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Fusion gene ID: 43105 |
FusionGeneSummary for ZNF22_ETV1 |
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Fusion gene information | Fusion gene name: ZNF22_ETV1 | Fusion gene ID: 43105 | Hgene | Tgene | Gene symbol | ZNF22 | ETV1 | Gene ID | 7570 | 2115 |
Gene name | zinc finger protein 22 | ETS variant 1 | |
Synonyms | HKR-T1|KOX15|ZNF422|Zfp422 | ER81 | |
Cytomap | 10q11.21 | 7p21.2 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein 22krox-26 proteinzinc finger protein 22 (KOX 15)zinc finger protein KOX15zinc finger protein Krox-26 | ETS translocation variant 1ets variant gene 1ets-related protein 81 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P17026 | P50549 | |
Ensembl transtripts involved in fusion gene | ENST00000298299, | ENST00000430479, ENST00000399357, ENST00000420159, ENST00000343495, ENST00000242066, ENST00000405192, ENST00000405358, ENST00000403527, ENST00000405218, ENST00000403685, ENST00000476720, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 11 X 14 X 3=462 |
# samples | 2 | 27 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(27/462*10)=-0.774933444365227 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ZNF22 [Title/Abstract] AND ETV1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ETV1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12750007 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LGG | TCGA-E1-5304-01A | ZNF22 | chr10 | 45496426 | + | ETV1 | chr7 | 13949325 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000298299 | ENST00000430479 | ZNF22 | chr10 | 45496426 | + | ETV1 | chr7 | 13949325 | - |
5UTR-3CDS | ENST00000298299 | ENST00000399357 | ZNF22 | chr10 | 45496426 | + | ETV1 | chr7 | 13949325 | - |
5UTR-3CDS | ENST00000298299 | ENST00000420159 | ZNF22 | chr10 | 45496426 | + | ETV1 | chr7 | 13949325 | - |
5UTR-3CDS | ENST00000298299 | ENST00000343495 | ZNF22 | chr10 | 45496426 | + | ETV1 | chr7 | 13949325 | - |
5UTR-3CDS | ENST00000298299 | ENST00000242066 | ZNF22 | chr10 | 45496426 | + | ETV1 | chr7 | 13949325 | - |
5UTR-3CDS | ENST00000298299 | ENST00000405192 | ZNF22 | chr10 | 45496426 | + | ETV1 | chr7 | 13949325 | - |
5UTR-3CDS | ENST00000298299 | ENST00000405358 | ZNF22 | chr10 | 45496426 | + | ETV1 | chr7 | 13949325 | - |
5UTR-3CDS | ENST00000298299 | ENST00000403527 | ZNF22 | chr10 | 45496426 | + | ETV1 | chr7 | 13949325 | - |
5UTR-3CDS | ENST00000298299 | ENST00000405218 | ZNF22 | chr10 | 45496426 | + | ETV1 | chr7 | 13949325 | - |
5UTR-3CDS | ENST00000298299 | ENST00000403685 | ZNF22 | chr10 | 45496426 | + | ETV1 | chr7 | 13949325 | - |
5UTR-intron | ENST00000298299 | ENST00000476720 | ZNF22 | chr10 | 45496426 | + | ETV1 | chr7 | 13949325 | - |
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FusionProtFeatures for ZNF22_ETV1 |
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Hgene | Tgene |
ZNF22 | ETV1 |
Binds DNA through the consensus sequence 5'-CAATG-3'.May be involved in transcriptional regulation and may play a rolein tooth formation (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF22_ETV1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZNF22_ETV1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZNF22 | APP, HIST1H1A, RPL14, RPL26L1, SRRM1, ZNF808, ZNF624, DDX52, HIST1H1C, RPS3A, NPM1, RPL36AL, MRPL27, MRPL9, MRPL30, MRPL20, MRPS18A, TRA2A, PRR11, ILF2, TPM2, RPL7, ZNF71, RPL30, PPAN, DGCR8, RPL18, WDR46, ZNF2, H2AFX, RPL37A | ETV1 | SPI1, MAPK8, MAPK3, MAPK14, MAPKAPK2, EP300, KAT2B, RFWD2, RPS6KA5, NSMCE2, CCND3, NCOA3, NCOA2, JUN, UBE2I, STK40, DET1, TP53, TERT, ATR |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF22_ETV1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF22_ETV1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ETV1 | C0033578 | Prostatic Neoplasms | 2 | CTD_human |