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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 43

FusionGeneSummary for AARSD1_CCR7

check button Fusion gene summary
Fusion gene informationFusion gene name: AARSD1_CCR7
Fusion gene ID: 43
HgeneTgene
Gene symbol

AARSD1

CCR7

Gene ID

80755

1236

Gene namealanyl-tRNA synthetase domain containing 1C-C motif chemokine receptor 7
Synonyms-BLR2|CC-CKR-7|CCR-7|CD197|CDw197|CMKBR7|EBI1
Cytomap

17q21.31

17q21.2

Type of geneprotein-codingprotein-coding
Descriptionalanyl-tRNA editing protein Aarsd1alanyl-tRNA synthetase domain-containing protein 1C-C chemokine receptor type 7Bukitt's lymphoma receptor 2CC chemokine receptor 7EBV-induced G protein-coupled receptor 1Epstein-Barr virus induced gene 1Epstein-Barr virus-induced G-protein coupled receptor 1MIP-3 beta receptorchemokine (C-C motif)
Modification date2018052320180527
UniProtAcc

Q9BTE6

P32248

Ensembl transtripts involved in fusion geneENST00000427569, ENST00000416949, 
ENST00000246657, ENST00000579344, 
Fusion gene scores* DoF score5 X 5 X 5=1256 X 2 X 6=72
# samples 57
** MAII scorelog2(5/125*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/72*10)=-0.0406419844973459
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AARSD1 [Title/Abstract] AND CCR7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCCR7

GO:0002408

myeloid dendritic cell chemotaxis

11602640

TgeneCCR7

GO:0071345

cellular response to cytokine stimulus

11602640

TgeneCCR7

GO:0090023

positive regulation of neutrophil chemotaxis

21051556


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-HC-7209-01AAARSD1chr17

41113209

-CCR7chr17

38715194

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000427569ENST00000246657AARSD1chr17

41113209

-CCR7chr17

38715194

-
5CDS-5UTRENST00000427569ENST00000579344AARSD1chr17

41113209

-CCR7chr17

38715194

-
5UTR-3CDSENST00000416949ENST00000246657AARSD1chr17

41113209

-CCR7chr17

38715194

-
5UTR-5UTRENST00000416949ENST00000579344AARSD1chr17

41113209

-CCR7chr17

38715194

-

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FusionProtFeatures for AARSD1_CCR7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AARSD1

Q9BTE6

CCR7

P32248

Functions in trans to edit the amino acid moiety fromincorrectly charged tRNA(Ala). {ECO:0000250}. Receptor for the MIP-3-beta chemokine. Probable mediatorof EBV effects on B-lymphocytes or of normal lymphocyte functions.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCCR7chr17:41113209chr17:38715194ENST00000246657-03117_1303379Topological domainExtracellular
TgeneCCR7chr17:41113209chr17:38715194ENST00000246657-03153_1703379Topological domainCytoplasmic
TgeneCCR7chr17:41113209chr17:38715194ENST00000246657-03192_2193379Topological domainExtracellular
TgeneCCR7chr17:41113209chr17:38715194ENST00000246657-03248_2633379Topological domainCytoplasmic
TgeneCCR7chr17:41113209chr17:38715194ENST00000246657-0325_593379Topological domainExtracellular
TgeneCCR7chr17:41113209chr17:38715194ENST00000246657-03290_3133379Topological domainExtracellular
TgeneCCR7chr17:41113209chr17:38715194ENST00000246657-03332_3783379Topological domainCytoplasmic
TgeneCCR7chr17:41113209chr17:38715194ENST00000246657-0387_953379Topological domainCytoplasmic
TgeneCCR7chr17:41113209chr17:38715194ENST00000246657-03131_1523379TransmembraneHelical%3B Name%3D3
TgeneCCR7chr17:41113209chr17:38715194ENST00000246657-03171_1913379TransmembraneHelical%3B Name%3D4
TgeneCCR7chr17:41113209chr17:38715194ENST00000246657-03220_2473379TransmembraneHelical%3B Name%3D5
TgeneCCR7chr17:41113209chr17:38715194ENST00000246657-03264_2893379TransmembraneHelical%3B Name%3D6
TgeneCCR7chr17:41113209chr17:38715194ENST00000246657-03314_3313379TransmembraneHelical%3B Name%3D7
TgeneCCR7chr17:41113209chr17:38715194ENST00000246657-0360_863379TransmembraneHelical%3B Name%3D1
TgeneCCR7chr17:41113209chr17:38715194ENST00000246657-0396_1163379TransmembraneHelical%3B Name%3D2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for AARSD1_CCR7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_AARSD1_ENST00000427569_chr17_41113209_-_CCR7_ENST00000246657_chr17_38715194_-_486aa
MAFWCQRDSYAREFTTTVVSCCPAELQTEGSNGKKEVLSGFQVVLEDTVLFPEGGGQPDDRGTINDISVLRVTRRGEQADHFTQTPLDPG
SQVLVRVDWERRFDHMQQHSGKPMKSVLVVALLVIFQVCLCQDEVTDDYIGDNTTVDYTLFESLCSKKDVRNFKAWFLPIMYSIICFVGL
LGNGLVVLTYIYFKRLKTMTDTYLLNLAVADILFLLTLPFWAYSAAKSWVFGVHFCKLIFAIYKMSFFSGMLLLLCISIDRYVAIVQAVS
AHRHRARVLLISKLSCVGIWILATVLSIPELLYSDLQRSSSEQAMRCSLITEHVEAFITIQVAQMVIGFLVPLLAMSFCYLVIIRTLLQA
RNFERNKAIKVIIAVVVVFIVFQLPYNGVVLAQTVANFNITSSTCELSKQLNIAYDVTYSLACVRCCVNPFLYAFIGVKFRNDLFKLFKD


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_AARSD1_ENST00000427569_chr17_41113209_-_CCR7_ENST00000246657_chr17_38715194_-_1458nt
ATGGCGTTCTGGTGTCAGCGTGACAGTTATGCCCGAGAGTTCACCACCACCGTGGTCTCCTGCTGTCCCGCGGAGCTGCAGACTGAAGGG
AGCAACGGCAAGAAAGAAGTGCTGAGCGGTTTCCAAGTGGTGCTGGAAGACACAGTGCTTTTCCCTGAGGGCGGGGGACAGCCTGATGAC
CGTGGTACAATCAATGACATCTCTGTGCTGAGAGTGACTCGCCGTGGGGAACAGGCTGATCATTTCACCCAGACACCCCTGGATCCAGGA
AGCCAGGTTCTGGTCCGGGTAGATTGGGAGCGGAGGTTTGACCACATGCAGCAGCATTCAGGGAAACCAATGAAAAGCGTGCTGGTGGTG
GCTCTCCTTGTCATTTTCCAGGTATGCCTGTGTCAAGATGAGGTCACGGACGATTACATCGGAGACAACACCACAGTGGACTACACTTTG
TTCGAGTCTTTGTGCTCCAAGAAGGACGTGCGGAACTTTAAAGCCTGGTTCCTCCCTATCATGTACTCCATCATTTGTTTCGTGGGCCTA
CTGGGCAATGGGCTGGTCGTGTTGACCTATATCTATTTCAAGAGGCTCAAGACCATGACCGATACCTACCTGCTCAACCTGGCGGTGGCA
GACATCCTCTTCCTCCTGACCCTTCCCTTCTGGGCCTACAGCGCGGCCAAGTCCTGGGTCTTCGGTGTCCACTTTTGCAAGCTCATCTTT
GCCATCTACAAGATGAGCTTCTTCAGTGGCATGCTCCTACTTCTTTGCATCAGCATTGACCGCTACGTGGCCATCGTCCAGGCTGTCTCA
GCTCACCGCCACCGTGCCCGCGTCCTTCTCATCAGCAAGCTGTCCTGTGTGGGCATCTGGATACTAGCCACAGTGCTCTCCATCCCAGAG
CTCCTGTACAGTGACCTCCAGAGGAGCAGCAGTGAGCAAGCGATGCGATGCTCTCTCATCACAGAGCATGTGGAGGCCTTTATCACCATC
CAGGTGGCCCAGATGGTGATCGGCTTTCTGGTCCCCCTGCTGGCCATGAGCTTCTGTTACCTTGTCATCATCCGCACCCTGCTCCAGGCA
CGCAACTTTGAGCGCAACAAGGCCATCAAGGTGATCATCGCTGTGGTCGTGGTCTTCATAGTCTTCCAGCTGCCCTACAATGGGGTGGTC
CTGGCCCAGACGGTGGCCAACTTCAACATCACCAGTAGCACCTGTGAGCTCAGTAAGCAACTCAACATCGCCTACGACGTCACCTACAGC
CTGGCCTGCGTCCGCTGCTGCGTCAACCCTTTCTTGTACGCCTTCATCGGCGTCAAGTTCCGCAACGATCTCTTCAAGCTCTTCAAGGAC
CTGGGCTGCCTCAGCCAGGAGCAGCTCCGGCAGTGGTCTTCCTGTCGGCACATCCGGCGCTCCTCCATGAGTGTGGAGGCCGAGACCACC


* Fusion transcript sequences (Full-length transcript).
>In-frame_AARSD1_ENST00000427569_chr17_41113209_-_CCR7_ENST00000246657_chr17_38715194_-_2467nt
TTCTCTGCGCGTGCGCCTCCTCACACGCCTGCAGGTATGGCGTTCTGGTGTCAGCGTGACAGTTATGCCCGAGAGTTCACCACCACCGTG
GTCTCCTGCTGTCCCGCGGAGCTGCAGACTGAAGGGAGCAACGGCAAGAAAGAAGTGCTGAGCGGTTTCCAAGTGGTGCTGGAAGACACA
GTGCTTTTCCCTGAGGGCGGGGGACAGCCTGATGACCGTGGTACAATCAATGACATCTCTGTGCTGAGAGTGACTCGCCGTGGGGAACAG
GCTGATCATTTCACCCAGACACCCCTGGATCCAGGAAGCCAGGTTCTGGTCCGGGTAGATTGGGAGCGGAGGTTTGACCACATGCAGCAG
CATTCAGGGAAACCAATGAAAAGCGTGCTGGTGGTGGCTCTCCTTGTCATTTTCCAGGTATGCCTGTGTCAAGATGAGGTCACGGACGAT
TACATCGGAGACAACACCACAGTGGACTACACTTTGTTCGAGTCTTTGTGCTCCAAGAAGGACGTGCGGAACTTTAAAGCCTGGTTCCTC
CCTATCATGTACTCCATCATTTGTTTCGTGGGCCTACTGGGCAATGGGCTGGTCGTGTTGACCTATATCTATTTCAAGAGGCTCAAGACC
ATGACCGATACCTACCTGCTCAACCTGGCGGTGGCAGACATCCTCTTCCTCCTGACCCTTCCCTTCTGGGCCTACAGCGCGGCCAAGTCC
TGGGTCTTCGGTGTCCACTTTTGCAAGCTCATCTTTGCCATCTACAAGATGAGCTTCTTCAGTGGCATGCTCCTACTTCTTTGCATCAGC
ATTGACCGCTACGTGGCCATCGTCCAGGCTGTCTCAGCTCACCGCCACCGTGCCCGCGTCCTTCTCATCAGCAAGCTGTCCTGTGTGGGC
ATCTGGATACTAGCCACAGTGCTCTCCATCCCAGAGCTCCTGTACAGTGACCTCCAGAGGAGCAGCAGTGAGCAAGCGATGCGATGCTCT
CTCATCACAGAGCATGTGGAGGCCTTTATCACCATCCAGGTGGCCCAGATGGTGATCGGCTTTCTGGTCCCCCTGCTGGCCATGAGCTTC
TGTTACCTTGTCATCATCCGCACCCTGCTCCAGGCACGCAACTTTGAGCGCAACAAGGCCATCAAGGTGATCATCGCTGTGGTCGTGGTC
TTCATAGTCTTCCAGCTGCCCTACAATGGGGTGGTCCTGGCCCAGACGGTGGCCAACTTCAACATCACCAGTAGCACCTGTGAGCTCAGT
AAGCAACTCAACATCGCCTACGACGTCACCTACAGCCTGGCCTGCGTCCGCTGCTGCGTCAACCCTTTCTTGTACGCCTTCATCGGCGTC
AAGTTCCGCAACGATCTCTTCAAGCTCTTCAAGGACCTGGGCTGCCTCAGCCAGGAGCAGCTCCGGCAGTGGTCTTCCTGTCGGCACATC
CGGCGCTCCTCCATGAGTGTGGAGGCCGAGACCACCACCACCTTCTCCCCATAGGCGACTCTTCTGCCTGGACTAGAGGGACCTCTCCCA
GGGTCCCTGGGGTGGGGATAGGGAGCAGATGCAATGACTCAGGACATCCCCCCGCCAAAAGCTGCTCAGGGAAAAGCAGCTCTCCCCTCA
GAGTGCAAGCCCCTGCTCCAGAAGATAGCTTCACCCCAATCCCAGCTACCTCAACCAATGCCAAAAAAAGACAGGGCTGATAAGCTAACA
CCAGACAGACAACACTGGGAAACAGAGGCTATTGTCCCCTAAACCAAAAACTGAAAGTGAAAGTCCAGAAACTGTTCCCACCTGCTGGAG
TGAAGGGGCCAAGGAGGGTGAGTGCAAGGGGCGTGGGAGTGGCCTGAAGAGTCCTCTGAATGAACCTTCTGGCCTCCCACAGACTCAAAT
GCTCAGACCAGCTCTTCCGAAAACCAGGCCTTATCTCCAAGACCAGAGATAGTGGGGAGACTTCTTGGCTTGGTGAGGAAAAGCGGACAT
CAGCTGGTCAAACAAACTCTCTGAACCCCTCCCTCCATCGTTTTCTTCACTGTCCTCCAAGCCAGCGGGAATGGCAGCTGCCACGCCGCC
CTAAAAGCACACTCATCCCCTCACTTGCCGCGTCGCCCTCCCAGGCTCTCAACAGGGGAGAGTGTGGTGTTTCCTGCAGGCCAGGCCAGC
TGCCTCCGCGTGATCAAAGCCACACTCTGGGCTCCAGAGTGGGGATGACATGCACTCAGCTCTTGGCTCCACTGGGATGGGAGGAGAGGA
CAAGGGAAATGTCAGGGGCGGGGAGGGTGACAGTGGCCGCCCAAGGCCCACGAGCTTGTTCTTTGTTCTTTGTCACAGGGACTGAAAACC
TCTCCTCATGTTCTGCTTTCGATTCGTTAAGAGAGCAACATTTTACCCACACACAGATAAAGTTTTCCCTTGAGGAAACAACAGCTTTAA


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FusionGenePPI for AARSD1_CCR7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
AARSD1ARPC1A, ARPC2, ARPC5, CALR, CALU, EFTUD2, GTF2E1, HARS, LAP3, PFDN1, PFDN5, PPP1R12A, PPP2CB, PRKACA, TRMT10A, RPA1, RPA3, RPRD1B, RPUSD2, SH3GL1, SH3GLB1, SH3GLB2, THG1L, TP53RK, TTC1, UBQLN2, XPO5, FUBP1, NIF3L1, TPD52L2, IRS4, DYNLT1, HECTD1, TUBA1A, HSPB1, SERPINH1, RHOJ, JADE2, TAT, PARVG, TARS, PPP1R14B, SBDS, SEPT2, SEPT8, SRM, TBCB, RGS20, TRIM45, YKT6, MAP3K7, DDHD2, NPHP3, C12orf74, ALKBH2, TAB1, USP10, ALMS1, LUZP1, SASS6, FIGNL1, ERCC6L, SSFA2, FBXO7, RBM14-RBM4, HPS5, POC5, WNK1, HOOK1, RPL23, UBXN1, APAF1, STIL, MLF1, BORA, FAM83H, KIF1A, RAD21, ARRB2, RICTOR, RIC8B, TRAPPC4, BRCA2, PEAK1, NCAPG, TRIP13CCR7CCL19, ZMIZ1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AARSD1_CCR7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AARSD1_CCR7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCCR7C0023493Adult T-Cell Lymphoma/Leukemia1CTD_human
TgeneCCR7C0038220Status Epilepticus1CTD_human
TgeneCCR7C0178417Anhedonia1PSYGENET