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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42775

FusionGeneSummary for ZFAS1_ZFAS1

check button Fusion gene summary
Fusion gene informationFusion gene name: ZFAS1_ZFAS1
Fusion gene ID: 42775
HgeneTgene
Gene symbol

ZFAS1

ZFAS1

Gene ID

441951

441951

Gene nameZNFX1 antisense RNA 1ZNFX1 antisense RNA 1
SynonymsC20orf199|HSUP1|HSUP2|NCRNA00275|ZNFX1-AS1C20orf199|HSUP1|HSUP2|NCRNA00275|ZNFX1-AS1
Cytomap

20q13.13

20q13.13

Type of genencRNAncRNA
DescriptionZNFX1 antisense RNA 1 (non-protein coding)ZNFX1 antisense gene protein 1ZNFX1 antisense RNA 1 (non-protein coding)ZNFX1 antisense gene protein 1
Modification date2018051920180519
UniProtAcc

Ensembl transtripts involved in fusion geneENST00000371743, ENST00000450535, 
ENST00000441722, ENST00000417721, 
ENST00000458653, ENST00000326677, 
ENST00000428008, 
ENST00000371743, 
ENST00000450535, ENST00000441722, 
ENST00000417721, ENST00000458653, 
ENST00000326677, ENST00000428008, 
Fusion gene scores* DoF score8 X 8 X 2=1284 X 4 X 3=48
# samples 94
** MAII scorelog2(9/128*10)=-0.508146903670325
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZFAS1 [Title/Abstract] AND ZFAS1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AJ712898ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000371743ENST00000371743ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
3UTR-3UTRENST00000371743ENST00000450535ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
3UTR-intronENST00000371743ENST00000441722ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
3UTR-intronENST00000371743ENST00000417721ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
3UTR-3UTRENST00000371743ENST00000458653ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
3UTR-intronENST00000371743ENST00000326677ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
3UTR-3UTRENST00000371743ENST00000428008ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
3UTR-3UTRENST00000450535ENST00000371743ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
3UTR-3UTRENST00000450535ENST00000450535ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
3UTR-intronENST00000450535ENST00000441722ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
3UTR-intronENST00000450535ENST00000417721ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
3UTR-3UTRENST00000450535ENST00000458653ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
3UTR-intronENST00000450535ENST00000326677ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
3UTR-3UTRENST00000450535ENST00000428008ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
intron-3UTRENST00000441722ENST00000371743ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
intron-3UTRENST00000441722ENST00000450535ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
intron-intronENST00000441722ENST00000441722ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
intron-intronENST00000441722ENST00000417721ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
intron-3UTRENST00000441722ENST00000458653ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
intron-intronENST00000441722ENST00000326677ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
intron-3UTRENST00000441722ENST00000428008ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
intron-3UTRENST00000417721ENST00000371743ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
intron-3UTRENST00000417721ENST00000450535ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
intron-intronENST00000417721ENST00000441722ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
intron-intronENST00000417721ENST00000417721ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
intron-3UTRENST00000417721ENST00000458653ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
intron-intronENST00000417721ENST00000326677ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
intron-3UTRENST00000417721ENST00000428008ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
3UTR-3UTRENST00000458653ENST00000371743ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
3UTR-3UTRENST00000458653ENST00000450535ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
3UTR-intronENST00000458653ENST00000441722ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
3UTR-intronENST00000458653ENST00000417721ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
3UTR-3UTRENST00000458653ENST00000458653ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
3UTR-intronENST00000458653ENST00000326677ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
3UTR-3UTRENST00000458653ENST00000428008ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
intron-3UTRENST00000326677ENST00000371743ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
intron-3UTRENST00000326677ENST00000450535ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
intron-intronENST00000326677ENST00000441722ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
intron-intronENST00000326677ENST00000417721ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
intron-3UTRENST00000326677ENST00000458653ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
intron-intronENST00000326677ENST00000326677ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
intron-3UTRENST00000326677ENST00000428008ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
3UTR-3UTRENST00000428008ENST00000371743ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
3UTR-3UTRENST00000428008ENST00000450535ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
3UTR-intronENST00000428008ENST00000441722ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
3UTR-intronENST00000428008ENST00000417721ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
3UTR-3UTRENST00000428008ENST00000458653ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
3UTR-intronENST00000428008ENST00000326677ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+
3UTR-3UTRENST00000428008ENST00000428008ZFAS1chr20

47897446

-ZFAS1chr20

47897474

+

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FusionProtFeatures for ZFAS1_ZFAS1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZFAS1

ZFAS1

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZFAS1_ZFAS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZFAS1_ZFAS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZFAS1_ZFAS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZFAS1_ZFAS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource