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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42694

FusionGeneSummary for ZDHHC21_ELAVL2

check button Fusion gene summary
Fusion gene informationFusion gene name: ZDHHC21_ELAVL2
Fusion gene ID: 42694
HgeneTgene
Gene symbol

ZDHHC21

ELAVL2

Gene ID

340481

1993

Gene namezinc finger DHHC-type containing 21ELAV like RNA binding protein 2
SynonymsDHHC-21|DHHC21|DNZ1|HSPC097HEL-N1|HELN1|HUB
Cytomap

9p22.3

9p21.3

Type of geneprotein-codingprotein-coding
Descriptionpalmitoyltransferase ZDHHC21zinc finger, DHHC domain containing 21ELAV-like protein 2ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)ELAV like neuron-specific RNA binding protein 2ELAV-like neuronal protein 1 isoform Hel-N2hu-antigen Bnervous system-specific RNA-binding protein Hel-N1
Modification date2018052320180519
UniProtAcc

Q8IVQ6

Q12926

Ensembl transtripts involved in fusion geneENST00000380916, ENST00000497966, 
ENST00000380110, ENST00000223951, 
ENST00000544538, ENST00000397312, 
ENST00000380117, ENST00000462649, 
Fusion gene scores* DoF score5 X 5 X 4=1004 X 2 X 4=32
# samples 54
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZDHHC21 [Title/Abstract] AND ELAVL2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZDHHC21

GO:0018345

protein palmitoylation

23034182


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-DQ-7589-01AZDHHC21chr9

14690335

-ELAVL2chr9

23731123

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000380916ENST00000380110ZDHHC21chr9

14690335

-ELAVL2chr9

23731123

-
5UTR-3CDSENST00000380916ENST00000223951ZDHHC21chr9

14690335

-ELAVL2chr9

23731123

-
5UTR-3CDSENST00000380916ENST00000544538ZDHHC21chr9

14690335

-ELAVL2chr9

23731123

-
5UTR-3CDSENST00000380916ENST00000397312ZDHHC21chr9

14690335

-ELAVL2chr9

23731123

-
5UTR-3CDSENST00000380916ENST00000380117ZDHHC21chr9

14690335

-ELAVL2chr9

23731123

-
5UTR-intronENST00000380916ENST00000462649ZDHHC21chr9

14690335

-ELAVL2chr9

23731123

-
5UTR-3CDSENST00000497966ENST00000380110ZDHHC21chr9

14690335

-ELAVL2chr9

23731123

-
5UTR-3CDSENST00000497966ENST00000223951ZDHHC21chr9

14690335

-ELAVL2chr9

23731123

-
5UTR-3CDSENST00000497966ENST00000544538ZDHHC21chr9

14690335

-ELAVL2chr9

23731123

-
5UTR-3CDSENST00000497966ENST00000397312ZDHHC21chr9

14690335

-ELAVL2chr9

23731123

-
5UTR-3CDSENST00000497966ENST00000380117ZDHHC21chr9

14690335

-ELAVL2chr9

23731123

-
5UTR-intronENST00000497966ENST00000462649ZDHHC21chr9

14690335

-ELAVL2chr9

23731123

-

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FusionProtFeatures for ZDHHC21_ELAVL2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZDHHC21

Q8IVQ6

ELAVL2

Q12926

Palmitoylates sex steroid hormone receptors, includingESR1, PGR and AR, thereby regulating their targeting to the plasmamembrane. This affects rapid intracellular signaling by sexhormones via ERK and AKT kinases and the generation of cAMP, butdoes not affect that mediated by their nuclear receptor (Bysimilarity). {ECO:0000250, ECO:0000269|PubMed:22031296}. Binds RNA. Seems to recognize a GAAA motif. Can bind toits own 3'-UTR, the FOS 3'-UTR and the ID 3'-UTR.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZDHHC21_ELAVL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZDHHC21_ELAVL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZDHHC21ESR1, CREB3, SLC22A9, CD97, TSPAN5, DPEP1, SLC7A1, C3AR1ELAVL2HNRNPAB, HOXC9, NR2E3, RBFOX2, CUL3, CDK2, CAND1, TARDBP, LIN28B, BMI1, HIST1H1A, TRA2A, RALYL, ZC3H3, ZBTB38, PRR11, ILF2, RBMX, UBXN8, ELAVL3, RBMXL1, POLR3H, RBM45, PUM2, CWF19L2, HNRNPCL1, SAFB2, CDC40, STRBP, YBX2, PABPC4L, ZC3H11A, RALY, HIST1H1T, GCFC2, APOBEC3F, YTHDC1, CLK2, RBMS2, CRNKL1, XAB2, PUM1, CDKN2AIP, PAIP2B, FAM120A, AQR, SUPV3L1, CASC3, TFIP11, CWF19L1, APOBEC3B, CCDC9, DGCR14, SYF2, MOV10, ZC3H14, PHAX, SRSF8, HNRNPC, UPF1, CLK3, ZFR, LARP1B, SUGP2, CDX1, ATXN2, IREB2, PAIP1, C17orf85, RBM22, PNN, STAU2, ZC3H18, ZNF346, HNRNPUL2, GTPBP3, ZCCHC3, IGF2BP3, ZNF326, SAFB, SRRT, HNRNPR, CCDC12, PABPC4, WDR46, ISY1, ACIN1, TROVE2, PRKRA, APOBEC3D, GSPT2, SRSF1, MKRN2, IGF2BP1, TRA2B, ESRP1, SNW1, ALG13, PPIE, PABPC1, CELF5, MATR3, DKC1, IGF2BP2, RNPS1, HNRNPL, LARP1, H2AFX, SRRM2, SRSF10, CDC5L, HIST1H1E, SYNCRIP, RBM3, G3BP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZDHHC21_ELAVL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZDHHC21_ELAVL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneELAVL2C0036341Schizophrenia1PSYGENET
TgeneELAVL2C0149925Small cell carcinoma of lung1CTD_human