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Fusion gene ID: 43002 |
FusionGeneSummary for ZNF12_CBX3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNF12_CBX3 | Fusion gene ID: 43002 | Hgene | Tgene | Gene symbol | ZNF12 | CBX3 | Gene ID | 7559 | 11335 |
| Gene name | zinc finger protein 12 | chromobox 3 | |
| Synonyms | GIOT-3|HZF11|KOX3|ZNF325 | HECH|HP1-GAMMA|HP1Hs-gamma | |
| Cytomap | 7p22.1 | 7p15.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein 12gonadotropin inducible transcription repressor 3gonadotropin-inducible ovary transcription repressor 3zinc finger protein 11zinc finger protein 325zinc finger protein KOX3 | chromobox protein homolog 3HP1 gamma homologchromobox homolog 3 (HP1 gamma homolog, Drosophila)heterochromatin protein 1 homolog gammaheterochromatin protein HP1 gammaheterochromatin-like protein 1modifier 2 protein | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | P17014 | Q13185 | |
| Ensembl transtripts involved in fusion gene | ENST00000404360, ENST00000405858, ENST00000342651, ENST00000491565, | ENST00000337620, ENST00000396386, ENST00000409747, ENST00000497498, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 4 X 4 X 1=16 |
| # samples | 2 | 5 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(5/16*10)=1.64385618977472 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ZNF12 [Title/Abstract] AND CBX3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ZNF12 | GO:0045892 | negative regulation of transcription, DNA-templated | 16806083 |
| Tgene | CBX3 | GO:0045892 | negative regulation of transcription, DNA-templated | 9636147 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE141848 | ZNF12 | chr7 | 6743120 | - | CBX3 | chr7 | 26251162 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000404360 | ENST00000337620 | ZNF12 | chr7 | 6743120 | - | CBX3 | chr7 | 26251162 | + |
| intron-intron | ENST00000404360 | ENST00000396386 | ZNF12 | chr7 | 6743120 | - | CBX3 | chr7 | 26251162 | + |
| intron-intron | ENST00000404360 | ENST00000409747 | ZNF12 | chr7 | 6743120 | - | CBX3 | chr7 | 26251162 | + |
| intron-intron | ENST00000404360 | ENST00000497498 | ZNF12 | chr7 | 6743120 | - | CBX3 | chr7 | 26251162 | + |
| intron-intron | ENST00000405858 | ENST00000337620 | ZNF12 | chr7 | 6743120 | - | CBX3 | chr7 | 26251162 | + |
| intron-intron | ENST00000405858 | ENST00000396386 | ZNF12 | chr7 | 6743120 | - | CBX3 | chr7 | 26251162 | + |
| intron-intron | ENST00000405858 | ENST00000409747 | ZNF12 | chr7 | 6743120 | - | CBX3 | chr7 | 26251162 | + |
| intron-intron | ENST00000405858 | ENST00000497498 | ZNF12 | chr7 | 6743120 | - | CBX3 | chr7 | 26251162 | + |
| intron-intron | ENST00000342651 | ENST00000337620 | ZNF12 | chr7 | 6743120 | - | CBX3 | chr7 | 26251162 | + |
| intron-intron | ENST00000342651 | ENST00000396386 | ZNF12 | chr7 | 6743120 | - | CBX3 | chr7 | 26251162 | + |
| intron-intron | ENST00000342651 | ENST00000409747 | ZNF12 | chr7 | 6743120 | - | CBX3 | chr7 | 26251162 | + |
| intron-intron | ENST00000342651 | ENST00000497498 | ZNF12 | chr7 | 6743120 | - | CBX3 | chr7 | 26251162 | + |
| intron-intron | ENST00000491565 | ENST00000337620 | ZNF12 | chr7 | 6743120 | - | CBX3 | chr7 | 26251162 | + |
| intron-intron | ENST00000491565 | ENST00000396386 | ZNF12 | chr7 | 6743120 | - | CBX3 | chr7 | 26251162 | + |
| intron-intron | ENST00000491565 | ENST00000409747 | ZNF12 | chr7 | 6743120 | - | CBX3 | chr7 | 26251162 | + |
| intron-intron | ENST00000491565 | ENST00000497498 | ZNF12 | chr7 | 6743120 | - | CBX3 | chr7 | 26251162 | + |
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FusionProtFeatures for ZNF12_CBX3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZNF12 | CBX3 |
| Seems to be involved in transcriptional silencing inheterochromatin-like complexes. Recognizes and binds histone H3tails methylated at 'Lys-9', leading to epigenetic repression. Maycontribute to the association of the heterochromatin with theinner nuclear membrane through its interaction with lamin Breceptor (LBR). Involved in the formation of functionalkinetochore through interaction with MIS12 complex proteins.Contributes to the conversion of local chromatin to aheterochromatin-like repressive state through H3 'Lys-9'trimethylation, mediates the recruitment of the methyltransferasesSUV39H1 and/or SUV39H2 by the PER complex to the E-box elements ofthe circadian target genes such as PER2 itself or PER1. Mediatesthe recruitement of NIPBL to sites of DNA damage at double-strandbreaks (DSBs) (PubMed:28167679). {ECO:0000250|UniProtKB:P23198,ECO:0000269|PubMed:28167679}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZNF12_CBX3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZNF12_CBX3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZNF12_CBX3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF12_CBX3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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