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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42951

FusionGeneSummary for ZMYM2_IFT88

check button Fusion gene summary
Fusion gene informationFusion gene name: ZMYM2_IFT88
Fusion gene ID: 42951
HgeneTgene
Gene symbol

ZMYM2

IFT88

Gene ID

7750

8100

Gene namezinc finger MYM-type containing 2intraflagellar transport 88
SynonymsFIM|MYM|RAMP|SCLL|ZNF198D13S1056E|DAF19|TG737|TTC10|hTg737
Cytomap

13q12.11

13q12.11

Type of geneprotein-codingprotein-coding
Descriptionzinc finger MYM-type protein 2fused in myeloproliferative disorders proteinrearranged in an atypical myeloproliferative disorderzinc finger protein 198zinc finger, MYM-type 2intraflagellar transport protein 88 homologTPR repeat protein 10intraflagellar transport 88 homologpolaris homologprobe hTg737 (polycystic kidney disease, autosomal recessive)recessive polycystic kidney disease protein Tg737 homologtesticular tissue
Modification date2018052320180523
UniProtAcc

Q9UBW7

Q13099

Ensembl transtripts involved in fusion geneENST00000382869, ENST00000382881, 
ENST00000382874, ENST00000382871, 
ENST00000382883, ENST00000494061, 
ENST00000382778, ENST00000351808, 
ENST00000319980, ENST00000537103, 
ENST00000461115, 
Fusion gene scores* DoF score6 X 3 X 6=1088 X 9 X 5=360
# samples 611
** MAII scorelog2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(11/360*10)=-1.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZMYM2 [Title/Abstract] AND IFT88 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-E7-A677-01AZMYM2chr13

20656270

+IFT88chr13

21212471

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000382869ENST00000382778ZMYM2chr13

20656270

+IFT88chr13

21212471

+
Frame-shiftENST00000382869ENST00000351808ZMYM2chr13

20656270

+IFT88chr13

21212471

+
Frame-shiftENST00000382869ENST00000319980ZMYM2chr13

20656270

+IFT88chr13

21212471

+
Frame-shiftENST00000382869ENST00000537103ZMYM2chr13

20656270

+IFT88chr13

21212471

+
5CDS-intronENST00000382869ENST00000461115ZMYM2chr13

20656270

+IFT88chr13

21212471

+
intron-3CDSENST00000382881ENST00000382778ZMYM2chr13

20656270

+IFT88chr13

21212471

+
intron-3CDSENST00000382881ENST00000351808ZMYM2chr13

20656270

+IFT88chr13

21212471

+
intron-3CDSENST00000382881ENST00000319980ZMYM2chr13

20656270

+IFT88chr13

21212471

+
intron-3CDSENST00000382881ENST00000537103ZMYM2chr13

20656270

+IFT88chr13

21212471

+
intron-intronENST00000382881ENST00000461115ZMYM2chr13

20656270

+IFT88chr13

21212471

+
Frame-shiftENST00000382874ENST00000382778ZMYM2chr13

20656270

+IFT88chr13

21212471

+
Frame-shiftENST00000382874ENST00000351808ZMYM2chr13

20656270

+IFT88chr13

21212471

+
Frame-shiftENST00000382874ENST00000319980ZMYM2chr13

20656270

+IFT88chr13

21212471

+
Frame-shiftENST00000382874ENST00000537103ZMYM2chr13

20656270

+IFT88chr13

21212471

+
5CDS-intronENST00000382874ENST00000461115ZMYM2chr13

20656270

+IFT88chr13

21212471

+
Frame-shiftENST00000382871ENST00000382778ZMYM2chr13

20656270

+IFT88chr13

21212471

+
Frame-shiftENST00000382871ENST00000351808ZMYM2chr13

20656270

+IFT88chr13

21212471

+
Frame-shiftENST00000382871ENST00000319980ZMYM2chr13

20656270

+IFT88chr13

21212471

+
Frame-shiftENST00000382871ENST00000537103ZMYM2chr13

20656270

+IFT88chr13

21212471

+
5CDS-intronENST00000382871ENST00000461115ZMYM2chr13

20656270

+IFT88chr13

21212471

+
intron-3CDSENST00000382883ENST00000382778ZMYM2chr13

20656270

+IFT88chr13

21212471

+
intron-3CDSENST00000382883ENST00000351808ZMYM2chr13

20656270

+IFT88chr13

21212471

+
intron-3CDSENST00000382883ENST00000319980ZMYM2chr13

20656270

+IFT88chr13

21212471

+
intron-3CDSENST00000382883ENST00000537103ZMYM2chr13

20656270

+IFT88chr13

21212471

+
intron-intronENST00000382883ENST00000461115ZMYM2chr13

20656270

+IFT88chr13

21212471

+
3UTR-3CDSENST00000494061ENST00000382778ZMYM2chr13

20656270

+IFT88chr13

21212471

+
3UTR-3CDSENST00000494061ENST00000351808ZMYM2chr13

20656270

+IFT88chr13

21212471

+
3UTR-3CDSENST00000494061ENST00000319980ZMYM2chr13

20656270

+IFT88chr13

21212471

+
3UTR-3CDSENST00000494061ENST00000537103ZMYM2chr13

20656270

+IFT88chr13

21212471

+
3UTR-intronENST00000494061ENST00000461115ZMYM2chr13

20656270

+IFT88chr13

21212471

+

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FusionProtFeatures for ZMYM2_IFT88


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZMYM2

Q9UBW7

IFT88

Q13099

Involved in primary cilium biogenesis. Also involved inautophagy since it is required for trafficking of ATG16L and theexpansion of the autophagic compartment.{ECO:0000250|UniProtKB:Q61371}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZMYM2_IFT88


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZMYM2_IFT88


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZMYM2HDAC2, KDM1A, FUS, SFPQ, HNRNPH3, HNRNPA2B1, UBTF, ZMYM4, HSPA4, RCOR1, HDAC1, TUBA1B, TUBB1, SUMO2, UBE2I, CREB1, SREBF2, ZBTB3, NR2E1, ELAVL1, CEBPE, PML, UBE2A, UBE2B, RAD18, USP15, CTCF, SKIL, SMAD4, ZNF512B, SOX2, HDAC11, SUMO1, EED, MAGEA1, SFXN3, SDF4, ST8SIA1, ALDH3B2, TRIM10, ARRDC1, NUP133, DYNLL1, ZSCAN5A, ZNF644, FOXG1, FOXJ2, FOXQ1, NFATC2, TSC22D2, ZNF263, ZNF202, PCK2, TSPYL6, MATN4, RPE65, PDDC1, TRIM35, PSG8, TRIM25, GTF2IRD1, GTF2IIFT88PRRC2A, IFT81, IFT46, IFT57, CCDC151, IFT80, LCA5, CSNK2A2, ZWINT, CDKN2AIP, SMC6, UBXN10, VCP, TTC30A, TTC30B, FGF8, IFT172, IFT20, IFT74, IFT27, TRAF3IP1, CLUAP1, HSPB11, TTC26, IFT22, IFT52, ICK


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZMYM2_IFT88


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZMYM2_IFT88


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneZMYM2C0027022Myeloproliferative disease1CTD_human
TgeneIFT88C0085548Autosomal Recessive Polycystic Kidney Disease2CTD_human
TgeneIFT88C0023903Liver neoplasms1CTD_human
TgeneIFT88C0032927Precancerous Conditions1CTD_human
TgeneIFT88C0152427Polydactyly1CTD_human