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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42700

FusionGeneSummary for ZDHHC24_FAM86A

check button Fusion gene summary
Fusion gene informationFusion gene name: ZDHHC24_FAM86A
Fusion gene ID: 42700
HgeneTgene
Gene symbol

ZDHHC24

FAM86A

Gene ID

254359

196483

Gene namezinc finger DHHC-type containing 24eukaryotic elongation factor 2 lysine methyltransferase
Synonyms-EFM3|FAM86A|SB153|eEF2-KMT
Cytomap

11q13.2

16p13.3

Type of geneprotein-codingprotein-coding
Descriptionprobable palmitoyltransferase ZDHHC24DHHC-24zinc finger DHHC domain-containing protein 24zinc finger, DHHC domain containing 24protein-lysine N-methyltransferase EEF2KMTeEF2-lysine methyltransferasefamily with sequence similarity 86, member Aprotein FAM86Aputative protein N-methyltransferase FAM86A
Modification date2018052320180519
UniProtAcc

Q6UX98

Ensembl transtripts involved in fusion geneENST00000526986, ENST00000310442, 
ENST00000525925, 
ENST00000458008, 
ENST00000427587, ENST00000587133, 
Fusion gene scores* DoF score3 X 2 X 3=182 X 2 X 2=8
# samples 32
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: ZDHHC24 [Title/Abstract] AND FAM86A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFAM86A

GO:0018023

peptidyl-lysine trimethylation

25231979


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-LG-A9QC-01AZDHHC24chr11

66311175

-FAM86Achr16

5135733

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000526986ENST00000458008ZDHHC24chr11

66311175

-FAM86Achr16

5135733

-
In-frameENST00000526986ENST00000427587ZDHHC24chr11

66311175

-FAM86Achr16

5135733

-
In-frameENST00000526986ENST00000587133ZDHHC24chr11

66311175

-FAM86Achr16

5135733

-
Frame-shiftENST00000310442ENST00000458008ZDHHC24chr11

66311175

-FAM86Achr16

5135733

-
Frame-shiftENST00000310442ENST00000427587ZDHHC24chr11

66311175

-FAM86Achr16

5135733

-
Frame-shiftENST00000310442ENST00000587133ZDHHC24chr11

66311175

-FAM86Achr16

5135733

-
5UTR-3CDSENST00000525925ENST00000458008ZDHHC24chr11

66311175

-FAM86Achr16

5135733

-
5UTR-3CDSENST00000525925ENST00000427587ZDHHC24chr11

66311175

-FAM86Achr16

5135733

-
5UTR-3CDSENST00000525925ENST00000587133ZDHHC24chr11

66311175

-FAM86Achr16

5135733

-

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FusionProtFeatures for ZDHHC24_FAM86A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZDHHC24

Q6UX98

FAM86A

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZDHHC24_FAM86A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ZDHHC24_ENST00000526986_chr11_66311175_-_FAM86A_ENST00000427587_chr16_5135733_-_220aa
MGQPWAAGSTDGAPAQLPLVLTALWAAAVGLELAYVLVLGPGPPPLGPLARALQLALAAFQLLNLLGNVGLFLRSDPSIRGVMLAGRGLG
QGWAYCYQCQSQVPPRSGHCSACRVCILRRDHHCRLLGRCVGFGNYRPFLCLLLHAAGVLLHVSVLLGPALSALLRAHTPLHMAALLLLP

>In-frame_ZDHHC24_ENST00000526986_chr11_66311175_-_FAM86A_ENST00000587133_chr16_5135733_-_220aa
MGQPWAAGSTDGAPAQLPLVLTALWAAAVGLELAYVLVLGPGPPPLGPLARALQLALAAFQLLNLLGNVGLFLRSDPSIRGVMLAGRGLG
QGWAYCYQCQSQVPPRSGHCSACRVCILRRDHHCRLLGRCVGFGNYRPFLCLLLHAAGVLLHVSVLLGPALSALLRAHTPLHMAALLLLP


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ZDHHC24_ENST00000526986_chr11_66311175_-_FAM86A_ENST00000427587_chr16_5135733_-_660nt
ATGGGGCAGCCCTGGGCGGCTGGGAGCACGGACGGGGCGCCCGCGCAGCTGCCTCTCGTGCTCACCGCGCTGTGGGCCGCGGCCGTGGGC
CTGGAGCTGGCTTACGTGCTGGTGCTCGGTCCCGGGCCGCCGCCGCTGGGACCCCTGGCCCGGGCCTTGCAGCTGGCGCTGGCCGCCTTC
CAGCTGCTCAACCTGCTGGGCAACGTGGGGCTCTTCCTGCGCTCGGATCCCAGCATCCGTGGCGTGATGCTGGCCGGCCGCGGTCTGGGC
CAGGGCTGGGCTTACTGCTACCAATGCCAAAGCCAGGTGCCGCCACGCAGCGGACACTGCTCTGCCTGCCGCGTCTGCATCCTGCGTCGG
GACCACCACTGCCGCCTGCTGGGCCGCTGCGTGGGCTTCGGCAACTACCGGCCCTTCCTGTGCCTGCTGCTTCATGCCGCCGGCGTCCTG
CTCCACGTCTCTGTGCTGCTGGGCCCTGCACTGTCGGCCCTGCTGCGAGCCCACACGCCCCTCCACATGGCTGCCCTCCTCCTGCTTCCC
TGGCTCATGTTGCTCACAGGCCGGGCCGGGATCAGATGGGAAGTGGAACCTCGTCATGAGCAGAAACTGTTTCCCTACGAAGAGCACTTG

>In-frame_ZDHHC24_ENST00000526986_chr11_66311175_-_FAM86A_ENST00000587133_chr16_5135733_-_660nt
ATGGGGCAGCCCTGGGCGGCTGGGAGCACGGACGGGGCGCCCGCGCAGCTGCCTCTCGTGCTCACCGCGCTGTGGGCCGCGGCCGTGGGC
CTGGAGCTGGCTTACGTGCTGGTGCTCGGTCCCGGGCCGCCGCCGCTGGGACCCCTGGCCCGGGCCTTGCAGCTGGCGCTGGCCGCCTTC
CAGCTGCTCAACCTGCTGGGCAACGTGGGGCTCTTCCTGCGCTCGGATCCCAGCATCCGTGGCGTGATGCTGGCCGGCCGCGGTCTGGGC
CAGGGCTGGGCTTACTGCTACCAATGCCAAAGCCAGGTGCCGCCACGCAGCGGACACTGCTCTGCCTGCCGCGTCTGCATCCTGCGTCGG
GACCACCACTGCCGCCTGCTGGGCCGCTGCGTGGGCTTCGGCAACTACCGGCCCTTCCTGTGCCTGCTGCTTCATGCCGCCGGCGTCCTG
CTCCACGTCTCTGTGCTGCTGGGCCCTGCACTGTCGGCCCTGCTGCGAGCCCACACGCCCCTCCACATGGCTGCCCTCCTCCTGCTTCCC
TGGCTCATGTTGCTCACAGGCCGGGCCGGGATCAGATGGGAAGTGGAACCTCGTCATGAGCAGAAACTGTTTCCCTACGAAGAGCACTTG


* Fusion transcript sequences (Full-length transcript).
>In-frame_ZDHHC24_ENST00000526986_chr11_66311175_-_FAM86A_ENST00000427587_chr16_5135733_-_2220nt
CACTCCGCGGCGTTATCCGGGCTCCAGCGCCGCGGGATTCCGAGCGCCTCCACTGCTGGTCCGTTGGCCAGATCAACTCGCCGCGTGGGC
CGGCCGTTCCCTGAGAGTCTGAGCGCTCGCCGCACCCCCTTCCGAGCTTCTATTGGCCGTAGCAGACGTCCGTCTGCCGCTATCTCCGCC
CCAATACGGAAGCGGCCTAGTCCTCCGGCTCCGACAGCTGGGTGTCCAGGCCATGGGGCAGCCCTGGGCGGCTGGGAGCACGGACGGGGC
GCCCGCGCAGCTGCCTCTCGTGCTCACCGCGCTGTGGGCCGCGGCCGTGGGCCTGGAGCTGGCTTACGTGCTGGTGCTCGGTCCCGGGCC
GCCGCCGCTGGGACCCCTGGCCCGGGCCTTGCAGCTGGCGCTGGCCGCCTTCCAGCTGCTCAACCTGCTGGGCAACGTGGGGCTCTTCCT
GCGCTCGGATCCCAGCATCCGTGGCGTGATGCTGGCCGGCCGCGGTCTGGGCCAGGGCTGGGCTTACTGCTACCAATGCCAAAGCCAGGT
GCCGCCACGCAGCGGACACTGCTCTGCCTGCCGCGTCTGCATCCTGCGTCGGGACCACCACTGCCGCCTGCTGGGCCGCTGCGTGGGCTT
CGGCAACTACCGGCCCTTCCTGTGCCTGCTGCTTCATGCCGCCGGCGTCCTGCTCCACGTCTCTGTGCTGCTGGGCCCTGCACTGTCGGC
CCTGCTGCGAGCCCACACGCCCCTCCACATGGCTGCCCTCCTCCTGCTTCCCTGGCTCATGTTGCTCACAGGCCGGGCCGGGATCAGATG
GGAAGTGGAACCTCGTCATGAGCAGAAACTGTTTCCCTACGAAGAGCACTTGGAGATGGCAATGCTGAATCTCACCCTGTAGGACTCACA
CACGACTCCAACGGGATTGTGAGAATCAAGTCACTCTCATGGGAAGAATTTTTATATGGGAAAGCGGATAAAACTTTCATTGGACTGGAA
TGTTTGGAGAATGTTAATTTCCAAATCAGGAACCACAAACTGCCCTCTAATAAGACATCGGCTATCTAAGCGTGTGGGTGCCCCCTTTCT
GCCAGCAGTTCTGGTTCTTAAGAAAATCACCATAAATCAGACATGAAAATTCTGGCTCCAAAAATAGCATTTTCTTTGTGCAAATAAAAA
CGTGTGTATCAAGTATGATGTTCCCCCAACGTGGACACACTCAGTTCCTCACAAAGCCAAGCCCACTGCAGCTGCCACATCCCTGGGCTT
ACGGTGCAGCAGGTGCTTTTTTCAAGACAGGAATCAAAATGTTAGGAACACGGCAGAAAGGGGACACCTGGAGACCAAACGCAGGATGAG
GAGTTCTGCAGAGGTCACAGGGAAGTCACAGAACAGTAATACGCTAGCAGGGGCATGGGGCGTGAAGAACAGAAGAAGAGAGGAAGCGTT
TCCAAGCCTCCAGAGAAGAAATCAAGGCCAACCAAAGCTTCCCGGGTCACAGAACCAATTCTTTTACCAGGCAGTACCACTGCTGTCATT
TCAGCTTCTGGCCACTGGGAGGTGCTGCTCGAAAGGGTTTGCCCTGAGACTCCAAGAAGAAGCTGCGGGAAGGACAGCAGGGGTCCTGGG
GTTTTAGCCTCTGGCCCAGGAGTTATGTGTCCATAACCAAAGGGAGCACAGTCTGCACCCAGCTCTCATCCCATCGGAGCTGCTGCGACT
CCCGCAGGTTCTTCCGGAACTGGTTTAGCTTGCCCGCAGGATCAGGAAAGTTTGAGAAAAGCATCTGCAAAAAAATAAAGAGCAGAGCTT
ACCTCATTGCCTGTCCCCACCCCATCCCAGGTCACCACCTGGCTGACCCCAGGTCCCCGACCCAACAACAACCCCTCCCAAGTCCCTAAC
TCCCTCACTTGGACTCGAGACCCTTCACACCCCAGCAGCACTCCGCCTCCAACTTGACATCACAGTTTCTGGAAACTTCCCCGCATGTCC
CACTTTCCCACACTTGGTGCCCTGGAGCACCTCCCGGCCTCTACGTGCTGCCCATTCCCCTGTGAGCACCCTCCTCTCGGCCTCTGGCCA
ACGCAGTCTCACCCATCTGTGGGTAACAAGGGGGTGTCGGTGTTCTTTGCAGCCTTGCTAAACTGTCTGAATCAAGGATCACAAACTACA

>In-frame_ZDHHC24_ENST00000526986_chr11_66311175_-_FAM86A_ENST00000587133_chr16_5135733_-_952nt
CACTCCGCGGCGTTATCCGGGCTCCAGCGCCGCGGGATTCCGAGCGCCTCCACTGCTGGTCCGTTGGCCAGATCAACTCGCCGCGTGGGC
CGGCCGTTCCCTGAGAGTCTGAGCGCTCGCCGCACCCCCTTCCGAGCTTCTATTGGCCGTAGCAGACGTCCGTCTGCCGCTATCTCCGCC
CCAATACGGAAGCGGCCTAGTCCTCCGGCTCCGACAGCTGGGTGTCCAGGCCATGGGGCAGCCCTGGGCGGCTGGGAGCACGGACGGGGC
GCCCGCGCAGCTGCCTCTCGTGCTCACCGCGCTGTGGGCCGCGGCCGTGGGCCTGGAGCTGGCTTACGTGCTGGTGCTCGGTCCCGGGCC
GCCGCCGCTGGGACCCCTGGCCCGGGCCTTGCAGCTGGCGCTGGCCGCCTTCCAGCTGCTCAACCTGCTGGGCAACGTGGGGCTCTTCCT
GCGCTCGGATCCCAGCATCCGTGGCGTGATGCTGGCCGGCCGCGGTCTGGGCCAGGGCTGGGCTTACTGCTACCAATGCCAAAGCCAGGT
GCCGCCACGCAGCGGACACTGCTCTGCCTGCCGCGTCTGCATCCTGCGTCGGGACCACCACTGCCGCCTGCTGGGCCGCTGCGTGGGCTT
CGGCAACTACCGGCCCTTCCTGTGCCTGCTGCTTCATGCCGCCGGCGTCCTGCTCCACGTCTCTGTGCTGCTGGGCCCTGCACTGTCGGC
CCTGCTGCGAGCCCACACGCCCCTCCACATGGCTGCCCTCCTCCTGCTTCCCTGGCTCATGTTGCTCACAGGCCGGGCCGGGATCAGATG
GGAAGTGGAACCTCGTCATGAGCAGAAACTGTTTCCCTACGAAGAGCACTTGGAGATGGCAATGCTGAATCTCACCCTGTAGGACTCACA


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FusionGenePPI for ZDHHC24_FAM86A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZDHHC24REL, TCF4, LMNAFAM86A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZDHHC24_FAM86A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZDHHC24_FAM86A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource