FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 42815

FusionGeneSummary for ZFP36L1_TMED9

check button Fusion gene summary
Fusion gene informationFusion gene name: ZFP36L1_TMED9
Fusion gene ID: 42815
HgeneTgene
Gene symbol

ZFP36L1

TMED9

Gene ID

677

54732

Gene nameZFP36 ring finger protein like 1transmembrane p24 trafficking protein 9
SynonymsBRF1|Berg36|ERF-1|ERF1|RNF162B|TIS11B|cMG1GMP25|HSGP25L2G|p24a2|p24alpha2|p25
Cytomap

14q24.1

5q35.3

Type of geneprotein-codingprotein-coding
DescriptionmRNA decay activator protein ZFP36L1EGF-response factor 1TPA-induced sequence 11bZFP36-like 1butyrate response factor 1early response factor Berg36zinc finger protein 36, C3H type-like 1zinc finger protein 36, C3H1 type-like 1zinc finger protein, transmembrane emp24 domain-containing protein 9glycoprotein 25L2p24 family protein alpha-2transmembrane emp24 protein transport domain containing 9
Modification date2018052320180523
UniProtAcc

Q07352

Q9BVK6

Ensembl transtripts involved in fusion geneENST00000555997, ENST00000439696, 
ENST00000336440, ENST00000408913, 
ENST00000332598, ENST00000507578, 
Fusion gene scores* DoF score3 X 3 X 1=92 X 2 X 1=4
# samples 32
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/4*10)=2.32192809488736
Context

PubMed: ZFP36L1 [Title/Abstract] AND TMED9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZFP36L1

GO:0000165

MAPK cascade

18326031|20166898

HgeneZFP36L1

GO:0009611

response to wounding

27182009

HgeneZFP36L1

GO:0010468

regulation of gene expression

20166898

HgeneZFP36L1

GO:0014065

phosphatidylinositol 3-kinase signaling

15538381

HgeneZFP36L1

GO:0031440

regulation of mRNA 3'-end processing

21832157

HgeneZFP36L1

GO:0032869

cellular response to insulin stimulus

15538381

HgeneZFP36L1

GO:0043488

regulation of mRNA stability

15467755|15538381|15687258|18326031|19179481|20702587|24700863|25014217|26542173

HgeneZFP36L1

GO:0045647

negative regulation of erythrocyte differentiation

20702587

HgeneZFP36L1

GO:0045657

positive regulation of monocyte differentiation

26542173

HgeneZFP36L1

GO:0061158

3'-UTR-mediated mRNA destabilization

15467755|15538381|15687258|18326031|19179481|24700863|26542173

HgeneZFP36L1

GO:0070371

ERK1 and ERK2 cascade

25106868

HgeneZFP36L1

GO:0071320

cellular response to cAMP

19179481

HgeneZFP36L1

GO:0071356

cellular response to tumor necrosis factor

20166898

HgeneZFP36L1

GO:0071364

cellular response to epidermal growth factor stimulus

20166898

HgeneZFP36L1

GO:0071375

cellular response to peptide hormone stimulus

15467755|19179481

HgeneZFP36L1

GO:0071385

cellular response to glucocorticoid stimulus

20166898

HgeneZFP36L1

GO:0071560

cellular response to transforming growth factor beta stimulus

20166898


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF382756ZFP36L1chr14

69256090

+TMED9chr5

177022906

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000555997ENST00000332598ZFP36L1chr14

69256090

+TMED9chr5

177022906

+
intron-intronENST00000555997ENST00000507578ZFP36L1chr14

69256090

+TMED9chr5

177022906

+
intron-3UTRENST00000439696ENST00000332598ZFP36L1chr14

69256090

+TMED9chr5

177022906

+
intron-intronENST00000439696ENST00000507578ZFP36L1chr14

69256090

+TMED9chr5

177022906

+
intron-3UTRENST00000336440ENST00000332598ZFP36L1chr14

69256090

+TMED9chr5

177022906

+
intron-intronENST00000336440ENST00000507578ZFP36L1chr14

69256090

+TMED9chr5

177022906

+
intron-3UTRENST00000408913ENST00000332598ZFP36L1chr14

69256090

+TMED9chr5

177022906

+
intron-intronENST00000408913ENST00000507578ZFP36L1chr14

69256090

+TMED9chr5

177022906

+

Top

FusionProtFeatures for ZFP36L1_TMED9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZFP36L1

Q07352

TMED9

Q9BVK6

Zinc-finger RNA-binding protein that destabilizesseveral cytoplasmic AU-rich element (ARE)-containing mRNAtranscripts by promoting their poly(A) tail removal ordeadenylation, and hence provide a mechanism for attenuatingprotein synthesis (PubMed:12198173, PubMed:15538381,PubMed:15467755, PubMed:17030608, PubMed:19179481,PubMed:20702587, PubMed:24700863, PubMed:25106868,PubMed:25014217, PubMed:26542173). Acts as a 3'-untranslatedregion (UTR) ARE mRNA-binding adapter protein to communicatesignaling events to the mRNA decay machinery (PubMed:15687258).Functions by recruiting the CCR4-NOT deadenylase complex andcomponents of the cytoplasmic RNA decay machinery to the boundARE-containing mRNAs, and hence promotes ARE-mediated mRNAdeadenylation and decay processes (PubMed:15687258,PubMed:18326031, PubMed:25106868). Induces also the degradation ofARE-containing mRNAs even in absence of poly(A) tail (Bysimilarity). Binds to 3'-UTR ARE of numerous mRNAs(PubMed:12198173, PubMed:15538381, PubMed:15467755,PubMed:17030608, PubMed:19179481, PubMed:20702587,PubMed:24700863, PubMed:25106868, PubMed:25014217,PubMed:26542173). Positively regulates early adipogenesis bypromoting ARE-mediated mRNA decay of immediate early genes (IEGs)(By similarity). Promotes ARE-mediated mRNA decay ofmineralocorticoid receptor NR3C2 mRNA in response to hypertonicstress (PubMed:24700863). Negatively regulateshematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA(PubMed:20702587). Positively regulates monocyte/macrophage celldifferentiation by promoting ARE-mediated mRNA decay of thecyclin-dependent kinase CDK6 mRNA (PubMed:26542173). Promotesdegradation of ARE-containing pluripotency-associated mRNAs inembryonic stem cells (ESCs), such as NANOG, through a fibroblastgrowth factor (FGF)-induced MAPK-dependent signaling pathway, andhence attenuates ESC self-renewal and positively regulatesmesendoderm differentiation (By similarity). May play a role inmediating pro-apoptotic effects in malignant B-cells by promotingARE-mediated mRNA decay of BCL2 mRNA (PubMed:25014217). Inassociation with ZFP36L2 maintains quiescence on developing Blymphocytes by promoting ARE-mediated decay of several mRNAsencoding cell cycle regulators that help B cells progress throughthe cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination and functional immune cell formation(By similarity). Together with ZFP36L2 is also necessary forthymocyte development and prevention of T-cell acute lymphoblasticleukemia (T-ALL) transformation by promoting ARE-mediated mRNAdecay of the oncogenic transcription factor NOTCH1 mRNA (Bysimilarity). Participates in the delivery of target ARE-mRNAs toprocessing bodies (PBs) (PubMed:17369404). In addition to itscytosolic mRNA-decay function, plays a role in the regulation ofnuclear mRNA 3'-end processing; modulates mRNA 3'-end maturationefficiency of the DLL4 mRNA through binding with an ARE embeddedin a weak noncanonical polyadenylation (poly(A)) signal inendothelial cells (PubMed:21832157). Also involved in theregulation of stress granule (SG) and P-body (PB) formation andfusion (PubMed:15967811). Plays a role in vasculogenesis andendocardial development (By similarity). Plays a role in theregulation of keratinocyte proliferation, differentiation andapoptosis (PubMed:27182009). Plays a role in myoblast celldifferentiation (By similarity). {ECO:0000250|UniProtKB:P17431,ECO:0000250|UniProtKB:P23950, ECO:0000269|PubMed:12198173,ECO:0000269|PubMed:15467755, ECO:0000269|PubMed:15538381,ECO:0000269|PubMed:15687258, ECO:0000269|PubMed:15967811,ECO:0000269|PubMed:17030608, ECO:0000269|PubMed:17369404,ECO:0000269|PubMed:18326031, ECO:0000269|PubMed:19179481,ECO:0000269|PubMed:20702587, ECO:0000269|PubMed:21832157,ECO:0000269|PubMed:24700863, ECO:0000269|PubMed:25014217,ECO:0000269|PubMed:25106868, ECO:0000269|PubMed:26542173,ECO:0000269|PubMed:27182009}. Appears to be involved in vesicular protein trafficking,mainly in the early secretory pathway. In COPI vesicle-mediatedretrograde transport involved in the coatomer recruitment tomembranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role inthe specific retention of p24 complexes in cis-Golgi membranes;specifically contributes to the coupled localization of TMED2 andTMED10 in the cis-Golgi network. May be involved in organizationof intracellular membranes, such as of the ER-Golgi intermediatecompartment and the Golgi apparatus. Involved in ER localizationof PTPN2 isoform PTPB. {ECO:0000269|PubMed:10852829,ECO:0000269|PubMed:14600267, ECO:0000269|PubMed:16595549,ECO:0000269|PubMed:18287528, ECO:0000269|PubMed:19296914}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ZFP36L1_TMED9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ZFP36L1_TMED9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ZFP36L1_TMED9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ZFP36L1_TMED9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource