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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42727

FusionGeneSummary for ZEB1_MSRB2

check button Fusion gene summary
Fusion gene informationFusion gene name: ZEB1_MSRB2
Fusion gene ID: 42727
HgeneTgene
Gene symbol

ZEB1

MSRB2

Gene ID

6935

22921

Gene namezinc finger E-box binding homeobox 1methionine sulfoxide reductase B2
SynonymsAREB6|BZP|DELTAEF1|FECD6|NIL2A|PPCD3|TCF8|ZFHEP|ZFHX1ACBS-1|CBS1|CGI-131|MSRB|PILB
Cytomap

10p11.22

10p12.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger E-box-binding homeobox 1delta-crystallin enhancer binding factor 1negative regulator of IL2posterior polymorphous corneal dystrophy 3transcription factor 8 (represses interleukin 2 expression)zinc finger homeodomain enhancer-binding protemethionine-R-sulfoxide reductase B2, mitochondrialpilin-like transcription factor
Modification date2018052720180523
UniProtAcc

P37275

Q9Y3D2

Ensembl transtripts involved in fusion geneENST00000320985, ENST00000361642, 
ENST00000559858, ENST00000560721, 
ENST00000542815, ENST00000446923, 
ENST00000376510, ENST00000468633, 
Fusion gene scores* DoF score5 X 4 X 3=602 X 1 X 2=4
# samples 62
** MAII scorelog2(6/60*10)=0log2(2/4*10)=2.32192809488736
Context

PubMed: ZEB1 [Title/Abstract] AND MSRB2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZEB1

GO:0000122

negative regulation of transcription by RNA polymerase II

23765923|23814079

HgeneZEB1

GO:0045892

negative regulation of transcription, DNA-templated

20418909


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-QQ-A5VC-01AZEB1chr10

31608221

+MSRB2chr10

23399171

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000320985ENST00000376510ZEB1chr10

31608221

+MSRB2chr10

23399171

+
5CDS-intronENST00000320985ENST00000468633ZEB1chr10

31608221

+MSRB2chr10

23399171

+
Frame-shitENST00000361642ENST00000376510ZEB1chr10

31608221

+MSRB2chr10

23399171

+
5CDS-intronENST00000361642ENST00000468633ZEB1chr10

31608221

+MSRB2chr10

23399171

+
3UTR-3CDSENST00000559858ENST00000376510ZEB1chr10

31608221

+MSRB2chr10

23399171

+
3UTR-intronENST00000559858ENST00000468633ZEB1chr10

31608221

+MSRB2chr10

23399171

+
Frame-shitENST00000560721ENST00000376510ZEB1chr10

31608221

+MSRB2chr10

23399171

+
5CDS-intronENST00000560721ENST00000468633ZEB1chr10

31608221

+MSRB2chr10

23399171

+
Frame-shitENST00000542815ENST00000376510ZEB1chr10

31608221

+MSRB2chr10

23399171

+
5CDS-intronENST00000542815ENST00000468633ZEB1chr10

31608221

+MSRB2chr10

23399171

+
intron-3CDSENST00000446923ENST00000376510ZEB1chr10

31608221

+MSRB2chr10

23399171

+
intron-intronENST00000446923ENST00000468633ZEB1chr10

31608221

+MSRB2chr10

23399171

+

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FusionProtFeatures for ZEB1_MSRB2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZEB1

P37275

MSRB2

Q9Y3D2

Methionine-sulfoxide reductase that specifically reducesmethionine (R)-sulfoxide back to methionine. While in many cases,methionine oxidation is the result of random oxidation followingoxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue.Upon oxidative stress, may play a role in the preservation ofmitochondrial integrity by decreasing the intracellular reactiveoxygen species build-up through its scavenging role, hencecontributing to cell survival and protein maintenance.{ECO:0000269|PubMed:18424444}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZEB1_MSRB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZEB1_MSRB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZEB1DRAP1, KAT5, SMAD2, SMAD3, SMAD1, CTBP1, CTBP2, SERPINH1, SMARCA4, SMAD6, SMAD7, SIRT1, SOX2, UBR4, GTF2A1, CDK6, EP300, CREBBP, USP7, CHEK1, ATM, DCAF15, EWSR1, SYNCRIP, MPHOSPH8, ZMIZ1, USP10, USP13, USP26, USP29, USP42, USP51, PAN2, USP53, USP54, UCHL3, VCPIP1MSRB2RAD21, ELAVL1, NEDD8, ADAM10, ZDHHC17, C14orf159, CECR5


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZEB1_MSRB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZEB1_MSRB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneZEB1C2750448CORNEAL DYSTROPHY, FUCHS ENDOTHELIAL, 63CTD_human;UNIPROT
HgeneZEB1C1458155Mammary Neoplasms2CTD_human
HgeneZEB1C0007621Neoplastic Cell Transformation1CTD_human
HgeneZEB1C0014170Endometrial Neoplasms1CTD_human
HgeneZEB1C0027626Neoplasm Invasiveness1CTD_human
HgeneZEB1C0029172Oral Submucous Fibrosis1CTD_human
HgeneZEB1C0036920Sezary Syndrome1CTD_human
HgeneZEB1C0079773Lymphoma, T-Cell, Cutaneous1CTD_human
HgeneZEB1C0151744Myocardial Ischemia1CTD_human
HgeneZEB1C0919267ovarian neoplasm1CTD_human