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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42777

FusionGeneSummary for ZFAT_S100A13

check button Fusion gene summary
Fusion gene informationFusion gene name: ZFAT_S100A13
Fusion gene ID: 42777
HgeneTgene
Gene symbol

ZFAT

S100A13

Gene ID

57623

6284

Gene namezinc finger and AT-hook domain containingS100 calcium binding protein A13
SynonymsAITD3|ZFAT1|ZNF406-
Cytomap

8q24.22

1q21.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein ZFATzinc finger gene in autoimmune thyroid diseasezinc finger protein 406zinc-finger gene in AITD susceptibility regionprotein S100-A13
Modification date2018052320180522
UniProtAcc

Q9P243

Q99584

Ensembl transtripts involved in fusion geneENST00000520356, ENST00000520727, 
ENST00000429442, ENST00000377838, 
ENST00000520214, ENST00000523399, 
ENST00000517307, 
ENST00000339556, 
ENST00000392622, ENST00000392623, 
ENST00000440685, ENST00000368699, 
ENST00000491177, 
Fusion gene scores* DoF score3 X 3 X 2=187 X 7 X 4=196
# samples 38
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(8/196*10)=-1.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZFAT [Title/Abstract] AND S100A13 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneS100A13

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

15033494

TgeneS100A13

GO:0050703

interleukin-1 alpha secretion

12746488


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BC025423ZFATchr8

135490351

-S100A13chr1

153604392

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000520356ENST00000339556ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000520356ENST00000392622ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000520356ENST00000392623ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000520356ENST00000440685ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000520356ENST00000368699ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000520356ENST00000491177ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000520727ENST00000339556ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000520727ENST00000392622ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000520727ENST00000392623ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000520727ENST00000440685ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000520727ENST00000368699ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000520727ENST00000491177ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000429442ENST00000339556ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000429442ENST00000392622ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000429442ENST00000392623ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000429442ENST00000440685ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000429442ENST00000368699ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000429442ENST00000491177ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000377838ENST00000339556ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000377838ENST00000392622ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000377838ENST00000392623ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000377838ENST00000440685ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000377838ENST00000368699ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000377838ENST00000491177ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000520214ENST00000339556ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000520214ENST00000392622ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000520214ENST00000392623ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000520214ENST00000440685ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000520214ENST00000368699ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000520214ENST00000491177ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000523399ENST00000339556ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000523399ENST00000392622ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000523399ENST00000392623ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000523399ENST00000440685ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000523399ENST00000368699ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000523399ENST00000491177ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000517307ENST00000339556ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000517307ENST00000392622ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000517307ENST00000392623ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000517307ENST00000440685ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000517307ENST00000368699ZFATchr8

135490351

-S100A13chr1

153604392

+
intron-intronENST00000517307ENST00000491177ZFATchr8

135490351

-S100A13chr1

153604392

+

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FusionProtFeatures for ZFAT_S100A13


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZFAT

Q9P243

S100A13

Q99584

Plays a role in the export of proteins that lack asignal peptide and are secreted by an alternative pathway. Bindstwo calcium ions per subunit. Binds one copper ion. Binding of onecopper ion does not interfere with calcium binding. Required forthe copper-dependent stress-induced export of IL1A and FGF1. Thecalcium-free protein binds to lipid vesicles containingphosphatidylserine, but not to vesicles containingphosphatidylcholine (By similarity). {ECO:0000250,ECO:0000269|PubMed:12746488, ECO:0000269|PubMed:20863990}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZFAT_S100A13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZFAT_S100A13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZFAT_S100A13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneS100A13Q99584DB00768OlopatadineProtein S100-A13small moleculeapproved
TgeneS100A13Q99584DB01164Calcium ChlorideProtein S100-A13small moleculeapproved
TgeneS100A13Q99584DB11093Calcium CitrateProtein S100-A13small moleculeapproved
TgeneS100A13Q99584DB11348Calcium PhosphateProtein S100-A13small moleculeapproved
TgeneS100A13Q99584DB01025AmlexanoxProtein S100-A13small moleculeapproved|investigational
TgeneS100A13Q99584DB01373CalciumProtein S100-A13small moleculeapproved|nutraceutical

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RelatedDiseases for ZFAT_S100A13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource