FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 43051

FusionGeneSummary for ZNF180_TOMM40

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF180_TOMM40
Fusion gene ID: 43051
HgeneTgene
Gene symbol

ZNF180

TOMM40

Gene ID

7733

10452

Gene namezinc finger protein 180translocase of outer mitochondrial membrane 40
SynonymsHHZ168C19orf1|D19S1177E|PER-EC1|PEREC1|TOM40
Cytomap

19q13.31

19q13.32

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 180mitochondrial import receptor subunit TOM40 homologmitochondrial outer membrane proteinp38.5protein Haymakertranslocase of outer membrane 40 kDa subunit homologtranslocase of outer mitochondrial membrane 40 homolog
Modification date2018052320180523
UniProtAcc

Q9UJW8

O96008

Ensembl transtripts involved in fusion geneENST00000391956, ENST00000221327, 
ENST00000592529, ENST00000586637, 
ENST00000587047, ENST00000585514, 
ENST00000405636, ENST00000252487, 
ENST00000592434, ENST00000426677, 
Fusion gene scores* DoF score3 X 3 X 3=273 X 2 X 3=18
# samples 33
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZNF180 [Title/Abstract] AND TOMM40 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A1-A0SQ-01AZNF180chr19

45001336

-TOMM40chr19

45406287

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000391956ENST00000405636ZNF180chr19

45001336

-TOMM40chr19

45406287

+
Frame-shiftENST00000391956ENST00000252487ZNF180chr19

45001336

-TOMM40chr19

45406287

+
5CDS-3UTRENST00000391956ENST00000592434ZNF180chr19

45001336

-TOMM40chr19

45406287

+
5CDS-3UTRENST00000391956ENST00000426677ZNF180chr19

45001336

-TOMM40chr19

45406287

+
Frame-shiftENST00000221327ENST00000405636ZNF180chr19

45001336

-TOMM40chr19

45406287

+
Frame-shiftENST00000221327ENST00000252487ZNF180chr19

45001336

-TOMM40chr19

45406287

+
5CDS-3UTRENST00000221327ENST00000592434ZNF180chr19

45001336

-TOMM40chr19

45406287

+
5CDS-3UTRENST00000221327ENST00000426677ZNF180chr19

45001336

-TOMM40chr19

45406287

+
In-frameENST00000592529ENST00000405636ZNF180chr19

45001336

-TOMM40chr19

45406287

+
Frame-shiftENST00000592529ENST00000252487ZNF180chr19

45001336

-TOMM40chr19

45406287

+
5CDS-3UTRENST00000592529ENST00000592434ZNF180chr19

45001336

-TOMM40chr19

45406287

+
5CDS-3UTRENST00000592529ENST00000426677ZNF180chr19

45001336

-TOMM40chr19

45406287

+
Frame-shiftENST00000586637ENST00000405636ZNF180chr19

45001336

-TOMM40chr19

45406287

+
Frame-shiftENST00000586637ENST00000252487ZNF180chr19

45001336

-TOMM40chr19

45406287

+
5CDS-3UTRENST00000586637ENST00000592434ZNF180chr19

45001336

-TOMM40chr19

45406287

+
5CDS-3UTRENST00000586637ENST00000426677ZNF180chr19

45001336

-TOMM40chr19

45406287

+
Frame-shiftENST00000587047ENST00000405636ZNF180chr19

45001336

-TOMM40chr19

45406287

+
Frame-shiftENST00000587047ENST00000252487ZNF180chr19

45001336

-TOMM40chr19

45406287

+
5CDS-3UTRENST00000587047ENST00000592434ZNF180chr19

45001336

-TOMM40chr19

45406287

+
5CDS-3UTRENST00000587047ENST00000426677ZNF180chr19

45001336

-TOMM40chr19

45406287

+
5UTR-3CDSENST00000585514ENST00000405636ZNF180chr19

45001336

-TOMM40chr19

45406287

+
5UTR-3CDSENST00000585514ENST00000252487ZNF180chr19

45001336

-TOMM40chr19

45406287

+
5UTR-3UTRENST00000585514ENST00000592434ZNF180chr19

45001336

-TOMM40chr19

45406287

+
5UTR-3UTRENST00000585514ENST00000426677ZNF180chr19

45001336

-TOMM40chr19

45406287

+

Top

FusionProtFeatures for ZNF180_TOMM40


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF180

Q9UJW8

TOMM40

O96008

May be involved in transcriptional regulation. Channel-forming protein essential for import of proteinprecursors into mitochondria. {ECO:0000269|PubMed:15644312}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ZNF180_TOMM40


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ZNF180_ENST00000592529_chr19_45001336_-_TOMM40_ENST00000405636_chr19_45406287_+_63aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ZNF180_ENST00000592529_chr19_45001336_-_TOMM40_ENST00000405636_chr19_45406287_+_191nt
ATGGAAGAGCAGGATGAGAAGCCCCCAGAGCCCCCGAAGGCCTGTGCACAGGCTCTGTGGATAGCAACTGGATCGTGGGTGCCACGCTGG
AGAAGAAGCTCCCACCCCTGCCCCTGACACTGGCCCTTGGGGCCTTCCTGAATCACCGCAAGAACAAGTTTCAGTGTGGCTTTGGCCTCA


