|
Fusion gene ID: 43057 |
FusionGeneSummary for ZNF189_BAAT |
Fusion gene summary |
Fusion gene information | Fusion gene name: ZNF189_BAAT | Fusion gene ID: 43057 | Hgene | Tgene | Gene symbol | ZNF189 | BAAT | Gene ID | 7743 | 570 |
Gene name | zinc finger protein 189 | bile acid-CoA:amino acid N-acyltransferase | |
Synonyms | - | BACAT|BAT | |
Cytomap | 9q31.1 | 9q31.1 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein 189 | bile acid-CoA:amino acid N-acyltransferasebile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)long-chain fatty-acyl-CoA hydrolase | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | O75820 | Q14032 | |
Ensembl transtripts involved in fusion gene | ENST00000374861, ENST00000259395, ENST00000339664, | ENST00000259407, ENST00000395051, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
# samples | 2 | 2 | |
** MAII score | log2(2/1*10)=4.32192809488736 | log2(2/1*10)=4.32192809488736 | |
Context | PubMed: ZNF189 [Title/Abstract] AND BAAT [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | BAAT | GO:0002152 | bile acid conjugation | 8034703|12810727 |
Tgene | BAAT | GO:0006544 | glycine metabolic process | 8034703 |
Tgene | BAAT | GO:0006637 | acyl-CoA metabolic process | 12810727 |
Tgene | BAAT | GO:0006699 | bile acid biosynthetic process | 8034703|12810727 |
Tgene | BAAT | GO:0019530 | taurine metabolic process | 8034703 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUSC | TCGA-18-3415-01A | ZNF189 | chr9 | 104162292 | + | BAAT | chr9 | 104133745 | - |
TCGA | RV | LUSC | TCGA-J1-A4AH-01A | ZNF189 | chr9 | 104162292 | + | BAAT | chr9 | 104133745 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000374861 | ENST00000259407 | ZNF189 | chr9 | 104162292 | + | BAAT | chr9 | 104133745 | - |
5CDS-5UTR | ENST00000374861 | ENST00000395051 | ZNF189 | chr9 | 104162292 | + | BAAT | chr9 | 104133745 | - |
5CDS-5UTR | ENST00000259395 | ENST00000259407 | ZNF189 | chr9 | 104162292 | + | BAAT | chr9 | 104133745 | - |
5CDS-5UTR | ENST00000259395 | ENST00000395051 | ZNF189 | chr9 | 104162292 | + | BAAT | chr9 | 104133745 | - |
5CDS-5UTR | ENST00000339664 | ENST00000259407 | ZNF189 | chr9 | 104162292 | + | BAAT | chr9 | 104133745 | - |
5CDS-5UTR | ENST00000339664 | ENST00000395051 | ZNF189 | chr9 | 104162292 | + | BAAT | chr9 | 104133745 | - |
Top |
FusionProtFeatures for ZNF189_BAAT |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
ZNF189 | BAAT |
Involved in bile acid metabolism. In liver hepatocytescatalyzes the second step in the conjugation of C24 bile acids(choloneates) to glycine and taurine before excretion into bilecanaliculi. The major components of bile are cholic acid andchenodeoxycholic acid. In a first step the bile acids areconverted to an acyl-CoA thioester, either in peroxisomes (primarybile acids deriving from the cholesterol pathway), or cytoplasmicat the endoplasmic reticulum (secondary bile acids). May catalyzethe conjugation of primary or secondary bile acids, or both. Theconjugation increases the detergent properties of bile acids inthe intestine, which facilitates lipid and fat-soluble vitaminabsorption. In turn, bile acids are deconjugated by bacteria inthe intestine and are recycled back to the liver for reconjugation(secondary bile acids). May also act as an acyl-CoA thioesterasethat regulates intracellular levels of free fatty acids. In vitro,catalyzes the hydrolysis of long- and very long-chain saturatedacyl-CoAs to the free fatty acid and coenzyme A (CoASH), andconjugates glycine to these acyl-CoAs.{ECO:0000269|PubMed:12810727, ECO:0000269|PubMed:8034703}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for ZNF189_BAAT |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for ZNF189_BAAT |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZNF189 | LYN, HIST1H1A, NOL12, PRR11, H2AFY2, GLTSCR2, DGCR8, ZNF2, RPL30 | BAAT | PEX5, GOLGA8EP, GOLGA8F, GOLGA8DP, STAU1 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for ZNF189_BAAT |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | BAAT | Q14032 | DB00145 | Glycine | Bile acid-CoA:amino acid N-acyltransferase {ECO:0000303|PubMed:8034703} | small molecule | approved|nutraceutical|vet_approved |
Top |
RelatedDiseases for ZNF189_BAAT |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | BAAT | C1843139 | Hypercholanemia, Familial | 1 | CTD_human;ORPHANET;UNIPROT |