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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43105

FusionGeneSummary for ZNF22_ETV1

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF22_ETV1
Fusion gene ID: 43105
HgeneTgene
Gene symbol

ZNF22

ETV1

Gene ID

7570

2115

Gene namezinc finger protein 22ETS variant 1
SynonymsHKR-T1|KOX15|ZNF422|Zfp422ER81
Cytomap

10q11.21

7p21.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 22krox-26 proteinzinc finger protein 22 (KOX 15)zinc finger protein KOX15zinc finger protein Krox-26ETS translocation variant 1ets variant gene 1ets-related protein 81
Modification date2018052320180523
UniProtAcc

P17026

P50549

Ensembl transtripts involved in fusion geneENST00000298299, ENST00000430479, 
ENST00000399357, ENST00000420159, 
ENST00000343495, ENST00000242066, 
ENST00000405192, ENST00000405358, 
ENST00000403527, ENST00000405218, 
ENST00000403685, ENST00000476720, 
Fusion gene scores* DoF score2 X 2 X 2=811 X 14 X 3=462
# samples 227
** MAII scorelog2(2/8*10)=1.32192809488736log2(27/462*10)=-0.774933444365227
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF22 [Title/Abstract] AND ETV1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneETV1

GO:0045944

positive regulation of transcription by RNA polymerase II

12750007


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLGGTCGA-E1-5304-01AZNF22chr10

45496426

+ETV1chr7

13949325

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000298299ENST00000430479ZNF22chr10

45496426

+ETV1chr7

13949325

-
5UTR-3CDSENST00000298299ENST00000399357ZNF22chr10

45496426

+ETV1chr7

13949325

-
5UTR-3CDSENST00000298299ENST00000420159ZNF22chr10

45496426

+ETV1chr7

13949325

-
5UTR-3CDSENST00000298299ENST00000343495ZNF22chr10

45496426

+ETV1chr7

13949325

-
5UTR-3CDSENST00000298299ENST00000242066ZNF22chr10

45496426

+ETV1chr7

13949325

-
5UTR-3CDSENST00000298299ENST00000405192ZNF22chr10

45496426

+ETV1chr7

13949325

-
5UTR-3CDSENST00000298299ENST00000405358ZNF22chr10

45496426

+ETV1chr7

13949325

-
5UTR-3CDSENST00000298299ENST00000403527ZNF22chr10

45496426

+ETV1chr7

13949325

-
5UTR-3CDSENST00000298299ENST00000405218ZNF22chr10

45496426

+ETV1chr7

13949325

-
5UTR-3CDSENST00000298299ENST00000403685ZNF22chr10

45496426

+ETV1chr7

13949325

-
5UTR-intronENST00000298299ENST00000476720ZNF22chr10

45496426

+ETV1chr7

13949325

-

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FusionProtFeatures for ZNF22_ETV1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF22

P17026

ETV1

P50549

Binds DNA through the consensus sequence 5'-CAATG-3'.May be involved in transcriptional regulation and may play a rolein tooth formation (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF22_ETV1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF22_ETV1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF22APP, HIST1H1A, RPL14, RPL26L1, SRRM1, ZNF808, ZNF624, DDX52, HIST1H1C, RPS3A, NPM1, RPL36AL, MRPL27, MRPL9, MRPL30, MRPL20, MRPS18A, TRA2A, PRR11, ILF2, TPM2, RPL7, ZNF71, RPL30, PPAN, DGCR8, RPL18, WDR46, ZNF2, H2AFX, RPL37AETV1SPI1, MAPK8, MAPK3, MAPK14, MAPKAPK2, EP300, KAT2B, RFWD2, RPS6KA5, NSMCE2, CCND3, NCOA3, NCOA2, JUN, UBE2I, STK40, DET1, TP53, TERT, ATR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF22_ETV1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF22_ETV1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneETV1C0033578Prostatic Neoplasms2CTD_human