* Fusion transcript sequences (Full-length transcript).
>In-frame_ZNF180_ENST00000592529_chr19_45001336_-_TOMM40_ENST00000405636_chr19_45406287_+_992nt
CACAAGAGCAGCCATTGTCCCGCGCGCGGACGCTTGCTGTCGCCGAGCAGCTCGGCCCTTCAGACTTAACCCCCAGCGGCCTTGCGGATG
CTGACTAGGAGAGGGGACCGAACTAGCTTAACCCGAGTCGGCCGTGTTGCAGAATCGGGGCAGGGGGTTGCCTAACCCGAGTTCGTCCTG
CCGCAGAGCCGTGCTAGGCACTGAGGCGGTGACAGGCCCAGCCTGGGCTGCGGGCCAGCGGACGCCCAGTGCAGCTCAGGACCTCAGCAC
CCTGCTGTGCCTGGAGGAGAGCATGGAAGAGCAGGATGAGAAGCCCCCAGAGCCCCCGAAGGCCTGTGCACAGGCTCTGTGGATAGCAAC
TGGATCGTGGGTGCCACGCTGGAGAAGAAGCTCCCACCCCTGCCCCTGACACTGGCCCTTGGGGCCTTCCTGAATCACCGCAAGAACAAG
TTTCAGTGTGGCTTTGGCCTCACCATCGGCTGAGCCCTCCTGGCCCCCGCCTTCCACGCCCTTCCGATTCCACCTCCACCTCCACCTCCC
CCTGCCACAGAGGGGAGACCTGAGCCCCCCTCCCTTCCCTCCCCCCTTGGGGGTCGGGGGGGACATTGGAAAGGAGGGACCCCGCCACCC
CAGCAGCTGAGGAGGGGATTCTGGAACTGAATGGCGCTTCGGGATTCTGAGTAGCAGGGGCAGCATGCCCAGTGGGCCTGGGGTCCCGGG
AGGGATTCCGGAATTGAGGGGCACGCAGGATTCTGAGCACCAGGGGCAGAGGCGGCCAGACAACCTCAGGGAGGAGTGTCCTGGCGTCCC
CATCCTCCAAAGGGCCTGGGCCCGCCCCGAGGGGGCAGCGAGAGGAGCTTCCCCATCCCCGGTCAGTCCACCCTGCCCCGTCCACTTTCC
CATCTCCTCGGTATAAATCATGTTTATAAGTTATGGAAGAACCGGGACATTTTACAGAAAAAAAACAAAAAACAACAAAAAATATACGTG


Top

FusionGenePPI for ZNF180_TOMM40


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF180KIFC3, NDEL1, KRTAP10-7TOMM40BAX, TOMM22, TOMM20, PINK1, TOMM7, TOMM70A, NIPBL, SF1, ABCB6, SRPRB, BAK1, SRP9, OXA1L, LAMTOR3, SDHB, FIS1, FAF2, C1QBP, SEPT11, SBDS, FLOT2, MRPL55, NDUFA7, SAMM50, TIMM50, CPT1A, ALDH5A1, NUPL1, TAX1BP3, PRDX5, UBAP2, ACAA2, SFPQ, RMDN3, ABCD3, EIF3A, SLC9A3R2, TIAL1, TAGLN2, SERPINH1, SNRPC, FMNL1, HSP90AA1, HSPA4, MTX1, PARK2, UBAC2, TRABD, SLAMF1, LYPD3, WNT4, LRRTM2, KLRF1, LDLRAD4, AIFM1, ANXA11, CAB39, CHCHD2, CISD1, COX5B, CPT2, CYC1, EEF2, FUBP1, MTCH1, MTCH2, NDUFA2, NDUFB8, NDUFS1, NDUFV1, PHB2, PRCP, QARS, RAB1B, SGPL1, SLC25A3, AP2B1, ATP1B1, ATP1B3, CAPZB, DLD, GSR, HADHA, HMGCL, HSD17B10, PSMD7, VAPA, VDAC1, VDAC2, VDAC3, ATP2B1, ATP5I, FKBP1A, ITIH1, RNF5, BAG2, NOS1AP, STUB1, CEPT1, FARS2, IMMT, CHCHD3, SLC35F6, CCDC94, PHACTR4, TUBB6, LAMA1, FOXA3, FOXB1, FOXI1, FOXJ2, FOXL1, COQ9, NDUFA4, OCIAD1, DUSP21, DUSP22, NCR3LG1, KRBA1, FOXRED2, CYP2C9, PDHA1, UBE2A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ZNF180_TOMM40


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ZNF180_TOMM40


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTOMM40C0033975Psychotic Disorders1PSYGENET
TgeneTOMM40C0041696Unipolar Depression1PSYGENET
TgeneTOMM40C0349204Nonorganic psychosis1PSYGENET
TgeneTOMM40C1269683Major Depressive Disorder1PSYGENET