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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42792

FusionGeneSummary for ZFHX3_DLG2

check button Fusion gene summary
Fusion gene informationFusion gene name: ZFHX3_DLG2
Fusion gene ID: 42792
HgeneTgene
Gene symbol

ZFHX3

DLG2

Gene ID

463

4355

Gene namezinc finger homeobox 3membrane palmitoylated protein 2
SynonymsATBF1|ATBT|ZNF927DLG2
Cytomap

16q22.2-q22.3

17q21.31

Type of geneprotein-codingprotein-coding
Descriptionzinc finger homeobox protein 3AT motif-binding factor 1AT-binding transcription factor 1ZFH-3alpha-fetoprotein enhancer binding proteinzinc finger homeodomain protein 3MAGUK p55 subfamily member 2discs large, homolog 2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
Modification date2018052320180519
UniProtAcc

Q15911

Q15700

Ensembl transtripts involved in fusion geneENST00000268489, ENST00000397992, 
ENST00000558842, 
ENST00000398309, 
ENST00000376104, ENST00000418306, 
ENST00000280241, ENST00000543673, 
ENST00000376106, ENST00000330014, 
ENST00000537455, ENST00000524982, 
ENST00000532653, ENST00000531015, 
ENST00000398301, ENST00000426717, 
ENST00000404783, ENST00000398304, 
ENST00000530800, ENST00000472545, 
Fusion gene scores* DoF score12 X 9 X 7=75616 X 15 X 6=1440
# samples 1520
** MAII scorelog2(15/756*10)=-2.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(20/1440*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZFHX3 [Title/Abstract] AND DLG2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZFHX3

GO:0000122

negative regulation of transcription by RNA polymerase II

11314020

HgeneZFHX3

GO:0045893

positive regulation of transcription, DNA-templated

20599712

HgeneZFHX3

GO:0071559

response to transforming growth factor beta

20599712


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-61-1728-01AZFHX3chr16

73092429

-DLG2chr11

84245774

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000268489ENST00000398309ZFHX3chr16

73092429

-DLG2chr11

84245774

-
intron-3CDSENST00000268489ENST00000376104ZFHX3chr16

73092429

-DLG2chr11

84245774

-
intron-intronENST00000268489ENST00000418306ZFHX3chr16

73092429

-DLG2chr11

84245774

-
intron-intronENST00000268489ENST00000280241ZFHX3chr16

73092429

-DLG2chr11

84245774

-
intron-intronENST00000268489ENST00000543673ZFHX3chr16

73092429

-DLG2chr11

84245774

-
intron-intronENST00000268489ENST00000376106ZFHX3chr16

73092429

-DLG2chr11

84245774

-
intron-intronENST00000268489ENST00000330014ZFHX3chr16

73092429

-DLG2chr11

84245774

-
intron-intronENST00000268489ENST00000537455ZFHX3chr16

73092429

-DLG2chr11

84245774

-
intron-intronENST00000268489ENST00000524982ZFHX3chr16

73092429

-DLG2chr11

84245774

-
intron-intronENST00000268489ENST00000532653ZFHX3chr16

73092429

-DLG2chr11

84245774

-
intron-intronENST00000268489ENST00000531015ZFHX3chr16

73092429

-DLG2chr11

84245774

-
intron-intronENST00000268489ENST00000398301ZFHX3chr16

73092429

-DLG2chr11

84245774

-
intron-intronENST00000268489ENST00000426717ZFHX3chr16

73092429

-DLG2chr11

84245774

-
intron-intronENST00000268489ENST00000404783ZFHX3chr16

73092429

-DLG2chr11

84245774

-
intron-intronENST00000268489ENST00000398304ZFHX3chr16

73092429

-DLG2chr11

84245774

-
intron-intronENST00000268489ENST00000530800ZFHX3chr16

73092429

-DLG2chr11

84245774

-
intron-intronENST00000268489ENST00000472545ZFHX3chr16

73092429

-DLG2chr11

84245774

-
5UTR-3CDSENST00000397992ENST00000398309ZFHX3chr16

73092429

-DLG2chr11

84245774

-
5UTR-3CDSENST00000397992ENST00000376104ZFHX3chr16

73092429

-DLG2chr11

84245774

-
5UTR-intronENST00000397992ENST00000418306ZFHX3chr16

73092429

-DLG2chr11

84245774

-
5UTR-intronENST00000397992ENST00000280241ZFHX3chr16

73092429

-DLG2chr11

84245774

-
5UTR-intronENST00000397992ENST00000543673ZFHX3chr16

73092429

-DLG2chr11

84245774

-
5UTR-intronENST00000397992ENST00000376106ZFHX3chr16

73092429

-DLG2chr11

84245774

-
5UTR-intronENST00000397992ENST00000330014ZFHX3chr16

73092429

-DLG2chr11

84245774

-
5UTR-intronENST00000397992ENST00000537455ZFHX3chr16

73092429

-DLG2chr11

84245774

-
5UTR-intronENST00000397992ENST00000524982ZFHX3chr16

73092429

-DLG2chr11

84245774

-
5UTR-intronENST00000397992ENST00000532653ZFHX3chr16

73092429

-DLG2chr11

84245774

-
5UTR-intronENST00000397992ENST00000531015ZFHX3chr16

73092429

-DLG2chr11

84245774

-
5UTR-intronENST00000397992ENST00000398301ZFHX3chr16

73092429

-DLG2chr11

84245774

-
5UTR-intronENST00000397992ENST00000426717ZFHX3chr16

73092429

-DLG2chr11

84245774

-
5UTR-intronENST00000397992ENST00000404783ZFHX3chr16

73092429

-DLG2chr11

84245774

-
5UTR-intronENST00000397992ENST00000398304ZFHX3chr16

73092429

-DLG2chr11

84245774

-
5UTR-intronENST00000397992ENST00000530800ZFHX3chr16

73092429

-DLG2chr11

84245774

-
5UTR-intronENST00000397992ENST00000472545ZFHX3chr16

73092429

-DLG2chr11

84245774

-
intron-3CDSENST00000558842ENST00000398309ZFHX3chr16

73092429

-DLG2chr11

84245774

-
intron-3CDSENST00000558842ENST00000376104ZFHX3chr16

73092429

-DLG2chr11

84245774

-
intron-intronENST00000558842ENST00000418306ZFHX3chr16

73092429

-DLG2chr11

84245774

-
intron-intronENST00000558842ENST00000280241ZFHX3chr16

73092429

-DLG2chr11

84245774

-
intron-intronENST00000558842ENST00000543673ZFHX3chr16

73092429

-DLG2chr11

84245774

-
intron-intronENST00000558842ENST00000376106ZFHX3chr16

73092429

-DLG2chr11

84245774

-
intron-intronENST00000558842ENST00000330014ZFHX3chr16

73092429

-DLG2chr11

84245774

-
intron-intronENST00000558842ENST00000537455ZFHX3chr16

73092429

-DLG2chr11

84245774

-
intron-intronENST00000558842ENST00000524982ZFHX3chr16

73092429

-DLG2chr11

84245774

-
intron-intronENST00000558842ENST00000532653ZFHX3chr16

73092429

-DLG2chr11

84245774

-
intron-intronENST00000558842ENST00000531015ZFHX3chr16

73092429

-DLG2chr11

84245774

-
intron-intronENST00000558842ENST00000398301ZFHX3chr16

73092429

-DLG2chr11

84245774

-
intron-intronENST00000558842ENST00000426717ZFHX3chr16

73092429

-DLG2chr11

84245774

-
intron-intronENST00000558842ENST00000404783ZFHX3chr16

73092429

-DLG2chr11

84245774

-
intron-intronENST00000558842ENST00000398304ZFHX3chr16

73092429

-DLG2chr11

84245774

-
intron-intronENST00000558842ENST00000530800ZFHX3chr16

73092429

-DLG2chr11

84245774

-
intron-intronENST00000558842ENST00000472545ZFHX3chr16

73092429

-DLG2chr11

84245774

-

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FusionProtFeatures for ZFHX3_DLG2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZFHX3

Q15911

DLG2

Q15700

Transcriptional regulator which can act as an activatoror a repressor. Inhibits the enhancer element of the AFP gene bybinding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFPvia its interaction with SMAD2/3 (PubMed:25105025). Regulates thecircadian locomotor rhythms via transcriptional activation ofneuropeptidergic genes which are essential for intercellularsynchrony and rhythm amplitude in the suprachiasmatic nucleus(SCN) of the brain (By similarity). Regulator of myoblastsdifferentiation through the binding to the AT-rich sequence ofMYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845).In association with RUNX3, upregulates CDKN1A promoter activityfollowing TGF-beta stimulation (PubMed:20599712). Inhibitsestrogen receptor (ESR1) function by selectively competing withcoactivator NCOA3 for binding to ESR1 in ESR1-positive breastcancer cells (PubMed:20720010). {ECO:0000250|UniProtKB:Q61329,ECO:0000269|PubMed:11312261, ECO:0000269|PubMed:17330845,ECO:0000269|PubMed:20599712, ECO:0000269|PubMed:20720010,ECO:0000269|PubMed:25105025}. Required for perception of chronic pain through NMDAreceptor signaling. Regulates surface expression of NMDA receptorsin dorsal horn neurons of the spinal cord. Interacts with thecytoplasmic tail of NMDA receptor subunits as well as inwardrectifying potassium channels. Involved in regulation of synapticstability at cholinergic synapses. Part of the postsynapticprotein scaffold of excitatory synapses (By similarity).{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZFHX3_DLG2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZFHX3_DLG2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZFHX3NINL, PRPF40A, TRIM25, ELAVL1, PIAS3, STAT3, KRT40, WRAP53, AURKADLG2LRP2, ERBB4, KCNJ12, KCNJ4, GRIN2B, KCNA4, DLGAP1, DYNLL1, DYNLL2, DLG4, NLGN2, NLGN1, NLGN3, GRIN2A, SEMA4C, NOS1, ATP2B2, ATP2B4, GUCY1A2, KHDRBS1, FASLG, MAP1A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZFHX3_DLG2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZFHX3_DLG2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneZFHX3C0004238Atrial Fibrillation3CTD_human
HgeneZFHX3C0033578Prostatic Neoplasms2CTD_human
TgeneDLG2C0036341Schizophrenia4PSYGENET
TgeneDLG2C0005586Bipolar Disorder2PSYGENET
TgeneDLG2C0025202melanoma1CTD_human
TgeneDLG2C0041696Unipolar Depression1PSYGENET
TgeneDLG2C0809983Schizophrenia and related disorders1PSYGENET
TgeneDLG2C1269683Major Depressive Disorder1PSYGENET