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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 42989

FusionGeneSummary for ZNF106_CNTLN

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF106_CNTLN
Fusion gene ID: 42989
HgeneTgene
Gene symbol

ZNF106

CNTLN

Gene ID

64397

54875

Gene namezinc finger protein 106centlein
SynonymsSH3BP3|ZFP106|ZNF474C9orf101|C9orf39|bA340N12.1
Cytomap

15q15.1

9p22.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 106SH3-domain binding protein 3zinc finger protein 474centleincentlein, centrosomal proteincentrosomal protein
Modification date2018052320180519
UniProtAcc

Q9H2Y7

Q9NXG0

Ensembl transtripts involved in fusion geneENST00000263805, ENST00000565380, 
ENST00000565611, ENST00000565660, 
ENST00000380647, ENST00000262360, 
ENST00000425824, ENST00000380641, 
ENST00000484374, 
Fusion gene scores* DoF score6 X 7 X 3=1264 X 4 X 4=64
# samples 95
** MAII scorelog2(9/126*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/64*10)=-0.356143810225275
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF106 [Title/Abstract] AND CNTLN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-BF-AAP2-01AZNF106chr15

42749156

-CNTLNchr9

17415786

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000263805ENST00000380647ZNF106chr15

42749156

-CNTLNchr9

17415786

+
In-frameENST00000263805ENST00000262360ZNF106chr15

42749156

-CNTLNchr9

17415786

+
In-frameENST00000263805ENST00000425824ZNF106chr15

42749156

-CNTLNchr9

17415786

+
5CDS-intronENST00000263805ENST00000380641ZNF106chr15

42749156

-CNTLNchr9

17415786

+
5CDS-intronENST00000263805ENST00000484374ZNF106chr15

42749156

-CNTLNchr9

17415786

+
intron-3CDSENST00000565380ENST00000380647ZNF106chr15

42749156

-CNTLNchr9

17415786

+
intron-3CDSENST00000565380ENST00000262360ZNF106chr15

42749156

-CNTLNchr9

17415786

+
intron-3CDSENST00000565380ENST00000425824ZNF106chr15

42749156

-CNTLNchr9

17415786

+
intron-intronENST00000565380ENST00000380641ZNF106chr15

42749156

-CNTLNchr9

17415786

+
intron-intronENST00000565380ENST00000484374ZNF106chr15

42749156

-CNTLNchr9

17415786

+
intron-3CDSENST00000565611ENST00000380647ZNF106chr15

42749156

-CNTLNchr9

17415786

+
intron-3CDSENST00000565611ENST00000262360ZNF106chr15

42749156

-CNTLNchr9

17415786

+
intron-3CDSENST00000565611ENST00000425824ZNF106chr15

42749156

-CNTLNchr9

17415786

+
intron-intronENST00000565611ENST00000380641ZNF106chr15

42749156

-CNTLNchr9

17415786

+
intron-intronENST00000565611ENST00000484374ZNF106chr15

42749156

-CNTLNchr9

17415786

+
intron-3CDSENST00000565660ENST00000380647ZNF106chr15

42749156

-CNTLNchr9

17415786

+
intron-3CDSENST00000565660ENST00000262360ZNF106chr15

42749156

-CNTLNchr9

17415786

+
intron-3CDSENST00000565660ENST00000425824ZNF106chr15

42749156

-CNTLNchr9

17415786

+
intron-intronENST00000565660ENST00000380641ZNF106chr15

42749156

-CNTLNchr9

17415786

+
intron-intronENST00000565660ENST00000484374ZNF106chr15

42749156

-CNTLNchr9

17415786

+

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FusionProtFeatures for ZNF106_CNTLN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF106

Q9H2Y7

CNTLN

Q9NXG0

Required for centrosome cohesion and recruitment ofCEP68 to centrosomes. {ECO:0000269|PubMed:24554434}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF106chr15:42749156chr9:17415786ENST00000263805-11920_44821884Zinc fingerNote=C2H2-type 1%3B atypical
TgeneCNTLNchr15:42749156chr9:17415786ENST00000380641+07613_655-9392Coiled coilOntology_term=ECO:0000255
TgeneCNTLNchr15:42749156chr9:17415786ENST00000380641+07681_793-9392Coiled coilOntology_term=ECO:0000255
TgeneCNTLNchr15:42749156chr9:17415786ENST00000380641+0795_126-9392Coiled coilOntology_term=ECO:0000255
TgeneCNTLNchr15:42749156chr9:17415786ENST00000380641+07980_1311-9392Coiled coilOntology_term=ECO:0000255
TgeneCNTLNchr15:42749156chr9:17415786ENST00000380647+1526980_13119321407Coiled coilOntology_term=ECO:0000255
TgeneCNTLNchr15:42749156chr9:17415786ENST00000380641+071398_1405-9392Compositional biasNote=Poly-Ser
TgeneCNTLNchr15:42749156chr9:17415786ENST00000380647+15261398_14059321407Compositional biasNote=Poly-Ser

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF106chr15:42749156chr9:17415786ENST00000263805-1191529_1568821884RepeatNote=WD 1
HgeneZNF106chr15:42749156chr9:17415786ENST00000263805-1191570_1611821884RepeatNote=WD 2
HgeneZNF106chr15:42749156chr9:17415786ENST00000263805-1191654_1695821884RepeatNote=WD 3
HgeneZNF106chr15:42749156chr9:17415786ENST00000263805-1191698_1737821884RepeatNote=WD 4
HgeneZNF106chr15:42749156chr9:17415786ENST00000263805-1191738_1775821884RepeatNote=WD 5
HgeneZNF106chr15:42749156chr9:17415786ENST00000263805-1191778_1815821884RepeatNote=WD 6
HgeneZNF106chr15:42749156chr9:17415786ENST00000565611-1181529_1568-1041069RepeatNote=WD 1
HgeneZNF106chr15:42749156chr9:17415786ENST00000565611-1181570_1611-1041069RepeatNote=WD 2
HgeneZNF106chr15:42749156chr9:17415786ENST00000565611-1181654_1695-1041069RepeatNote=WD 3
HgeneZNF106chr15:42749156chr9:17415786ENST00000565611-1181698_1737-1041069RepeatNote=WD 4
HgeneZNF106chr15:42749156chr9:17415786ENST00000565611-1181738_1775-1041069RepeatNote=WD 5
HgeneZNF106chr15:42749156chr9:17415786ENST00000565611-1181778_1815-1041069RepeatNote=WD 6
HgeneZNF106chr15:42749156chr9:17415786ENST00000263805-1191813_1838821884Zinc fingerNote=C2H2-type 2%3B atypical
HgeneZNF106chr15:42749156chr9:17415786ENST00000565611-1181813_1838-1041069Zinc fingerNote=C2H2-type 2%3B atypical
HgeneZNF106chr15:42749156chr9:17415786ENST00000565611-11820_44-1041069Zinc fingerNote=C2H2-type 1%3B atypical
TgeneCNTLNchr15:42749156chr9:17415786ENST00000380647+1526613_6559321407Coiled coilOntology_term=ECO:0000255
TgeneCNTLNchr15:42749156chr9:17415786ENST00000380647+1526681_7939321407Coiled coilOntology_term=ECO:0000255
TgeneCNTLNchr15:42749156chr9:17415786ENST00000380647+152695_1269321407Coiled coilOntology_term=ECO:0000255


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FusionGeneSequence for ZNF106_CNTLN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ZNF106_ENST00000263805_chr15_42749156_-_CNTLN_ENST00000380647_chr9_17415786_+_557aa
MPVGRIECPSSPSFPRDISHECRVCGVTEVGLSAYAKHISGQLHKDNVDAQEREDDGKGEEEEEDYFDKELIQLIKQRKEQSRTIFMIRM
PKNQLFKRRIARCKRVHIQQFLLESTEKSTKIXLPRNQVAILFYYENGLYPCNNKTVYFRMPRKQQNCLLKNIKKLMKSSSINSKYPIND
FRQAGRQXRSXIWIWLGFGKKKKIYXRNWSPHLKSQVWQKKIPRXHFHGYKLHHLVLQGAWIWKXSNCSINXRMLLMNSLNSHQMXRLXN
LNSXQKKNTXRKCMKRYLEWRGIXLXKDIXXRTXNFDRKXIWKVTRVLVKCYKILIKRXRHXLKNVPTRRYQLIHXSKDLTLLXKKSHSM
NRCIRNLKRSXKKRISSLLSXYQEXVRLNLQWQKLKQQHLSSFKNXHCKVNRSXKVHRRHCCXPMKKXKSSPHLXRLWPKSCKMMSMWXG
DKXESLKKXRKTGTPVKPQPIKPRPWQLLSXTFHGQIXRKYXTQKIKWKLKKQKLMLKMTRNGCCTFRNFLKDSFLLPHIYXKQYWKKXM

>In-frame_ZNF106_ENST00000263805_chr15_42749156_-_CNTLN_ENST00000262360_chr9_17415786_+_556aa
MPVGRIECPSSPSFPRDISHECRVCGVTEVGLSAYAKHISGQLHKDNVDAQEREDDGKGEEEEEDYFDKELIQLIKQRKEQSRTIFMIRM
PKNQLFKRRIARCKRVHIQQFLLESTEKSTKIXLPRNQVAILFYYENGLYPCNNKTVYFRMPRKQQNCLLKNIKKLMKSSSINSKYPIND
FRQAGRQXRSXIWIWLGFGKKKKIYXRNWSPHLKSQVWQKKIPRXHFHGYKLHHLVLQGAWIWKXSNCSINXRMLLMNSLNSHQMXRLXN
LNSXQKKNTXRKCMKRYLEWRGIXLXKDIXXRTXNFDRKXIWKVTRVLVKCYKILIKRXRHXLKNVPTRRYQLIHXSKDLTLLXKKSHSM
NRCIRNLKRSXKKRISSLLSXYQEXVRLNLQWQKLKQQHLSSFKNXHCKVNRSXKVHRRHCCXPMKKXKSSPHLXRLWPKSCKMMSMWXG
DKXESLKKXRKTGTPVKPQPIKPRPWQLLSXTFHGQIXRKYXTQKIKWKLKKQKLMLKMTRNGCCTFRNFLKDRVLLCLPGXSAMAQSWL

>In-frame_ZNF106_ENST00000263805_chr15_42749156_-_CNTLN_ENST00000425824_chr9_17415786_+_557aa
MPVGRIECPSSPSFPRDISHECRVCGVTEVGLSAYAKHISGQLHKDNVDAQEREDDGKGEEEEEDYFDKELIQLIKQRKEQSRTIFMIRM
PKNQLFKRRIARCKRVHIQQFLLESTEKSTKIXLPRNQVAILFYYENGLYPCNNKTVYFRMPRKQQNCLLKNIKKLMKSSSINSKYPIND
FRQAGRQXRSXIWIWLGFGKKKKIYXRNWSPHLKSQVWQKKIPRXHFHGYKLHHLVLQGAWIWKXSNCSINXRMLLMNSLNSHQMXRLXN
LNSXQKKNTXRKCMKRYLEWRGIXLXKDIXXRTXNFDRKXIWKVTRVLVKCYKILIKRXRHXLKNVPTRRYQLIHXSKDLTLLXKKSHSM
NRCIRNLKRSXKKRISSLLSXYQEXVRLNLQWQKLKQQHLSSFKNXHCKVNRSXKVHRRHCCXPMKKXKSSPHLXRLWPKSCKMMSMWXG
DKXESLKKXRKTGTPVKPQPIKPRPWQLLSXTFHGQIXRKYXTQKIKWKLKKQKLMLKMTRNGCCTFRNFLKDSFLLPHIYXKQYWKKXM


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ZNF106_ENST00000263805_chr15_42749156_-_CNTLN_ENST00000380647_chr9_17415786_+_1673nt
ATGCCAGTGGGGAGAATTGAATGTCCCTCATCTCCCTCTTTCCCTAGGGACATTAGTCATGAGTGCCGAGTGTGCGGGGTCACAGAAGTG
GGTCTTTCTGCATATGCAAAGCACATTTCTGGCCAGTTGCACAAAGATAACGTTGATGCCCAGGAAAGAGAAGATGATGGAAAAGGAGAG
GAAGAGGAAGAAGATTATTTTGACAAGGAACTCATTCAGTTAATAAAACAAAGGAAAGAACAAAGTCGGACTATTTTCATGATAAGAATG
CCAAAAAACCAACTTTTCAAAAGAAGAATTGCAAGATGCAAAAGAGTTCACATACAGCAGTTCCTACTAGAGTCAACAGAGAAAAGTACA
AAAATATAACTGCCCAGAAATCAAGTAGCAATATTATTTTATTACGAGAACGGATTATATCCTTGCAACAACAAAACAGTGTACTTCAGA
ATGCCAAGAAAACAGCAGAATTGTCTGTTAAAGAATATAAAGAAGTTAATGAAAAGCTCCTCCATCAACAGCAAGTATCCGATCAACGAT
TTCAGACAAGCAGGCAGACAATAAAGAAGCTAAATTTGGATTTGGCTGGGCTTCGGAAAGAAAAAGAAGATTTACTAAAGAAATTGGAGT
CCTCATCTGAAATCACAAGTTTGGCAGAAGAAAATTCCCAGGTAACATTTCCACGGATACAAGTTACATCACTTAGTCCTTCAAGGAGCA
TGGATTTGGAAATGAAGCAATTGCAGTATAAACTAAAGAATGCTACTAATGAACTCACTAAACAGTCATCAAATGTGAAGACTTTGAAAT
TTGAACTCCTAGCAAAAGAAGAACACATAAAGGAAATGCATGAAAAGATATCTCGAATGGAGAGGGATATAACTATGAAAAGACATTTGA
TAGAGGACTTGAAATTTCGACAGAAAGTAAATTTGGAAAGTAACAAGAGTTTTAGTGAAATGTTACAAAATCTTGATAAAAAGGTAAAGA
CATTAACTGAAGAATGTTCCAACAAGAAGGTATCAATTGATTCACTAAAGCAAAGACTTAACGTTGCTGTAAAAGAAAAGTCACAGTATG
AACAGATGTATCAGAAATCTAAAGAGGAGTTAGAAAAAAAGGATCTCAAGCTTACTCTCCTAGTATCAAGAATAAGTGAGACTGAATCTG
CAATGGCAGAAATTGAAACAGCAGCATCTAAGCAGCTTCAAGAATTAGCATTGCAAAGTGAACAGGTCCTAGAAGGTGCACAGAAGACAT
TGCTGTTAGCCAATGAAAAAGTAGAAGAGTTCACCACATTTGTGAAGGCTTTGGCCAAAGAGTTGCAAAATGATGTCCATGTGGTAAGGC
GACAAATAAGAGAGCTTAAAAAAATGAAGAAAAACAGGGACGCCTGTAAAACCTCAACCCATAAAGCCCAGACCTTGGCAGCTTCTATCC
TGAACATTTCACGGTCAGATTTAGAGGAAATATTAGACACAGAAGATCAAGTGGAAATTGAAAAAACAAAAATTGATGCTGAAAATGACA
AGGAATGGATGTTGTACATTCAGAAACTTCTTGAAGGACAGCTTCCTTTTGCCTCATATTTACTAGAAGCAGTACTGGAAAAAATAAATG

>In-frame_ZNF106_ENST00000263805_chr15_42749156_-_CNTLN_ENST00000262360_chr9_17415786_+_1670nt
ATGCCAGTGGGGAGAATTGAATGTCCCTCATCTCCCTCTTTCCCTAGGGACATTAGTCATGAGTGCCGAGTGTGCGGGGTCACAGAAGTG
GGTCTTTCTGCATATGCAAAGCACATTTCTGGCCAGTTGCACAAAGATAACGTTGATGCCCAGGAAAGAGAAGATGATGGAAAAGGAGAG
GAAGAGGAAGAAGATTATTTTGACAAGGAACTCATTCAGTTAATAAAACAAAGGAAAGAACAAAGTCGGACTATTTTCATGATAAGAATG
CCAAAAAACCAACTTTTCAAAAGAAGAATTGCAAGATGCAAAAGAGTTCACATACAGCAGTTCCTACTAGAGTCAACAGAGAAAAGTACA
AAAATATAACTGCCCAGAAATCAAGTAGCAATATTATTTTATTACGAGAACGGATTATATCCTTGCAACAACAAAACAGTGTACTTCAGA
ATGCCAAGAAAACAGCAGAATTGTCTGTTAAAGAATATAAAGAAGTTAATGAAAAGCTCCTCCATCAACAGCAAGTATCCGATCAACGAT
TTCAGACAAGCAGGCAGACAATAAAGAAGCTAAATTTGGATTTGGCTGGGCTTCGGAAAGAAAAAGAAGATTTACTAAAGAAATTGGAGT
CCTCATCTGAAATCACAAGTTTGGCAGAAGAAAATTCCCAGGTAACATTTCCACGGATACAAGTTACATCACTTAGTCCTTCAAGGAGCA
TGGATTTGGAAATGAAGCAATTGCAGTATAAACTAAAGAATGCTACTAATGAACTCACTAAACAGTCATCAAATGTGAAGACTTTGAAAT
TTGAACTCCTAGCAAAAGAAGAACACATAAAGGAAATGCATGAAAAGATATCTCGAATGGAGAGGGATATAACTATGAAAAGACATTTGA
TAGAGGACTTGAAATTTCGACAGAAAGTAAATTTGGAAAGTAACAAGAGTTTTAGTGAAATGTTACAAAATCTTGATAAAAAGGTAAAGA
CATTAACTGAAGAATGTTCCAACAAGAAGGTATCAATTGATTCACTAAAGCAAAGACTTAACGTTGCTGTAAAAGAAAAGTCACAGTATG
AACAGATGTATCAGAAATCTAAAGAGGAGTTAGAAAAAAAGGATCTCAAGCTTACTCTCCTAGTATCAAGAATAAGTGAGACTGAATCTG
CAATGGCAGAAATTGAAACAGCAGCATCTAAGCAGCTTCAAGAATTAGCATTGCAAAGTGAACAGGTCCTAGAAGGTGCACAGAAGACAT
TGCTGTTAGCCAATGAAAAAGTAGAAGAGTTCACCACATTTGTGAAGGCTTTGGCCAAAGAGTTGCAAAATGATGTCCATGTGGTAAGGC
GACAAATAAGAGAGCTTAAAAAAATGAAGAAAAACAGGGACGCCTGTAAAACCTCAACCCATAAAGCCCAGACCTTGGCAGCTTCTATCC
TGAACATTTCACGGTCAGATTTAGAGGAAATATTAGACACAGAAGATCAAGTGGAAATTGAAAAAACAAAAATTGATGCTGAAAATGACA
AGGAATGGATGTTGTACATTCAGAAACTTCTTGAAGGACAGAGTCTTGCTCTGTCTCCCAGGCTGAAGTGCAATGGCGCAATCGTGGCTC

>In-frame_ZNF106_ENST00000263805_chr15_42749156_-_CNTLN_ENST00000425824_chr9_17415786_+_1673nt
ATGCCAGTGGGGAGAATTGAATGTCCCTCATCTCCCTCTTTCCCTAGGGACATTAGTCATGAGTGCCGAGTGTGCGGGGTCACAGAAGTG
GGTCTTTCTGCATATGCAAAGCACATTTCTGGCCAGTTGCACAAAGATAACGTTGATGCCCAGGAAAGAGAAGATGATGGAAAAGGAGAG
GAAGAGGAAGAAGATTATTTTGACAAGGAACTCATTCAGTTAATAAAACAAAGGAAAGAACAAAGTCGGACTATTTTCATGATAAGAATG
CCAAAAAACCAACTTTTCAAAAGAAGAATTGCAAGATGCAAAAGAGTTCACATACAGCAGTTCCTACTAGAGTCAACAGAGAAAAGTACA
AAAATATAACTGCCCAGAAATCAAGTAGCAATATTATTTTATTACGAGAACGGATTATATCCTTGCAACAACAAAACAGTGTACTTCAGA
ATGCCAAGAAAACAGCAGAATTGTCTGTTAAAGAATATAAAGAAGTTAATGAAAAGCTCCTCCATCAACAGCAAGTATCCGATCAACGAT
TTCAGACAAGCAGGCAGACAATAAAGAAGCTAAATTTGGATTTGGCTGGGCTTCGGAAAGAAAAAGAAGATTTACTAAAGAAATTGGAGT
CCTCATCTGAAATCACAAGTTTGGCAGAAGAAAATTCCCAGGTAACATTTCCACGGATACAAGTTACATCACTTAGTCCTTCAAGGAGCA
TGGATTTGGAAATGAAGCAATTGCAGTATAAACTAAAGAATGCTACTAATGAACTCACTAAACAGTCATCAAATGTGAAGACTTTGAAAT
TTGAACTCCTAGCAAAAGAAGAACACATAAAGGAAATGCATGAAAAGATATCTCGAATGGAGAGGGATATAACTATGAAAAGACATTTGA
TAGAGGACTTGAAATTTCGACAGAAAGTAAATTTGGAAAGTAACAAGAGTTTTAGTGAAATGTTACAAAATCTTGATAAAAAGGTAAAGA
CATTAACTGAAGAATGTTCCAACAAGAAGGTATCAATTGATTCACTAAAGCAAAGACTTAACGTTGCTGTAAAAGAAAAGTCACAGTATG
AACAGATGTATCAGAAATCTAAAGAGGAGTTAGAAAAAAAGGATCTCAAGCTTACTCTCCTAGTATCAAGAATAAGTGAGACTGAATCTG
CAATGGCAGAAATTGAAACAGCAGCATCTAAGCAGCTTCAAGAATTAGCATTGCAAAGTGAACAGGTCCTAGAAGGTGCACAGAAGACAT
TGCTGTTAGCCAATGAAAAAGTAGAAGAGTTCACCACATTTGTGAAGGCTTTGGCCAAAGAGTTGCAAAATGATGTCCATGTGGTAAGGC
GACAAATAAGAGAGCTTAAAAAAATGAAGAAAAACAGGGACGCCTGTAAAACCTCAACCCATAAAGCCCAGACCTTGGCAGCTTCTATCC
TGAACATTTCACGGTCAGATTTAGAGGAAATATTAGACACAGAAGATCAAGTGGAAATTGAAAAAACAAAAATTGATGCTGAAAATGACA
AGGAATGGATGTTGTACATTCAGAAACTTCTTGAAGGACAGCTTCCTTTTGCCTCATATTTACTAGAAGCAGTACTGGAAAAAATAAATG


* Fusion transcript sequences (Full-length transcript).
>In-frame_ZNF106_ENST00000263805_chr15_42749156_-_CNTLN_ENST00000380647_chr9_17415786_+_3271nt
GAGTGCAGCTGGCACCATGGGTGTGCTCCAGAGCAACTTCTGCTTGCTCTGAGCCCCCTGCCCTGCCTCCCCTTTCACCATGTTTCCTCT
GACAAGATTTTAAGTACAGCAATTCAAGAAGATTTCTCCTCCTAAACGACATTTATCTGAAGTCTATTGCCTCTTGATTGCTGGAAAAGA
ATCTTAAAATCATTTCAAAAGTAACTTATAAACAAACTTATTAAAAGTGATGAAAGGAGCATTGAAATTAATTAGCACTAATTTTTCACT
GTGCCAAAGTGTGCAGTGTCCTTCAGAGGAAACAATAACAGATCTGGTGAGTGTGCCATGCCAGTGGGGAGAATTGAATGTCCCTCATCT
CCCTCTTTCCCTAGGGACATTAGTCATGAGTGCCGAGTGTGCGGGGTCACAGAAGTGGGTCTTTCTGCATATGCAAAGCACATTTCTGGC
CAGTTGCACAAAGATAACGTTGATGCCCAGGAAAGAGAAGATGATGGAAAAGGAGAGGAAGAGGAAGAAGATTATTTTGACAAGGAACTC
ATTCAGTTAATAAAACAAAGGAAAGAACAAAGTCGGACTATTTTCATGATAAGAATGCCAAAAAACCAACTTTTCAAAAGAAGAATTGCA
AGATGCAAAAGAGTTCACATACAGCAGTTCCTACTAGAGTCAACAGAGAAAAGTACAAAAATATAACTGCCCAGAAATCAAGTAGCAATA
TTATTTTATTACGAGAACGGATTATATCCTTGCAACAACAAAACAGTGTACTTCAGAATGCCAAGAAAACAGCAGAATTGTCTGTTAAAG
AATATAAAGAAGTTAATGAAAAGCTCCTCCATCAACAGCAAGTATCCGATCAACGATTTCAGACAAGCAGGCAGACAATAAAGAAGCTAA
ATTTGGATTTGGCTGGGCTTCGGAAAGAAAAAGAAGATTTACTAAAGAAATTGGAGTCCTCATCTGAAATCACAAGTTTGGCAGAAGAAA
ATTCCCAGGTAACATTTCCACGGATACAAGTTACATCACTTAGTCCTTCAAGGAGCATGGATTTGGAAATGAAGCAATTGCAGTATAAAC
TAAAGAATGCTACTAATGAACTCACTAAACAGTCATCAAATGTGAAGACTTTGAAATTTGAACTCCTAGCAAAAGAAGAACACATAAAGG
AAATGCATGAAAAGATATCTCGAATGGAGAGGGATATAACTATGAAAAGACATTTGATAGAGGACTTGAAATTTCGACAGAAAGTAAATT
TGGAAAGTAACAAGAGTTTTAGTGAAATGTTACAAAATCTTGATAAAAAGGTAAAGACATTAACTGAAGAATGTTCCAACAAGAAGGTAT
CAATTGATTCACTAAAGCAAAGACTTAACGTTGCTGTAAAAGAAAAGTCACAGTATGAACAGATGTATCAGAAATCTAAAGAGGAGTTAG
AAAAAAAGGATCTCAAGCTTACTCTCCTAGTATCAAGAATAAGTGAGACTGAATCTGCAATGGCAGAAATTGAAACAGCAGCATCTAAGC
AGCTTCAAGAATTAGCATTGCAAAGTGAACAGGTCCTAGAAGGTGCACAGAAGACATTGCTGTTAGCCAATGAAAAAGTAGAAGAGTTCA
CCACATTTGTGAAGGCTTTGGCCAAAGAGTTGCAAAATGATGTCCATGTGGTAAGGCGACAAATAAGAGAGCTTAAAAAAATGAAGAAAA
ACAGGGACGCCTGTAAAACCTCAACCCATAAAGCCCAGACCTTGGCAGCTTCTATCCTGAACATTTCACGGTCAGATTTAGAGGAAATAT
TAGACACAGAAGATCAAGTGGAAATTGAAAAAACAAAAATTGATGCTGAAAATGACAAGGAATGGATGTTGTACATTCAGAAACTTCTTG
AAGGACAGCTTCCTTTTGCCTCATATTTACTAGAAGCAGTACTGGAAAAAATAAATGAAAAAAAGAAACTAGTTGAAGGATATTTCACAA
TTATGAAAGATATTAGATGATATTAAAATGGAGAGCTTTATTGCAAATGTGAAAACTTTTTATGTGGTGTGATTGGAATACATGCATTGC
AATCCTGACACGGTATCTGCTCCAACTATCAATAGTCAGGTTCAATACCAAAATAAGAAGTCTCTGAAAATAATTAATTGCTGAACAAGT
GAAACTAATTAAGTACATAGCCATTTAAAAGGAAATAGTGTAGCATCTGATGGTCGAATACAAATATTGCCACAAATCAGTGCAAACTTA
AAAATGATTTTCCTTCTAGTGCATTAAAAGAAACTGAGCAGGCTTGGTACACACAAATTGGCCTGAGCATAAGAAGAAAAAGTATCAACT
AAGGATTTAATGTTTTACGTTTCATGAAGAAACTAGACTTTTTACATAAAACTGCTATAGATGGCCATAAGTGGTCCAGGGAGCAACAGA
TTTGTAGTATGAGCAAATATAAAATGAAGCATCATAACTTGAGCATTTATTGAAATAAATTGTGTGGTCCAATTGAATCTGTTCTCATTG
ATGTGCTGGTTTATGTAGGAGATACTGTGTATTTCTACAACTCTTTGGCAAAAACAAAAACATTTTCTTCTTCTCTCTCTTAACTTCACA
ATACTATACGTTGTGTAGTCATATAAATTTGCAGGGAACCACAAACCCAATGTATAAAATTAGGCTCTATTTAACAGAACTACTACTGTG
GTCAGCTAATTTAAGTTACATTCTTAACCATGATGTCATCCTTATTTAGATTCCTGGACATTCCCACCTCATTTCACCTCTTCACCGTGT
TCCTGCCATACCCTTTTTGGTTCCTCTAATTCACCATACTGGTGCCTGCCTCCCACATTTGCCCTTGGTCTTCTCTCTTTCTAGAATACT
CTGCACTCAACTTTCCTCATGGCTGGCTCCTTGTCATCATTCAGCTCCACCTTCCCCGGTCCCTCAGAGACACATTCTCTGACCAGCTTA
CTATTTTATTTCCTCATAGCACAAAATTATCTATCTGTTCATGTATTTGTTTTCTTGTTTATTTTCTTCTTTTCCCTCTTTAGTATGTAG
GTCCCATGAGATTAAGGCAAGGGTTGGCAGATTATAGCCTGCAGGGCGAATCTGGCCTGCCACCTGTTTTGTATGGCCCACAAGCTAAGA
ATGGTTTTTGCCTTATTAAATGGTTTTTAAAAAATCAAAAGGAGAATAATATTTTGTAGCATGTGAAAATTATATAAAATTCAAATTTTG

>In-frame_ZNF106_ENST00000263805_chr15_42749156_-_CNTLN_ENST00000262360_chr9_17415786_+_1997nt
GAGTGCAGCTGGCACCATGGGTGTGCTCCAGAGCAACTTCTGCTTGCTCTGAGCCCCCTGCCCTGCCTCCCCTTTCACCATGTTTCCTCT
GACAAGATTTTAAGTACAGCAATTCAAGAAGATTTCTCCTCCTAAACGACATTTATCTGAAGTCTATTGCCTCTTGATTGCTGGAAAAGA
ATCTTAAAATCATTTCAAAAGTAACTTATAAACAAACTTATTAAAAGTGATGAAAGGAGCATTGAAATTAATTAGCACTAATTTTTCACT
GTGCCAAAGTGTGCAGTGTCCTTCAGAGGAAACAATAACAGATCTGGTGAGTGTGCCATGCCAGTGGGGAGAATTGAATGTCCCTCATCT
CCCTCTTTCCCTAGGGACATTAGTCATGAGTGCCGAGTGTGCGGGGTCACAGAAGTGGGTCTTTCTGCATATGCAAAGCACATTTCTGGC
CAGTTGCACAAAGATAACGTTGATGCCCAGGAAAGAGAAGATGATGGAAAAGGAGAGGAAGAGGAAGAAGATTATTTTGACAAGGAACTC
ATTCAGTTAATAAAACAAAGGAAAGAACAAAGTCGGACTATTTTCATGATAAGAATGCCAAAAAACCAACTTTTCAAAAGAAGAATTGCA
AGATGCAAAAGAGTTCACATACAGCAGTTCCTACTAGAGTCAACAGAGAAAAGTACAAAAATATAACTGCCCAGAAATCAAGTAGCAATA
TTATTTTATTACGAGAACGGATTATATCCTTGCAACAACAAAACAGTGTACTTCAGAATGCCAAGAAAACAGCAGAATTGTCTGTTAAAG
AATATAAAGAAGTTAATGAAAAGCTCCTCCATCAACAGCAAGTATCCGATCAACGATTTCAGACAAGCAGGCAGACAATAAAGAAGCTAA
ATTTGGATTTGGCTGGGCTTCGGAAAGAAAAAGAAGATTTACTAAAGAAATTGGAGTCCTCATCTGAAATCACAAGTTTGGCAGAAGAAA
ATTCCCAGGTAACATTTCCACGGATACAAGTTACATCACTTAGTCCTTCAAGGAGCATGGATTTGGAAATGAAGCAATTGCAGTATAAAC
TAAAGAATGCTACTAATGAACTCACTAAACAGTCATCAAATGTGAAGACTTTGAAATTTGAACTCCTAGCAAAAGAAGAACACATAAAGG
AAATGCATGAAAAGATATCTCGAATGGAGAGGGATATAACTATGAAAAGACATTTGATAGAGGACTTGAAATTTCGACAGAAAGTAAATT
TGGAAAGTAACAAGAGTTTTAGTGAAATGTTACAAAATCTTGATAAAAAGGTAAAGACATTAACTGAAGAATGTTCCAACAAGAAGGTAT
CAATTGATTCACTAAAGCAAAGACTTAACGTTGCTGTAAAAGAAAAGTCACAGTATGAACAGATGTATCAGAAATCTAAAGAGGAGTTAG
AAAAAAAGGATCTCAAGCTTACTCTCCTAGTATCAAGAATAAGTGAGACTGAATCTGCAATGGCAGAAATTGAAACAGCAGCATCTAAGC
AGCTTCAAGAATTAGCATTGCAAAGTGAACAGGTCCTAGAAGGTGCACAGAAGACATTGCTGTTAGCCAATGAAAAAGTAGAAGAGTTCA
CCACATTTGTGAAGGCTTTGGCCAAAGAGTTGCAAAATGATGTCCATGTGGTAAGGCGACAAATAAGAGAGCTTAAAAAAATGAAGAAAA
ACAGGGACGCCTGTAAAACCTCAACCCATAAAGCCCAGACCTTGGCAGCTTCTATCCTGAACATTTCACGGTCAGATTTAGAGGAAATAT
TAGACACAGAAGATCAAGTGGAAATTGAAAAAACAAAAATTGATGCTGAAAATGACAAGGAATGGATGTTGTACATTCAGAAACTTCTTG
AAGGACAGAGTCTTGCTCTGTCTCCCAGGCTGAAGTGCAATGGCGCAATCGTGGCTCACCAAAACCTCCGCCTGCCAGACTCGAGCAGTT

>In-frame_ZNF106_ENST00000263805_chr15_42749156_-_CNTLN_ENST00000425824_chr9_17415786_+_3265nt
GAGTGCAGCTGGCACCATGGGTGTGCTCCAGAGCAACTTCTGCTTGCTCTGAGCCCCCTGCCCTGCCTCCCCTTTCACCATGTTTCCTCT
GACAAGATTTTAAGTACAGCAATTCAAGAAGATTTCTCCTCCTAAACGACATTTATCTGAAGTCTATTGCCTCTTGATTGCTGGAAAAGA
ATCTTAAAATCATTTCAAAAGTAACTTATAAACAAACTTATTAAAAGTGATGAAAGGAGCATTGAAATTAATTAGCACTAATTTTTCACT
GTGCCAAAGTGTGCAGTGTCCTTCAGAGGAAACAATAACAGATCTGGTGAGTGTGCCATGCCAGTGGGGAGAATTGAATGTCCCTCATCT
CCCTCTTTCCCTAGGGACATTAGTCATGAGTGCCGAGTGTGCGGGGTCACAGAAGTGGGTCTTTCTGCATATGCAAAGCACATTTCTGGC
CAGTTGCACAAAGATAACGTTGATGCCCAGGAAAGAGAAGATGATGGAAAAGGAGAGGAAGAGGAAGAAGATTATTTTGACAAGGAACTC
ATTCAGTTAATAAAACAAAGGAAAGAACAAAGTCGGACTATTTTCATGATAAGAATGCCAAAAAACCAACTTTTCAAAAGAAGAATTGCA
AGATGCAAAAGAGTTCACATACAGCAGTTCCTACTAGAGTCAACAGAGAAAAGTACAAAAATATAACTGCCCAGAAATCAAGTAGCAATA
TTATTTTATTACGAGAACGGATTATATCCTTGCAACAACAAAACAGTGTACTTCAGAATGCCAAGAAAACAGCAGAATTGTCTGTTAAAG
AATATAAAGAAGTTAATGAAAAGCTCCTCCATCAACAGCAAGTATCCGATCAACGATTTCAGACAAGCAGGCAGACAATAAAGAAGCTAA
ATTTGGATTTGGCTGGGCTTCGGAAAGAAAAAGAAGATTTACTAAAGAAATTGGAGTCCTCATCTGAAATCACAAGTTTGGCAGAAGAAA
ATTCCCAGGTAACATTTCCACGGATACAAGTTACATCACTTAGTCCTTCAAGGAGCATGGATTTGGAAATGAAGCAATTGCAGTATAAAC
TAAAGAATGCTACTAATGAACTCACTAAACAGTCATCAAATGTGAAGACTTTGAAATTTGAACTCCTAGCAAAAGAAGAACACATAAAGG
AAATGCATGAAAAGATATCTCGAATGGAGAGGGATATAACTATGAAAAGACATTTGATAGAGGACTTGAAATTTCGACAGAAAGTAAATT
TGGAAAGTAACAAGAGTTTTAGTGAAATGTTACAAAATCTTGATAAAAAGGTAAAGACATTAACTGAAGAATGTTCCAACAAGAAGGTAT
CAATTGATTCACTAAAGCAAAGACTTAACGTTGCTGTAAAAGAAAAGTCACAGTATGAACAGATGTATCAGAAATCTAAAGAGGAGTTAG
AAAAAAAGGATCTCAAGCTTACTCTCCTAGTATCAAGAATAAGTGAGACTGAATCTGCAATGGCAGAAATTGAAACAGCAGCATCTAAGC
AGCTTCAAGAATTAGCATTGCAAAGTGAACAGGTCCTAGAAGGTGCACAGAAGACATTGCTGTTAGCCAATGAAAAAGTAGAAGAGTTCA
CCACATTTGTGAAGGCTTTGGCCAAAGAGTTGCAAAATGATGTCCATGTGGTAAGGCGACAAATAAGAGAGCTTAAAAAAATGAAGAAAA
ACAGGGACGCCTGTAAAACCTCAACCCATAAAGCCCAGACCTTGGCAGCTTCTATCCTGAACATTTCACGGTCAGATTTAGAGGAAATAT
TAGACACAGAAGATCAAGTGGAAATTGAAAAAACAAAAATTGATGCTGAAAATGACAAGGAATGGATGTTGTACATTCAGAAACTTCTTG
AAGGACAGCTTCCTTTTGCCTCATATTTACTAGAAGCAGTACTGGAAAAAATAAATGAAAAAAAGAAACTAGTTGAAGGATATTTCACAA
TTATGAAAGATATTAGATGATATTAAAATGGAGAGCTTTATTGCAAATGTGAAAACTTTTTATGTGGTGTGATTGGAATACATGCATTGC
AATCCTGACACGGTATCTGCTCCAACTATCAATAGTCAGGTTCAATACCAAAATAAGAAGTCTCTGAAAATAATTAATTGCTGAACAAGT
GAAACTAATTAAGTACATAGCCATTTAAAAGGAAATAGTGTAGCATCTGATGGTCGAATACAAATATTGCCACAAATCAGTGCAAACTTA
AAAATGATTTTCCTTCTAGTGCATTAAAAGAAACTGAGCAGGCTTGGTACACACAAATTGGCCTGAGCATAAGAAGAAAAAGTATCAACT
AAGGATTTAATGTTTTACGTTTCATGAAGAAACTAGACTTTTTACATAAAACTGCTATAGATGGCCATAAGTGGTCCAGGGAGCAACAGA
TTTGTAGTATGAGCAAATATAAAATGAAGCATCATAACTTGAGCATTTATTGAAATAAATTGTGTGGTCCAATTGAATCTGTTCTCATTG
ATGTGCTGGTTTATGTAGGAGATACTGTGTATTTCTACAACTCTTTGGCAAAAACAAAAACATTTTCTTCTTCTCTCTCTTAACTTCACA
ATACTATACGTTGTGTAGTCATATAAATTTGCAGGGAACCACAAACCCAATGTATAAAATTAGGCTCTATTTAACAGAACTACTACTGTG
GTCAGCTAATTTAAGTTACATTCTTAACCATGATGTCATCCTTATTTAGATTCCTGGACATTCCCACCTCATTTCACCTCTTCACCGTGT
TCCTGCCATACCCTTTTTGGTTCCTCTAATTCACCATACTGGTGCCTGCCTCCCACATTTGCCCTTGGTCTTCTCTCTTTCTAGAATACT
CTGCACTCAACTTTCCTCATGGCTGGCTCCTTGTCATCATTCAGCTCCACCTTCCCCGGTCCCTCAGAGACACATTCTCTGACCAGCTTA
CTATTTTATTTCCTCATAGCACAAAATTATCTATCTGTTCATGTATTTGTTTTCTTGTTTATTTTCTTCTTTTCCCTCTTTAGTATGTAG
GTCCCATGAGATTAAGGCAAGGGTTGGCAGATTATAGCCTGCAGGGCGAATCTGGCCTGCCACCTGTTTTGTATGGCCCACAAGCTAAGA
ATGGTTTTTGCCTTATTAAATGGTTTTTAAAAAATCAAAAGGAGAATAATATTTTGTAGCATGTGAAAATTATATAAAATTCAAATTTTG


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FusionGenePPI for ZNF106_CNTLN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF106WNK1, UBE2I, APC, SKIL, NXF1, CSNK2A2, CLEC11A, CAPZA2, GAK, EXOSC9, PPP1CB, MATR3, GTSE1, KIF21A, KNOP1, KLHL40, NXF2, FBXL5, PLOD1, STAMBPL1CNTLNSP1, BRCA1, HDAC6, TPM1, C9orf41, PRSS12, GOPC


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF106_CNTLN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF106_CNTLN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource