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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42943

FusionGeneSummary for ZMIZ2_FAM3C

check button Fusion gene summary
Fusion gene informationFusion gene name: ZMIZ2_FAM3C
Fusion gene ID: 42943
HgeneTgene
Gene symbol

ZMIZ2

FAM3C

Gene ID

83637

10447

Gene namezinc finger MIZ-type containing 2family with sequence similarity 3 member C
SynonymsNET27|TRAFIP20|ZIMP7|hZIMP7GS3786|ILEI
Cytomap

7p13

7q31.31

Type of geneprotein-codingprotein-coding
Descriptionzinc finger MIZ domain-containing protein 2PIAS-like protein Zimp7protein FAM3Cinterleukin-like EMT inducerinterleukin-like epithelial-mesenchymal transition inducerpredicted osteoblast protein
Modification date2018052220180522
UniProtAcc

Q8NF64

Q92520

Ensembl transtripts involved in fusion geneENST00000413916, ENST00000309315, 
ENST00000441627, ENST00000433667, 
ENST00000265346, ENST00000463931, 
ENST00000359943, 
Fusion gene scores* DoF score3 X 3 X 1=93 X 3 X 1=9
# samples 53
** MAII scorelog2(5/9*10)=2.47393118833241
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZMIZ2 [Title/Abstract] AND FAM3C [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZMIZ2

GO:0045944

positive regulation of transcription by RNA polymerase II

16051670


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BC016968ZMIZ2chr7

44805086

+FAM3Cchr7

120988956

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000413916ENST00000359943ZMIZ2chr7

44805086

+FAM3Cchr7

120988956

-
5CDS-3UTRENST00000309315ENST00000359943ZMIZ2chr7

44805086

+FAM3Cchr7

120988956

-
5CDS-3UTRENST00000441627ENST00000359943ZMIZ2chr7

44805086

+FAM3Cchr7

120988956

-
5CDS-3UTRENST00000433667ENST00000359943ZMIZ2chr7

44805086

+FAM3Cchr7

120988956

-
5CDS-3UTRENST00000265346ENST00000359943ZMIZ2chr7

44805086

+FAM3Cchr7

120988956

-
intron-3UTRENST00000463931ENST00000359943ZMIZ2chr7

44805086

+FAM3Cchr7

120988956

-

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FusionProtFeatures for ZMIZ2_FAM3C


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZMIZ2

Q8NF64

FAM3C

Q92520

May be involved in retinal laminar formation. Promotesepithelial to mesenchymal transition.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZMIZ2_FAM3C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZMIZ2_FAM3C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZMIZ2_FAM3C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZMIZ2_FAM3C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource