FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 42851

FusionGeneSummary for ZFR_SND1

check button Fusion gene summary
Fusion gene informationFusion gene name: ZFR_SND1
Fusion gene ID: 42851
HgeneTgene
Gene symbol

ZFR

SND1

Gene ID

51663

27044

Gene namezinc finger RNA binding proteinstaphylococcal nuclease and tudor domain containing 1
SynonymsSPG71|ZFR1TDRD11|Tudor-SN|p100
Cytomap

5p13.3

7q32.1

Type of geneprotein-codingprotein-coding
Descriptionzinc finger RNA-binding proteinM-phase phosphoprotein homologstaphylococcal nuclease domain-containing protein 1EBNA2 coactivator p100testis tissue sperm-binding protein Li 82Ptudor domain-containing protein 11
Modification date2018052320180523
UniProtAcc

Q96KR1

Q7KZF4

Ensembl transtripts involved in fusion geneENST00000265069, ENST00000510369, 
ENST00000354725, ENST00000467238, 
Fusion gene scores* DoF score7 X 5 X 6=21020 X 15 X 10=3000
# samples 821
** MAII scorelog2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(21/3000*10)=-3.83650126771712
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZFR [Title/Abstract] AND SND1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVOVTCGA-24-1470-01AZFRchr5

32444335

-SND1chr7

127527955

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000265069ENST00000354725ZFRchr5

32444335

-SND1chr7

127527955

+
5CDS-intronENST00000265069ENST00000467238ZFRchr5

32444335

-SND1chr7

127527955

+
intron-3CDSENST00000510369ENST00000354725ZFRchr5

32444335

-SND1chr7

127527955

+
intron-intronENST00000510369ENST00000467238ZFRchr5

32444335

-SND1chr7

127527955

+

Top

FusionProtFeatures for ZFR_SND1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZFR

Q96KR1

SND1

Q7KZF4

Functions as a bridging factor between STAT6 and thebasal transcription factor. Plays a role in PIM1 regulation of MYBactivity. Functions as a transcriptional coactivator for theEpstein-Barr virus nuclear antigen 2 (EBNA2).{ECO:0000269|PubMed:7651391}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSND1chr5:32444335chr7:127527955ENST00000354725+1124525_660447911DomainTNase-like 4
TgeneSND1chr5:32444335chr7:127527955ENST00000354725+1124729_787447911DomainTudor

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZFRchr5:32444335chr7:127527955ENST00000265069-22036_302451075Compositional biasNote=Ala-rich
HgeneZFRchr5:32444335chr7:127527955ENST00000265069-220703_1073451075DomainDZF
TgeneSND1chr5:32444335chr7:127527955ENST00000354725+112418_166447911DomainTNase-like 1
TgeneSND1chr5:32444335chr7:127527955ENST00000354725+1124193_328447911DomainTNase-like 2
TgeneSND1chr5:32444335chr7:127527955ENST00000354725+1124341_496447911DomainTNase-like 3
TgeneSND1chr5:32444335chr7:127527955ENST00000354725+1124321_325447911MotifNuclear localization signal
TgeneSND1chr5:32444335chr7:127527955ENST00000354725+1124388_392447911MotifNuclear localization signal


Top

FusionGeneSequence for ZFR_SND1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ZFR_ENST00000265069_chr5_32444335_-_SND1_ENST00000354725_chr7_127527955_+_509aa
MIPICPVVSFTYVPSRLGEDAKMATGNYFGFTHSGAAAAAAAAQYRNIAEALVSKGLATVIRYRQDDDQRSSHYDELLAAEARAIKNGKG
LHSKKEVPIHRVADISGDTQKAKQFLPFLQRAGRSEAVVEYVFSGSRLKLYLPKETCLITFLLAGIECPRGARNLPGLVQEGEPFSEEAT
LFTKELVLQREVEVEVESMDKAGNFIGWLHIDGANLSVLLVEHALSKVHFTAERSSYYKSLLSAEEAAKQKKEKVWAHYEEQPVEEVMPV
LEEKERSASYKPVFVTEITDDLHFYVQDVETGTQLEKLMENMRNDIASHPPVEGSYAPRRGEFCIAKFVDGEWYRARVEKVESPAKIHVF
YIDYGNREVLPSTRLGTLSPAFSTRVLPAQATEYAFAFIQVPQDDDARTDAVDSVVRDIQNTQCLLNVEHLSAGCPHVTLQFADSKGDVG


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ZFR_ENST00000265069_chr5_32444335_-_SND1_ENST00000354725_chr7_127527955_+_1527nt
ATGATTCCCATATGCCCTGTAGTTTCTTTCACCTATGTGCCCAGCCGGCTGGGGGAAGATGCCAAAATGGCGACCGGCAACTACTTTGGA
TTCACCCACAGCGGGGCGGCGGCGGCGGCGGCTGCGGCCCAATATAGAAACATTGCTGAGGCTCTTGTCAGCAAAGGTCTAGCCACAGTG
ATCAGATACCGGCAGGATGATGACCAGAGATCATCACACTACGATGAACTGCTTGCTGCAGAGGCCAGAGCTATTAAGAATGGCAAAGGA
TTGCATAGCAAGAAGGAAGTGCCTATCCACCGTGTTGCAGATATATCTGGGGATACCCAAAAAGCAAAGCAGTTCCTGCCTTTTCTTCAG
CGGGCAGGTCGTTCTGAAGCTGTGGTGGAATACGTCTTCAGTGGTTCTCGTCTCAAACTCTATTTGCCAAAGGAAACTTGCCTTATCACC
TTCTTGCTTGCAGGCATTGAATGCCCCAGAGGAGCCCGAAACCTCCCAGGCTTGGTGCAGGAAGGAGAGCCCTTCAGCGAGGAAGCTACA
CTTTTCACCAAGGAACTGGTGCTGCAGCGAGAGGTGGAGGTGGAGGTGGAGAGCATGGACAAGGCCGGCAACTTTATCGGCTGGCTGCAC
ATCGACGGTGCCAACCTGTCCGTCCTGCTGGTGGAGCACGCGCTCTCCAAGGTCCACTTCACCGCCGAACGCAGCTCCTACTACAAGTCC
CTGCTGTCTGCCGAGGAGGCCGCAAAGCAGAAGAAAGAGAAGGTCTGGGCCCACTATGAGGAGCAGCCCGTGGAGGAGGTGATGCCAGTG
CTGGAGGAGAAGGAGCGATCTGCTAGCTACAAGCCCGTGTTTGTGACTGAGATCACTGATGACCTGCACTTCTACGTGCAGGATGTGGAG
ACCGGCACCCAGTTGGAGAAGCTGATGGAGAACATGCGCAATGACATTGCCAGTCACCCCCCTGTAGAGGGCTCCTATGCCCCCCGCAGG
GGAGAGTTCTGCATTGCCAAATTTGTAGATGGAGAATGGTACCGTGCCCGAGTAGAGAAAGTCGAGTCTCCTGCCAAAATACATGTCTTC
TACATTGACTACGGCAACAGAGAGGTCCTGCCATCCACCCGCCTGGGTACCCTATCACCTGCCTTCAGCACTCGGGTGCTGCCAGCTCAA
GCCACGGAGTATGCCTTCGCCTTCATCCAGGTGCCCCAAGATGATGATGCCCGCACGGACGCCGTGGACAGCGTAGTTCGGGATATCCAG
AACACTCAGTGCCTGCTCAACGTGGAACACCTGAGTGCCGGCTGCCCCCATGTCACCCTGCAGTTTGCAGATTCCAAGGGCGATGTGGGG
CTGGGCTTGGTGAAGGAAGGGCTGGTCATGGTGGAGGTGCGCAAGGAGAAACAGTTCCAGAAAGTGATCACAGAATACCTGAATGCCCAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_ZFR_ENST00000265069_chr5_32444335_-_SND1_ENST00000354725_chr7_127527955_+_2179nt
AGTGCGGTCGGAGGCGGCGGTCTGTTCTCCGCTGAGGAGGAGCGGGGCAGAGGAGGGAGGCAGCGGGTGAGAGTTCAGAGTTCAGCAGCA
GCAGCCCGAGCCCATGATTCCCATATGCCCTGTAGTTTCTTTCACCTATGTGCCCAGCCGGCTGGGGGAAGATGCCAAAATGGCGACCGG
CAACTACTTTGGATTCACCCACAGCGGGGCGGCGGCGGCGGCGGCTGCGGCCCAATATAGAAACATTGCTGAGGCTCTTGTCAGCAAAGG
TCTAGCCACAGTGATCAGATACCGGCAGGATGATGACCAGAGATCATCACACTACGATGAACTGCTTGCTGCAGAGGCCAGAGCTATTAA
GAATGGCAAAGGATTGCATAGCAAGAAGGAAGTGCCTATCCACCGTGTTGCAGATATATCTGGGGATACCCAAAAAGCAAAGCAGTTCCT
GCCTTTTCTTCAGCGGGCAGGTCGTTCTGAAGCTGTGGTGGAATACGTCTTCAGTGGTTCTCGTCTCAAACTCTATTTGCCAAAGGAAAC
TTGCCTTATCACCTTCTTGCTTGCAGGCATTGAATGCCCCAGAGGAGCCCGAAACCTCCCAGGCTTGGTGCAGGAAGGAGAGCCCTTCAG
CGAGGAAGCTACACTTTTCACCAAGGAACTGGTGCTGCAGCGAGAGGTGGAGGTGGAGGTGGAGAGCATGGACAAGGCCGGCAACTTTAT
CGGCTGGCTGCACATCGACGGTGCCAACCTGTCCGTCCTGCTGGTGGAGCACGCGCTCTCCAAGGTCCACTTCACCGCCGAACGCAGCTC
CTACTACAAGTCCCTGCTGTCTGCCGAGGAGGCCGCAAAGCAGAAGAAAGAGAAGGTCTGGGCCCACTATGAGGAGCAGCCCGTGGAGGA
GGTGATGCCAGTGCTGGAGGAGAAGGAGCGATCTGCTAGCTACAAGCCCGTGTTTGTGACTGAGATCACTGATGACCTGCACTTCTACGT
GCAGGATGTGGAGACCGGCACCCAGTTGGAGAAGCTGATGGAGAACATGCGCAATGACATTGCCAGTCACCCCCCTGTAGAGGGCTCCTA
TGCCCCCCGCAGGGGAGAGTTCTGCATTGCCAAATTTGTAGATGGAGAATGGTACCGTGCCCGAGTAGAGAAAGTCGAGTCTCCTGCCAA
AATACATGTCTTCTACATTGACTACGGCAACAGAGAGGTCCTGCCATCCACCCGCCTGGGTACCCTATCACCTGCCTTCAGCACTCGGGT
GCTGCCAGCTCAAGCCACGGAGTATGCCTTCGCCTTCATCCAGGTGCCCCAAGATGATGATGCCCGCACGGACGCCGTGGACAGCGTAGT
TCGGGATATCCAGAACACTCAGTGCCTGCTCAACGTGGAACACCTGAGTGCCGGCTGCCCCCATGTCACCCTGCAGTTTGCAGATTCCAA
GGGCGATGTGGGGCTGGGCTTGGTGAAGGAAGGGCTGGTCATGGTGGAGGTGCGCAAGGAGAAACAGTTCCAGAAAGTGATCACAGAATA
CCTGAATGCCCAAGAGTCAGCCAAGAGCGCCAGGCTGAACCTGTGGCGCTATGGAGACTTTCGAGCTGATGATGCAGACGAATTTGGCTA
CAGCCGCTAAGGAGGGGATCGGGTTTGGCCCCCAGCCCCGCTCACGCCAGTCCCTCTTCCTCTGCCGGGAGGGTGTTTTCAACTCCAAAC
CCCAGAGAGGGGTTGTAGATTGGGTCCAGCTTTGCTTCAGTGTGTGGAAATGTCTCGTGGGGTGGCATCGGGGCTGCGGGGTGGGGACCC
CAAGGCTTTCTGGGGCAGACCCTTGTCCTCTGGGATGATGGGCACTGCTATCCACAGTCTCTGCCAGTTGGTTTTATTTGGAGGTTTGTG
GGCTTTTTTTAAAAAAAAAAAGTCCTCAAATCAGGAAGAAACATCAAAGACTATGTCCTAGTGGAGGGAGTAATCCTAACACCCAGGCTG
GCCGCCAGCTGGCACCTGCCTCTATCCCAGACTGCCCTCGTCCCAGCTCTCTGTCCAACTGTTGATTATGTGATTTTTCTGATACGTCCA
TTCTCAAATGCCAGTGTGTTCACATCTTCGCTCTGGCCAGCCCATTCTGTATTTAAAGCTTTTGAGGCCCAATAAAATAGTACGTGCTGT


Top

FusionGenePPI for ZFR_SND1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZFRUSP33, USP45, MEPCE, HNRNPA1, RPAP1, ELAVL1, SIRT7, CUL3, COPS5, CAND1, VDAC2, ACAA2, S100A10, ATP6V1E1, VPS29, PRDX1, USP48, SF1, THY1, VPS25, HADHA, UBAP2, THUMPD3, QARS, SERPINH1, DYNC1LI1, VCP, CBX8, HDAC11, TARDBP, RPA3, RPA2, RPA1, ADARB1, STAU1, MOV10, NXF1, CUL7, OBSL1, CCDC8, RNF2, BMI1, FBXW11, TRA2A, RBM4B, ILF2, PCED1B, DNMT1, SCARNA22, FOXB1, FOXE1, FOXL2, FOXP3, FOXQ1, FOXS1, FBXW7, EGFR, ZYX, HNRNPR, ELAVL2, FGF8, APOBEC3D, CDX1, ZNF169, TRIM25, BRCA1SND1IKBKE, SNW1, RBPJ, GTF2E2, GTF2E1, MYB, PIM1, STAT6, POLR2A, USP22, PDPK1, PRKAA1, UBA5, LZTR1, DHX9, CREBBP, RBM39, SIRT7, CUL3, CDK2, CAND1, APP, RPS3, HNRNPM, TOMM22, RPL19, MYBBP1A, SMNDC1, RPS20, NENF, RPL4, VDAC2, ILF2, SRSF3, HNRNPU, RPN1, HNRNPR, SSR3, FN1, VCAM1, CSNK2A1, ITGA4, G3BP1, PRPF8, RNU1-1, RNU2-1, RNU4-1, RNU6-1, RNU5A-1, MAK, TARDBP, EIF3CL, RPS11, RPS2, RPS6, RPS9, DDX3X, RPL23A, RPL35, RPS16, RPS26, RPS27, RPS3A, SHFM1, LIN28A, HUWE1, RAPGEF2, MDM2, CUL7, OBSL1, CCDC8, UBE2I, ESR1, MMP28, TDRD3, TXNDC5, NTRK1, NPM1, RPL10, CNOT1, MCM2, U2AF2, CDH1, PTP4A1, MTDH, PA2G4, TRAP1, ANXA5, SNRPB2, EIF5B, GPI, IDH2, PDIA3, UBE2N, MRPL12, CRNN, ZNF207, CPNE3, CS, PYGL, SF3A3, DNAJC8, PLS3, CPSF6, NANS, SF3A1, ECHS1, SRP68, MYL12B, AIMP1, CYLD, DLD, DLST, PDHA1, SOD1, TRIM25, BRCA1, YAP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ZFR_SND1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ZFR_SND1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSND1C0004352Autistic Disorder1CTD_human
TgeneSND1C0024121Lung Neoplasms1CTD_human