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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42988

FusionGeneSummary for ZNF106_ADK

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF106_ADK
Fusion gene ID: 42988
HgeneTgene
Gene symbol

ZNF106

ADK

Gene ID

64397

132

Gene namezinc finger protein 106adenosine kinase
SynonymsSH3BP3|ZFP106|ZNF474AK
Cytomap

15q15.1

10q22.2|10q11-q24

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 106SH3-domain binding protein 3zinc finger protein 474adenosine kinaseadenosine 5'-phosphotransferasetesticular tissue protein Li 14
Modification date2018052320180523
UniProtAcc

Q9H2Y7

P55263

Ensembl transtripts involved in fusion geneENST00000263805, ENST00000565380, 
ENST00000565611, ENST00000565660, 
ENST00000539909, ENST00000286621, 
ENST00000372734, ENST00000541550, 
ENST00000467840, 
Fusion gene scores* DoF score6 X 7 X 3=12618 X 8 X 11=1584
# samples 921
** MAII scorelog2(9/126*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/1584*10)=-2.91511110241349
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF106 [Title/Abstract] AND ADK [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AO-A03P-01AZNF106chr15

42710003

-ADKchr10

76429941

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000263805ENST00000539909ZNF106chr15

42710003

-ADKchr10

76429941

+
Frame-shiftENST00000263805ENST00000286621ZNF106chr15

42710003

-ADKchr10

76429941

+
Frame-shiftENST00000263805ENST00000372734ZNF106chr15

42710003

-ADKchr10

76429941

+
Frame-shiftENST00000263805ENST00000541550ZNF106chr15

42710003

-ADKchr10

76429941

+
5CDS-intronENST00000263805ENST00000467840ZNF106chr15

42710003

-ADKchr10

76429941

+
Frame-shiftENST00000565380ENST00000539909ZNF106chr15

42710003

-ADKchr10

76429941

+
Frame-shiftENST00000565380ENST00000286621ZNF106chr15

42710003

-ADKchr10

76429941

+
Frame-shiftENST00000565380ENST00000372734ZNF106chr15

42710003

-ADKchr10

76429941

+
Frame-shiftENST00000565380ENST00000541550ZNF106chr15

42710003

-ADKchr10

76429941

+
5CDS-intronENST00000565380ENST00000467840ZNF106chr15

42710003

-ADKchr10

76429941

+
Frame-shiftENST00000565611ENST00000539909ZNF106chr15

42710003

-ADKchr10

76429941

+
Frame-shiftENST00000565611ENST00000286621ZNF106chr15

42710003

-ADKchr10

76429941

+
Frame-shiftENST00000565611ENST00000372734ZNF106chr15

42710003

-ADKchr10

76429941

+
Frame-shiftENST00000565611ENST00000541550ZNF106chr15

42710003

-ADKchr10

76429941

+
5CDS-intronENST00000565611ENST00000467840ZNF106chr15

42710003

-ADKchr10

76429941

+
intron-3CDSENST00000565660ENST00000539909ZNF106chr15

42710003

-ADKchr10

76429941

+
intron-3CDSENST00000565660ENST00000286621ZNF106chr15

42710003

-ADKchr10

76429941

+
intron-3CDSENST00000565660ENST00000372734ZNF106chr15

42710003

-ADKchr10

76429941

+
intron-3CDSENST00000565660ENST00000541550ZNF106chr15

42710003

-ADKchr10

76429941

+
intron-intronENST00000565660ENST00000467840ZNF106chr15

42710003

-ADKchr10

76429941

+

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FusionProtFeatures for ZNF106_ADK


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF106

Q9H2Y7

ADK

P55263


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZNF106_ADK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZNF106_ADK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZNF106WNK1, UBE2I, APC, SKIL, NXF1, CSNK2A2, CLEC11A, CAPZA2, GAK, EXOSC9, PPP1CB, MATR3, GTSE1, KIF21A, KNOP1, KLHL40, NXF2, FBXL5, PLOD1, STAMBPL1ADKFICD, SRD5A3, ASS1, CAPG, DAZAP1, KYNU, LDHA, PIR, PTGR1, SOD1, NNMT, NQO1, PCBP1, PITPNB, RBM12, NPLOC4, FGB


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZNF106_ADK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneADKP55263DB00811RibavirinAdenosine kinasesmall moleculeapproved

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RelatedDiseases for ZNF106_ADK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneADKC0036341Schizophrenia1PSYGENET
TgeneADKC0242184Hypoxia1CTD_human
TgeneADKC3280381HYPERMETHIONINEMIA DUE TO ADENOSINE KINASE DEFICIENCY1CTD_human;ORPHANET;UNIPROT
TgeneADKC3714756Intellectual Disability1CTD_human