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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42830

FusionGeneSummary for ZFP90_NUTF2

check button Fusion gene summary
Fusion gene informationFusion gene name: ZFP90_NUTF2
Fusion gene ID: 42830
HgeneTgene
Gene symbol

ZFP90

NUTF2

Gene ID

146198

10204

Gene nameZFP90 zinc finger proteinnuclear transport factor 2
SynonymsFIK|NK10|ZNF756|zfp-90NTF-2|NTF2|PP15
Cytomap

16q22.1

16q22.1

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 90 homologFOXP3-interacting KRAB domain-containing proteinzinc finger protein 476zinc finger protein 756nuclear transport factor 2placental protein 15
Modification date2018052320180523
UniProtAcc

Q8TF47

P61970

Ensembl transtripts involved in fusion geneENST00000570884, ENST00000570495, 
ENST00000563169, ENST00000564323, 
ENST00000398253, 
ENST00000219169, 
ENST00000569436, ENST00000568396, 
Fusion gene scores* DoF score3 X 3 X 3=277 X 4 X 5=140
# samples 37
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZFP90 [Title/Abstract] AND NUTF2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNUTF2

GO:0006606

protein import into nucleus

7744965|10679025

TgeneNUTF2

GO:0006611

protein export from nucleus

16449645


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDUCECTCGA-A5-A7WK-01AZFP90chr16

68573372

+NUTF2chr16

67899005

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000570884ENST00000219169ZFP90chr16

68573372

+NUTF2chr16

67899005

+
intron-5UTRENST00000570884ENST00000569436ZFP90chr16

68573372

+NUTF2chr16

67899005

+
intron-5UTRENST00000570884ENST00000568396ZFP90chr16

68573372

+NUTF2chr16

67899005

+
5UTR-5UTRENST00000570495ENST00000219169ZFP90chr16

68573372

+NUTF2chr16

67899005

+
5UTR-5UTRENST00000570495ENST00000569436ZFP90chr16

68573372

+NUTF2chr16

67899005

+
5UTR-5UTRENST00000570495ENST00000568396ZFP90chr16

68573372

+NUTF2chr16

67899005

+
5UTR-5UTRENST00000563169ENST00000219169ZFP90chr16

68573372

+NUTF2chr16

67899005

+
5UTR-5UTRENST00000563169ENST00000569436ZFP90chr16

68573372

+NUTF2chr16

67899005

+
5UTR-5UTRENST00000563169ENST00000568396ZFP90chr16

68573372

+NUTF2chr16

67899005

+
5UTR-5UTRENST00000564323ENST00000219169ZFP90chr16

68573372

+NUTF2chr16

67899005

+
5UTR-5UTRENST00000564323ENST00000569436ZFP90chr16

68573372

+NUTF2chr16

67899005

+
5UTR-5UTRENST00000564323ENST00000568396ZFP90chr16

68573372

+NUTF2chr16

67899005

+
intron-5UTRENST00000398253ENST00000219169ZFP90chr16

68573372

+NUTF2chr16

67899005

+
intron-5UTRENST00000398253ENST00000569436ZFP90chr16

68573372

+NUTF2chr16

67899005

+
intron-5UTRENST00000398253ENST00000568396ZFP90chr16

68573372

+NUTF2chr16

67899005

+

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FusionProtFeatures for ZFP90_NUTF2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZFP90

Q8TF47

NUTF2

P61970

Inhibits the transcriptional repressor activity of RESTby inhibiting its binding to DNA, thereby derepressingtranscription of REST target genes. {ECO:0000269|PubMed:21284946}. Isoform 2: Acts as a bridge between FOXP3 and thecorepressor TRIM28, and is required for the transcriptionalrepressor activity of FOXP3 in regulatory T-cells (Treg).{ECO:0000269|PubMed:23543754}. Mediates the import of GDP-bound RAN from the cytoplasminto the nucleus which is essential for the function of RAN incargo receptor-mediated nucleocytoplasmic transport. Thereby,plays indirectly a more general role in cargo receptor-mediatednucleocytoplasmic transport. Interacts with GDP-bound RAN in thecytosol, recruits it to the nuclear pore complex via itsinteraction with nucleoporins and promotes its nuclear import.{ECO:0000269|PubMed:10679025, ECO:0000269|PubMed:7744965}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZFP90_NUTF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZFP90_NUTF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZFP90NUTF2NUP153, RAN, LUC7L2, NUP62, NUP54, KPNB1, NUTF2, ELAVL1, NXF1, SHMT2, MOV10, AP2A1, AP2A2, APOA1BP, CTH, GPX4, HINT1, FKBP2, KCNAB2, PGAM1, PGAM2, RAB11A, RAB11B, RPE, SCLY, SOD1, TAGLN, TAGLN2, TAGLN3, XPNPEP1, PRCP, RAB7A, RHOA, TANGO2, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZFP90_NUTF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZFP90_NUTF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNUTF2C0019693HIV Infections1CTD_human