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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42834

FusionGeneSummary for ZFP91_NOX4

check button Fusion gene summary
Fusion gene informationFusion gene name: ZFP91_NOX4
Fusion gene ID: 42834
HgeneTgene
Gene symbol

ZFP91

NOX4

Gene ID

80829

50507

Gene nameZFP91 zinc finger proteinNADPH oxidase 4
SynonymsDMS-8|DSM-8|FKSG11|PZF|ZFP-91|ZNF757KOX|KOX-1|RENOX
Cytomap

11q12.1

11q14.3

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase ZFP91RING-type E3 ubiquitin transferase ZFP91drug resistance-associated sequence in melanoma 8penta zinc finger proteinzinc finger protein 757zinc finger protein 91 homologzinc finger protein homologous to Zfp91 in mouseNADPH oxidase 4kidney oxidase-1kidney superoxide-producing NADPH oxidaserenal NAD(P)H-oxidase
Modification date2018051920180519
UniProtAcc

Q96JP5

Q9NPH5

Ensembl transtripts involved in fusion geneENST00000316059, ENST00000535633, 
ENST00000424319, ENST00000343727, 
ENST00000534731, ENST00000525196, 
ENST00000263317, ENST00000532825, 
ENST00000527956, ENST00000542487, 
ENST00000527626, ENST00000528341, 
ENST00000413594, ENST00000375979, 
ENST00000531342, ENST00000393282, 
Fusion gene scores* DoF score5 X 4 X 2=404 X 3 X 2=24
# samples 104
** MAII scorelog2(10/40*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZFP91 [Title/Abstract] AND NOX4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZFP91

GO:0007250

activation of NF-kappaB-inducing kinase activity

20682767

HgeneZFP91

GO:0070534

protein K63-linked ubiquitination

20682767

TgeneNOX4

GO:0006801

superoxide metabolic process

18760347

TgeneNOX4

GO:0050667

homocysteine metabolic process

20031578

TgeneNOX4

GO:0055114

oxidation-reduction process

10869423

TgeneNOX4

GO:0072593

reactive oxygen species metabolic process

10869423


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A1-A0SJ-01AZFP91chr11

58352357

+NOX4chr11

89088211

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000316059ENST00000535633ZFP91chr11

58352357

+NOX4chr11

89088211

-
In-frameENST00000316059ENST00000424319ZFP91chr11

58352357

+NOX4chr11

89088211

-
In-frameENST00000316059ENST00000343727ZFP91chr11

58352357

+NOX4chr11

89088211

-
In-frameENST00000316059ENST00000534731ZFP91chr11

58352357

+NOX4chr11

89088211

-
5CDS-intronENST00000316059ENST00000525196ZFP91chr11

58352357

+NOX4chr11

89088211

-
5CDS-intronENST00000316059ENST00000263317ZFP91chr11

58352357

+NOX4chr11

89088211

-
5CDS-intronENST00000316059ENST00000532825ZFP91chr11

58352357

+NOX4chr11

89088211

-
5CDS-intronENST00000316059ENST00000527956ZFP91chr11

58352357

+NOX4chr11

89088211

-
5CDS-intronENST00000316059ENST00000542487ZFP91chr11

58352357

+NOX4chr11

89088211

-
5CDS-intronENST00000316059ENST00000527626ZFP91chr11

58352357

+NOX4chr11

89088211

-
5CDS-intronENST00000316059ENST00000528341ZFP91chr11

58352357

+NOX4chr11

89088211

-
5CDS-intronENST00000316059ENST00000413594ZFP91chr11

58352357

+NOX4chr11

89088211

-
5CDS-intronENST00000316059ENST00000375979ZFP91chr11

58352357

+NOX4chr11

89088211

-
5CDS-intronENST00000316059ENST00000531342ZFP91chr11

58352357

+NOX4chr11

89088211

-
5CDS-intronENST00000316059ENST00000393282ZFP91chr11

58352357

+NOX4chr11

89088211

-

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FusionProtFeatures for ZFP91_NOX4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZFP91

Q96JP5

NOX4

Q9NPH5

Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize andactivate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an importantrole in cell proliferation and/or anti-apoptosis.{ECO:0000269|PubMed:12738986, ECO:0000269|PubMed:20682767}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZFP91chr11:58352357chr11:89088211ENST00000316059+21121_67123571Compositional biasNote=Ala-rich
HgeneZFP91chr11:58352357chr11:89088211ENST00000316059+21148_81123571Compositional biasNote=Arg-rich
TgeneNOX4chr11:58352357chr11:89088211ENST00000375979-29304_41971272DomainFAD-binding FR-type
TgeneNOX4chr11:58352357chr11:89088211ENST00000393282-03304_419-10755DomainFAD-binding FR-type
TgeneNOX4chr11:58352357chr11:89088211ENST00000393282-0358_303-10755DomainNote=Ferric oxidoreductase
TgeneNOX4chr11:58352357chr11:89088211ENST00000531342-28304_41971232DomainFAD-binding FR-type
TgeneNOX4chr11:58352357chr11:89088211ENST00000263317-1118446_578378579Topological domainCytoplasmic
TgeneNOX4chr11:58352357chr11:89088211ENST00000375979-29125_15471272Topological domainExtracellular
TgeneNOX4chr11:58352357chr11:89088211ENST00000375979-29176_18871272Topological domainCytoplasmic
TgeneNOX4chr11:58352357chr11:89088211ENST00000375979-29210_42471272Topological domainExtracellular
TgeneNOX4chr11:58352357chr11:89088211ENST00000375979-29446_57871272Topological domainCytoplasmic
TgeneNOX4chr11:58352357chr11:89088211ENST00000375979-2984_10371272Topological domainCytoplasmic
TgeneNOX4chr11:58352357chr11:89088211ENST00000393282-03125_154-10755Topological domainExtracellular
TgeneNOX4chr11:58352357chr11:89088211ENST00000393282-03176_188-10755Topological domainCytoplasmic
TgeneNOX4chr11:58352357chr11:89088211ENST00000393282-031_16-10755Topological domainCytoplasmic
TgeneNOX4chr11:58352357chr11:89088211ENST00000393282-03210_424-10755Topological domainExtracellular
TgeneNOX4chr11:58352357chr11:89088211ENST00000393282-0338_62-10755Topological domainExtracellular
TgeneNOX4chr11:58352357chr11:89088211ENST00000393282-03446_578-10755Topological domainCytoplasmic
TgeneNOX4chr11:58352357chr11:89088211ENST00000393282-0384_103-10755Topological domainCytoplasmic
TgeneNOX4chr11:58352357chr11:89088211ENST00000531342-28125_15471232Topological domainExtracellular
TgeneNOX4chr11:58352357chr11:89088211ENST00000531342-28176_18871232Topological domainCytoplasmic
TgeneNOX4chr11:58352357chr11:89088211ENST00000531342-28210_42471232Topological domainExtracellular
TgeneNOX4chr11:58352357chr11:89088211ENST00000531342-28446_57871232Topological domainCytoplasmic
TgeneNOX4chr11:58352357chr11:89088211ENST00000531342-2884_10371232Topological domainCytoplasmic
TgeneNOX4chr11:58352357chr11:89088211ENST00000534731-1117446_578378539Topological domainCytoplasmic
TgeneNOX4chr11:58352357chr11:89088211ENST00000263317-1118425_445378579TransmembraneHelical
TgeneNOX4chr11:58352357chr11:89088211ENST00000375979-29104_12471272TransmembraneHelical
TgeneNOX4chr11:58352357chr11:89088211ENST00000375979-29155_17571272TransmembraneHelical
TgeneNOX4chr11:58352357chr11:89088211ENST00000375979-29189_20971272TransmembraneHelical
TgeneNOX4chr11:58352357chr11:89088211ENST00000375979-29425_44571272TransmembraneHelical
TgeneNOX4chr11:58352357chr11:89088211ENST00000393282-03104_124-10755TransmembraneHelical
TgeneNOX4chr11:58352357chr11:89088211ENST00000393282-03155_175-10755TransmembraneHelical
TgeneNOX4chr11:58352357chr11:89088211ENST00000393282-0317_37-10755TransmembraneHelical
TgeneNOX4chr11:58352357chr11:89088211ENST00000393282-03189_209-10755TransmembraneHelical
TgeneNOX4chr11:58352357chr11:89088211ENST00000393282-03425_445-10755TransmembraneHelical
TgeneNOX4chr11:58352357chr11:89088211ENST00000393282-0363_83-10755TransmembraneHelical
TgeneNOX4chr11:58352357chr11:89088211ENST00000531342-28104_12471232TransmembraneHelical
TgeneNOX4chr11:58352357chr11:89088211ENST00000531342-28155_17571232TransmembraneHelical
TgeneNOX4chr11:58352357chr11:89088211ENST00000531342-28189_20971232TransmembraneHelical
TgeneNOX4chr11:58352357chr11:89088211ENST00000531342-28425_44571232TransmembraneHelical
TgeneNOX4chr11:58352357chr11:89088211ENST00000534731-1117425_445378539TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZFP91chr11:58352357chr11:89088211ENST00000316059+211197_282123571Compositional biasNote=Glu-rich
HgeneZFP91chr11:58352357chr11:89088211ENST00000316059+211311_336123571Zinc fingerC2H2-type 1
HgeneZFP91chr11:58352357chr11:89088211ENST00000316059+211342_366123571Zinc fingerC2H2-type 2
HgeneZFP91chr11:58352357chr11:89088211ENST00000316059+211372_394123571Zinc fingerC2H2-type 3
HgeneZFP91chr11:58352357chr11:89088211ENST00000316059+211400_422123571Zinc fingerC2H2-type 4
HgeneZFP91chr11:58352357chr11:89088211ENST00000316059+211430_453123571Zinc fingerC2H2-type 5
TgeneNOX4chr11:58352357chr11:89088211ENST00000263317-1118304_419378579DomainFAD-binding FR-type
TgeneNOX4chr11:58352357chr11:89088211ENST00000263317-111858_303378579DomainNote=Ferric oxidoreductase
TgeneNOX4chr11:58352357chr11:89088211ENST00000375979-2958_30371272DomainNote=Ferric oxidoreductase
TgeneNOX4chr11:58352357chr11:89088211ENST00000531342-2858_30371232DomainNote=Ferric oxidoreductase
TgeneNOX4chr11:58352357chr11:89088211ENST00000534731-1117304_419378539DomainFAD-binding FR-type
TgeneNOX4chr11:58352357chr11:89088211ENST00000534731-111758_303378539DomainNote=Ferric oxidoreductase
TgeneNOX4chr11:58352357chr11:89088211ENST00000263317-1118125_154378579Topological domainExtracellular
TgeneNOX4chr11:58352357chr11:89088211ENST00000263317-1118176_188378579Topological domainCytoplasmic
TgeneNOX4chr11:58352357chr11:89088211ENST00000263317-11181_16378579Topological domainCytoplasmic
TgeneNOX4chr11:58352357chr11:89088211ENST00000263317-1118210_424378579Topological domainExtracellular
TgeneNOX4chr11:58352357chr11:89088211ENST00000263317-111838_62378579Topological domainExtracellular
TgeneNOX4chr11:58352357chr11:89088211ENST00000263317-111884_103378579Topological domainCytoplasmic
TgeneNOX4chr11:58352357chr11:89088211ENST00000375979-291_1671272Topological domainCytoplasmic
TgeneNOX4chr11:58352357chr11:89088211ENST00000375979-2938_6271272Topological domainExtracellular
TgeneNOX4chr11:58352357chr11:89088211ENST00000531342-281_1671232Topological domainCytoplasmic
TgeneNOX4chr11:58352357chr11:89088211ENST00000531342-2838_6271232Topological domainExtracellular
TgeneNOX4chr11:58352357chr11:89088211ENST00000534731-1117125_154378539Topological domainExtracellular
TgeneNOX4chr11:58352357chr11:89088211ENST00000534731-1117176_188378539Topological domainCytoplasmic
TgeneNOX4chr11:58352357chr11:89088211ENST00000534731-11171_16378539Topological domainCytoplasmic
TgeneNOX4chr11:58352357chr11:89088211ENST00000534731-1117210_424378539Topological domainExtracellular
TgeneNOX4chr11:58352357chr11:89088211ENST00000534731-111738_62378539Topological domainExtracellular
TgeneNOX4chr11:58352357chr11:89088211ENST00000534731-111784_103378539Topological domainCytoplasmic
TgeneNOX4chr11:58352357chr11:89088211ENST00000263317-1118104_124378579TransmembraneHelical
TgeneNOX4chr11:58352357chr11:89088211ENST00000263317-1118155_175378579TransmembraneHelical
TgeneNOX4chr11:58352357chr11:89088211ENST00000263317-111817_37378579TransmembraneHelical
TgeneNOX4chr11:58352357chr11:89088211ENST00000263317-1118189_209378579TransmembraneHelical
TgeneNOX4chr11:58352357chr11:89088211ENST00000263317-111863_83378579TransmembraneHelical
TgeneNOX4chr11:58352357chr11:89088211ENST00000375979-2917_3771272TransmembraneHelical
TgeneNOX4chr11:58352357chr11:89088211ENST00000375979-2963_8371272TransmembraneHelical
TgeneNOX4chr11:58352357chr11:89088211ENST00000531342-2817_3771232TransmembraneHelical
TgeneNOX4chr11:58352357chr11:89088211ENST00000531342-2863_8371232TransmembraneHelical
TgeneNOX4chr11:58352357chr11:89088211ENST00000534731-1117104_124378539TransmembraneHelical
TgeneNOX4chr11:58352357chr11:89088211ENST00000534731-1117155_175378539TransmembraneHelical
TgeneNOX4chr11:58352357chr11:89088211ENST00000534731-111717_37378539TransmembraneHelical
TgeneNOX4chr11:58352357chr11:89088211ENST00000534731-1117189_209378539TransmembraneHelical
TgeneNOX4chr11:58352357chr11:89088211ENST00000534731-111763_83378539TransmembraneHelical


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FusionGeneSequence for ZFP91_NOX4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ZFP91_ENST00000316059_chr11_58352357_+_NOX4_ENST00000535633_chr11_89088211_-_324aa
MPGETEEPRPPEQQDQEGGEAAKAAPEEPQQRPPEAVAAAPAGTTSSRVLRGGRDRGRAAAAAAAAAVSRRRKAEYPRRRRSSPSARPPD
VPGQQPQAAKSPSPVQGKKSPRLLCIEKVTTDKERFRDLLLPPSSQDSEILPFIQSRNYPKLYIDGPFGSPFEESLNYEVSLCVAGGIGV
TPFASILNTLLDDWKPYKLRRLYFIWVCRDIQSFRWFADLLCMLHNKFWQENRPDYVNIQLYLSQTDGIQKIIGEKYHALNSRLFIGRPR

>In-frame_ZFP91_ENST00000316059_chr11_58352357_+_NOX4_ENST00000424319_chr11_89088211_-_324aa
MPGETEEPRPPEQQDQEGGEAAKAAPEEPQQRPPEAVAAAPAGTTSSRVLRGGRDRGRAAAAAAAAAVSRRRKAEYPRRRRSSPSARPPD
VPGQQPQAAKSPSPVQGKKSPRLLCIEKVTTDKERFRDLLLPPSSQDSEILPFIQSRNYPKLYIDGPFGSPFEESLNYEVSLCVAGGIGV
TPFASILNTLLDDWKPYKLRRLYFIWVCRDIQSFRWFADLLCMLHNKFWQENRPDYVNIQLYLSQTDGIQKIIGEKYHALNSRLFIGRPR

>In-frame_ZFP91_ENST00000316059_chr11_58352357_+_NOX4_ENST00000343727_chr11_89088211_-_324aa
MPGETEEPRPPEQQDQEGGEAAKAAPEEPQQRPPEAVAAAPAGTTSSRVLRGGRDRGRAAAAAAAAAVSRRRKAEYPRRRRSSPSARPPD
VPGQQPQAAKSPSPVQGKKSPRLLCIEKVTTDKERFRDLLLPPSSQDSEILPFIQSRNYPKLYIDGPFGSPFEESLNYEVSLCVAGGIGV
TPFASILNTLLDDWKPYKLRRLYFIWVCRDIQSFRWFADLLCMLHNKFWQENRPDYVNIQLYLSQTDGIQKIIGEKYHALNSRLFIGRPR

>In-frame_ZFP91_ENST00000316059_chr11_58352357_+_NOX4_ENST00000534731_chr11_89088211_-_284aa
MPGETEEPRPPEQQDQEGGEAAKAAPEEPQQRPPEAVAAAPAGTTSSRVLRGGRDRGRAAAAAAAAAVSRRRKAEYPRRRRSSPSARPPD
VPGQQPQAAKSPSPVQGKKSPRLLCIEKVTTDKERFRDLLLPPSSQDSEILPFIQSRNYPKDDWKPYKLRRLYFIWVCRDIQSFRWFADL
LCMLHNKFWQENRPDYVNIQLYLSQTDGIQKIIGEKYHALNSRLFIGRPRWKLLFDEIAKYNRGKTVGVFCCGPNSLSKTLHKLSNQNNS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ZFP91_ENST00000316059_chr11_58352357_+_NOX4_ENST00000535633_chr11_89088211_-_972nt
ATGCCGGGGGAGACGGAAGAGCCGAGACCCCCGGAGCAGCAGGACCAGGAAGGGGGAGAGGCGGCCAAGGCGGCTCCGGAGGAGCCCCAA
CAACGGCCCCCTGAGGCGGTCGCGGCGGCGCCTGCAGGGACCACTAGCAGCCGCGTGCTGAGGGGAGGTCGGGACCGAGGCCGGGCCGCT
GCGGCCGCCGCCGCCGCAGCTGTGTCCCGCCGGAGGAAGGCCGAGTATCCCCGCCGGCGGAGGAGCAGCCCCAGCGCCAGGCCTCCCGAC
GTCCCCGGGCAGCAGCCCCAGGCCGCGAAGTCCCCGTCTCCAGTTCAGGGCAAGAAGAGTCCGCGACTCCTATGCATAGAAAAAGTAACA
ACTGATAAAGAACGATTTCGAGATTTACTACTGCCTCCATCTAGTCAAGACTCCGAAATTCTGCCCTTCATTCAATCTAGAAATTATCCC
AAGCTGTATATTGATGGTCCTTTTGGAAGTCCATTTGAGGAATCACTGAACTATGAGGTCAGCCTCTGCGTGGCTGGAGGCATTGGAGTA
ACTCCATTTGCATCAATACTCAACACCCTGTTGGATGACTGGAAACCATACAAGCTTAGAAGACTATACTTTATTTGGGTATGCAGAGAT
ATCCAGTCCTTCCGTTGGTTTGCAGATTTACTCTGTATGTTGCATAACAAGTTTTGGCAAGAGAACAGACCTGACTATGTCAACATCCAG
CTGTACCTCAGTCAAACAGATGGGATACAGAAGATAATTGGAGAAAAATATCATGCACTGAATTCAAGACTGTTTATAGGACGTCCTCGG
TGGAAACTTTTGTTTGATGAAATAGCAAAATATAACAGAGGAAAAACAGTTGGTGTTTTCTGTTGTGGACCCAATTCACTATCCAAGACT

>In-frame_ZFP91_ENST00000316059_chr11_58352357_+_NOX4_ENST00000424319_chr11_89088211_-_972nt
ATGCCGGGGGAGACGGAAGAGCCGAGACCCCCGGAGCAGCAGGACCAGGAAGGGGGAGAGGCGGCCAAGGCGGCTCCGGAGGAGCCCCAA
CAACGGCCCCCTGAGGCGGTCGCGGCGGCGCCTGCAGGGACCACTAGCAGCCGCGTGCTGAGGGGAGGTCGGGACCGAGGCCGGGCCGCT
GCGGCCGCCGCCGCCGCAGCTGTGTCCCGCCGGAGGAAGGCCGAGTATCCCCGCCGGCGGAGGAGCAGCCCCAGCGCCAGGCCTCCCGAC
GTCCCCGGGCAGCAGCCCCAGGCCGCGAAGTCCCCGTCTCCAGTTCAGGGCAAGAAGAGTCCGCGACTCCTATGCATAGAAAAAGTAACA
ACTGATAAAGAACGATTTCGAGATTTACTACTGCCTCCATCTAGTCAAGACTCCGAAATTCTGCCCTTCATTCAATCTAGAAATTATCCC
AAGCTGTATATTGATGGTCCTTTTGGAAGTCCATTTGAGGAATCACTGAACTATGAGGTCAGCCTCTGCGTGGCTGGAGGCATTGGAGTA
ACTCCATTTGCATCAATACTCAACACCCTGTTGGATGACTGGAAACCATACAAGCTTAGAAGACTATACTTTATTTGGGTATGCAGAGAT
ATCCAGTCCTTCCGTTGGTTTGCAGATTTACTCTGTATGTTGCATAACAAGTTTTGGCAAGAGAACAGACCTGACTATGTCAACATCCAG
CTGTACCTCAGTCAAACAGATGGGATACAGAAGATAATTGGAGAAAAATATCATGCACTGAATTCAAGACTGTTTATAGGACGTCCTCGG
TGGAAACTTTTGTTTGATGAAATAGCAAAATATAACAGAGGAAAAACAGTTGGTGTTTTCTGTTGTGGACCCAATTCACTATCCAAGACT

>In-frame_ZFP91_ENST00000316059_chr11_58352357_+_NOX4_ENST00000343727_chr11_89088211_-_972nt
ATGCCGGGGGAGACGGAAGAGCCGAGACCCCCGGAGCAGCAGGACCAGGAAGGGGGAGAGGCGGCCAAGGCGGCTCCGGAGGAGCCCCAA
CAACGGCCCCCTGAGGCGGTCGCGGCGGCGCCTGCAGGGACCACTAGCAGCCGCGTGCTGAGGGGAGGTCGGGACCGAGGCCGGGCCGCT
GCGGCCGCCGCCGCCGCAGCTGTGTCCCGCCGGAGGAAGGCCGAGTATCCCCGCCGGCGGAGGAGCAGCCCCAGCGCCAGGCCTCCCGAC
GTCCCCGGGCAGCAGCCCCAGGCCGCGAAGTCCCCGTCTCCAGTTCAGGGCAAGAAGAGTCCGCGACTCCTATGCATAGAAAAAGTAACA
ACTGATAAAGAACGATTTCGAGATTTACTACTGCCTCCATCTAGTCAAGACTCCGAAATTCTGCCCTTCATTCAATCTAGAAATTATCCC
AAGCTGTATATTGATGGTCCTTTTGGAAGTCCATTTGAGGAATCACTGAACTATGAGGTCAGCCTCTGCGTGGCTGGAGGCATTGGAGTA
ACTCCATTTGCATCAATACTCAACACCCTGTTGGATGACTGGAAACCATACAAGCTTAGAAGACTATACTTTATTTGGGTATGCAGAGAT
ATCCAGTCCTTCCGTTGGTTTGCAGATTTACTCTGTATGTTGCATAACAAGTTTTGGCAAGAGAACAGACCTGACTATGTCAACATCCAG
CTGTACCTCAGTCAAACAGATGGGATACAGAAGATAATTGGAGAAAAATATCATGCACTGAATTCAAGACTGTTTATAGGACGTCCTCGG
TGGAAACTTTTGTTTGATGAAATAGCAAAATATAACAGAGGAAAAACAGTTGGTGTTTTCTGTTGTGGACCCAATTCACTATCCAAGACT

>In-frame_ZFP91_ENST00000316059_chr11_58352357_+_NOX4_ENST00000534731_chr11_89088211_-_852nt
ATGCCGGGGGAGACGGAAGAGCCGAGACCCCCGGAGCAGCAGGACCAGGAAGGGGGAGAGGCGGCCAAGGCGGCTCCGGAGGAGCCCCAA
CAACGGCCCCCTGAGGCGGTCGCGGCGGCGCCTGCAGGGACCACTAGCAGCCGCGTGCTGAGGGGAGGTCGGGACCGAGGCCGGGCCGCT
GCGGCCGCCGCCGCCGCAGCTGTGTCCCGCCGGAGGAAGGCCGAGTATCCCCGCCGGCGGAGGAGCAGCCCCAGCGCCAGGCCTCCCGAC
GTCCCCGGGCAGCAGCCCCAGGCCGCGAAGTCCCCGTCTCCAGTTCAGGGCAAGAAGAGTCCGCGACTCCTATGCATAGAAAAAGTAACA
ACTGATAAAGAACGATTTCGAGATTTACTACTGCCTCCATCTAGTCAAGACTCCGAAATTCTGCCCTTCATTCAATCTAGAAATTATCCC
AAGGATGACTGGAAACCATACAAGCTTAGAAGACTATACTTTATTTGGGTATGCAGAGATATCCAGTCCTTCCGTTGGTTTGCAGATTTA
CTCTGTATGTTGCATAACAAGTTTTGGCAAGAGAACAGACCTGACTATGTCAACATCCAGCTGTACCTCAGTCAAACAGATGGGATACAG
AAGATAATTGGAGAAAAATATCATGCACTGAATTCAAGACTGTTTATAGGACGTCCTCGGTGGAAACTTTTGTTTGATGAAATAGCAAAA
TATAACAGAGGAAAAACAGTTGGTGTTTTCTGTTGTGGACCCAATTCACTATCCAAGACTCTTCATAAACTGAGTAACCAGAACAACTCA


* Fusion transcript sequences (Full-length transcript).
>In-frame_ZFP91_ENST00000316059_chr11_58352357_+_NOX4_ENST00000535633_chr11_89088211_-_3543nt
GGGGTGGGGGGGGCGCCCTCGGAGCCGGGCGGAGGGGAGGGGGGAAAGAGGAGCGCAGGGTGAGAGTGAGCCGCAGGCTTCGGGAGGCGA
GGGGGCGGGGGGAGCAGCGCCGAGGCCGCCGCCTCCGCCTCCGCCGCCTAGGACTAGGGGGTGGGGGACGGACAAGCCCCGATGCCGGGG
GAGACGGAAGAGCCGAGACCCCCGGAGCAGCAGGACCAGGAAGGGGGAGAGGCGGCCAAGGCGGCTCCGGAGGAGCCCCAACAACGGCCC
CCTGAGGCGGTCGCGGCGGCGCCTGCAGGGACCACTAGCAGCCGCGTGCTGAGGGGAGGTCGGGACCGAGGCCGGGCCGCTGCGGCCGCC
GCCGCCGCAGCTGTGTCCCGCCGGAGGAAGGCCGAGTATCCCCGCCGGCGGAGGAGCAGCCCCAGCGCCAGGCCTCCCGACGTCCCCGGG
CAGCAGCCCCAGGCCGCGAAGTCCCCGTCTCCAGTTCAGGGCAAGAAGAGTCCGCGACTCCTATGCATAGAAAAAGTAACAACTGATAAA
GAACGATTTCGAGATTTACTACTGCCTCCATCTAGTCAAGACTCCGAAATTCTGCCCTTCATTCAATCTAGAAATTATCCCAAGCTGTAT
ATTGATGGTCCTTTTGGAAGTCCATTTGAGGAATCACTGAACTATGAGGTCAGCCTCTGCGTGGCTGGAGGCATTGGAGTAACTCCATTT
GCATCAATACTCAACACCCTGTTGGATGACTGGAAACCATACAAGCTTAGAAGACTATACTTTATTTGGGTATGCAGAGATATCCAGTCC
TTCCGTTGGTTTGCAGATTTACTCTGTATGTTGCATAACAAGTTTTGGCAAGAGAACAGACCTGACTATGTCAACATCCAGCTGTACCTC
AGTCAAACAGATGGGATACAGAAGATAATTGGAGAAAAATATCATGCACTGAATTCAAGACTGTTTATAGGACGTCCTCGGTGGAAACTT
TTGTTTGATGAAATAGCAAAATATAACAGAGGAAAAACAGTTGGTGTTTTCTGTTGTGGACCCAATTCACTATCCAAGACTCTTCATAAA
CTGAGTAACCAGAACAACTCATATGGGACAAGATTTGAATACAATAAAGAGTCTTTCAGCTGAAAACTTTTGCCATGAAGCAGGACTCTA
AAGAAGGAATGAGTGCAATTTCTAAGACTTTGAAACTCAGCGGAATCAATCAGCTGTGTTATGCCAAAGAATAGTAAGGTTTTCTTATTT
ATGATTATTTAAAATGGAAATGTGAGAATGTGGCAAGATGACCGTCACATTACATGTTTAATCTGGAAACCAAAGAGACCCTGAAGAATA
TTTGATGTGATGATTCACTTTTCAGTTCTCAAATTAAAAGAAAACTGTTAGATGCACACTGTTGATTTTCATGGTGGATTCAAGAACTCC
CTAGTGAGGAGCTGAACTTGCTCAATCTAAGGCTGATTGTCGTGTTCCTCTTTAAATTGTTTTTGGTTGAACAAATGCAAGATTGAACAA
AATTAAAAATTCATTGAAGCTGAAATTCCATTTTCTGTGTTGTGTATAAACAGAGTAGCTTTAATTTGCAAGCACTCCAGGCAAATATAT
TAGATGTTTGAAAACACAGCACAAGACTCTGTATTGATACGGGTACTTTGTGTCAATATCTAATCGTCTCCACTACTTATGCTAATACCT
CTATTTGATATCTGAAGACTATATGCTAACTGAACCTTCCTCAAATGTTGTTATAGTATCTATTTTTATATATTTTTTTCTTTTTATTCC
TCTCTCTAGGGAAATATGCCTTCCCTTAGCATGCATTAGACATAATGATTTAATAGGTCCCTTTCATCTTCATTTAAATCTATCACTATT
GCATGGTAATGAAAATATTCCTACTATAAATTATAAAGGGATATATATATATGGATATATATATGTATATACACATATATATATACACAC
ACACACACATATATATATATATATATATATATACACATATACTAATAACTTTTCCCTTTTTTCAGCATTTTTGTCTCTATTATTATTATT
GTTTTTTTCCCAGGTAGGGTTTGTCTTAGGCTGTAGCCTCTAAGGATAGTTAGTTAATTTGCACTTTGAGACCAAAGGACATCATGTGTG
TCAGTAGGGACTGAATATAAGATTTATCTCCTTTGCCACACATTGGTTTATGATGGAGACATTGAAAGTCTAGTCATATTCCTGAACAGT
AAAACCTGTATTTTACCTTTTAAGTAAGAGGAAATATGATATTCTTATTCAAACTTAAGTTTAGAATCCAGAATATTACTGTCGCACTTT
TTGGTATCCTGAGTTTCCATAGGGAACTATTGGGTTTAAAGTCACCGTTGGAACTACACTGTGTGATCTTATAAACTTATGTTCCCTGGC
TATCATATTCTTGGCTCAGAACAATATTTCCCATTACTATCTTAAGAATTAAGGCATTCATGGCTCACGCCTGTAATCCCGGCACTTTGG
GAGGCCAAGGCAGGTGGATCACGAGGTCAGAGTTCAAGACCAGCCTGACCAAGTTGGTGAAACCCCATCGCTACTAAAAATACAAATATT
AGGCGGGTGTGGTGGCGGGTGCCTATAATCCCAACTACTCGGGAGACTGAGGCAAAGAATCGCTTGAACCCGGTGGGCGGAGGTTGCAGT
GAGCCAAGATTGCACCACTGCACTCCAGCCTGGGTGACAGAGCAAGATTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAGAATTAA
AGCATTCATACAGTTTAGTGATTTTGTTTAGTAGTCGGCTATCAATTGCTATCAAATATAACACTGCTGAAATCAGCAGTGTGACTTACC
TTGCCATTGTTAAAATGTTACATAAAACATAACATGATAGATGCTAAGGCCTTTTTTTGCTATAATTCACCAATAGCAATCAAGCATGCT
AACCCATACTGAATGATATTTACTTGTAGATATTTCTTCCTTTCCTTGAAATTCTCCTTTCTATGGAAAGAAGATGAACCCAAAAAAGTG
ATAGGAAATGTGGAATGCTCATGCAGATTTAGCTCTGAAGGCATATTTAATAACTAGTATGTCTTGACAACAGTCTTTAGATTAAAAAGA
ATTTTCATGGAAACATTTAACAGAAAGAACTAGTAAAAAGACACTTTGAGTTAGTCCAGGCTTAATGTGCAATACTGACTCTATACTGAT
CATAATTTATTTATGCGATCATATTAATAGACCTAATTTCATTAAAACAGGTAGAAGATTTTTCAAAAGAAAGATGATGTTTCAAAGCTG
GTCTGCCATTCTAGATGAGCCTCCTTGCTTATTTAAGTTCCAGTAGGTGTTCAAATGTTAAATGTTAAACATAGGTCATCTTTGCTTCTG
CAGGGCTTCATCTTGCATGTTTAAGAGAACTTTGTTTTATTTTGAGGGATTATTTCTCTGGGGATCATTCTTATAATACAAGCCTTAAAT

>In-frame_ZFP91_ENST00000316059_chr11_58352357_+_NOX4_ENST00000424319_chr11_89088211_-_3543nt
GGGGTGGGGGGGGCGCCCTCGGAGCCGGGCGGAGGGGAGGGGGGAAAGAGGAGCGCAGGGTGAGAGTGAGCCGCAGGCTTCGGGAGGCGA
GGGGGCGGGGGGAGCAGCGCCGAGGCCGCCGCCTCCGCCTCCGCCGCCTAGGACTAGGGGGTGGGGGACGGACAAGCCCCGATGCCGGGG
GAGACGGAAGAGCCGAGACCCCCGGAGCAGCAGGACCAGGAAGGGGGAGAGGCGGCCAAGGCGGCTCCGGAGGAGCCCCAACAACGGCCC
CCTGAGGCGGTCGCGGCGGCGCCTGCAGGGACCACTAGCAGCCGCGTGCTGAGGGGAGGTCGGGACCGAGGCCGGGCCGCTGCGGCCGCC
GCCGCCGCAGCTGTGTCCCGCCGGAGGAAGGCCGAGTATCCCCGCCGGCGGAGGAGCAGCCCCAGCGCCAGGCCTCCCGACGTCCCCGGG
CAGCAGCCCCAGGCCGCGAAGTCCCCGTCTCCAGTTCAGGGCAAGAAGAGTCCGCGACTCCTATGCATAGAAAAAGTAACAACTGATAAA
GAACGATTTCGAGATTTACTACTGCCTCCATCTAGTCAAGACTCCGAAATTCTGCCCTTCATTCAATCTAGAAATTATCCCAAGCTGTAT
ATTGATGGTCCTTTTGGAAGTCCATTTGAGGAATCACTGAACTATGAGGTCAGCCTCTGCGTGGCTGGAGGCATTGGAGTAACTCCATTT
GCATCAATACTCAACACCCTGTTGGATGACTGGAAACCATACAAGCTTAGAAGACTATACTTTATTTGGGTATGCAGAGATATCCAGTCC
TTCCGTTGGTTTGCAGATTTACTCTGTATGTTGCATAACAAGTTTTGGCAAGAGAACAGACCTGACTATGTCAACATCCAGCTGTACCTC
AGTCAAACAGATGGGATACAGAAGATAATTGGAGAAAAATATCATGCACTGAATTCAAGACTGTTTATAGGACGTCCTCGGTGGAAACTT
TTGTTTGATGAAATAGCAAAATATAACAGAGGAAAAACAGTTGGTGTTTTCTGTTGTGGACCCAATTCACTATCCAAGACTCTTCATAAA
CTGAGTAACCAGAACAACTCATATGGGACAAGATTTGAATACAATAAAGAGTCTTTCAGCTGAAAACTTTTGCCATGAAGCAGGACTCTA
AAGAAGGAATGAGTGCAATTTCTAAGACTTTGAAACTCAGCGGAATCAATCAGCTGTGTTATGCCAAAGAATAGTAAGGTTTTCTTATTT
ATGATTATTTAAAATGGAAATGTGAGAATGTGGCAAGATGACCGTCACATTACATGTTTAATCTGGAAACCAAAGAGACCCTGAAGAATA
TTTGATGTGATGATTCACTTTTCAGTTCTCAAATTAAAAGAAAACTGTTAGATGCACACTGTTGATTTTCATGGTGGATTCAAGAACTCC
CTAGTGAGGAGCTGAACTTGCTCAATCTAAGGCTGATTGTCGTGTTCCTCTTTAAATTGTTTTTGGTTGAACAAATGCAAGATTGAACAA
AATTAAAAATTCATTGAAGCTGAAATTCCATTTTCTGTGTTGTGTATAAACAGAGTAGCTTTAATTTGCAAGCACTCCAGGCAAATATAT
TAGATGTTTGAAAACACAGCACAAGACTCTGTATTGATACGGGTACTTTGTGTCAATATCTAATCGTCTCCACTACTTATGCTAATACCT
CTATTTGATATCTGAAGACTATATGCTAACTGAACCTTCCTCAAATGTTGTTATAGTATCTATTTTTATATATTTTTTTCTTTTTATTCC
TCTCTCTAGGGAAATATGCCTTCCCTTAGCATGCATTAGACATAATGATTTAATAGGTCCCTTTCATCTTCATTTAAATCTATCACTATT
GCATGGTAATGAAAATATTCCTACTATAAATTATAAAGGGATATATATATATGGATATATATATGTATATACACATATATATATACACAC
ACACACACATATATATATATATATATATATATACACATATACTAATAACTTTTCCCTTTTTTCAGCATTTTTGTCTCTATTATTATTATT
GTTTTTTTCCCAGGTAGGGTTTGTCTTAGGCTGTAGCCTCTAAGGATAGTTAGTTAATTTGCACTTTGAGACCAAAGGACATCATGTGTG
TCAGTAGGGACTGAATATAAGATTTATCTCCTTTGCCACACATTGGTTTATGATGGAGACATTGAAAGTCTAGTCATATTCCTGAACAGT
AAAACCTGTATTTTACCTTTTAAGTAAGAGGAAATATGATATTCTTATTCAAACTTAAGTTTAGAATCCAGAATATTACTGTCGCACTTT
TTGGTATCCTGAGTTTCCATAGGGAACTATTGGGTTTAAAGTCACCGTTGGAACTACACTGTGTGATCTTATAAACTTATGTTCCCTGGC
TATCATATTCTTGGCTCAGAACAATATTTCCCATTACTATCTTAAGAATTAAGGCATTCATGGCTCACGCCTGTAATCCCGGCACTTTGG
GAGGCCAAGGCAGGTGGATCACGAGGTCAGAGTTCAAGACCAGCCTGACCAAGTTGGTGAAACCCCATCGCTACTAAAAATACAAATATT
AGGCGGGTGTGGTGGCGGGTGCCTATAATCCCAACTACTCGGGAGACTGAGGCAAAGAATCGCTTGAACCCGGTGGGCGGAGGTTGCAGT
GAGCCAAGATTGCACCACTGCACTCCAGCCTGGGTGACAGAGCAAGATTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAGAATTAA
AGCATTCATACAGTTTAGTGATTTTGTTTAGTAGTCGGCTATCAATTGCTATCAAATATAACACTGCTGAAATCAGCAGTGTGACTTACC
TTGCCATTGTTAAAATGTTACATAAAACATAACATGATAGATGCTAAGGCCTTTTTTTGCTATAATTCACCAATAGCAATCAAGCATGCT
AACCCATACTGAATGATATTTACTTGTAGATATTTCTTCCTTTCCTTGAAATTCTCCTTTCTATGGAAAGAAGATGAACCCAAAAAAGTG
ATAGGAAATGTGGAATGCTCATGCAGATTTAGCTCTGAAGGCATATTTAATAACTAGTATGTCTTGACAACAGTCTTTAGATTAAAAAGA
ATTTTCATGGAAACATTTAACAGAAAGAACTAGTAAAAAGACACTTTGAGTTAGTCCAGGCTTAATGTGCAATACTGACTCTATACTGAT
CATAATTTATTTATGCGATCATATTAATAGACCTAATTTCATTAAAACAGGTAGAAGATTTTTCAAAAGAAAGATGATGTTTCAAAGCTG
GTCTGCCATTCTAGATGAGCCTCCTTGCTTATTTAAGTTCCAGTAGGTGTTCAAATGTTAAATGTTAAACATAGGTCATCTTTGCTTCTG
CAGGGCTTCATCTTGCATGTTTAAGAGAACTTTGTTTTATTTTGAGGGATTATTTCTCTGGGGATCATTCTTATAATACAAGCCTTAAAT

>In-frame_ZFP91_ENST00000316059_chr11_58352357_+_NOX4_ENST00000343727_chr11_89088211_-_2531nt
GGGGTGGGGGGGGCGCCCTCGGAGCCGGGCGGAGGGGAGGGGGGAAAGAGGAGCGCAGGGTGAGAGTGAGCCGCAGGCTTCGGGAGGCGA
GGGGGCGGGGGGAGCAGCGCCGAGGCCGCCGCCTCCGCCTCCGCCGCCTAGGACTAGGGGGTGGGGGACGGACAAGCCCCGATGCCGGGG
GAGACGGAAGAGCCGAGACCCCCGGAGCAGCAGGACCAGGAAGGGGGAGAGGCGGCCAAGGCGGCTCCGGAGGAGCCCCAACAACGGCCC
CCTGAGGCGGTCGCGGCGGCGCCTGCAGGGACCACTAGCAGCCGCGTGCTGAGGGGAGGTCGGGACCGAGGCCGGGCCGCTGCGGCCGCC
GCCGCCGCAGCTGTGTCCCGCCGGAGGAAGGCCGAGTATCCCCGCCGGCGGAGGAGCAGCCCCAGCGCCAGGCCTCCCGACGTCCCCGGG
CAGCAGCCCCAGGCCGCGAAGTCCCCGTCTCCAGTTCAGGGCAAGAAGAGTCCGCGACTCCTATGCATAGAAAAAGTAACAACTGATAAA
GAACGATTTCGAGATTTACTACTGCCTCCATCTAGTCAAGACTCCGAAATTCTGCCCTTCATTCAATCTAGAAATTATCCCAAGCTGTAT
ATTGATGGTCCTTTTGGAAGTCCATTTGAGGAATCACTGAACTATGAGGTCAGCCTCTGCGTGGCTGGAGGCATTGGAGTAACTCCATTT
GCATCAATACTCAACACCCTGTTGGATGACTGGAAACCATACAAGCTTAGAAGACTATACTTTATTTGGGTATGCAGAGATATCCAGTCC
TTCCGTTGGTTTGCAGATTTACTCTGTATGTTGCATAACAAGTTTTGGCAAGAGAACAGACCTGACTATGTCAACATCCAGCTGTACCTC
AGTCAAACAGATGGGATACAGAAGATAATTGGAGAAAAATATCATGCACTGAATTCAAGACTGTTTATAGGACGTCCTCGGTGGAAACTT
TTGTTTGATGAAATAGCAAAATATAACAGAGGAAAAACAGTTGGTGTTTTCTGTTGTGGACCCAATTCACTATCCAAGACTCTTCATAAA
CTGAGTAACCAGAACAACTCATATGGGACAAGATTTGAATACAATAAAGAGTCTTTCAGCTGAAAACTTTTGCCATGAAGCAGGACTCTA
AAGAAGGAATGAGTGCAATTTCTAAGACTTTGAAACTCAGCGGAATCAATCAGCTGTGTTATGCCAAAGAATAGTAAGGTTTTCTTATTT
ATGATTATTTAAAATGGAAATGTGAGAATGTGGCAAGATGACCGTCACATTACATGTTTAATCTGGAAACCAAAGAGACCCTGAAGAATA
TTTGATGTGATGATTCACTTTTCAGTTCTCAAATTAAAAGAAAACTGTTAGATGCACACTGTTGATTTTCATGGTGGATTCAAGAACTCC
CTAGTGAGGAGCTGAACTTGCTCAATCTAAGGCTGATTGTCGTGTTCCTCTTTAAATTGTTTTTGGTTGAACAAATGCAAGATTGAACAA
AATTAAAAATTCATTGAAGCTGAAATTCCATTTTCTGTGTTGTGTATAAACAGAGTAGCTTTAATTTGCAAGCACTCCAGGCAAATATAT
TAGATGTTTGAAAACACAGCACAAGACTCTGTATTGATACGGGTACTTTGTGTCAATATCTAATCGTCTCCACTACTTATGCTAATACCT
CTATTTGATATCTGAAGACTATATGCTAACTGAACCTTCCTCAAATGTTGTTATAGTATCTATTTTTATATATTTTTTTCTTTTTATTCC
TCTCTCTAGGGAAATATGCCTTCCCTTAGCATGCATTAGACATAATGATTTAATAGGTCCCTTTCATCTTCATTTAAATCTATCACTATT
GCATGGTAATGAAAATATTCCTACTATAAATTATAAAGGGATATATATATATGGATATATATATGTATATACACATATATATATACACAC
ACACACACATATATATATATATATATATATATACACATATACTAATAACTTTTCCCTTTTTTCAGCATTTTTGTCTCTATTATTATTATT
GTTTTTTTCCCAGGTAGGGTTTGTCTTAGGCTGTAGCCTCTAAGGATAGTTAGTTAATTTGCACTTTGAGACCAAAGGACATCATGTGTG
TCAGTAGGGACTGAATATAAGATTTATCTCCTTTGCCACACATTGGTTTATGATGGAGACATTGAAAGTCTAGTCATATTCCTGAACAGT
AAAACCTGTATTTTACCTTTTAAGTAAGAGGAAATATGATATTCTTATTCAAACTTAAGTTTAGAATCCAGAATATTACTGTCGCACTTT
TTGGTATCCTGAGTTTCCATAGGGAACTATTGGGTTTAAAGTCACCGTTGGAACTACACTGTGTGATCTTATAAACTTATGTTCCCTGGC
TATCATATTCTTGGCTCAGAACAATATTTCCCATTACTATCTTAAGAATTAAGGCATTCATGGCTCACGCCTGTAATCCCGGCACTTTGG

>In-frame_ZFP91_ENST00000316059_chr11_58352357_+_NOX4_ENST00000534731_chr11_89088211_-_1480nt
GGGGTGGGGGGGGCGCCCTCGGAGCCGGGCGGAGGGGAGGGGGGAAAGAGGAGCGCAGGGTGAGAGTGAGCCGCAGGCTTCGGGAGGCGA
GGGGGCGGGGGGAGCAGCGCCGAGGCCGCCGCCTCCGCCTCCGCCGCCTAGGACTAGGGGGTGGGGGACGGACAAGCCCCGATGCCGGGG
GAGACGGAAGAGCCGAGACCCCCGGAGCAGCAGGACCAGGAAGGGGGAGAGGCGGCCAAGGCGGCTCCGGAGGAGCCCCAACAACGGCCC
CCTGAGGCGGTCGCGGCGGCGCCTGCAGGGACCACTAGCAGCCGCGTGCTGAGGGGAGGTCGGGACCGAGGCCGGGCCGCTGCGGCCGCC
GCCGCCGCAGCTGTGTCCCGCCGGAGGAAGGCCGAGTATCCCCGCCGGCGGAGGAGCAGCCCCAGCGCCAGGCCTCCCGACGTCCCCGGG
CAGCAGCCCCAGGCCGCGAAGTCCCCGTCTCCAGTTCAGGGCAAGAAGAGTCCGCGACTCCTATGCATAGAAAAAGTAACAACTGATAAA
GAACGATTTCGAGATTTACTACTGCCTCCATCTAGTCAAGACTCCGAAATTCTGCCCTTCATTCAATCTAGAAATTATCCCAAGGATGAC
TGGAAACCATACAAGCTTAGAAGACTATACTTTATTTGGGTATGCAGAGATATCCAGTCCTTCCGTTGGTTTGCAGATTTACTCTGTATG
TTGCATAACAAGTTTTGGCAAGAGAACAGACCTGACTATGTCAACATCCAGCTGTACCTCAGTCAAACAGATGGGATACAGAAGATAATT
GGAGAAAAATATCATGCACTGAATTCAAGACTGTTTATAGGACGTCCTCGGTGGAAACTTTTGTTTGATGAAATAGCAAAATATAACAGA
GGAAAAACAGTTGGTGTTTTCTGTTGTGGACCCAATTCACTATCCAAGACTCTTCATAAACTGAGTAACCAGAACAACTCATATGGGACA
AGATTTGAATACAATAAAGAGTCTTTCAGCTGAAAACTTTTGCCATGAAGCAGGACTCTAAAGAAGGAATGAGTGCAATTTCTAAGACTT
TGAAACTCAGCGGAATCAATCAGCTGTGTTATGCCAAAGAATAGTAAGGTTTTCTTATTTATGATTATTTAAAATGGAAATGTGAGAATG
TGGCAAGATGACCGTCACATTACATGTTTAATCTGGAAACCAAAGAGACCCTGAAGAATATTTGATGTGATGATTCACTTTTCAGTTCTC
AAATTAAAAGAAAACTGTTAGATGCACACTGTTGATTTTCATGGTGGATTCAAGAACTCCCTAGTGAGGAGCTGAACTTGCTCAATCTAA
GGCTGATTGTCGTGTTCCTCTTTAAATTGTTTTTGGTTGAACAAATGCAAGATTGAACAAAATTAAAAATTCATTGAAGCTGAAATTCCA


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FusionGenePPI for ZFP91_NOX4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZFP91CENPA, MAP3K14, ELAVL1, USP5, UTP20, RNF2, FBL, LUC7L, CASQ2, HIST1H2BG, SRPK2, DLG3, GBA, PAEP, CTR9, FTSJ1, TNFRSF13B, CHCHD10, PRDM5, AURKAIP1, CLEC3A, BHLHA15, APC, FOXA1, CRBNNOX4ACTBL2, MYO18A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneZFP91chr11:58352357chr11:89088211ENST00000316059+211338_368123571MAP3K14/NIK


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZFP91_NOX4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZFP91_NOX4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNOX4C0009375Colonic Neoplasms1CTD_human
TgeneNOX4C0018801Heart failure1CTD_human
TgeneNOX4C0022661Kidney Failure, Chronic1CTD_human
TgeneNOX4C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneNOX4C1565489Renal Insufficiency1CTD_human
TgeneNOX4C4277682Chemical and Drug Induced Liver Injury1CTD_human