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Fusion gene ID: 42869 |
FusionGeneSummary for ZFYVE26_MFSD2A |
Fusion gene summary |
Fusion gene information | Fusion gene name: ZFYVE26_MFSD2A | Fusion gene ID: 42869 | Hgene | Tgene | Gene symbol | ZFYVE26 | MFSD2A | Gene ID | 23503 | 84879 |
Gene name | zinc finger FYVE-type containing 26 | major facilitator superfamily domain containing 2A | |
Synonyms | FYVE-CENT|SPG15 | MCPH15|MFSD2|NLS1 | |
Cytomap | 14q24.1 | 1p34.2 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger FYVE domain-containing protein 26FYVE domain-containing centrosomal proteinspastizinzinc finger, FYVE domain containing 26 | sodium-dependent lysophosphatidylcholine symporter 1major facilitator superfamily domain-containing protein 2Asodium-dependent LPC symporter 1 | |
Modification date | 20180522 | 20180329 | |
UniProtAcc | Q68DK2 | Q8NA29 | |
Ensembl transtripts involved in fusion gene | ENST00000347230, ENST00000557306, ENST00000555452, | ENST00000372811, ENST00000420632, ENST00000372809, ENST00000480630, | |
Fusion gene scores | * DoF score | 4 X 4 X 4=64 | 6 X 6 X 3=108 |
# samples | 4 | 7 | |
** MAII score | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/108*10)=-0.625604485218502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ZFYVE26 [Title/Abstract] AND MFSD2A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | MFSD2A | GO:0051977 | lysophospholipid transport | 24828044 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AK308233 | ZFYVE26 | chr14 | 68264439 | - | MFSD2A | chr1 | 40435454 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000347230 | ENST00000372811 | ZFYVE26 | chr14 | 68264439 | - | MFSD2A | chr1 | 40435454 | + |
intron-intron | ENST00000347230 | ENST00000420632 | ZFYVE26 | chr14 | 68264439 | - | MFSD2A | chr1 | 40435454 | + |
intron-3UTR | ENST00000347230 | ENST00000372809 | ZFYVE26 | chr14 | 68264439 | - | MFSD2A | chr1 | 40435454 | + |
intron-3UTR | ENST00000347230 | ENST00000480630 | ZFYVE26 | chr14 | 68264439 | - | MFSD2A | chr1 | 40435454 | + |
intron-3UTR | ENST00000557306 | ENST00000372811 | ZFYVE26 | chr14 | 68264439 | - | MFSD2A | chr1 | 40435454 | + |
intron-intron | ENST00000557306 | ENST00000420632 | ZFYVE26 | chr14 | 68264439 | - | MFSD2A | chr1 | 40435454 | + |
intron-3UTR | ENST00000557306 | ENST00000372809 | ZFYVE26 | chr14 | 68264439 | - | MFSD2A | chr1 | 40435454 | + |
intron-3UTR | ENST00000557306 | ENST00000480630 | ZFYVE26 | chr14 | 68264439 | - | MFSD2A | chr1 | 40435454 | + |
intron-3UTR | ENST00000555452 | ENST00000372811 | ZFYVE26 | chr14 | 68264439 | - | MFSD2A | chr1 | 40435454 | + |
intron-intron | ENST00000555452 | ENST00000420632 | ZFYVE26 | chr14 | 68264439 | - | MFSD2A | chr1 | 40435454 | + |
intron-3UTR | ENST00000555452 | ENST00000372809 | ZFYVE26 | chr14 | 68264439 | - | MFSD2A | chr1 | 40435454 | + |
intron-3UTR | ENST00000555452 | ENST00000480630 | ZFYVE26 | chr14 | 68264439 | - | MFSD2A | chr1 | 40435454 | + |
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FusionProtFeatures for ZFYVE26_MFSD2A |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
ZFYVE26 | MFSD2A |
Sodium-dependent lysophosphatidylcholine (LPC)symporter, which plays an essential role for blood-brain barrierformation and function (By similarity). Specifically expressed inendothelium of the blood-brain barrier of micro-vessels andtransports LPC into the brain (By similarity). Transport of LPC isessential because it constitutes the major mechanism by whichdocosahexaenoic acid (DHA), an omega-3 fatty acid that isessential for normal brain growth and cognitive function, entersthe brain (PubMed:26005868). Transports LPC carrying long-chainfatty acids such LPC oleate and LPC palmitate with a minimum acylchain length of 14 carbons (By similarity). Does not transportdocosahexaenoic acid in unesterified fatty acid (By similarity).Specifically required for blood-brain barrier formation andfunction, probably by mediating lipid transport (By similarity).Not required for central nervous system vascular morphogenesis (Bysimilarity). Acts as a transporter for tunicamycin, an inhibitorof asparagine-linked glycosylation (PubMed:21677192). In placenta,acts as a receptor for ERVFRD-1/syncytin-2 and is required fortrophoblast fusion (PubMed:18988732, PubMed:23177091).{ECO:0000250|UniProtKB:Q9DA75, ECO:0000269|PubMed:18988732,ECO:0000269|PubMed:21677192, ECO:0000269|PubMed:23177091,ECO:0000269|PubMed:26005868}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZFYVE26_MFSD2A |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZFYVE26_MFSD2A |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZFYVE26_MFSD2A |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZFYVE26_MFSD2A |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | MFSD2A | C0025958 | Microcephaly | 2 | CTD_human |
Tgene | MFSD2A | C4225310 | MICROCEPHALY 15, PRIMARY, AUTOSOMAL RECESSIVE | 2 | UNIPROT |
Tgene | MFSD2A | C0037822 | Speech Disorders | 1 | CTD_human |
Tgene | MFSD2A | C3714756 | Intellectual Disability | 1 | CTD_human |