FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 42952

FusionGeneSummary for ZMYM2_LATS2

check button Fusion gene summary
Fusion gene informationFusion gene name: ZMYM2_LATS2
Fusion gene ID: 42952
HgeneTgene
Gene symbol

ZMYM2

LATS2

Gene ID

7750

26524

Gene namezinc finger MYM-type containing 2large tumor suppressor kinase 2
SynonymsFIM|MYM|RAMP|SCLL|ZNF198KPM
Cytomap

13q12.11

13q12.11

Type of geneprotein-codingprotein-coding
Descriptionzinc finger MYM-type protein 2fused in myeloproliferative disorders proteinrearranged in an atypical myeloproliferative disorderzinc finger protein 198zinc finger, MYM-type 2serine/threonine-protein kinase LATS2LATS (large tumor suppressor, Drosophila) homolog 2LATS, large tumor suppressor, homolog 2kinase phosphorylated during mitosis proteinlarge tumor suppressor homolog 2serine/threonine kinase KPMserine/threonine-pr
Modification date2018052320180523
UniProtAcc

Q9UBW7

Q9NRM7

Ensembl transtripts involved in fusion geneENST00000382869, ENST00000382881, 
ENST00000382874, ENST00000382871, 
ENST00000382883, ENST00000494061, 
ENST00000382592, ENST00000542899, 
ENST00000472754, 
Fusion gene scores* DoF score6 X 3 X 6=1082 X 2 X 2=8
# samples 62
** MAII scorelog2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: ZMYM2 [Title/Abstract] AND LATS2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLATS2

GO:0000082

G1/S transition of mitotic cell cycle

12853976

TgeneLATS2

GO:0006468

protein phosphorylation

10871863

TgeneLATS2

GO:0009755

hormone-mediated signaling pathway

15131260

TgeneLATS2

GO:0035329

hippo signaling

20412773

TgeneLATS2

GO:0035556

intracellular signal transduction

10871863

TgeneLATS2

GO:0045736

negative regulation of cyclin-dependent protein serine/threonine kinase activity

12853976


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDESCATCGA-L5-A43I-01AZMYM2chr13

20534166

+LATS2chr13

21620369

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000382869ENST00000382592ZMYM2chr13

20534166

+LATS2chr13

21620369

-
5UTR-5UTRENST00000382869ENST00000542899ZMYM2chr13

20534166

+LATS2chr13

21620369

-
5UTR-intronENST00000382869ENST00000472754ZMYM2chr13

20534166

+LATS2chr13

21620369

-
5UTR-5UTRENST00000382881ENST00000382592ZMYM2chr13

20534166

+LATS2chr13

21620369

-
5UTR-5UTRENST00000382881ENST00000542899ZMYM2chr13

20534166

+LATS2chr13

21620369

-
5UTR-intronENST00000382881ENST00000472754ZMYM2chr13

20534166

+LATS2chr13

21620369

-
5UTR-5UTRENST00000382874ENST00000382592ZMYM2chr13

20534166

+LATS2chr13

21620369

-
5UTR-5UTRENST00000382874ENST00000542899ZMYM2chr13

20534166

+LATS2chr13

21620369

-
5UTR-intronENST00000382874ENST00000472754ZMYM2chr13

20534166

+LATS2chr13

21620369

-
5UTR-5UTRENST00000382871ENST00000382592ZMYM2chr13

20534166

+LATS2chr13

21620369

-
5UTR-5UTRENST00000382871ENST00000542899ZMYM2chr13

20534166

+LATS2chr13

21620369

-
5UTR-intronENST00000382871ENST00000472754ZMYM2chr13

20534166

+LATS2chr13

21620369

-
intron-5UTRENST00000382883ENST00000382592ZMYM2chr13

20534166

+LATS2chr13

21620369

-
intron-5UTRENST00000382883ENST00000542899ZMYM2chr13

20534166

+LATS2chr13

21620369

-
intron-intronENST00000382883ENST00000472754ZMYM2chr13

20534166

+LATS2chr13

21620369

-
intron-5UTRENST00000494061ENST00000382592ZMYM2chr13

20534166

+LATS2chr13

21620369

-
intron-5UTRENST00000494061ENST00000542899ZMYM2chr13

20534166

+LATS2chr13

21620369

-
intron-intronENST00000494061ENST00000472754ZMYM2chr13

20534166

+LATS2chr13

21620369

-

Top

FusionProtFeatures for ZMYM2_LATS2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZMYM2

Q9UBW7

LATS2

Q9NRM7

Negative regulator of YAP1 in the Hippo signalingpathway that plays a pivotal role in organ size control and tumorsuppression by restricting proliferation and promoting apoptosis.The core of this pathway is composed of a kinase cascade whereinSTK3/MST2 and STK4/MST1, in complex with its regulatory proteinSAV1, phosphorylates and activates LATS1/2 in complex with itsregulatory protein MOB1, which in turn phosphorylates andinactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation ofYAP1 by LATS2 inhibits its translocation into the nucleus toregulate cellular genes important for cell proliferation, celldeath, and cell migration. Acts as a tumor suppressor which playsa critical role in centrosome duplication, maintenance of mitoticfidelity and genomic stability. Negatively regulates G1/Stransition by down-regulating cyclin E/CDK2 kinase activity.Negative regulator of the androgen receptor. Phosphorylates SNAI1in the nucleus leading to its nuclear retention and stabilization,which enhances its epithelial-mesenchymal transition and tumorcell invasion/migration activities. This tumor-promoting activityis independent of its effects upon YAP1 or WWTR1/TAZ.{ECO:0000269|PubMed:10871863, ECO:0000269|PubMed:12853976,ECO:0000269|PubMed:15131260, ECO:0000269|PubMed:18158288,ECO:0000269|PubMed:21952048}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ZMYM2_LATS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ZMYM2_LATS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZMYM2HDAC2, KDM1A, FUS, SFPQ, HNRNPH3, HNRNPA2B1, UBTF, ZMYM4, HSPA4, RCOR1, HDAC1, TUBA1B, TUBB1, SUMO2, UBE2I, CREB1, SREBF2, ZBTB3, NR2E1, ELAVL1, CEBPE, PML, UBE2A, UBE2B, RAD18, USP15, CTCF, SKIL, SMAD4, ZNF512B, SOX2, HDAC11, SUMO1, EED, MAGEA1, SFXN3, SDF4, ST8SIA1, ALDH3B2, TRIM10, ARRDC1, NUP133, DYNLL1, ZSCAN5A, ZNF644, FOXG1, FOXJ2, FOXQ1, NFATC2, TSC22D2, ZNF263, ZNF202, PCK2, TSPYL6, MATN4, RPE65, PDDC1, TRIM35, PSG8, TRIM25, GTF2IRD1, GTF2ILATS2WWC1, LATS1, ELAVL1, YAP1, AR, AURKB, AURKA, PPP1R13B, MOB1A, MOB1B, MOB3A, MOB3B, MOB3C, MOB4, CHEK1, CHEK2, YWHAG, STK3, MDM2, SNAI1, AMOTL2, HIST2H2BE, HRAS, AJUBA, DYRK1A, CDK2, ALDH18A1, ALMS1, AMOT, AMOTL1, ANAPC1, ANAPC5, APC, CEP131, BAG2, BAG5, CCDC77, CCDC85C, CCDC88C, CCP110, CENPJ, CEP192, CEP72, CEP85, CEP89, CGN, CNTROB, CPVL, CSPP1, CTNNB1, CUL7, CYLD, DCAF7, DNAJA3, EIF4ENIF1, ERC1, AMER1, FBXL16, FUBP3, GIGYF1, GRIP1, IFFO1, INADL, KIAA0368, KIAA1462, KIAA1549, KIAA1671, CEP295, LATS2, LETM1, LIMD1, LIN7C, LNX2, LONP1, LZTS2, MAGI1, MIA3, MIPOL1, MLLT4, MPDZ, MPHOSPH9, MPP5, NCKAP5L, NIN, NINL, NME7, NOTCH1, NOTCH2, NUP160, OFD1, PAK4, PARD3, PCM1, PDZD11, PHLDB2, PKP4, PLEKHA1, PLEKHA5, PLEKHA7, PLEKHG1, PLOD1, PNMA2, PPFIA1, PPFIBP1, PPP2R1A, PPP2R2A, PTPN13, PTPN14, RADIL, RASAL2, RBM15, RCN2, SDCCAG3, SEC16A, SIPA1L1, SIPA1L2, SIPA1L3, SKP1, SKP2, SORBS1, SPICE1, SSX2IP, STK4, STXBP4, TANC2, TBK1, TBKBP1, TCHP, TJP1, TJP2, TNRC6B, TP53BP2, TRIM27, TRIM37, TUBB2A, TUBB6, USP54, USP9X, UTRN, YWHAH, SAV1, HSP90AB1, TAZ, ABL1, CDKN1A, NF2, WTIP, WWC2, WWC3, CEP128, RASSF1, SIAH1, SKI, WWTR1, KIF23, NEDD4, IKBKB, ZYX, SIAH2, EZH2, SUZ12


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ZMYM2_LATS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ZMYM2_LATS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneZMYM2C0027022Myeloproliferative disease1CTD_human
TgeneLATS2C0004114Astrocytoma1CTD_human