ENST00000378465ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
intron-5UTRENST00000395867ENST00000378458ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
intron-intronENST00000395867ENST00000478076ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
intron-intronENST00000395867ENST00000378462ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
intron-5UTRENST00000395867ENST00000496330ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
intron-intronENST00000395867ENST00000479731ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
intron-intronENST00000395867ENST00000471815ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
intron-intronENST00000374648ENST00000181796ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
intron-intronENST00000374648ENST00000378470ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
intron-intronENST00000374648ENST00000468747ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
intron-5UTRENST00000374648ENST00000378467ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
intron-intronENST00000374648ENST00000378465ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
intron-5UTRENST00000374648ENST00000378458ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
intron-intronENST00000374648ENST00000478076ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
intron-intronENST00000374648ENST00000378462ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
intron-5UTRENST00000374648ENST00000496330ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
intron-intronENST00000374648ENST00000479731ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
intron-intronENST00000374648ENST00000471815ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
intron-intronENST00000357328ENST00000181796ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
intron-intronENST00000357328ENST00000378470ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
intron-intronENST00000357328ENST00000468747ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
intron-5UTRENST00000357328ENST00000378467ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
intron-intronENST00000357328ENST00000378465ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
intron-5UTRENST00000357328ENST00000378458ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
intron-intronENST00000357328ENST00000478076ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
intron-intronENST00000357328ENST00000378462ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
intron-5UTRENST00000357328ENST00000496330ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
intron-intronENST00000357328ENST00000479731ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
intron-intronENST00000357328ENST00000471815ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
5UTR-intronENST00000494133ENST00000181796ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
5UTR-intronENST00000494133ENST00000378470ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
5UTR-intronENST00000494133ENST00000468747ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
5UTR-5UTRENST00000494133ENST00000378467ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
5UTR-intronENST00000494133ENST00000378465ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
5UTR-5UTRENST00000494133ENST00000378458ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
5UTR-intronENST00000494133ENST00000478076ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
5UTR-intronENST00000494133ENST00000378462ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
5UTR-5UTRENST00000494133ENST00000496330ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
5UTR-intronENST00000494133ENST00000479731ZNF248chr10

38120160

-FAM107Bchr10

14595386

-
5UTR-intronENST00000494133ENST00000471815ZNF248chr10

38120160

-FAM107Bchr10

14595386

-

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FusionProtFeatures for ZNF248_FAM107B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF248

Q8NDW4

FAM107B

Q9H098

May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF248_FAM107B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF248_FAM107B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF248MOV10FAM107BELAVL1, BAG3, U2AF2, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF248_FAM107B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF248_FAM107B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource