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Fusion gene ID: 42883 |
FusionGeneSummary for ZGPAT_HELZ2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZGPAT_HELZ2 | Fusion gene ID: 42883 | Hgene | Tgene | Gene symbol | ZGPAT | HELZ2 | Gene ID | 84619 | 85441 |
| Gene name | zinc finger CCCH-type and G-patch domain containing | helicase with zinc finger 2 | |
| Synonyms | GPATC6|GPATCH6|KIAA1847|ZC3H9|ZC3HDC9|ZIP | PDIP-1|PRIC285 | |
| Cytomap | 20q13.33 | 20q13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger CCCH-type with G patch domain-containing proteing patch domain-containing protein 6zinc finger CCCH domain-containing protein 9zinc finger and G patch domain-containing proteinzinc finger, CCCH-type with G patch domain | helicase with zinc finger domain 2ATP-dependent helicase PRIC285PDIP1PPAR gamma DBD-interacting protein 1PPAR-alpha-interacting complex protein 285PPAR-gamma DNA-binding domain-interacting protein 1PPARG-DBD-interacting protein 1PPARgamma-DNA-bindi | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8N5A5 | Q9BYK8 | |
| Ensembl transtripts involved in fusion gene | ENST00000448100, ENST00000355969, ENST00000357119, ENST00000369967, ENST00000328969, ENST00000478385, | ENST00000427522, ENST00000467148, ENST00000479540, | |
| Fusion gene scores | * DoF score | 3 X 2 X 2=12 | 3 X 3 X 2=18 |
| # samples | 2 | 5 | |
| ** MAII score | log2(2/12*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/18*10)=1.47393118833241 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ZGPAT [Title/Abstract] AND HELZ2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ZGPAT | GO:0000122 | negative regulation of transcription by RNA polymerase II | 19644445 |
| Hgene | ZGPAT | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity | 19644445 |
| Hgene | ZGPAT | GO:0045892 | negative regulation of transcription, DNA-templated | 19644445 |
| Tgene | HELZ2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 16239304 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-E2-A105-01A | ZGPAT | chr20 | 62340516 | + | HELZ2 | chr20 | 62190723 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000448100 | ENST00000427522 | ZGPAT | chr20 | 62340516 | + | HELZ2 | chr20 | 62190723 | - |
| In-frame | ENST00000448100 | ENST00000467148 | ZGPAT | chr20 | 62340516 | + | HELZ2 | chr20 | 62190723 | - |
| 5CDS-intron | ENST00000448100 | ENST00000479540 | ZGPAT | chr20 | 62340516 | + | HELZ2 | chr20 | 62190723 | - |
| Frame-shift | ENST00000355969 | ENST00000427522 | ZGPAT | chr20 | 62340516 | + | HELZ2 | chr20 | 62190723 | - |
| In-frame | ENST00000355969 | ENST00000467148 | ZGPAT | chr20 | 62340516 | + | HELZ2 | chr20 | 62190723 | - |
| 5CDS-intron | ENST00000355969 | ENST00000479540 | ZGPAT | chr20 | 62340516 | + | HELZ2 | chr20 | 62190723 | - |
| Frame-shift | ENST00000357119 | ENST00000427522 | ZGPAT | chr20 | 62340516 | + | HELZ2 | chr20 | 62190723 | - |
| In-frame | ENST00000357119 | ENST00000467148 | ZGPAT | chr20 | 62340516 | + | HELZ2 | chr20 | 62190723 | - |
| 5CDS-intron | ENST00000357119 | ENST00000479540 | ZGPAT | chr20 | 62340516 | + | HELZ2 | chr20 | 62190723 | - |
| Frame-shift | ENST00000369967 | ENST00000427522 | ZGPAT | chr20 | 62340516 | + | HELZ2 | chr20 | 62190723 | - |
| In-frame | ENST00000369967 | ENST00000467148 | ZGPAT | chr20 | 62340516 | + | HELZ2 | chr20 | 62190723 | - |
| 5CDS-intron | ENST00000369967 | ENST00000479540 | ZGPAT | chr20 | 62340516 | + | HELZ2 | chr20 | 62190723 | - |
| Frame-shift | ENST00000328969 | ENST00000427522 | ZGPAT | chr20 | 62340516 | + | HELZ2 | chr20 | 62190723 | - |
| In-frame | ENST00000328969 | ENST00000467148 | ZGPAT | chr20 | 62340516 | + | HELZ2 | chr20 | 62190723 | - |
| 5CDS-intron | ENST00000328969 | ENST00000479540 | ZGPAT | chr20 | 62340516 | + | HELZ2 | chr20 | 62190723 | - |
| 3UTR-3CDS | ENST00000478385 | ENST00000427522 | ZGPAT | chr20 | 62340516 | + | HELZ2 | chr20 | 62190723 | - |
| 3UTR-3CDS | ENST00000478385 | ENST00000467148 | ZGPAT | chr20 | 62340516 | + | HELZ2 | chr20 | 62190723 | - |
| 3UTR-intron | ENST00000478385 | ENST00000479540 | ZGPAT | chr20 | 62340516 | + | HELZ2 | chr20 | 62190723 | - |
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FusionProtFeatures for ZGPAT_HELZ2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZGPAT | HELZ2 |
| Helicase that acts as a transcriptional coactivator fora number of nuclear receptors including PPARA, PPARG, THRA, THRBand RXRA. {ECO:0000269|PubMed:16239304,ECO:0000269|PubMed:23525231}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZGPAT_HELZ2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ZGPAT_ENST00000448100_chr20_62340516_+_HELZ2_ENST00000467148_chr20_62190723_-_236aa MDEESLESALQTYRAQLQQVELALGAGLDSSEQADLRQLQGDLKELIELTEASLVSVRKSSLLAALDEERPGRQEDAEYQAFREAITEAV EAPAAARGSGSETVPKAEAGPESAAGGQEEEEGEDEEELSGTKVSAPYYSSWGTLEYHNAMVVGTEEAEDGSAGVRVLYLYPTHKSLKPC >In-frame_ZGPAT_ENST00000355969_chr20_62340516_+_HELZ2_ENST00000467148_chr20_62190723_-_236aa MDEESLESALQTYRAQLQQVELALGAGLDSSEQADLRQLQGDLKELIELTEASLVSVRKSSLLAALDEERPGRQEDAEYQAFREAITEAV EAPAAARGSGSETVPKAEAGPESAAGGQEEEEGEDEEELSGTKVSAPYYSSWGTLEYHNAMVVGTEEAEDGSAGVRVLYLYPTHKSLKPC >In-frame_ZGPAT_ENST00000357119_chr20_62340516_+_HELZ2_ENST00000467148_chr20_62190723_-_236aa MDEESLESALQTYRAQLQQVELALGAGLDSSEQADLRQLQGDLKELIELTEASLVSVRKSSLLAALDEERPGRQEDAEYQAFREAITEAV EAPAAARGSGSETVPKAEAGPESAAGGQEEEEGEDEEELSGTKVSAPYYSSWGTLEYHNAMVVGTEEAEDGSAGVRVLYLYPTHKSLKPC >In-frame_ZGPAT_ENST00000369967_chr20_62340516_+_HELZ2_ENST00000467148_chr20_62190723_-_236aa MDEESLESALQTYRAQLQQVELALGAGLDSSEQADLRQLQGDLKELIELTEASLVSVRKSSLLAALDEERPGRQEDAEYQAFREAITEAV EAPAAARGSGSETVPKAEAGPESAAGGQEEEEGEDEEELSGTKVSAPYYSSWGTLEYHNAMVVGTEEAEDGSAGVRVLYLYPTHKSLKPC >In-frame_ZGPAT_ENST00000328969_chr20_62340516_+_HELZ2_ENST00000467148_chr20_62190723_-_236aa MDEESLESALQTYRAQLQQVELALGAGLDSSEQADLRQLQGDLKELIELTEASLVSVRKSSLLAALDEERPGRQEDAEYQAFREAITEAV EAPAAARGSGSETVPKAEAGPESAAGGQEEEEGEDEEELSGTKVSAPYYSSWGTLEYHNAMVVGTEEAEDGSAGVRVLYLYPTHKSLKPC |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ZGPAT_ENST00000448100_chr20_62340516_+_HELZ2_ENST00000467148_chr20_62190723_-_709nt ATGGACGAGGAGAGCCTGGAGTCGGCCTTGCAGACCTACCGTGCGCAGCTGCAGCAGGTGGAGCTGGCCTTGGGCGCCGGCCTGGATTCG TCTGAGCAGGCTGACCTGCGCCAGCTGCAGGGGGACCTGAAGGAGCTCATCGAGCTCACCGAGGCCAGCCTGGTGTCTGTCAGGAAGAGC AGCTTGTTGGCCGCGCTGGACGAAGAGCGCCCGGGCCGCCAGGAAGATGCTGAGTACCAGGCTTTCCGGGAGGCCATCACTGAGGCGGTG GAGGCACCAGCAGCGGCCCGTGGGTCCGGATCAGAGACCGTTCCTAAAGCAGAGGCGGGGCCAGAATCTGCGGCAGGTGGGCAGGAGGAG GAAGAGGGAGAGGACGAGGAAGAGCTGAGTGGGACAAAGGTGAGCGCGCCCTACTACAGCTCCTGGGGCACTCTGGAGTATCACAACGCC ATGGTGGTGGGAACGGAAGAGGCGGAGGATGGCTCGGCGGGTGTCCGTGTGCTTTACCTGTACCCCACTCACAAGTCTCTGAAGCCGTGC CCGTTCTTCCTGGAGGGAAAGTGCCGCTTTAAGGAGAACTGCAGGAGACCACCTCCTTCTGCGCTGCTGCCCCCTCTGGCGTAGCCTCCT >In-frame_ZGPAT_ENST00000355969_chr20_62340516_+_HELZ2_ENST00000467148_chr20_62190723_-_709nt ATGGACGAGGAGAGCCTGGAGTCGGCCTTGCAGACCTACCGTGCGCAGCTGCAGCAGGTGGAGCTGGCCTTGGGCGCCGGCCTGGATTCG TCTGAGCAGGCTGACCTGCGCCAGCTGCAGGGGGACCTGAAGGAGCTCATCGAGCTCACCGAGGCCAGCCTGGTGTCTGTCAGGAAGAGC AGCTTGTTGGCCGCGCTGGACGAAGAGCGCCCGGGCCGCCAGGAAGATGCTGAGTACCAGGCTTTCCGGGAGGCCATCACTGAGGCGGTG GAGGCACCAGCAGCGGCCCGTGGGTCCGGATCAGAGACCGTTCCTAAAGCAGAGGCGGGGCCAGAATCTGCGGCAGGTGGGCAGGAGGAG GAAGAGGGAGAGGACGAGGAAGAGCTGAGTGGGACAAAGGTGAGCGCGCCCTACTACAGCTCCTGGGGCACTCTGGAGTATCACAACGCC ATGGTGGTGGGAACGGAAGAGGCGGAGGATGGCTCGGCGGGTGTCCGTGTGCTTTACCTGTACCCCACTCACAAGTCTCTGAAGCCGTGC CCGTTCTTCCTGGAGGGAAAGTGCCGCTTTAAGGAGAACTGCAGGAGACCACCTCCTTCTGCGCTGCTGCCCCCTCTGGCGTAGCCTCCT >In-frame_ZGPAT_ENST00000357119_chr20_62340516_+_HELZ2_ENST00000467148_chr20_62190723_-_709nt ATGGACGAGGAGAGCCTGGAGTCGGCCTTGCAGACCTACCGTGCGCAGCTGCAGCAGGTGGAGCTGGCCTTGGGCGCCGGCCTGGATTCG TCTGAGCAGGCTGACCTGCGCCAGCTGCAGGGGGACCTGAAGGAGCTCATCGAGCTCACCGAGGCCAGCCTGGTGTCTGTCAGGAAGAGC AGCTTGTTGGCCGCGCTGGACGAAGAGCGCCCGGGCCGCCAGGAAGATGCTGAGTACCAGGCTTTCCGGGAGGCCATCACTGAGGCGGTG GAGGCACCAGCAGCGGCCCGTGGGTCCGGATCAGAGACCGTTCCTAAAGCAGAGGCGGGGCCAGAATCTGCGGCAGGTGGGCAGGAGGAG GAAGAGGGAGAGGACGAGGAAGAGCTGAGTGGGACAAAGGTGAGCGCGCCCTACTACAGCTCCTGGGGCACTCTGGAGTATCACAACGCC ATGGTGGTGGGAACGGAAGAGGCGGAGGATGGCTCGGCGGGTGTCCGTGTGCTTTACCTGTACCCCACTCACAAGTCTCTGAAGCCGTGC CCGTTCTTCCTGGAGGGAAAGTGCCGCTTTAAGGAGAACTGCAGGAGACCACCTCCTTCTGCGCTGCTGCCCCCTCTGGCGTAGCCTCCT >In-frame_ZGPAT_ENST00000369967_chr20_62340516_+_HELZ2_ENST00000467148_chr20_62190723_-_709nt ATGGACGAGGAGAGCCTGGAGTCGGCCTTGCAGACCTACCGTGCGCAGCTGCAGCAGGTGGAGCTGGCCTTGGGCGCCGGCCTGGATTCG TCTGAGCAGGCTGACCTGCGCCAGCTGCAGGGGGACCTGAAGGAGCTCATCGAGCTCACCGAGGCCAGCCTGGTGTCTGTCAGGAAGAGC AGCTTGTTGGCCGCGCTGGACGAAGAGCGCCCGGGCCGCCAGGAAGATGCTGAGTACCAGGCTTTCCGGGAGGCCATCACTGAGGCGGTG GAGGCACCAGCAGCGGCCCGTGGGTCCGGATCAGAGACCGTTCCTAAAGCAGAGGCGGGGCCAGAATCTGCGGCAGGTGGGCAGGAGGAG GAAGAGGGAGAGGACGAGGAAGAGCTGAGTGGGACAAAGGTGAGCGCGCCCTACTACAGCTCCTGGGGCACTCTGGAGTATCACAACGCC ATGGTGGTGGGAACGGAAGAGGCGGAGGATGGCTCGGCGGGTGTCCGTGTGCTTTACCTGTACCCCACTCACAAGTCTCTGAAGCCGTGC CCGTTCTTCCTGGAGGGAAAGTGCCGCTTTAAGGAGAACTGCAGGAGACCACCTCCTTCTGCGCTGCTGCCCCCTCTGGCGTAGCCTCCT >In-frame_ZGPAT_ENST00000328969_chr20_62340516_+_HELZ2_ENST00000467148_chr20_62190723_-_709nt ATGGACGAGGAGAGCCTGGAGTCGGCCTTGCAGACCTACCGTGCGCAGCTGCAGCAGGTGGAGCTGGCCTTGGGCGCCGGCCTGGATTCG TCTGAGCAGGCTGACCTGCGCCAGCTGCAGGGGGACCTGAAGGAGCTCATCGAGCTCACCGAGGCCAGCCTGGTGTCTGTCAGGAAGAGC AGCTTGTTGGCCGCGCTGGACGAAGAGCGCCCGGGCCGCCAGGAAGATGCTGAGTACCAGGCTTTCCGGGAGGCCATCACTGAGGCGGTG GAGGCACCAGCAGCGGCCCGTGGGTCCGGATCAGAGACCGTTCCTAAAGCAGAGGCGGGGCCAGAATCTGCGGCAGGTGGGCAGGAGGAG GAAGAGGGAGAGGACGAGGAAGAGCTGAGTGGGACAAAGGTGAGCGCGCCCTACTACAGCTCCTGGGGCACTCTGGAGTATCACAACGCC ATGGTGGTGGGAACGGAAGAGGCGGAGGATGGCTCGGCGGGTGTCCGTGTGCTTTACCTGTACCCCACTCACAAGTCTCTGAAGCCGTGC CCGTTCTTCCTGGAGGGAAAGTGCCGCTTTAAGGAGAACTGCAGGAGACCACCTCCTTCTGCGCTGCTGCCCCCTCTGGCGTAGCCTCCT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ZGPAT_ENST00000448100_chr20_62340516_+_HELZ2_ENST00000467148_chr20_62190723_-_876nt CGCCTGGGCCACGGCACCCTCGAGCGCCAGCCCCGCGCCCCACCCGGGAGCAGCGAGCCACCGGCGCGCTCCCCAGGAGCCCCTGCAGGC GCCGGCCCTGGTCCAGCGCCTCCCTCTCTCAGCATGGACGAGGAGAGCCTGGAGTCGGCCTTGCAGACCTACCGTGCGCAGCTGCAGCAG GTGGAGCTGGCCTTGGGCGCCGGCCTGGATTCGTCTGAGCAGGCTGACCTGCGCCAGCTGCAGGGGGACCTGAAGGAGCTCATCGAGCTC ACCGAGGCCAGCCTGGTGTCTGTCAGGAAGAGCAGCTTGTTGGCCGCGCTGGACGAAGAGCGCCCGGGCCGCCAGGAAGATGCTGAGTAC CAGGCTTTCCGGGAGGCCATCACTGAGGCGGTGGAGGCACCAGCAGCGGCCCGTGGGTCCGGATCAGAGACCGTTCCTAAAGCAGAGGCG GGGCCAGAATCTGCGGCAGGTGGGCAGGAGGAGGAAGAGGGAGAGGACGAGGAAGAGCTGAGTGGGACAAAGGTGAGCGCGCCCTACTAC AGCTCCTGGGGCACTCTGGAGTATCACAACGCCATGGTGGTGGGAACGGAAGAGGCGGAGGATGGCTCGGCGGGTGTCCGTGTGCTTTAC CTGTACCCCACTCACAAGTCTCTGAAGCCGTGCCCGTTCTTCCTGGAGGGAAAGTGCCGCTTTAAGGAGAACTGCAGGAGACCACCTCCT TCTGCGCTGCTGCCCCCTCTGGCGTAGCCTCCTGGACTTCTGCGAGGCTCAGCAGACCCTCGTGCCTGCCGGCCAGGTGCGCGTCTGCAG >In-frame_ZGPAT_ENST00000355969_chr20_62340516_+_HELZ2_ENST00000467148_chr20_62190723_-_865nt AAGCACTTCCGGAAGCGGCGGCGCTCGGGAGGAAGTGCCGATCGGCTGCTGGGGCGAAAAGGGGGCGCCGGGCCGCTCTAGCCGCCCTGG TCCAGCGCCTCCCTCTCTCAGCATGGACGAGGAGAGCCTGGAGTCGGCCTTGCAGACCTACCGTGCGCAGCTGCAGCAGGTGGAGCTGGC CTTGGGCGCCGGCCTGGATTCGTCTGAGCAGGCTGACCTGCGCCAGCTGCAGGGGGACCTGAAGGAGCTCATCGAGCTCACCGAGGCCAG CCTGGTGTCTGTCAGGAAGAGCAGCTTGTTGGCCGCGCTGGACGAAGAGCGCCCGGGCCGCCAGGAAGATGCTGAGTACCAGGCTTTCCG GGAGGCCATCACTGAGGCGGTGGAGGCACCAGCAGCGGCCCGTGGGTCCGGATCAGAGACCGTTCCTAAAGCAGAGGCGGGGCCAGAATC TGCGGCAGGTGGGCAGGAGGAGGAAGAGGGAGAGGACGAGGAAGAGCTGAGTGGGACAAAGGTGAGCGCGCCCTACTACAGCTCCTGGGG CACTCTGGAGTATCACAACGCCATGGTGGTGGGAACGGAAGAGGCGGAGGATGGCTCGGCGGGTGTCCGTGTGCTTTACCTGTACCCCAC TCACAAGTCTCTGAAGCCGTGCCCGTTCTTCCTGGAGGGAAAGTGCCGCTTTAAGGAGAACTGCAGGAGACCACCTCCTTCTGCGCTGCT GCCCCCTCTGGCGTAGCCTCCTGGACTTCTGCGAGGCTCAGCAGACCCTCGTGCCTGCCGGCCAGGTGCGCGTCTGCAGGAGGCCAACTA >In-frame_ZGPAT_ENST00000357119_chr20_62340516_+_HELZ2_ENST00000467148_chr20_62190723_-_917nt CGGCGCTCGGGAGGAAGTGCCGATCGGCTGCTGGGGCGAAAAGGGGGCGCCGGGCCGCTCTAGCCGGTGAGGCCGGCGGGCTCTCTGTGG CTGCGGCTGGGAAACCGCGCGGAGGAGGTGCCCGGCCGGGGACCAGCCCTGGTCCAGCGCCTCCCTCTCTCAGCATGGACGAGGAGAGCC TGGAGTCGGCCTTGCAGACCTACCGTGCGCAGCTGCAGCAGGTGGAGCTGGCCTTGGGCGCCGGCCTGGATTCGTCTGAGCAGGCTGACC TGCGCCAGCTGCAGGGGGACCTGAAGGAGCTCATCGAGCTCACCGAGGCCAGCCTGGTGTCTGTCAGGAAGAGCAGCTTGTTGGCCGCGC TGGACGAAGAGCGCCCGGGCCGCCAGGAAGATGCTGAGTACCAGGCTTTCCGGGAGGCCATCACTGAGGCGGTGGAGGCACCAGCAGCGG CCCGTGGGTCCGGATCAGAGACCGTTCCTAAAGCAGAGGCGGGGCCAGAATCTGCGGCAGGTGGGCAGGAGGAGGAAGAGGGAGAGGACG AGGAAGAGCTGAGTGGGACAAAGGTGAGCGCGCCCTACTACAGCTCCTGGGGCACTCTGGAGTATCACAACGCCATGGTGGTGGGAACGG AAGAGGCGGAGGATGGCTCGGCGGGTGTCCGTGTGCTTTACCTGTACCCCACTCACAAGTCTCTGAAGCCGTGCCCGTTCTTCCTGGAGG GAAAGTGCCGCTTTAAGGAGAACTGCAGGAGACCACCTCCTTCTGCGCTGCTGCCCCCTCTGGCGTAGCCTCCTGGACTTCTGCGAGGCT CAGCAGACCCTCGTGCCTGCCGGCCAGGTGCGCGTCTGCAGGAGGCCAACTATGCCTTCCTGAAGAGCCCTCTCCACCTGCAAGGTGCCA >In-frame_ZGPAT_ENST00000369967_chr20_62340516_+_HELZ2_ENST00000467148_chr20_62190723_-_884nt GGGCGAAAAGGGGGCGCCGGGCCGCTCTAGCCGGTGAGGCCGGCGGGCTCTCTGTGGCTGCGGCTGGGAAACCGCGCGGAGGAGGTGCCC GGCCGGGGACCAGCCCTGGTCCAGCGCCTCCCTCTCTCAGCATGGACGAGGAGAGCCTGGAGTCGGCCTTGCAGACCTACCGTGCGCAGC TGCAGCAGGTGGAGCTGGCCTTGGGCGCCGGCCTGGATTCGTCTGAGCAGGCTGACCTGCGCCAGCTGCAGGGGGACCTGAAGGAGCTCA TCGAGCTCACCGAGGCCAGCCTGGTGTCTGTCAGGAAGAGCAGCTTGTTGGCCGCGCTGGACGAAGAGCGCCCGGGCCGCCAGGAAGATG CTGAGTACCAGGCTTTCCGGGAGGCCATCACTGAGGCGGTGGAGGCACCAGCAGCGGCCCGTGGGTCCGGATCAGAGACCGTTCCTAAAG CAGAGGCGGGGCCAGAATCTGCGGCAGGTGGGCAGGAGGAGGAAGAGGGAGAGGACGAGGAAGAGCTGAGTGGGACAAAGGTGAGCGCGC CCTACTACAGCTCCTGGGGCACTCTGGAGTATCACAACGCCATGGTGGTGGGAACGGAAGAGGCGGAGGATGGCTCGGCGGGTGTCCGTG TGCTTTACCTGTACCCCACTCACAAGTCTCTGAAGCCGTGCCCGTTCTTCCTGGAGGGAAAGTGCCGCTTTAAGGAGAACTGCAGGAGAC CACCTCCTTCTGCGCTGCTGCCCCCTCTGGCGTAGCCTCCTGGACTTCTGCGAGGCTCAGCAGACCCTCGTGCCTGCCGGCCAGGTGCGC >In-frame_ZGPAT_ENST00000328969_chr20_62340516_+_HELZ2_ENST00000467148_chr20_62190723_-_880nt GAAAAGGGGGCGCCGGGCCGCTCTAGCCGGTGAGGCCGGCGGGCTCTCTGTGGCTGCGGCTGGGAAACCGCGCGGAGGAGGTGCCCGGCC GGGGACCAGCCCTGGTCCAGCGCCTCCCTCTCTCAGCATGGACGAGGAGAGCCTGGAGTCGGCCTTGCAGACCTACCGTGCGCAGCTGCA GCAGGTGGAGCTGGCCTTGGGCGCCGGCCTGGATTCGTCTGAGCAGGCTGACCTGCGCCAGCTGCAGGGGGACCTGAAGGAGCTCATCGA GCTCACCGAGGCCAGCCTGGTGTCTGTCAGGAAGAGCAGCTTGTTGGCCGCGCTGGACGAAGAGCGCCCGGGCCGCCAGGAAGATGCTGA GTACCAGGCTTTCCGGGAGGCCATCACTGAGGCGGTGGAGGCACCAGCAGCGGCCCGTGGGTCCGGATCAGAGACCGTTCCTAAAGCAGA GGCGGGGCCAGAATCTGCGGCAGGTGGGCAGGAGGAGGAAGAGGGAGAGGACGAGGAAGAGCTGAGTGGGACAAAGGTGAGCGCGCCCTA CTACAGCTCCTGGGGCACTCTGGAGTATCACAACGCCATGGTGGTGGGAACGGAAGAGGCGGAGGATGGCTCGGCGGGTGTCCGTGTGCT TTACCTGTACCCCACTCACAAGTCTCTGAAGCCGTGCCCGTTCTTCCTGGAGGGAAAGTGCCGCTTTAAGGAGAACTGCAGGAGACCACC TCCTTCTGCGCTGCTGCCCCCTCTGGCGTAGCCTCCTGGACTTCTGCGAGGCTCAGCAGACCCTCGTGCCTGCCGGCCAGGTGCGCGTCT |
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FusionGenePPI for ZGPAT_HELZ2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ZGPAT | CTNNA1, TERF2, UPF2, RBBP7, HDAC1, MTA2, HAT1, AES, DHX15, PHC2, GOLGA2, KIFC3, KRT15, TRIM27, TP53BP2, AIMP2, BLZF1, MID2, IKZF3, CCNDBP1, LDOC1, TFIP11, AMOTL2, TRIM54, BEND5, CCDC33, CEP70, LZTS2, SSX2IP, KRT40, DYDC1, MIPOL1, FAM9B, STAC3, CCDC57, ZBTB8A, SPIN1, KRAS, SPAG5, DVL2, CEP57L1, CCDC36, CDCA7L, PRPF4, LDHD, PCGF1, DPPA4, NANOG, POU5F1, LSM5, PRPF3, SNRPE, FADS3, PNLIP, FAM153B, ID2, SNRPG | HELZ2 | PPARA, BCL6, SIRT7, ISG15, BMI1, IFI16, CACNG5, LGALS3BP, ZNF324B, APOBEC3D, G3BP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZGPAT_HELZ2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZGPAT_HELZ2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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