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Fusion gene ID: 42789 |
FusionGeneSummary for ZFHX3_ALS2CR11 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZFHX3_ALS2CR11 | Fusion gene ID: 42789 | Hgene | Tgene | Gene symbol | ZFHX3 | ALS2CR11 | Gene ID | 463 |
| Gene name | zinc finger homeobox 3 | ||
| Synonyms | ATBF1|ATBT|ZNF927 | ||
| Cytomap | 16q22.2-q22.3 | ||
| Type of gene | protein-coding | ||
| Description | zinc finger homeobox protein 3AT motif-binding factor 1AT-binding transcription factor 1ZFH-3alpha-fetoprotein enhancer binding proteinzinc finger homeodomain protein 3 | ||
| Modification date | 20180523 | ||
| UniProtAcc | Q15911 | ||
| Ensembl transtripts involved in fusion gene | ENST00000268489, ENST00000397992, ENST00000558842, | ENST00000286195, ENST00000439802, ENST00000439140, ENST00000482942, ENST00000450242, | |
| Fusion gene scores | * DoF score | 12 X 9 X 7=756 | 2 X 2 X 2=8 |
| # samples | 15 | 2 | |
| ** MAII score | log2(15/756*10)=-2.33342373372519 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: ZFHX3 [Title/Abstract] AND ALS2CR11 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ZFHX3 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 11314020 |
| Hgene | ZFHX3 | GO:0045893 | positive regulation of transcription, DNA-templated | 20599712 |
| Hgene | ZFHX3 | GO:0071559 | response to transforming growth factor beta | 20599712 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-HC-7232-01A | ZFHX3 | chr16 | 72984368 | - | ALS2CR11 | chr2 | 202440049 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000268489 | ENST00000286195 | ZFHX3 | chr16 | 72984368 | - | ALS2CR11 | chr2 | 202440049 | - |
| Frame-shift | ENST00000268489 | ENST00000439802 | ZFHX3 | chr16 | 72984368 | - | ALS2CR11 | chr2 | 202440049 | - |
| Frame-shift | ENST00000268489 | ENST00000439140 | ZFHX3 | chr16 | 72984368 | - | ALS2CR11 | chr2 | 202440049 | - |
| 5CDS-intron | ENST00000268489 | ENST00000482942 | ZFHX3 | chr16 | 72984368 | - | ALS2CR11 | chr2 | 202440049 | - |
| 5CDS-intron | ENST00000268489 | ENST00000450242 | ZFHX3 | chr16 | 72984368 | - | ALS2CR11 | chr2 | 202440049 | - |
| Frame-shift | ENST00000397992 | ENST00000286195 | ZFHX3 | chr16 | 72984368 | - | ALS2CR11 | chr2 | 202440049 | - |
| Frame-shift | ENST00000397992 | ENST00000439802 | ZFHX3 | chr16 | 72984368 | - | ALS2CR11 | chr2 | 202440049 | - |
| Frame-shift | ENST00000397992 | ENST00000439140 | ZFHX3 | chr16 | 72984368 | - | ALS2CR11 | chr2 | 202440049 | - |
| 5CDS-intron | ENST00000397992 | ENST00000482942 | ZFHX3 | chr16 | 72984368 | - | ALS2CR11 | chr2 | 202440049 | - |
| 5CDS-intron | ENST00000397992 | ENST00000450242 | ZFHX3 | chr16 | 72984368 | - | ALS2CR11 | chr2 | 202440049 | - |
| intron-3CDS | ENST00000558842 | ENST00000286195 | ZFHX3 | chr16 | 72984368 | - | ALS2CR11 | chr2 | 202440049 | - |
| intron-3CDS | ENST00000558842 | ENST00000439802 | ZFHX3 | chr16 | 72984368 | - | ALS2CR11 | chr2 | 202440049 | - |
| intron-3CDS | ENST00000558842 | ENST00000439140 | ZFHX3 | chr16 | 72984368 | - | ALS2CR11 | chr2 | 202440049 | - |
| intron-intron | ENST00000558842 | ENST00000482942 | ZFHX3 | chr16 | 72984368 | - | ALS2CR11 | chr2 | 202440049 | - |
| intron-intron | ENST00000558842 | ENST00000450242 | ZFHX3 | chr16 | 72984368 | - | ALS2CR11 | chr2 | 202440049 | - |
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FusionProtFeatures for ZFHX3_ALS2CR11 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZFHX3 | ALS2CR11 |
| Transcriptional regulator which can act as an activatoror a repressor. Inhibits the enhancer element of the AFP gene bybinding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFPvia its interaction with SMAD2/3 (PubMed:25105025). Regulates thecircadian locomotor rhythms via transcriptional activation ofneuropeptidergic genes which are essential for intercellularsynchrony and rhythm amplitude in the suprachiasmatic nucleus(SCN) of the brain (By similarity). Regulator of myoblastsdifferentiation through the binding to the AT-rich sequence ofMYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845).In association with RUNX3, upregulates CDKN1A promoter activityfollowing TGF-beta stimulation (PubMed:20599712). Inhibitsestrogen receptor (ESR1) function by selectively competing withcoactivator NCOA3 for binding to ESR1 in ESR1-positive breastcancer cells (PubMed:20720010). {ECO:0000250|UniProtKB:Q61329,ECO:0000269|PubMed:11312261, ECO:0000269|PubMed:17330845,ECO:0000269|PubMed:20599712, ECO:0000269|PubMed:20720010,ECO:0000269|PubMed:25105025}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZFHX3_ALS2CR11 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZFHX3_ALS2CR11 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ZFHX3 | NINL, PRPF40A, TRIM25, ELAVL1, PIAS3, STAT3, KRT40, WRAP53, AURKA | ALS2CR11 | VIM, CCDC85B, SSSCA1, MCM6, TEX11, CDR2, GOLGA2, KRT13, KRT15, KRT31, TRAF1, DNAJA3, MTUS2, TFIP11, TRIM54, CARD9, KRT40, BRCA1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZFHX3_ALS2CR11 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZFHX3_ALS2CR11 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ZFHX3 | C0004238 | Atrial Fibrillation | 3 | CTD_human |
| Hgene | ZFHX3 | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
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