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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43086

FusionGeneSummary for ZNF217_BCAS3

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF217_BCAS3
Fusion gene ID: 43086
HgeneTgene
Gene symbol

ZNF217

BCAS3

Gene ID

7764

54828

Gene namezinc finger protein 217BCAS3, microtubule associated cell migration factor
SynonymsZABC1GAOB1|MAAB
Cytomap

20q13.2

17q23.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 217breast carcinoma-amplified sequence 3BCAS4/BCAS3 fusionRudhirabreast carcinoma amplified sequence 4/3 fusion proteinmetastasis associated antigen of breast cancerprotein Maab1
Modification date2018052320180523
UniProtAcc

O75362

Q9H6U6

Ensembl transtripts involved in fusion geneENST00000371471, ENST00000302342, 
ENST00000540425, 
ENST00000589222, 
ENST00000407086, ENST00000390652, 
ENST00000408905, ENST00000588462, 
ENST00000585744, ENST00000588874, 
ENST00000585812, 
Fusion gene scores* DoF score7 X 6 X 5=21026 X 15 X 15=5850
# samples 741
** MAII scorelog2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(41/5850*10)=-3.83474080985268
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF217 [Title/Abstract] AND BCAS3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZNF217

GO:0000122

negative regulation of transcription by RNA polymerase II

17130829

HgeneZNF217

GO:0006355

regulation of transcription, DNA-templated

18625718

HgeneZNF217

GO:0045892

negative regulation of transcription, DNA-templated

16940172

TgeneBCAS3

GO:0043085

positive regulation of catalytic activity

17505058

TgeneBCAS3

GO:0045944

positive regulation of transcription by RNA polymerase II

17505058

TgeneBCAS3

GO:0071391

cellular response to estrogen stimulus

17505058


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AQ-A0Y5-01AZNF217chr20

52214170

-BCAS3chr17

59445688

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000371471ENST00000589222ZNF217chr20

52214170

-BCAS3chr17

59445688

+
intron-3CDSENST00000371471ENST00000407086ZNF217chr20

52214170

-BCAS3chr17

59445688

+
intron-3CDSENST00000371471ENST00000390652ZNF217chr20

52214170

-BCAS3chr17

59445688

+
intron-3CDSENST00000371471ENST00000408905ZNF217chr20

52214170

-BCAS3chr17

59445688

+
intron-3CDSENST00000371471ENST00000588462ZNF217chr20

52214170

-BCAS3chr17

59445688

+
intron-3CDSENST00000371471ENST00000585744ZNF217chr20

52214170

-BCAS3chr17

59445688

+
intron-3CDSENST00000371471ENST00000588874ZNF217chr20

52214170

-BCAS3chr17

59445688

+
intron-3UTRENST00000371471ENST00000585812ZNF217chr20

52214170

-BCAS3chr17

59445688

+
intron-3CDSENST00000302342ENST00000589222ZNF217chr20

52214170

-BCAS3chr17

59445688

+
intron-3CDSENST00000302342ENST00000407086ZNF217chr20

52214170

-BCAS3chr17

59445688

+
intron-3CDSENST00000302342ENST00000390652ZNF217chr20

52214170

-BCAS3chr17

59445688

+
intron-3CDSENST00000302342ENST00000408905ZNF217chr20

52214170

-BCAS3chr17

59445688

+
intron-3CDSENST00000302342ENST00000588462ZNF217chr20

52214170

-BCAS3chr17

59445688

+
intron-3CDSENST00000302342ENST00000585744ZNF217chr20

52214170

-BCAS3chr17

59445688

+
intron-3CDSENST00000302342ENST00000588874ZNF217chr20

52214170

-BCAS3chr17

59445688

+
intron-3UTRENST00000302342ENST00000585812ZNF217chr20

52214170

-BCAS3chr17

59445688

+
5UTR-3CDSENST00000540425ENST00000589222ZNF217chr20

52214170

-BCAS3chr17

59445688

+
5UTR-3CDSENST00000540425ENST00000407086ZNF217chr20

52214170

-BCAS3chr17

59445688

+
5UTR-3CDSENST00000540425ENST00000390652ZNF217chr20

52214170

-BCAS3chr17

59445688

+
5UTR-3CDSENST00000540425ENST00000408905ZNF217chr20

52214170

-BCAS3chr17

59445688

+
5UTR-3CDSENST00000540425ENST00000588462ZNF217chr20

52214170

-BCAS3chr17

59445688

+
5UTR-3CDSENST00000540425ENST00000585744ZNF217chr20

52214170

-BCAS3chr17

59445688

+
5UTR-3CDSENST00000540425ENST00000588874ZNF217chr20

52214170

-BCAS3chr17

59445688

+
5UTR-3UTRENST00000540425ENST00000585812ZNF217chr20

52214170

-BCAS3chr17

59445688

+

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FusionProtFeatures for ZNF217_BCAS3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF217

O75362

BCAS3

Q9H6U6

Binds to the promoters of target genes and functions asrepressor. Promotes cell proliferation and antagonizes cell death.Promotes phosphorylation of AKT1 at 'Ser-473'.{ECO:0000269|PubMed:16203743, ECO:0000269|PubMed:16940172,ECO:0000269|PubMed:17259635, ECO:0000269|PubMed:18625718}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF217_BCAS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF217_BCAS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF217KDM1A, RCOR1, EHMT2, CTBP1, KDM5B, CTBP2, HDAC2, HIST3H3, ELAVL1, HDAC1, PIPOX, NFATC2BCAS3CTBP1, CTBP2, CDC23, C16orf70, ZDHHC17, ESR1, PELP1, HIST1H3A, KAT2B, WIPI2, ATM, BAG4, CCND1, FBXW7, KRAS, PALB2, PHB, PTPN1, SMAD4, STK11, TGFB1, TSG101, XRCC3, OFD1, CEP128, FBF1, NPHP1, SCLT1, XPO1, CD14, HDAC1, IRF3, MAGEE1, IL17RA, DOCK5, VWA5A, RAB2B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF217_BCAS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF217_BCAS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource