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Fusion gene ID: 42700 |
FusionGeneSummary for ZDHHC24_FAM86A |
Fusion gene summary |
Fusion gene information | Fusion gene name: ZDHHC24_FAM86A | Fusion gene ID: 42700 | Hgene | Tgene | Gene symbol | ZDHHC24 | FAM86A | Gene ID | 254359 | 196483 |
Gene name | zinc finger DHHC-type containing 24 | eukaryotic elongation factor 2 lysine methyltransferase | |
Synonyms | - | EFM3|FAM86A|SB153|eEF2-KMT | |
Cytomap | 11q13.2 | 16p13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | probable palmitoyltransferase ZDHHC24DHHC-24zinc finger DHHC domain-containing protein 24zinc finger, DHHC domain containing 24 | protein-lysine N-methyltransferase EEF2KMTeEF2-lysine methyltransferasefamily with sequence similarity 86, member Aprotein FAM86Aputative protein N-methyltransferase FAM86A | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q6UX98 | ||
Ensembl transtripts involved in fusion gene | ENST00000526986, ENST00000310442, ENST00000525925, | ENST00000458008, ENST00000427587, ENST00000587133, | |
Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 2 X 2 X 2=8 |
# samples | 3 | 2 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: ZDHHC24 [Title/Abstract] AND FAM86A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | FAM86A | GO:0018023 | peptidyl-lysine trimethylation | 25231979 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LIHC | TCGA-LG-A9QC-01A | ZDHHC24 | chr11 | 66311175 | - | FAM86A | chr16 | 5135733 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000526986 | ENST00000458008 | ZDHHC24 | chr11 | 66311175 | - | FAM86A | chr16 | 5135733 | - |
In-frame | ENST00000526986 | ENST00000427587 | ZDHHC24 | chr11 | 66311175 | - | FAM86A | chr16 | 5135733 | - |
In-frame | ENST00000526986 | ENST00000587133 | ZDHHC24 | chr11 | 66311175 | - | FAM86A | chr16 | 5135733 | - |
Frame-shift | ENST00000310442 | ENST00000458008 | ZDHHC24 | chr11 | 66311175 | - | FAM86A | chr16 | 5135733 | - |
Frame-shift | ENST00000310442 | ENST00000427587 | ZDHHC24 | chr11 | 66311175 | - | FAM86A | chr16 | 5135733 | - |
Frame-shift | ENST00000310442 | ENST00000587133 | ZDHHC24 | chr11 | 66311175 | - | FAM86A | chr16 | 5135733 | - |
5UTR-3CDS | ENST00000525925 | ENST00000458008 | ZDHHC24 | chr11 | 66311175 | - | FAM86A | chr16 | 5135733 | - |
5UTR-3CDS | ENST00000525925 | ENST00000427587 | ZDHHC24 | chr11 | 66311175 | - | FAM86A | chr16 | 5135733 | - |
5UTR-3CDS | ENST00000525925 | ENST00000587133 | ZDHHC24 | chr11 | 66311175 | - | FAM86A | chr16 | 5135733 | - |
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FusionProtFeatures for ZDHHC24_FAM86A |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
ZDHHC24 | FAM86A |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZDHHC24_FAM86A |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_ZDHHC24_ENST00000526986_chr11_66311175_-_FAM86A_ENST00000427587_chr16_5135733_-_220aa MGQPWAAGSTDGAPAQLPLVLTALWAAAVGLELAYVLVLGPGPPPLGPLARALQLALAAFQLLNLLGNVGLFLRSDPSIRGVMLAGRGLG QGWAYCYQCQSQVPPRSGHCSACRVCILRRDHHCRLLGRCVGFGNYRPFLCLLLHAAGVLLHVSVLLGPALSALLRAHTPLHMAALLLLP >In-frame_ZDHHC24_ENST00000526986_chr11_66311175_-_FAM86A_ENST00000587133_chr16_5135733_-_220aa MGQPWAAGSTDGAPAQLPLVLTALWAAAVGLELAYVLVLGPGPPPLGPLARALQLALAAFQLLNLLGNVGLFLRSDPSIRGVMLAGRGLG QGWAYCYQCQSQVPPRSGHCSACRVCILRRDHHCRLLGRCVGFGNYRPFLCLLLHAAGVLLHVSVLLGPALSALLRAHTPLHMAALLLLP |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_ZDHHC24_ENST00000526986_chr11_66311175_-_FAM86A_ENST00000427587_chr16_5135733_-_660nt ATGGGGCAGCCCTGGGCGGCTGGGAGCACGGACGGGGCGCCCGCGCAGCTGCCTCTCGTGCTCACCGCGCTGTGGGCCGCGGCCGTGGGC CTGGAGCTGGCTTACGTGCTGGTGCTCGGTCCCGGGCCGCCGCCGCTGGGACCCCTGGCCCGGGCCTTGCAGCTGGCGCTGGCCGCCTTC CAGCTGCTCAACCTGCTGGGCAACGTGGGGCTCTTCCTGCGCTCGGATCCCAGCATCCGTGGCGTGATGCTGGCCGGCCGCGGTCTGGGC CAGGGCTGGGCTTACTGCTACCAATGCCAAAGCCAGGTGCCGCCACGCAGCGGACACTGCTCTGCCTGCCGCGTCTGCATCCTGCGTCGG GACCACCACTGCCGCCTGCTGGGCCGCTGCGTGGGCTTCGGCAACTACCGGCCCTTCCTGTGCCTGCTGCTTCATGCCGCCGGCGTCCTG CTCCACGTCTCTGTGCTGCTGGGCCCTGCACTGTCGGCCCTGCTGCGAGCCCACACGCCCCTCCACATGGCTGCCCTCCTCCTGCTTCCC TGGCTCATGTTGCTCACAGGCCGGGCCGGGATCAGATGGGAAGTGGAACCTCGTCATGAGCAGAAACTGTTTCCCTACGAAGAGCACTTG >In-frame_ZDHHC24_ENST00000526986_chr11_66311175_-_FAM86A_ENST00000587133_chr16_5135733_-_660nt ATGGGGCAGCCCTGGGCGGCTGGGAGCACGGACGGGGCGCCCGCGCAGCTGCCTCTCGTGCTCACCGCGCTGTGGGCCGCGGCCGTGGGC CTGGAGCTGGCTTACGTGCTGGTGCTCGGTCCCGGGCCGCCGCCGCTGGGACCCCTGGCCCGGGCCTTGCAGCTGGCGCTGGCCGCCTTC CAGCTGCTCAACCTGCTGGGCAACGTGGGGCTCTTCCTGCGCTCGGATCCCAGCATCCGTGGCGTGATGCTGGCCGGCCGCGGTCTGGGC CAGGGCTGGGCTTACTGCTACCAATGCCAAAGCCAGGTGCCGCCACGCAGCGGACACTGCTCTGCCTGCCGCGTCTGCATCCTGCGTCGG GACCACCACTGCCGCCTGCTGGGCCGCTGCGTGGGCTTCGGCAACTACCGGCCCTTCCTGTGCCTGCTGCTTCATGCCGCCGGCGTCCTG CTCCACGTCTCTGTGCTGCTGGGCCCTGCACTGTCGGCCCTGCTGCGAGCCCACACGCCCCTCCACATGGCTGCCCTCCTCCTGCTTCCC TGGCTCATGTTGCTCACAGGCCGGGCCGGGATCAGATGGGAAGTGGAACCTCGTCATGAGCAGAAACTGTTTCCCTACGAAGAGCACTTG |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_ZDHHC24_ENST00000526986_chr11_66311175_-_FAM86A_ENST00000427587_chr16_5135733_-_2220nt CACTCCGCGGCGTTATCCGGGCTCCAGCGCCGCGGGATTCCGAGCGCCTCCACTGCTGGTCCGTTGGCCAGATCAACTCGCCGCGTGGGC CGGCCGTTCCCTGAGAGTCTGAGCGCTCGCCGCACCCCCTTCCGAGCTTCTATTGGCCGTAGCAGACGTCCGTCTGCCGCTATCTCCGCC CCAATACGGAAGCGGCCTAGTCCTCCGGCTCCGACAGCTGGGTGTCCAGGCCATGGGGCAGCCCTGGGCGGCTGGGAGCACGGACGGGGC GCCCGCGCAGCTGCCTCTCGTGCTCACCGCGCTGTGGGCCGCGGCCGTGGGCCTGGAGCTGGCTTACGTGCTGGTGCTCGGTCCCGGGCC GCCGCCGCTGGGACCCCTGGCCCGGGCCTTGCAGCTGGCGCTGGCCGCCTTCCAGCTGCTCAACCTGCTGGGCAACGTGGGGCTCTTCCT GCGCTCGGATCCCAGCATCCGTGGCGTGATGCTGGCCGGCCGCGGTCTGGGCCAGGGCTGGGCTTACTGCTACCAATGCCAAAGCCAGGT GCCGCCACGCAGCGGACACTGCTCTGCCTGCCGCGTCTGCATCCTGCGTCGGGACCACCACTGCCGCCTGCTGGGCCGCTGCGTGGGCTT CGGCAACTACCGGCCCTTCCTGTGCCTGCTGCTTCATGCCGCCGGCGTCCTGCTCCACGTCTCTGTGCTGCTGGGCCCTGCACTGTCGGC CCTGCTGCGAGCCCACACGCCCCTCCACATGGCTGCCCTCCTCCTGCTTCCCTGGCTCATGTTGCTCACAGGCCGGGCCGGGATCAGATG GGAAGTGGAACCTCGTCATGAGCAGAAACTGTTTCCCTACGAAGAGCACTTGGAGATGGCAATGCTGAATCTCACCCTGTAGGACTCACA CACGACTCCAACGGGATTGTGAGAATCAAGTCACTCTCATGGGAAGAATTTTTATATGGGAAAGCGGATAAAACTTTCATTGGACTGGAA TGTTTGGAGAATGTTAATTTCCAAATCAGGAACCACAAACTGCCCTCTAATAAGACATCGGCTATCTAAGCGTGTGGGTGCCCCCTTTCT GCCAGCAGTTCTGGTTCTTAAGAAAATCACCATAAATCAGACATGAAAATTCTGGCTCCAAAAATAGCATTTTCTTTGTGCAAATAAAAA CGTGTGTATCAAGTATGATGTTCCCCCAACGTGGACACACTCAGTTCCTCACAAAGCCAAGCCCACTGCAGCTGCCACATCCCTGGGCTT ACGGTGCAGCAGGTGCTTTTTTCAAGACAGGAATCAAAATGTTAGGAACACGGCAGAAAGGGGACACCTGGAGACCAAACGCAGGATGAG GAGTTCTGCAGAGGTCACAGGGAAGTCACAGAACAGTAATACGCTAGCAGGGGCATGGGGCGTGAAGAACAGAAGAAGAGAGGAAGCGTT TCCAAGCCTCCAGAGAAGAAATCAAGGCCAACCAAAGCTTCCCGGGTCACAGAACCAATTCTTTTACCAGGCAGTACCACTGCTGTCATT TCAGCTTCTGGCCACTGGGAGGTGCTGCTCGAAAGGGTTTGCCCTGAGACTCCAAGAAGAAGCTGCGGGAAGGACAGCAGGGGTCCTGGG GTTTTAGCCTCTGGCCCAGGAGTTATGTGTCCATAACCAAAGGGAGCACAGTCTGCACCCAGCTCTCATCCCATCGGAGCTGCTGCGACT CCCGCAGGTTCTTCCGGAACTGGTTTAGCTTGCCCGCAGGATCAGGAAAGTTTGAGAAAAGCATCTGCAAAAAAATAAAGAGCAGAGCTT ACCTCATTGCCTGTCCCCACCCCATCCCAGGTCACCACCTGGCTGACCCCAGGTCCCCGACCCAACAACAACCCCTCCCAAGTCCCTAAC TCCCTCACTTGGACTCGAGACCCTTCACACCCCAGCAGCACTCCGCCTCCAACTTGACATCACAGTTTCTGGAAACTTCCCCGCATGTCC CACTTTCCCACACTTGGTGCCCTGGAGCACCTCCCGGCCTCTACGTGCTGCCCATTCCCCTGTGAGCACCCTCCTCTCGGCCTCTGGCCA ACGCAGTCTCACCCATCTGTGGGTAACAAGGGGGTGTCGGTGTTCTTTGCAGCCTTGCTAAACTGTCTGAATCAAGGATCACAAACTACA >In-frame_ZDHHC24_ENST00000526986_chr11_66311175_-_FAM86A_ENST00000587133_chr16_5135733_-_952nt CACTCCGCGGCGTTATCCGGGCTCCAGCGCCGCGGGATTCCGAGCGCCTCCACTGCTGGTCCGTTGGCCAGATCAACTCGCCGCGTGGGC CGGCCGTTCCCTGAGAGTCTGAGCGCTCGCCGCACCCCCTTCCGAGCTTCTATTGGCCGTAGCAGACGTCCGTCTGCCGCTATCTCCGCC CCAATACGGAAGCGGCCTAGTCCTCCGGCTCCGACAGCTGGGTGTCCAGGCCATGGGGCAGCCCTGGGCGGCTGGGAGCACGGACGGGGC GCCCGCGCAGCTGCCTCTCGTGCTCACCGCGCTGTGGGCCGCGGCCGTGGGCCTGGAGCTGGCTTACGTGCTGGTGCTCGGTCCCGGGCC GCCGCCGCTGGGACCCCTGGCCCGGGCCTTGCAGCTGGCGCTGGCCGCCTTCCAGCTGCTCAACCTGCTGGGCAACGTGGGGCTCTTCCT GCGCTCGGATCCCAGCATCCGTGGCGTGATGCTGGCCGGCCGCGGTCTGGGCCAGGGCTGGGCTTACTGCTACCAATGCCAAAGCCAGGT GCCGCCACGCAGCGGACACTGCTCTGCCTGCCGCGTCTGCATCCTGCGTCGGGACCACCACTGCCGCCTGCTGGGCCGCTGCGTGGGCTT CGGCAACTACCGGCCCTTCCTGTGCCTGCTGCTTCATGCCGCCGGCGTCCTGCTCCACGTCTCTGTGCTGCTGGGCCCTGCACTGTCGGC CCTGCTGCGAGCCCACACGCCCCTCCACATGGCTGCCCTCCTCCTGCTTCCCTGGCTCATGTTGCTCACAGGCCGGGCCGGGATCAGATG GGAAGTGGAACCTCGTCATGAGCAGAAACTGTTTCCCTACGAAGAGCACTTGGAGATGGCAATGCTGAATCTCACCCTGTAGGACTCACA |
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FusionGenePPI for ZDHHC24_FAM86A |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZDHHC24 | REL, TCF4, LMNA | FAM86A |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZDHHC24_FAM86A |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZDHHC24_FAM86A |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |