FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 42882

FusionGeneSummary for ZGPAT_FAM171A1

check button Fusion gene summary
Fusion gene informationFusion gene name: ZGPAT_FAM171A1
Fusion gene ID: 42882
HgeneTgene
Gene symbol

ZGPAT

FAM171A1

Gene ID

84619

221061

Gene namezinc finger CCCH-type and G-patch domain containingfamily with sequence similarity 171 member A1
SynonymsGPATC6|GPATCH6|KIAA1847|ZC3H9|ZC3HDC9|ZIPC10orf38
Cytomap

20q13.33

10p13

Type of geneprotein-codingprotein-coding
Descriptionzinc finger CCCH-type with G patch domain-containing proteing patch domain-containing protein 6zinc finger CCCH domain-containing protein 9zinc finger and G patch domain-containing proteinzinc finger, CCCH-type with G patch domainprotein FAM171A1astroprincin
Modification date2018052320180519
UniProtAcc

Q8N5A5

Q5VUB5

Ensembl transtripts involved in fusion geneENST00000448100, ENST00000355969, 
ENST00000357119, ENST00000369967, 
ENST00000328969, ENST00000478385, 
ENST00000378116, ENST00000477161, 
Fusion gene scores* DoF score3 X 2 X 2=123 X 3 X 3=27
# samples 23
** MAII scorelog2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZGPAT [Title/Abstract] AND FAM171A1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZGPAT

GO:0000122

negative regulation of transcription by RNA polymerase II

19644445

HgeneZGPAT

GO:0007175

negative regulation of epidermal growth factor-activated receptor activity

19644445

HgeneZGPAT

GO:0045892

negative regulation of transcription, DNA-templated

19644445


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF803702ZGPATchr20

62365353

-FAM171A1chr10

15254180

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000448100ENST00000378116ZGPATchr20

62365353

-FAM171A1chr10

15254180

-
intron-intronENST00000448100ENST00000477161ZGPATchr20

62365353

-FAM171A1chr10

15254180

-
intron-3UTRENST00000355969ENST00000378116ZGPATchr20

62365353

-FAM171A1chr10

15254180

-
intron-intronENST00000355969ENST00000477161ZGPATchr20

62365353

-FAM171A1chr10

15254180

-
intron-3UTRENST00000357119ENST00000378116ZGPATchr20

62365353

-FAM171A1chr10

15254180

-
intron-intronENST00000357119ENST00000477161ZGPATchr20

62365353

-FAM171A1chr10

15254180

-
intron-3UTRENST00000369967ENST00000378116ZGPATchr20

62365353

-FAM171A1chr10

15254180

-
intron-intronENST00000369967ENST00000477161ZGPATchr20

62365353

-FAM171A1chr10

15254180

-
intron-3UTRENST00000328969ENST00000378116ZGPATchr20

62365353

-FAM171A1chr10

15254180

-
intron-intronENST00000328969ENST00000477161ZGPATchr20

62365353

-FAM171A1chr10

15254180

-
intron-3UTRENST00000478385ENST00000378116ZGPATchr20

62365353

-FAM171A1chr10

15254180

-
intron-intronENST00000478385ENST00000477161ZGPATchr20

62365353

-FAM171A1chr10

15254180

-

Top

FusionProtFeatures for ZGPAT_FAM171A1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZGPAT

Q8N5A5

FAM171A1

Q5VUB5


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ZGPAT_FAM171A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ZGPAT_FAM171A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ZGPAT_FAM171A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ZGPAT_FAM171A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource