	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
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	RelatedDiseases

Fusion gene ID: 43049

FusionGeneSummary for ZNF177_TECR

Fusion gene summary

Fusion gene information	Fusion gene name: ZNF177_TECR
	Fusion gene ID: 43049
		Hgene	Tgene
	Gene symbol	ZNF177	TECR
	Gene ID	7730	9524
	Gene name	zinc finger protein 177	trans-2,3-enoyl-CoA reductase
	Synonyms	PIGX	GPSN2\|MRT14\|SC2\|TER
	Cytomap	19p13.2	19p13.12
	Type of gene	protein-coding	protein-coding
	Description	zinc finger protein 177	very-long-chain enoyl-CoA reductaseglycoprotein, synaptic 2synaptic glycoprotein SC2
	Modification date	20180523	20180523
	UniProtAcc	Q13360	Q9NZ01
	Ensembl transtripts involved in fusion gene	ENST00000446085, ENST00000541595, ENST00000602738, ENST00000605471, ENST00000602856, ENST00000343499, ENST00000589262, ENST00000434737, ENST00000590616,	ENST00000215567, ENST00000596073, ENST00000600083, ENST00000436007, ENST00000596164,
Fusion gene scores	* DoF score	3 X 2 X 2=12	8 X 2 X 5=80
	# samples	3	8
	** MAII score	log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(8/80*10)=0
Context	PubMed: ZNF177 [Title/Abstract] AND TECR [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	TECR	GO:0030497	fatty acid elongation	12482854
Tgene	TECR	GO:0042761	very long-chain fatty acid biosynthetic process	12482854

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	SARC	TCGA-X6-A8C5-01A	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000446085	ENST00000215567	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
5UTR-5UTR	ENST00000446085	ENST00000596073	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
5UTR-5UTR	ENST00000446085	ENST00000600083	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
5UTR-5UTR	ENST00000446085	ENST00000436007	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
5UTR-3UTR	ENST00000446085	ENST00000596164	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
5UTR-3CDS	ENST00000541595	ENST00000215567	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
5UTR-5UTR	ENST00000541595	ENST00000596073	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
5UTR-5UTR	ENST00000541595	ENST00000600083	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
5UTR-5UTR	ENST00000541595	ENST00000436007	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
5UTR-3UTR	ENST00000541595	ENST00000596164	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
5UTR-3CDS	ENST00000602738	ENST00000215567	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
5UTR-5UTR	ENST00000602738	ENST00000596073	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
5UTR-5UTR	ENST00000602738	ENST00000600083	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
5UTR-5UTR	ENST00000602738	ENST00000436007	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
5UTR-3UTR	ENST00000602738	ENST00000596164	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
intron-3CDS	ENST00000605471	ENST00000215567	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
intron-5UTR	ENST00000605471	ENST00000596073	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
intron-5UTR	ENST00000605471	ENST00000600083	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
intron-5UTR	ENST00000605471	ENST00000436007	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
intron-3UTR	ENST00000605471	ENST00000596164	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
5UTR-3CDS	ENST00000602856	ENST00000215567	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
5UTR-5UTR	ENST00000602856	ENST00000596073	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
5UTR-5UTR	ENST00000602856	ENST00000600083	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
5UTR-5UTR	ENST00000602856	ENST00000436007	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
5UTR-3UTR	ENST00000602856	ENST00000596164	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
5UTR-3CDS	ENST00000343499	ENST00000215567	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
5UTR-5UTR	ENST00000343499	ENST00000596073	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
5UTR-5UTR	ENST00000343499	ENST00000600083	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
5UTR-5UTR	ENST00000343499	ENST00000436007	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
5UTR-3UTR	ENST00000343499	ENST00000596164	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
intron-3CDS	ENST00000589262	ENST00000215567	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
intron-5UTR	ENST00000589262	ENST00000596073	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
intron-5UTR	ENST00000589262	ENST00000600083	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
intron-5UTR	ENST00000589262	ENST00000436007	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
intron-3UTR	ENST00000589262	ENST00000596164	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
intron-3CDS	ENST00000434737	ENST00000215567	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
intron-5UTR	ENST00000434737	ENST00000596073	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
intron-5UTR	ENST00000434737	ENST00000600083	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
intron-5UTR	ENST00000434737	ENST00000436007	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
intron-3UTR	ENST00000434737	ENST00000596164	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
intron-3CDS	ENST00000590616	ENST00000215567	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
intron-5UTR	ENST00000590616	ENST00000596073	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
intron-5UTR	ENST00000590616	ENST00000600083	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
intron-5UTR	ENST00000590616	ENST00000436007	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+
intron-3UTR	ENST00000590616	ENST00000596164	ZNF177	chr19	9475624	+	TECR	chr19	14673337	+

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FusionProtFeatures for ZNF177_TECR

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ZNF177 Q13360	TECR Q9NZ01
May be involved in transcriptional regulation.	Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to thechain of long- and very long-chain fatty acids/VLCFAs per cycle.This enzyme reduces the trans-2,3-enoyl-CoA fatty acidintermediate to an acyl-CoA that can be further elongated byentering a new cycle of elongation. Thereby, it participates inthe production of VLCFAs of different chain lengths that areinvolved in multiple biological processes as precursors ofmembrane lipids and lipid mediators.{ECO:0000269\|PubMed:12482854}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for ZNF177_TECR

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF177_TECR

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
ZNF177	SLC37A3, ARHGAP21, RHOU	TECR	CUL3, CAND1, NOS3, PAXIP1, RPN1, RHOT2, MOGS, DSP, ESR1, UBL4A, CLN3, EGFR, ELOVL1, CERS2, DYRK4, HIPK4, MAPK4, DYRK1B, HECW2, ILK, PTPLB, CUL7, RNF2, ARAF, ABCE1, NTRK1, ACADM, ATP5C1, CANX, CCT6A, CISD1, CLTC, DDOST, DDX39B, EHD1, GORASP2, HSD17B12, HSPA8, JAGN1, RAB1A, RAB1B, SCAMP3, SEC61A1, SGPL1, SLC25A3, SSR1, SSR4, ATP1A1, MAGT1, NDUFS1, VDAC3, TOMM22, UQCRC2, VDAC1, VDAC2, TCTN2, CREB3, XRCC3, MBOAT1, DPF3, COX15, DLST, SOAT1, RNF157

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for ZNF177_TECR

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for ZNF177_TECR

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	ZNF177	C0038356	Stomach Neoplasms	1	CTD_human
Tgene	TECR	C3151462	MENTAL RETARDATION, AUTOSOMAL RECESSIVE 14	1	UNIPROT

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Fusion gene ID: 43049

FusionGeneSummary for ZNF177_TECR

FusionProtFeatures for ZNF177_TECR

FusionGeneSequence for ZNF177_TECR

FusionGenePPI for ZNF177_TECR

RelatedDrugs for ZNF177_TECR

RelatedDiseases for ZNF177_TECR