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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42736

FusionGeneSummary for ZEB2_RBFOX1

check button Fusion gene summary
Fusion gene informationFusion gene name: ZEB2_RBFOX1
Fusion gene ID: 42736
HgeneTgene
Gene symbol

ZEB2

RBFOX1

Gene ID

9839

54715

Gene namezinc finger E-box binding homeobox 2RNA binding fox-1 homolog 1
SynonymsHSPC082|SIP-1|SIP1|SMADIP1|ZFHX1B2BP1|A2BP1|FOX-1|FOX1|HRNBP1
Cytomap

2q22.3

16p13.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger E-box-binding homeobox 2SMAD interacting protein 1Smad-interacting protein 1zinc finger homeobox 1bRNA binding protein fox-1 homolog 1RNA binding protein, fox-1 homolog 1ataxin 2-binding protein 1fox-1 homolog Afox-1-like RNA-binding protein 1hexaribonucleotide binding protein 1 isoform alphahexaribonucleotide binding protein 1 isoform betahexar
Modification date2018051920180523
UniProtAcc

O60315

Q9NWB1

Ensembl transtripts involved in fusion geneENST00000558170, ENST00000409487, 
ENST00000303660, ENST00000539609, 
ENST00000493689, ENST00000470879, 
ENST00000465070, ENST00000462355, 
ENST00000550418, ENST00000553186, 
ENST00000547372, ENST00000422070, 
ENST00000535565, ENST00000547427, 
ENST00000552089, ENST00000547338, 
ENST00000436368, ENST00000311745, 
ENST00000355637, ENST00000340209, 
Fusion gene scores* DoF score5 X 5 X 2=5014 X 12 X 6=1008
# samples 514
** MAII scorelog2(5/50*10)=0log2(14/1008*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZEB2 [Title/Abstract] AND RBFOX1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZEB2

GO:0000122

negative regulation of transcription by RNA polymerase II

12837246|20516212


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF948186ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000558170ENST00000550418ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000558170ENST00000553186ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000558170ENST00000547372ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000558170ENST00000422070ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000558170ENST00000535565ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000558170ENST00000547427ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000558170ENST00000552089ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000558170ENST00000547338ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000558170ENST00000436368ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000558170ENST00000311745ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000558170ENST00000355637ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000558170ENST00000340209ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000409487ENST00000550418ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000409487ENST00000553186ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000409487ENST00000547372ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000409487ENST00000422070ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000409487ENST00000535565ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000409487ENST00000547427ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000409487ENST00000552089ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000409487ENST00000547338ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000409487ENST00000436368ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000409487ENST00000311745ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000409487ENST00000355637ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000409487ENST00000340209ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000303660ENST00000550418ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000303660ENST00000553186ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000303660ENST00000547372ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000303660ENST00000422070ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000303660ENST00000535565ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000303660ENST00000547427ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000303660ENST00000552089ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000303660ENST00000547338ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000303660ENST00000436368ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000303660ENST00000311745ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000303660ENST00000355637ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000303660ENST00000340209ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000539609ENST00000550418ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000539609ENST00000553186ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000539609ENST00000547372ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000539609ENST00000422070ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000539609ENST00000535565ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000539609ENST00000547427ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000539609ENST00000552089ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000539609ENST00000547338ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000539609ENST00000436368ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000539609ENST00000311745ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000539609ENST00000355637ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000539609ENST00000340209ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000493689ENST00000550418ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000493689ENST00000553186ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000493689ENST00000547372ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000493689ENST00000422070ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000493689ENST00000535565ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000493689ENST00000547427ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000493689ENST00000552089ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000493689ENST00000547338ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000493689ENST00000436368ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000493689ENST00000311745ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000493689ENST00000355637ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000493689ENST00000340209ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000470879ENST00000550418ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000470879ENST00000553186ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000470879ENST00000547372ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000470879ENST00000422070ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000470879ENST00000535565ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000470879ENST00000547427ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000470879ENST00000552089ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000470879ENST00000547338ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000470879ENST00000436368ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000470879ENST00000311745ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000470879ENST00000355637ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000470879ENST00000340209ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000465070ENST00000550418ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000465070ENST00000553186ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000465070ENST00000547372ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000465070ENST00000422070ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000465070ENST00000535565ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000465070ENST00000547427ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000465070ENST00000552089ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000465070ENST00000547338ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000465070ENST00000436368ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000465070ENST00000311745ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000465070ENST00000355637ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000465070ENST00000340209ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000462355ENST00000550418ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000462355ENST00000553186ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000462355ENST00000547372ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000462355ENST00000422070ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000462355ENST00000535565ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000462355ENST00000547427ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000462355ENST00000552089ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000462355ENST00000547338ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000462355ENST00000436368ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000462355ENST00000311745ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000462355ENST00000355637ZEB2chr2

145156278

+RBFOX1chr16

7055658

-
intron-intronENST00000462355ENST00000340209ZEB2chr2

145156278

+RBFOX1chr16

7055658

-

Top

FusionProtFeatures for ZEB2_RBFOX1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZEB2

O60315

RBFOX1

Q9NWB1

Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin. {ECO:0000269|PubMed:16061479}. RNA-binding protein that regulates alternative splicingevents by binding to 5'-UGCAUGU-3' elements. Regulates alternativesplicing of tissue-specific exons and of differentially splicedexons during erythropoiesis. {ECO:0000269|PubMed:16537540}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZEB2_RBFOX1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ZEB2_RBFOX1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ZEB2_RBFOX1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ZEB2_RBFOX1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneZEB2C1856113Mowat-Wilson syndrome5CTD_human;UNIPROT
HgeneZEB2C0007621Neoplastic Cell Transformation1CTD_human
HgeneZEB2C0018798Congenital Heart Defects1CTD_human
HgeneZEB2C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneZEB2C0027626Neoplasm Invasiveness1CTD_human
HgeneZEB2C1458155Mammary Neoplasms1CTD_human
TgeneRBFOX1C0004352Autistic Disorder2CTD_human
TgeneRBFOX1C0036572Seizures1CTD_human