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Fusion gene ID: 42729 |
FusionGeneSummary for ZEB1_SYT1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZEB1_SYT1 | Fusion gene ID: 42729 | Hgene | Tgene | Gene symbol | ZEB1 | SYT1 | Gene ID | 6935 | 6857 |
| Gene name | zinc finger E-box binding homeobox 1 | synaptotagmin 1 | |
| Synonyms | AREB6|BZP|DELTAEF1|FECD6|NIL2A|PPCD3|TCF8|ZFHEP|ZFHX1A | P65|SVP65|SYT | |
| Cytomap | 10p11.22 | 12q21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger E-box-binding homeobox 1delta-crystallin enhancer binding factor 1negative regulator of IL2posterior polymorphous corneal dystrophy 3transcription factor 8 (represses interleukin 2 expression)zinc finger homeodomain enhancer-binding prote | synaptotagmin-1synaptotagmin IsytI | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | P37275 | P21579 | |
| Ensembl transtripts involved in fusion gene | ENST00000320985, ENST00000361642, ENST00000559858, ENST00000560721, ENST00000542815, ENST00000446923, | ENST00000393240, ENST00000261205, ENST00000457153, ENST00000552744, ENST00000549454, | |
| Fusion gene scores | * DoF score | 5 X 4 X 3=60 | 15 X 9 X 6=810 |
| # samples | 6 | 16 | |
| ** MAII score | log2(6/60*10)=0 | log2(16/810*10)=-2.33985000288462 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ZEB1 [Title/Abstract] AND SYT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ZEB1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 23765923|23814079 |
| Hgene | ZEB1 | GO:0045892 | negative regulation of transcription, DNA-templated | 20418909 |
| Tgene | SYT1 | GO:1903861 | positive regulation of dendrite extension | 23999003 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-A6BG-01A | ZEB1 | chr10 | 31608221 | + | SYT1 | chr12 | 79258778 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000320985 | ENST00000393240 | ZEB1 | chr10 | 31608221 | + | SYT1 | chr12 | 79258778 | + |
| 5CDS-5UTR | ENST00000320985 | ENST00000261205 | ZEB1 | chr10 | 31608221 | + | SYT1 | chr12 | 79258778 | + |
| 5CDS-5UTR | ENST00000320985 | ENST00000457153 | ZEB1 | chr10 | 31608221 | + | SYT1 | chr12 | 79258778 | + |
| 5CDS-intron | ENST00000320985 | ENST00000552744 | ZEB1 | chr10 | 31608221 | + | SYT1 | chr12 | 79258778 | + |
| 5CDS-intron | ENST00000320985 | ENST00000549454 | ZEB1 | chr10 | 31608221 | + | SYT1 | chr12 | 79258778 | + |
| 5CDS-5UTR | ENST00000361642 | ENST00000393240 | ZEB1 | chr10 | 31608221 | + | SYT1 | chr12 | 79258778 | + |
| 5CDS-5UTR | ENST00000361642 | ENST00000261205 | ZEB1 | chr10 | 31608221 | + | SYT1 | chr12 | 79258778 | + |
| 5CDS-5UTR | ENST00000361642 | ENST00000457153 | ZEB1 | chr10 | 31608221 | + | SYT1 | chr12 | 79258778 | + |
| 5CDS-intron | ENST00000361642 | ENST00000552744 | ZEB1 | chr10 | 31608221 | + | SYT1 | chr12 | 79258778 | + |
| 5CDS-intron | ENST00000361642 | ENST00000549454 | ZEB1 | chr10 | 31608221 | + | SYT1 | chr12 | 79258778 | + |
| 3UTR-5UTR | ENST00000559858 | ENST00000393240 | ZEB1 | chr10 | 31608221 | + | SYT1 | chr12 | 79258778 | + |
| 3UTR-5UTR | ENST00000559858 | ENST00000261205 | ZEB1 | chr10 | 31608221 | + | SYT1 | chr12 | 79258778 | + |
| 3UTR-5UTR | ENST00000559858 | ENST00000457153 | ZEB1 | chr10 | 31608221 | + | SYT1 | chr12 | 79258778 | + |
| 3UTR-intron | ENST00000559858 | ENST00000552744 | ZEB1 | chr10 | 31608221 | + | SYT1 | chr12 | 79258778 | + |
| 3UTR-intron | ENST00000559858 | ENST00000549454 | ZEB1 | chr10 | 31608221 | + | SYT1 | chr12 | 79258778 | + |
| 5CDS-5UTR | ENST00000560721 | ENST00000393240 | ZEB1 | chr10 | 31608221 | + | SYT1 | chr12 | 79258778 | + |
| 5CDS-5UTR | ENST00000560721 | ENST00000261205 | ZEB1 | chr10 | 31608221 | + | SYT1 | chr12 | 79258778 | + |
| 5CDS-5UTR | ENST00000560721 | ENST00000457153 | ZEB1 | chr10 | 31608221 | + | SYT1 | chr12 | 79258778 | + |
| 5CDS-intron | ENST00000560721 | ENST00000552744 | ZEB1 | chr10 | 31608221 | + | SYT1 | chr12 | 79258778 | + |
| 5CDS-intron | ENST00000560721 | ENST00000549454 | ZEB1 | chr10 | 31608221 | + | SYT1 | chr12 | 79258778 | + |
| 5CDS-5UTR | ENST00000542815 | ENST00000393240 | ZEB1 | chr10 | 31608221 | + | SYT1 | chr12 | 79258778 | + |
| 5CDS-5UTR | ENST00000542815 | ENST00000261205 | ZEB1 | chr10 | 31608221 | + | SYT1 | chr12 | 79258778 | + |
| 5CDS-5UTR | ENST00000542815 | ENST00000457153 | ZEB1 | chr10 | 31608221 | + | SYT1 | chr12 | 79258778 | + |
| 5CDS-intron | ENST00000542815 | ENST00000552744 | ZEB1 | chr10 | 31608221 | + | SYT1 | chr12 | 79258778 | + |
| 5CDS-intron | ENST00000542815 | ENST00000549454 | ZEB1 | chr10 | 31608221 | + | SYT1 | chr12 | 79258778 | + |
| intron-5UTR | ENST00000446923 | ENST00000393240 | ZEB1 | chr10 | 31608221 | + | SYT1 | chr12 | 79258778 | + |
| intron-5UTR | ENST00000446923 | ENST00000261205 | ZEB1 | chr10 | 31608221 | + | SYT1 | chr12 | 79258778 | + |
| intron-5UTR | ENST00000446923 | ENST00000457153 | ZEB1 | chr10 | 31608221 | + | SYT1 | chr12 | 79258778 | + |
| intron-intron | ENST00000446923 | ENST00000552744 | ZEB1 | chr10 | 31608221 | + | SYT1 | chr12 | 79258778 | + |
| intron-intron | ENST00000446923 | ENST00000549454 | ZEB1 | chr10 | 31608221 | + | SYT1 | chr12 | 79258778 | + |
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FusionProtFeatures for ZEB1_SYT1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZEB1 | SYT1 |
| May have a regulatory role in the membrane interactionsduring trafficking of synaptic vesicles at the active zone of thesynapse. It binds acidic phospholipids with a specificity thatrequires the presence of both an acidic head group and a diacylbackbone. A Ca(2+)-dependent interaction between synaptotagmin andputative receptors for activated protein kinase C has also beenreported. It can bind to at least three additional proteins in aCa(2+)-independent manner; these are neurexins, syntaxin and AP2.Plays a role in dendrite formation by melanocytes(PubMed:23999003). {ECO:0000269|PubMed:23999003}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZEB1_SYT1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZEB1_SYT1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ZEB1 | DRAP1, KAT5, SMAD2, SMAD3, SMAD1, CTBP1, CTBP2, SERPINH1, SMARCA4, SMAD6, SMAD7, SIRT1, SOX2, UBR4, GTF2A1, CDK6, EP300, CREBBP, USP7, CHEK1, ATM, DCAF15, EWSR1, SYNCRIP, MPHOSPH8, ZMIZ1, USP10, USP13, USP26, USP29, USP42, USP51, PAN2, USP53, USP54, UCHL3, VCPIP1 | SYT1 | SV2B, C6orf15, SV2C, GOLM1, S100A13, CALM1, STX1A, STON2, SYNCRIP, SNAP25, CACNA1A, STX2, STX3, STX4, FGF1, IKBKG, RBM14, SIN3A, NEDD4, VAMP2, SMAD2, ARMC1, HAX1, NUFIP1, DGUOK, DNAAF2, SYT5, NTRK1, SYT2, VLDLR, CWC22, EIF2B3, EIF2B5, EIF2B4, PGK2, EIF2B2, LRP2, CDCA8, RRP7A |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZEB1_SYT1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZEB1_SYT1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ZEB1 | C2750448 | CORNEAL DYSTROPHY, FUCHS ENDOTHELIAL, 6 | 3 | CTD_human;UNIPROT |
| Hgene | ZEB1 | C1458155 | Mammary Neoplasms | 2 | CTD_human |
| Hgene | ZEB1 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
| Hgene | ZEB1 | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
| Hgene | ZEB1 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| Hgene | ZEB1 | C0029172 | Oral Submucous Fibrosis | 1 | CTD_human |
| Hgene | ZEB1 | C0036920 | Sezary Syndrome | 1 | CTD_human |
| Hgene | ZEB1 | C0079773 | Lymphoma, T-Cell, Cutaneous | 1 | CTD_human |
| Hgene | ZEB1 | C0151744 | Myocardial Ischemia | 1 | CTD_human |
| Hgene | ZEB1 | C0919267 | ovarian neoplasm | 1 | CTD_human |
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