FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 42869

FusionGeneSummary for ZFYVE26_MFSD2A

check button Fusion gene summary
Fusion gene informationFusion gene name: ZFYVE26_MFSD2A
Fusion gene ID: 42869
HgeneTgene
Gene symbol

ZFYVE26

MFSD2A

Gene ID

23503

84879

Gene namezinc finger FYVE-type containing 26major facilitator superfamily domain containing 2A
SynonymsFYVE-CENT|SPG15MCPH15|MFSD2|NLS1
Cytomap

14q24.1

1p34.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger FYVE domain-containing protein 26FYVE domain-containing centrosomal proteinspastizinzinc finger, FYVE domain containing 26sodium-dependent lysophosphatidylcholine symporter 1major facilitator superfamily domain-containing protein 2Asodium-dependent LPC symporter 1
Modification date2018052220180329
UniProtAcc

Q68DK2

Q8NA29

Ensembl transtripts involved in fusion geneENST00000347230, ENST00000557306, 
ENST00000555452, 
ENST00000372811, 
ENST00000420632, ENST00000372809, 
ENST00000480630, 
Fusion gene scores* DoF score4 X 4 X 4=646 X 6 X 3=108
# samples 47
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/108*10)=-0.625604485218502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZFYVE26 [Title/Abstract] AND MFSD2A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMFSD2A

GO:0051977

lysophospholipid transport

24828044


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AK308233ZFYVE26chr14

68264439

-MFSD2Achr1

40435454

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000347230ENST00000372811ZFYVE26chr14

68264439

-MFSD2Achr1

40435454

+
intron-intronENST00000347230ENST00000420632ZFYVE26chr14

68264439

-MFSD2Achr1

40435454

+
intron-3UTRENST00000347230ENST00000372809ZFYVE26chr14

68264439

-MFSD2Achr1

40435454

+
intron-3UTRENST00000347230ENST00000480630ZFYVE26chr14

68264439

-MFSD2Achr1

40435454

+
intron-3UTRENST00000557306ENST00000372811ZFYVE26chr14

68264439

-MFSD2Achr1

40435454

+
intron-intronENST00000557306ENST00000420632ZFYVE26chr14

68264439

-MFSD2Achr1

40435454

+
intron-3UTRENST00000557306ENST00000372809ZFYVE26chr14

68264439

-MFSD2Achr1

40435454

+
intron-3UTRENST00000557306ENST00000480630ZFYVE26chr14

68264439

-MFSD2Achr1

40435454

+
intron-3UTRENST00000555452ENST00000372811ZFYVE26chr14

68264439

-MFSD2Achr1

40435454

+
intron-intronENST00000555452ENST00000420632ZFYVE26chr14

68264439

-MFSD2Achr1

40435454

+
intron-3UTRENST00000555452ENST00000372809ZFYVE26chr14

68264439

-MFSD2Achr1

40435454

+
intron-3UTRENST00000555452ENST00000480630ZFYVE26chr14

68264439

-MFSD2Achr1

40435454

+

Top

FusionProtFeatures for ZFYVE26_MFSD2A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZFYVE26

Q68DK2

MFSD2A

Q8NA29

Sodium-dependent lysophosphatidylcholine (LPC)symporter, which plays an essential role for blood-brain barrierformation and function (By similarity). Specifically expressed inendothelium of the blood-brain barrier of micro-vessels andtransports LPC into the brain (By similarity). Transport of LPC isessential because it constitutes the major mechanism by whichdocosahexaenoic acid (DHA), an omega-3 fatty acid that isessential for normal brain growth and cognitive function, entersthe brain (PubMed:26005868). Transports LPC carrying long-chainfatty acids such LPC oleate and LPC palmitate with a minimum acylchain length of 14 carbons (By similarity). Does not transportdocosahexaenoic acid in unesterified fatty acid (By similarity).Specifically required for blood-brain barrier formation andfunction, probably by mediating lipid transport (By similarity).Not required for central nervous system vascular morphogenesis (Bysimilarity). Acts as a transporter for tunicamycin, an inhibitorof asparagine-linked glycosylation (PubMed:21677192). In placenta,acts as a receptor for ERVFRD-1/syncytin-2 and is required fortrophoblast fusion (PubMed:18988732, PubMed:23177091).{ECO:0000250|UniProtKB:Q9DA75, ECO:0000269|PubMed:18988732,ECO:0000269|PubMed:21677192, ECO:0000269|PubMed:23177091,ECO:0000269|PubMed:26005868}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ZFYVE26_MFSD2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ZFYVE26_MFSD2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ZFYVE26_MFSD2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ZFYVE26_MFSD2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMFSD2AC0025958Microcephaly2CTD_human
TgeneMFSD2AC4225310MICROCEPHALY 15, PRIMARY, AUTOSOMAL RECESSIVE2UNIPROT
TgeneMFSD2AC0037822Speech Disorders1CTD_human
TgeneMFSD2AC3714756Intellectual Disability1CTD_human