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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43093

FusionGeneSummary for ZNF219_ZNF219

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF219_ZNF219
Fusion gene ID: 43093
HgeneTgene
Gene symbol

ZNF219

ZNF219

Gene ID

51222

51222

Gene namezinc finger protein 219zinc finger protein 219
SynonymsZFP219ZFP219
Cytomap

14q11.2

14q11.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 219zinc finger protein 219
Modification date2018052320180523
UniProtAcc

Q9P2Y4

Q9P2Y4

Ensembl transtripts involved in fusion geneENST00000360947, ENST00000451119, 
ENST00000421093, ENST00000556101, 
ENST00000360947, ENST00000451119, 
ENST00000421093, ENST00000556101, 
Fusion gene scores* DoF score2 X 2 X 2=81 X 1 X 1=1
# samples 21
** MAII scorelog2(2/8*10)=1.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: ZNF219 [Title/Abstract] AND ZNF219 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZNF219

GO:0000122

negative regulation of transcription by RNA polymerase II

14621294

HgeneZNF219

GO:0006351

transcription, DNA-templated

14621294

HgeneZNF219

GO:0045892

negative regulation of transcription, DNA-templated

14621294

TgeneZNF219

GO:0000122

negative regulation of transcription by RNA polymerase II

14621294

TgeneZNF219

GO:0006351

transcription, DNA-templated

14621294

TgeneZNF219

GO:0045892

negative regulation of transcription, DNA-templated

14621294


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI829676ZNF219chr14

21560669

+ZNF219chr14

21559222

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000360947ENST00000360947ZNF219chr14

21560669

+ZNF219chr14

21559222

+
intron-3CDSENST00000360947ENST00000451119ZNF219chr14

21560669

+ZNF219chr14

21559222

+
intron-3CDSENST00000360947ENST00000421093ZNF219chr14

21560669

+ZNF219chr14

21559222

+
intron-intronENST00000360947ENST00000556101ZNF219chr14

21560669

+ZNF219chr14

21559222

+
intron-3CDSENST00000451119ENST00000360947ZNF219chr14

21560669

+ZNF219chr14

21559222

+
intron-3CDSENST00000451119ENST00000451119ZNF219chr14

21560669

+ZNF219chr14

21559222

+
intron-3CDSENST00000451119ENST00000421093ZNF219chr14

21560669

+ZNF219chr14

21559222

+
intron-intronENST00000451119ENST00000556101ZNF219chr14

21560669

+ZNF219chr14

21559222

+
intron-3CDSENST00000421093ENST00000360947ZNF219chr14

21560669

+ZNF219chr14

21559222

+
intron-3CDSENST00000421093ENST00000451119ZNF219chr14

21560669

+ZNF219chr14

21559222

+
intron-3CDSENST00000421093ENST00000421093ZNF219chr14

21560669

+ZNF219chr14

21559222

+
intron-intronENST00000421093ENST00000556101ZNF219chr14

21560669

+ZNF219chr14

21559222

+
intron-3CDSENST00000556101ENST00000360947ZNF219chr14

21560669

+ZNF219chr14

21559222

+
intron-3CDSENST00000556101ENST00000451119ZNF219chr14

21560669

+ZNF219chr14

21559222

+
intron-3CDSENST00000556101ENST00000421093ZNF219chr14

21560669

+ZNF219chr14

21559222

+
intron-intronENST00000556101ENST00000556101ZNF219chr14

21560669

+ZNF219chr14

21559222

+

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FusionProtFeatures for ZNF219_ZNF219


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF219

Q9P2Y4

ZNF219

Q9P2Y4

Transcriptional regulator (PubMed:14621294,PubMed:19549071). Recognizes and binds 2 copies of the core DNAsequence motif 5'-GGGGG-3' (PubMed:14621294). Binds to the HMGN1promoter and may repress HMGN1 expression (PubMed:14621294).Regulates SNCA expression in primary cortical neurons(PubMed:19549071). Binds to the COL2A1 promoter and activatesCOL2A1 expression, as part of a complex with SOX9 (By similarity).Plays a role in chondrocyte differentiation (By similarity).{ECO:0000250|UniProtKB:Q6IQX8, ECO:0000269|PubMed:14621294,ECO:0000269|PubMed:19549071}. Transcriptional regulator (PubMed:14621294,PubMed:19549071). Recognizes and binds 2 copies of the core DNAsequence motif 5'-GGGGG-3' (PubMed:14621294). Binds to the HMGN1promoter and may repress HMGN1 expression (PubMed:14621294).Regulates SNCA expression in primary cortical neurons(PubMed:19549071). Binds to the COL2A1 promoter and activatesCOL2A1 expression, as part of a complex with SOX9 (By similarity).Plays a role in chondrocyte differentiation (By similarity).{ECO:0000250|UniProtKB:Q6IQX8, ECO:0000269|PubMed:14621294,ECO:0000269|PubMed:19549071}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF219_ZNF219


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF219_ZNF219


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF219_ZNF219


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF219_ZNF219


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource