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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42968

FusionGeneSummary for ZMYND11_ZFAND4

check button Fusion gene summary
Fusion gene informationFusion gene name: ZMYND11_ZFAND4
Fusion gene ID: 42968
HgeneTgene
Gene symbol

ZMYND11

ZFAND4

Gene ID

10771

93550

Gene namezinc finger MYND-type containing 11zinc finger AN1-type containing 4
SynonymsBRAM1|BS69|MRD30ANUBL1
Cytomap

10p15.3

10q11.22

Type of geneprotein-codingprotein-coding
Descriptionzinc finger MYND domain-containing protein 11adenovirus 5 E1A-binding proteinbone morphogenetic protein receptor-associated molecule 1AN1-type zinc finger protein 4AN1, ubiquitin-like, homologAN1-type zinc finger and ubiquitin domain-containing protein 1AN1-type zinc finger and ubiquitin domain-containing protein-like 1zinc finger, AN1-type domain 4
Modification date2018052220180522
UniProtAcc

Q15326

Q86XD8

Ensembl transtripts involved in fusion geneENST00000381602, ENST00000397962, 
ENST00000309776, ENST00000509513, 
ENST00000397959, ENST00000381591, 
ENST00000403354, ENST00000381607, 
ENST00000402736, ENST00000602682, 
ENST00000381604, ENST00000381584, 
ENST00000558098, ENST00000545619, 
ENST00000535374, ENST00000473115, 
ENST00000344646, ENST00000374366, 
ENST00000374371, ENST00000374370, 
ENST00000335258, 
Fusion gene scores* DoF score6 X 5 X 5=1502 X 2 X 1=4
# samples 127
** MAII scorelog2(12/150*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/4*10)=4.12928301694497
Context

PubMed: ZMYND11 [Title/Abstract] AND ZFAND4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZMYND11

GO:0051607

defense response to virus

26845565


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BC036186ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
ChiTaRS3.1BI457833ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
ChiTaRS3.1BC048967ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
ChiTaRS3.1DB500938ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
ChiTaRS3.1BI669215ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
ChiTaRS3.1DB487719ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000381602ENST00000344646ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
5UTR-3CDSENST00000381602ENST00000374366ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
5UTR-3CDSENST00000381602ENST00000374371ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
5UTR-5UTRENST00000381602ENST00000374370ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
5UTR-intronENST00000381602ENST00000335258ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
Frame-shiftENST00000397962ENST00000344646ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
Frame-shiftENST00000397962ENST00000374366ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
Frame-shiftENST00000397962ENST00000374371ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
5CDS-5UTRENST00000397962ENST00000374370ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
5CDS-intronENST00000397962ENST00000335258ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
5UTR-3CDSENST00000309776ENST00000344646ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
5UTR-3CDSENST00000309776ENST00000374366ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
5UTR-3CDSENST00000309776ENST00000374371ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
5UTR-5UTRENST00000309776ENST00000374370ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
5UTR-intronENST00000309776ENST00000335258ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
Frame-shiftENST00000509513ENST00000344646ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
Frame-shiftENST00000509513ENST00000374366ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
Frame-shiftENST00000509513ENST00000374371ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
5CDS-5UTRENST00000509513ENST00000374370ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
5CDS-intronENST00000509513ENST00000335258ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
Frame-shiftENST00000397959ENST00000344646ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
Frame-shiftENST00000397959ENST00000374366ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
Frame-shiftENST00000397959ENST00000374371ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
5CDS-5UTRENST00000397959ENST00000374370ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
5CDS-intronENST00000397959ENST00000335258ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
Frame-shiftENST00000381591ENST00000344646ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
Frame-shiftENST00000381591ENST00000374366ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
Frame-shiftENST00000381591ENST00000374371ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
5CDS-5UTRENST00000381591ENST00000374370ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
5CDS-intronENST00000381591ENST00000335258ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
Frame-shiftENST00000403354ENST00000344646ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
Frame-shiftENST00000403354ENST00000374366ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
Frame-shiftENST00000403354ENST00000374371ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
5CDS-5UTRENST00000403354ENST00000374370ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
5CDS-intronENST00000403354ENST00000335258ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
5UTR-3CDSENST00000381607ENST00000344646ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
5UTR-3CDSENST00000381607ENST00000374366ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
5UTR-3CDSENST00000381607ENST00000374371ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
5UTR-5UTRENST00000381607ENST00000374370ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
5UTR-intronENST00000381607ENST00000335258ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
Frame-shiftENST00000402736ENST00000344646ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
Frame-shiftENST00000402736ENST00000374366ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
Frame-shiftENST00000402736ENST00000374371ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
5CDS-5UTRENST00000402736ENST00000374370ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
5CDS-intronENST00000402736ENST00000335258ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
Frame-shiftENST00000602682ENST00000344646ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
Frame-shiftENST00000602682ENST00000374366ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
Frame-shiftENST00000602682ENST00000374371ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
5CDS-5UTRENST00000602682ENST00000374370ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
5CDS-intronENST00000602682ENST00000335258ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
5UTR-3CDSENST00000381604ENST00000344646ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
5UTR-3CDSENST00000381604ENST00000374366ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
5UTR-3CDSENST00000381604ENST00000374371ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
5UTR-5UTRENST00000381604ENST00000374370ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
5UTR-intronENST00000381604ENST00000335258ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
5UTR-3CDSENST00000381584ENST00000344646ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
5UTR-3CDSENST00000381584ENST00000374366ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
5UTR-3CDSENST00000381584ENST00000374371ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
5UTR-5UTRENST00000381584ENST00000374370ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
5UTR-intronENST00000381584ENST00000335258ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
Frame-shiftENST00000558098ENST00000344646ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
Frame-shiftENST00000558098ENST00000374366ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
Frame-shiftENST00000558098ENST00000374371ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
5CDS-5UTRENST00000558098ENST00000374370ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
5CDS-intronENST00000558098ENST00000335258ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
intron-3CDSENST00000545619ENST00000344646ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
intron-3CDSENST00000545619ENST00000374366ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
intron-3CDSENST00000545619ENST00000374371ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
intron-5UTRENST00000545619ENST00000374370ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
intron-intronENST00000545619ENST00000335258ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
intron-3CDSENST00000535374ENST00000344646ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
intron-3CDSENST00000535374ENST00000374366ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
intron-3CDSENST00000535374ENST00000374371ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
intron-5UTRENST00000535374ENST00000374370ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
intron-intronENST00000535374ENST00000335258ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
intron-3CDSENST00000473115ENST00000344646ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
intron-3CDSENST00000473115ENST00000374366ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
intron-3CDSENST00000473115ENST00000374371ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
intron-5UTRENST00000473115ENST00000374370ZMYND11chr10

226068

+ZFAND4chr10

46143982

-
intron-intronENST00000473115ENST00000335258ZMYND11chr10

226068

+ZFAND4chr10

46143982

-

Top

FusionProtFeatures for ZMYND11_ZFAND4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZMYND11

Q15326

ZFAND4

Q86XD8


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZMYND11_ZFAND4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZMYND11_ZFAND4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZMYND11C11orf30, ETS2, ZHX1, NCOR1, BMPR1A, TAB1, MYB, SMARCA2, HDAC1, EZH2, EZH1, E2F6, TP53, EP400, PDLIM7, TRAF6, HOXD4, ELAVL1, LTBR, ZMYND11, PIAS1, UBE2I, TRAF1, TRAF2, TRAF3, TRAF5, SMAD2, TRADD, SMAD3, SRPK1, MAGEC2, H3F3A, HIST3H3, PRPF8, SRRM2, SNRNP200, SRRM1, PNN, SRSF4, SRSF1, PABPC1, EFTUD2, SAP18, PPIG, MAGOHB, SRSF10, RNU4-1, RNU5A-1, RNU6-1, CDK2, GBA, RPL10ZFAND4TFAP2C, A2ML1, SERPINB4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZMYND11_ZFAND4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZMYND11_ZFAND4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneZMYND11C0004352Autistic Disorder1CTD_human