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Fusion gene ID: 42715 |
FusionGeneSummary for ZDHHC6_ACSL5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZDHHC6_ACSL5 | Fusion gene ID: 42715 | Hgene | Tgene | Gene symbol | ZDHHC6 | ACSL5 | Gene ID | 64429 | 51703 |
| Gene name | zinc finger DHHC-type containing 6 | acyl-CoA synthetase long chain family member 5 | |
| Synonyms | DHHC-6|ZNF376 | ACS2|ACS5|FACL5 | |
| Cytomap | 10q25.2 | 10q25.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | palmitoyltransferase ZDHHC6transmembrane protein H4zinc finger DHHC domain-containing protein 6zinc finger protein 376 | long-chain-fatty-acid--CoA ligase 5FACL5 for fatty acid coenzyme A ligase 5LACS 5fatty acid coenzyme A ligase 5fatty-acid-Coenzyme A ligase, long-chain 5long-chain acyl-CoA synthetase 5long-chain fatty acid coenzyme A ligase 5 | |
| Modification date | 20180525 | 20180519 | |
| UniProtAcc | Q9H6R6 | Q9ULC5 | |
| Ensembl transtripts involved in fusion gene | ENST00000369405, ENST00000369404, ENST00000482410, | ENST00000354655, ENST00000479936, ENST00000393081, ENST00000433418, ENST00000356116, ENST00000354273, ENST00000369410, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 5 X 5 X 4=100 |
| # samples | 3 | 5 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ZDHHC6 [Title/Abstract] AND ACSL5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ZDHHC6 | GO:0018345 | protein palmitoylation | 22728137|23034182|25368151|28826475 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-44-7662-01A | ZDHHC6 | chr10 | 114200292 | - | ACSL5 | chr10 | 114168180 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000369405 | ENST00000354655 | ZDHHC6 | chr10 | 114200292 | - | ACSL5 | chr10 | 114168180 | + |
| 5CDS-3UTR | ENST00000369405 | ENST00000479936 | ZDHHC6 | chr10 | 114200292 | - | ACSL5 | chr10 | 114168180 | + |
| 5CDS-3UTR | ENST00000369405 | ENST00000393081 | ZDHHC6 | chr10 | 114200292 | - | ACSL5 | chr10 | 114168180 | + |
| 5CDS-3UTR | ENST00000369405 | ENST00000433418 | ZDHHC6 | chr10 | 114200292 | - | ACSL5 | chr10 | 114168180 | + |
| 5CDS-3UTR | ENST00000369405 | ENST00000356116 | ZDHHC6 | chr10 | 114200292 | - | ACSL5 | chr10 | 114168180 | + |
| 5CDS-3UTR | ENST00000369405 | ENST00000354273 | ZDHHC6 | chr10 | 114200292 | - | ACSL5 | chr10 | 114168180 | + |
| 5CDS-intron | ENST00000369405 | ENST00000369410 | ZDHHC6 | chr10 | 114200292 | - | ACSL5 | chr10 | 114168180 | + |
| Frame-shift | ENST00000369404 | ENST00000354655 | ZDHHC6 | chr10 | 114200292 | - | ACSL5 | chr10 | 114168180 | + |
| 5CDS-3UTR | ENST00000369404 | ENST00000479936 | ZDHHC6 | chr10 | 114200292 | - | ACSL5 | chr10 | 114168180 | + |
| 5CDS-3UTR | ENST00000369404 | ENST00000393081 | ZDHHC6 | chr10 | 114200292 | - | ACSL5 | chr10 | 114168180 | + |
| 5CDS-3UTR | ENST00000369404 | ENST00000433418 | ZDHHC6 | chr10 | 114200292 | - | ACSL5 | chr10 | 114168180 | + |
| 5CDS-3UTR | ENST00000369404 | ENST00000356116 | ZDHHC6 | chr10 | 114200292 | - | ACSL5 | chr10 | 114168180 | + |
| 5CDS-3UTR | ENST00000369404 | ENST00000354273 | ZDHHC6 | chr10 | 114200292 | - | ACSL5 | chr10 | 114168180 | + |
| 5CDS-intron | ENST00000369404 | ENST00000369410 | ZDHHC6 | chr10 | 114200292 | - | ACSL5 | chr10 | 114168180 | + |
| intron-3CDS | ENST00000482410 | ENST00000354655 | ZDHHC6 | chr10 | 114200292 | - | ACSL5 | chr10 | 114168180 | + |
| intron-3UTR | ENST00000482410 | ENST00000479936 | ZDHHC6 | chr10 | 114200292 | - | ACSL5 | chr10 | 114168180 | + |
| intron-3UTR | ENST00000482410 | ENST00000393081 | ZDHHC6 | chr10 | 114200292 | - | ACSL5 | chr10 | 114168180 | + |
| intron-3UTR | ENST00000482410 | ENST00000433418 | ZDHHC6 | chr10 | 114200292 | - | ACSL5 | chr10 | 114168180 | + |
| intron-3UTR | ENST00000482410 | ENST00000356116 | ZDHHC6 | chr10 | 114200292 | - | ACSL5 | chr10 | 114168180 | + |
| intron-3UTR | ENST00000482410 | ENST00000354273 | ZDHHC6 | chr10 | 114200292 | - | ACSL5 | chr10 | 114168180 | + |
| intron-intron | ENST00000482410 | ENST00000369410 | ZDHHC6 | chr10 | 114200292 | - | ACSL5 | chr10 | 114168180 | + |
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FusionProtFeatures for ZDHHC6_ACSL5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZDHHC6 | ACSL5 |
| Endoplasmic reticulum palmitoyl acyltransferase thatmediates palmitoylation of proteins such as AMFR, CALX, ITPR1 andTFRC (PubMed:22314232, PubMed:22728137, PubMed:25368151,PubMed:28826475). Palmitoylates calnexin (CALX), which is requiredfor its association with the ribosome-translocon complex andefficient folding of glycosylated proteins (PubMed:22314232).Mediates palmitoylation of AMFR, promoting AMFR distribution tothe peripheral endoplasmic reticulum (PubMed:22728137). Togetherwith SELENOK, palmitoylates ITPR1 in immune cells, leading toregulate ITPR1 stability and function (PubMed:25368151).{ECO:0000269|PubMed:22314232, ECO:0000269|PubMed:22728137,ECO:0000269|PubMed:25368151, ECO:0000269|PubMed:28826475}. | Acyl-CoA synthetases (ACSL) activate long-chain fattyacids for both synthesis of cellular lipids, and degradation viabeta-oxidation. ACSL5 may activate fatty acids from exogenoussources for the synthesis of triacylglycerol destined forintracellular storage (By similarity). Utilizes a wide range ofsaturated fatty acids with a preference for C16-C18 unsaturatedfatty acids (By similarity). It was suggested that it may alsostimulate fatty acid oxidation (By similarity). At the villus tipof the crypt-villus axis of the small intestine may sensitizeepithelial cells to apoptosis specifically triggered by the deathligand TRAIL. May have a role in the survival of glioma cells.{ECO:0000250, ECO:0000269|PubMed:17681178,ECO:0000269|PubMed:18806831, ECO:0000269|PubMed:19459852}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZDHHC6_ACSL5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZDHHC6_ACSL5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ZDHHC6 | KHDRBS1, MOV10, NXF1, TSPAN5, POMK, VSIG4, WBP1, PLVAP, KLRG2, ADAM33, LRRC32, TSPAN2, ICOSLG, SLC22A9, STS, C3AR1 | ACSL5 | CREB3, KIF11, FAM136A, COQ9 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZDHHC6_ACSL5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZDHHC6_ACSL5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | ACSL5 | C0993582 | Arthritis, Experimental | 1 | CTD_human |
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