	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 42746

FusionGeneSummary for ZFAND2B_ZFAND2B

Fusion gene summary

Fusion gene information	Fusion gene name: ZFAND2B_ZFAND2B
	Fusion gene ID: 42746
		Hgene	Tgene
	Gene symbol	ZFAND2B	ZFAND2B
	Gene ID	130617	130617
	Gene name	zinc finger AN1-type containing 2B	zinc finger AN1-type containing 2B
	Synonyms	AIRAPL	AIRAPL
	Cytomap	2q35	2q35
	Type of gene	protein-coding	protein-coding
	Description	AN1-type zinc finger protein 2BAIRAP-like proteinarsenite-inducible RNA-associated protein-like proteinzinc finger, AN1-type domain 2B	AN1-type zinc finger protein 2BAIRAP-like proteinarsenite-inducible RNA-associated protein-like proteinzinc finger, AN1-type domain 2B
	Modification date	20180523	20180523
	UniProtAcc	Q8WV99	Q8WV99
	Ensembl transtripts involved in fusion gene	ENST00000409206, ENST00000409594, ENST00000289528, ENST00000409412, ENST00000409097, ENST00000409336, ENST00000409217, ENST00000468301, ENST00000409319, ENST00000444522,	ENST00000409206, ENST00000409594, ENST00000289528, ENST00000409412, ENST00000409097, ENST00000409336, ENST00000409217, ENST00000468301, ENST00000409319, ENST00000444522,
Fusion gene scores	* DoF score	2 X 3 X 2=12	2 X 3 X 1=6
	# samples	4	4
	** MAII score	log2(4/12*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(4/6*10)=2.73696559416621
Context	PubMed: ZFAND2B [Title/Abstract] AND ZFAND2B [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AW968850	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
ChiTaRS3.1			AA490922	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
ChiTaRS3.1			AA491105	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3UTR	ENST00000409206	ENST00000409206	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-3UTR	ENST00000409206	ENST00000409594	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-3UTR	ENST00000409206	ENST00000289528	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000409206	ENST00000409412	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000409206	ENST00000409097	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000409206	ENST00000409336	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000409206	ENST00000409217	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000409206	ENST00000468301	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000409206	ENST00000409319	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000409206	ENST00000444522	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
3UTR-3UTR	ENST00000409594	ENST00000409206	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
3UTR-3UTR	ENST00000409594	ENST00000409594	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
3UTR-3UTR	ENST00000409594	ENST00000289528	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
3UTR-intron	ENST00000409594	ENST00000409412	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
3UTR-intron	ENST00000409594	ENST00000409097	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
3UTR-intron	ENST00000409594	ENST00000409336	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
3UTR-intron	ENST00000409594	ENST00000409217	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
3UTR-intron	ENST00000409594	ENST00000468301	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
3UTR-intron	ENST00000409594	ENST00000409319	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
3UTR-intron	ENST00000409594	ENST00000444522	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
3UTR-3UTR	ENST00000289528	ENST00000409206	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
3UTR-3UTR	ENST00000289528	ENST00000409594	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
3UTR-3UTR	ENST00000289528	ENST00000289528	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
3UTR-intron	ENST00000289528	ENST00000409412	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
3UTR-intron	ENST00000289528	ENST00000409097	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
3UTR-intron	ENST00000289528	ENST00000409336	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
3UTR-intron	ENST00000289528	ENST00000409217	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
3UTR-intron	ENST00000289528	ENST00000468301	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
3UTR-intron	ENST00000289528	ENST00000409319	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
3UTR-intron	ENST00000289528	ENST00000444522	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-3UTR	ENST00000409412	ENST00000409206	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-3UTR	ENST00000409412	ENST00000409594	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-3UTR	ENST00000409412	ENST00000289528	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000409412	ENST00000409412	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000409412	ENST00000409097	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000409412	ENST00000409336	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000409412	ENST00000409217	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000409412	ENST00000468301	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000409412	ENST00000409319	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000409412	ENST00000444522	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
3UTR-3UTR	ENST00000409097	ENST00000409206	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
3UTR-3UTR	ENST00000409097	ENST00000409594	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
3UTR-3UTR	ENST00000409097	ENST00000289528	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
3UTR-intron	ENST00000409097	ENST00000409412	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
3UTR-intron	ENST00000409097	ENST00000409097	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
3UTR-intron	ENST00000409097	ENST00000409336	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
3UTR-intron	ENST00000409097	ENST00000409217	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
3UTR-intron	ENST00000409097	ENST00000468301	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
3UTR-intron	ENST00000409097	ENST00000409319	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
3UTR-intron	ENST00000409097	ENST00000444522	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
5CDS-3UTR	ENST00000409336	ENST00000409206	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
5CDS-3UTR	ENST00000409336	ENST00000409594	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
5CDS-3UTR	ENST00000409336	ENST00000289528	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
5CDS-intron	ENST00000409336	ENST00000409412	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
5CDS-intron	ENST00000409336	ENST00000409097	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
5CDS-intron	ENST00000409336	ENST00000409336	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
5CDS-intron	ENST00000409336	ENST00000409217	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
5CDS-intron	ENST00000409336	ENST00000468301	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
5CDS-intron	ENST00000409336	ENST00000409319	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
5CDS-intron	ENST00000409336	ENST00000444522	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-3UTR	ENST00000409217	ENST00000409206	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-3UTR	ENST00000409217	ENST00000409594	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-3UTR	ENST00000409217	ENST00000289528	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000409217	ENST00000409412	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000409217	ENST00000409097	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000409217	ENST00000409336	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000409217	ENST00000409217	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000409217	ENST00000468301	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000409217	ENST00000409319	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000409217	ENST00000444522	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-3UTR	ENST00000468301	ENST00000409206	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-3UTR	ENST00000468301	ENST00000409594	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-3UTR	ENST00000468301	ENST00000289528	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000468301	ENST00000409412	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000468301	ENST00000409097	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000468301	ENST00000409336	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000468301	ENST00000409217	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000468301	ENST00000468301	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000468301	ENST00000409319	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000468301	ENST00000444522	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-3UTR	ENST00000409319	ENST00000409206	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-3UTR	ENST00000409319	ENST00000409594	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-3UTR	ENST00000409319	ENST00000289528	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000409319	ENST00000409412	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000409319	ENST00000409097	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000409319	ENST00000409336	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000409319	ENST00000409217	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000409319	ENST00000468301	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000409319	ENST00000409319	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000409319	ENST00000444522	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-3UTR	ENST00000444522	ENST00000409206	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-3UTR	ENST00000444522	ENST00000409594	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-3UTR	ENST00000444522	ENST00000289528	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000444522	ENST00000409412	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000444522	ENST00000409097	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000444522	ENST00000409336	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000444522	ENST00000409217	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000444522	ENST00000468301	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000444522	ENST00000409319	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
intron-intron	ENST00000444522	ENST00000444522	ZFAND2B	chr2	220074145	-	ZFAND2B	chr2	220073150	+
3UTR-intron	ENST00000409206	ENST00000409206	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
3UTR-3UTR	ENST00000409206	ENST00000409594	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
3UTR-3UTR	ENST00000409206	ENST00000289528	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
3UTR-intron	ENST00000409206	ENST00000409412	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
3UTR-3UTR	ENST00000409206	ENST00000409097	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
3UTR-intron	ENST00000409206	ENST00000409336	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
3UTR-intron	ENST00000409206	ENST00000409217	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
3UTR-intron	ENST00000409206	ENST00000468301	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
3UTR-intron	ENST00000409206	ENST00000409319	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
3UTR-intron	ENST00000409206	ENST00000444522	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
3UTR-intron	ENST00000409594	ENST00000409206	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
3UTR-3UTR	ENST00000409594	ENST00000409594	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
3UTR-3UTR	ENST00000409594	ENST00000289528	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
3UTR-intron	ENST00000409594	ENST00000409412	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
3UTR-3UTR	ENST00000409594	ENST00000409097	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
3UTR-intron	ENST00000409594	ENST00000409336	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
3UTR-intron	ENST00000409594	ENST00000409217	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
3UTR-intron	ENST00000409594	ENST00000468301	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
3UTR-intron	ENST00000409594	ENST00000409319	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
3UTR-intron	ENST00000409594	ENST00000444522	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000289528	ENST00000409206	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-3UTR	ENST00000289528	ENST00000409594	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-3UTR	ENST00000289528	ENST00000289528	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000289528	ENST00000409412	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-3UTR	ENST00000289528	ENST00000409097	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000289528	ENST00000409336	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000289528	ENST00000409217	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000289528	ENST00000468301	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000289528	ENST00000409319	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000289528	ENST00000444522	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000409412	ENST00000409206	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-3UTR	ENST00000409412	ENST00000409594	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-3UTR	ENST00000409412	ENST00000289528	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000409412	ENST00000409412	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-3UTR	ENST00000409412	ENST00000409097	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000409412	ENST00000409336	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000409412	ENST00000409217	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000409412	ENST00000468301	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000409412	ENST00000409319	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000409412	ENST00000444522	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000409097	ENST00000409206	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-3UTR	ENST00000409097	ENST00000409594	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-3UTR	ENST00000409097	ENST00000289528	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000409097	ENST00000409412	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-3UTR	ENST00000409097	ENST00000409097	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000409097	ENST00000409336	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000409097	ENST00000409217	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000409097	ENST00000468301	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000409097	ENST00000409319	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000409097	ENST00000444522	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000409336	ENST00000409206	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-3UTR	ENST00000409336	ENST00000409594	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-3UTR	ENST00000409336	ENST00000289528	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000409336	ENST00000409412	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-3UTR	ENST00000409336	ENST00000409097	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000409336	ENST00000409336	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000409336	ENST00000409217	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000409336	ENST00000468301	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000409336	ENST00000409319	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000409336	ENST00000444522	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000409217	ENST00000409206	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-3UTR	ENST00000409217	ENST00000409594	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-3UTR	ENST00000409217	ENST00000289528	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000409217	ENST00000409412	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-3UTR	ENST00000409217	ENST00000409097	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000409217	ENST00000409336	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000409217	ENST00000409217	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000409217	ENST00000468301	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000409217	ENST00000409319	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000409217	ENST00000444522	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000468301	ENST00000409206	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-3UTR	ENST00000468301	ENST00000409594	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-3UTR	ENST00000468301	ENST00000289528	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000468301	ENST00000409412	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-3UTR	ENST00000468301	ENST00000409097	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000468301	ENST00000409336	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000468301	ENST00000409217	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000468301	ENST00000468301	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000468301	ENST00000409319	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000468301	ENST00000444522	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000409319	ENST00000409206	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-3UTR	ENST00000409319	ENST00000409594	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-3UTR	ENST00000409319	ENST00000289528	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000409319	ENST00000409412	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-3UTR	ENST00000409319	ENST00000409097	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000409319	ENST00000409336	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000409319	ENST00000409217	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000409319	ENST00000468301	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000409319	ENST00000409319	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000409319	ENST00000444522	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000444522	ENST00000409206	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-3UTR	ENST00000444522	ENST00000409594	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-3UTR	ENST00000444522	ENST00000289528	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000444522	ENST00000409412	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-3UTR	ENST00000444522	ENST00000409097	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000444522	ENST00000409336	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000444522	ENST00000409217	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000444522	ENST00000468301	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000444522	ENST00000409319	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+
intron-intron	ENST00000444522	ENST00000444522	ZFAND2B	chr2	220073150	-	ZFAND2B	chr2	220074145	+

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FusionProtFeatures for ZFAND2B_ZFAND2B

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ZFAND2B Q8WV99	ZFAND2B Q8WV99
Plays a role in protein homeostasis by regulating boththe translocation and the ubiquitin-mediated proteasomaldegradation of nascent proteins at the endoplasmic reticulum. Itis involved in the regulation of signal-mediated translocation ofproteins into the endoplasmic reticulum. It also plays a role inthe ubiquitin-mediated proteasomal degradation of proteins forwhich signal-mediated translocation to the endoplasmic reticulumhas failed. May therefore function in the endoplasmic reticulumstress-induced pre-emptive quality control, a mechanism thatselectively attenuates the translocation of newly synthesizedproteins into the endoplasmic reticulum and reroutes them to thecytosol for proteasomal degradation (By similarity). Bycontrolling the steady-state expression of the IGF1R receptor,indirectly regulates the insulin-like growth factor receptorsignaling pathway (PubMed:26692333).{ECO:0000250\|UniProtKB:Q91X58, ECO:0000269\|PubMed:26692333}.	Plays a role in protein homeostasis by regulating boththe translocation and the ubiquitin-mediated proteasomaldegradation of nascent proteins at the endoplasmic reticulum. Itis involved in the regulation of signal-mediated translocation ofproteins into the endoplasmic reticulum. It also plays a role inthe ubiquitin-mediated proteasomal degradation of proteins forwhich signal-mediated translocation to the endoplasmic reticulumhas failed. May therefore function in the endoplasmic reticulumstress-induced pre-emptive quality control, a mechanism thatselectively attenuates the translocation of newly synthesizedproteins into the endoplasmic reticulum and reroutes them to thecytosol for proteasomal degradation (By similarity). Bycontrolling the steady-state expression of the IGF1R receptor,indirectly regulates the insulin-like growth factor receptorsignaling pathway (PubMed:26692333).{ECO:0000250\|UniProtKB:Q91X58, ECO:0000269\|PubMed:26692333}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for ZFAND2B_ZFAND2B

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZFAND2B_ZFAND2B

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for ZFAND2B_ZFAND2B

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for ZFAND2B_ZFAND2B

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Statistics

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Fusion gene ID: 42746

FusionGeneSummary for ZFAND2B_ZFAND2B

FusionProtFeatures for ZFAND2B_ZFAND2B

FusionGeneSequence for ZFAND2B_ZFAND2B

FusionGenePPI for ZFAND2B_ZFAND2B

RelatedDrugs for ZFAND2B_ZFAND2B

RelatedDiseases for ZFAND2B_ZFAND2B