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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42696

FusionGeneSummary for ZDHHC21_PRDM2

check button Fusion gene summary
Fusion gene informationFusion gene name: ZDHHC21_PRDM2
Fusion gene ID: 42696
HgeneTgene
Gene symbol

ZDHHC21

PRDM2

Gene ID

340481

7799

Gene namezinc finger DHHC-type containing 21PR/SET domain 2
SynonymsDHHC-21|DHHC21|DNZ1|HSPC097HUMHOXY1|KMT8|KMT8A|MTB-ZF|RIZ|RIZ1|RIZ2
Cytomap

9p22.3

1p36.21

Type of geneprotein-codingprotein-coding
Descriptionpalmitoyltransferase ZDHHC21zinc finger, DHHC domain containing 21PR domain zinc finger protein 2GATA-3 binding protein G3BMTE-binding proteinPR domain 2PR domain containing 2, with ZNF domainPR domain-containing protein 2lysine N-methyltransferase 8retinoblastoma protein-binding zinc finger proteinretinoblastom
Modification date2018052320180523
UniProtAcc

Q8IVQ6

Q13029

Ensembl transtripts involved in fusion geneENST00000380916, ENST00000497966, 
ENST00000376048, ENST00000311066, 
ENST00000235372, ENST00000502727, 
ENST00000413440, ENST00000343137, 
ENST00000503842, ENST00000505823, 
Fusion gene scores* DoF score5 X 5 X 4=1004 X 4 X 3=48
# samples 55
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZDHHC21 [Title/Abstract] AND PRDM2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZDHHC21

GO:0018345

protein palmitoylation

23034182

TgenePRDM2

GO:0045944

positive regulation of transcription by RNA polymerase II

8654390


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW893619ZDHHC21chr9

14592523

+PRDM2chr1

14111804

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000380916ENST00000376048ZDHHC21chr9

14592523

+PRDM2chr1

14111804

-
intron-intronENST00000380916ENST00000311066ZDHHC21chr9

14592523

+PRDM2chr1

14111804

-
intron-intronENST00000380916ENST00000235372ZDHHC21chr9

14592523

+PRDM2chr1

14111804

-
intron-intronENST00000380916ENST00000502727ZDHHC21chr9

14592523

+PRDM2chr1

14111804

-
intron-intronENST00000380916ENST00000413440ZDHHC21chr9

14592523

+PRDM2chr1

14111804

-
intron-intronENST00000380916ENST00000343137ZDHHC21chr9

14592523

+PRDM2chr1

14111804

-
intron-intronENST00000380916ENST00000503842ZDHHC21chr9

14592523

+PRDM2chr1

14111804

-
intron-intronENST00000380916ENST00000505823ZDHHC21chr9

14592523

+PRDM2chr1

14111804

-
intron-intronENST00000497966ENST00000376048ZDHHC21chr9

14592523

+PRDM2chr1

14111804

-
intron-intronENST00000497966ENST00000311066ZDHHC21chr9

14592523

+PRDM2chr1

14111804

-
intron-intronENST00000497966ENST00000235372ZDHHC21chr9

14592523

+PRDM2chr1

14111804

-
intron-intronENST00000497966ENST00000502727ZDHHC21chr9

14592523

+PRDM2chr1

14111804

-
intron-intronENST00000497966ENST00000413440ZDHHC21chr9

14592523

+PRDM2chr1

14111804

-
intron-intronENST00000497966ENST00000343137ZDHHC21chr9

14592523

+PRDM2chr1

14111804

-
intron-intronENST00000497966ENST00000503842ZDHHC21chr9

14592523

+PRDM2chr1

14111804

-
intron-intronENST00000497966ENST00000505823ZDHHC21chr9

14592523

+PRDM2chr1

14111804

-

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FusionProtFeatures for ZDHHC21_PRDM2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZDHHC21

Q8IVQ6

PRDM2

Q13029

Palmitoylates sex steroid hormone receptors, includingESR1, PGR and AR, thereby regulating their targeting to the plasmamembrane. This affects rapid intracellular signaling by sexhormones via ERK and AKT kinases and the generation of cAMP, butdoes not affect that mediated by their nuclear receptor (Bysimilarity). {ECO:0000250, ECO:0000269|PubMed:22031296}. S-adenosyl-L-methionine-dependent histonemethyltransferase that specifically methylates 'Lys-9' of histoneH3. May function as a DNA-binding transcription factor. Binds tothe macrophage-specific TPA-responsive element (MTE) of the HMOX1(heme oxygenase 1) gene and may act as a transcriptional activatorof this gene. {ECO:0000269|PubMed:14633678}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZDHHC21_PRDM2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZDHHC21_PRDM2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZDHHC21_PRDM2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZDHHC21_PRDM2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePRDM2C0005695Bladder Neoplasm1CTD_human
TgenePRDM2C0040136Thyroid Neoplasm1CTD_human
TgenePRDM2C0236733Amphetamine-Related Disorders1CTD_human