FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 43057

FusionGeneSummary for ZNF189_BAAT

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF189_BAAT
Fusion gene ID: 43057
HgeneTgene
Gene symbol

ZNF189

BAAT

Gene ID

7743

570

Gene namezinc finger protein 189bile acid-CoA:amino acid N-acyltransferase
Synonyms-BACAT|BAT
Cytomap

9q31.1

9q31.1

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 189bile acid-CoA:amino acid N-acyltransferasebile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)long-chain fatty-acyl-CoA hydrolase
Modification date2018051920180523
UniProtAcc

O75820

Q14032

Ensembl transtripts involved in fusion geneENST00000374861, ENST00000259395, 
ENST00000339664, 
ENST00000259407, 
ENST00000395051, 
Fusion gene scores* DoF score1 X 1 X 1=11 X 1 X 1=1
# samples 22
** MAII scorelog2(2/1*10)=4.32192809488736log2(2/1*10)=4.32192809488736
Context

PubMed: ZNF189 [Title/Abstract] AND BAAT [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBAAT

GO:0002152

bile acid conjugation

8034703|12810727

TgeneBAAT

GO:0006544

glycine metabolic process

8034703

TgeneBAAT

GO:0006637

acyl-CoA metabolic process

12810727

TgeneBAAT

GO:0006699

bile acid biosynthetic process

8034703|12810727

TgeneBAAT

GO:0019530

taurine metabolic process

8034703


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-18-3415-01AZNF189chr9

104162292

+BAATchr9

104133745

-
TCGARVLUSCTCGA-J1-A4AH-01AZNF189chr9

104162292

+BAATchr9

104133745

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000374861ENST00000259407ZNF189chr9

104162292

+BAATchr9

104133745

-
5CDS-5UTRENST00000374861ENST00000395051ZNF189chr9

104162292

+BAATchr9

104133745

-
5CDS-5UTRENST00000259395ENST00000259407ZNF189chr9

104162292

+BAATchr9

104133745

-
5CDS-5UTRENST00000259395ENST00000395051ZNF189chr9

104162292

+BAATchr9

104133745

-
5CDS-5UTRENST00000339664ENST00000259407ZNF189chr9

104162292

+BAATchr9

104133745

-
5CDS-5UTRENST00000339664ENST00000395051ZNF189chr9

104162292

+BAATchr9

104133745

-

Top

FusionProtFeatures for ZNF189_BAAT


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF189

O75820

BAAT

Q14032

Involved in bile acid metabolism. In liver hepatocytescatalyzes the second step in the conjugation of C24 bile acids(choloneates) to glycine and taurine before excretion into bilecanaliculi. The major components of bile are cholic acid andchenodeoxycholic acid. In a first step the bile acids areconverted to an acyl-CoA thioester, either in peroxisomes (primarybile acids deriving from the cholesterol pathway), or cytoplasmicat the endoplasmic reticulum (secondary bile acids). May catalyzethe conjugation of primary or secondary bile acids, or both. Theconjugation increases the detergent properties of bile acids inthe intestine, which facilitates lipid and fat-soluble vitaminabsorption. In turn, bile acids are deconjugated by bacteria inthe intestine and are recycled back to the liver for reconjugation(secondary bile acids). May also act as an acyl-CoA thioesterasethat regulates intracellular levels of free fatty acids. In vitro,catalyzes the hydrolysis of long- and very long-chain saturatedacyl-CoAs to the free fatty acid and coenzyme A (CoASH), andconjugates glycine to these acyl-CoAs.{ECO:0000269|PubMed:12810727, ECO:0000269|PubMed:8034703}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ZNF189_BAAT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ZNF189_BAAT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF189LYN, HIST1H1A, NOL12, PRR11, H2AFY2, GLTSCR2, DGCR8, ZNF2, RPL30BAATPEX5, GOLGA8EP, GOLGA8F, GOLGA8DP, STAU1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ZNF189_BAAT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneBAATQ14032DB00145GlycineBile acid-CoA:amino acid N-acyltransferase {ECO:0000303|PubMed:8034703}small moleculeapproved|nutraceutical|vet_approved

Top

RelatedDiseases for ZNF189_BAAT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneBAATC1843139Hypercholanemia, Familial1CTD_human;ORPHANET;UNIPROT