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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42908

FusionGeneSummary for ZKSCAN1_SNAPC5

check button Fusion gene summary
Fusion gene informationFusion gene name: ZKSCAN1_SNAPC5
Fusion gene ID: 42908
HgeneTgene
Gene symbol

ZKSCAN1

SNAPC5

Gene ID

7586

10302

Gene namezinc finger with KRAB and SCAN domains 1small nuclear RNA activating complex polypeptide 5
SynonymsKOX18|PHZ-37|ZNF139|ZNF36|ZSCAN33SNAP19
Cytomap

7q22.1

15q22.31

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein with KRAB and SCAN domains 1zinc finger protein 139zinc finger protein 36 (KOX 18)snRNA-activating protein complex subunit 5SNAPc 19 kDa subunitSNAPc subunit 5snRNA-activating protein complex 19 kDa subunit
Modification date2018051920180523
UniProtAcc

P17029

O75971

Ensembl transtripts involved in fusion geneENST00000324306, ENST00000426572, 
ENST00000535170, 
ENST00000563480, 
ENST00000395589, ENST00000316634, 
ENST00000307979, ENST00000566658, 
Fusion gene scores* DoF score7 X 9 X 3=1892 X 2 X 2=8
# samples 102
** MAII scorelog2(10/189*10)=-0.918386234446348
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: ZKSCAN1 [Title/Abstract] AND SNAPC5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM457580ZKSCAN1chr7

99633738

+SNAPC5chr15

66785751

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000324306ENST00000563480ZKSCAN1chr7

99633738

+SNAPC5chr15

66785751

-
3UTR-intronENST00000324306ENST00000395589ZKSCAN1chr7

99633738

+SNAPC5chr15

66785751

-
3UTR-intronENST00000324306ENST00000316634ZKSCAN1chr7

99633738

+SNAPC5chr15

66785751

-
3UTR-intronENST00000324306ENST00000307979ZKSCAN1chr7

99633738

+SNAPC5chr15

66785751

-
3UTR-intronENST00000324306ENST00000566658ZKSCAN1chr7

99633738

+SNAPC5chr15

66785751

-
intron-intronENST00000426572ENST00000563480ZKSCAN1chr7

99633738

+SNAPC5chr15

66785751

-
intron-intronENST00000426572ENST00000395589ZKSCAN1chr7

99633738

+SNAPC5chr15

66785751

-
intron-intronENST00000426572ENST00000316634ZKSCAN1chr7

99633738

+SNAPC5chr15

66785751

-
intron-intronENST00000426572ENST00000307979ZKSCAN1chr7

99633738

+SNAPC5chr15

66785751

-
intron-intronENST00000426572ENST00000566658ZKSCAN1chr7

99633738

+SNAPC5chr15

66785751

-
3UTR-intronENST00000535170ENST00000563480ZKSCAN1chr7

99633738

+SNAPC5chr15

66785751

-
3UTR-intronENST00000535170ENST00000395589ZKSCAN1chr7

99633738

+SNAPC5chr15

66785751

-
3UTR-intronENST00000535170ENST00000316634ZKSCAN1chr7

99633738

+SNAPC5chr15

66785751

-
3UTR-intronENST00000535170ENST00000307979ZKSCAN1chr7

99633738

+SNAPC5chr15

66785751

-
3UTR-intronENST00000535170ENST00000566658ZKSCAN1chr7

99633738

+SNAPC5chr15

66785751

-

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FusionProtFeatures for ZKSCAN1_SNAPC5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZKSCAN1

P17029

SNAPC5

O75971

May be involved in transcriptional regulation. Part of the SNAPc complex required for the transcriptionof both RNA polymerase II and III small-nuclear RNA genes. Bindsto the proximal sequence element (PSE), a non-TATA-box basalpromoter element common to these 2 types of genes. Recruits TBPand BRF2 to the U6 snRNA TATA box.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZKSCAN1_SNAPC5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZKSCAN1_SNAPC5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZKSCAN1_SNAPC5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZKSCAN1_SNAPC5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource