|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 42663 |
FusionGeneSummary for ZDHHC14_FKBP5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZDHHC14_FKBP5 | Fusion gene ID: 42663 | Hgene | Tgene | Gene symbol | ZDHHC14 | FKBP5 | Gene ID | 79683 | 2289 |
| Gene name | zinc finger DHHC-type containing 14 | FK506 binding protein 5 | |
| Synonyms | NEW1CP | AIG6|FKBP51|FKBP54|P54|PPIase|Ptg-10 | |
| Cytomap | 6q25.3 | 6p21.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | probable palmitoyltransferase ZDHHC14DHHC-14NEW1 domain-containing proteinzinc finger DHHC domain-containing protein 14zinc finger, DHHC domain containing 14 | peptidyl-prolyl cis-trans isomerase FKBP551 kDa FK506-binding protein51 kDa FKBP54 kDa progesterone receptor-associated immunophilinFF1 antigenFKBP-51HSP90-binding immunophilinPPIase FKBP5T-cell FK506-binding proteinandrogen-regulated protein 6p | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q8IZN3 | Q13451 | |
| Ensembl transtripts involved in fusion gene | ENST00000414563, ENST00000359775, ENST00000341375, | ENST00000539068, ENST00000536438, ENST00000357266, ENST00000540787, ENST00000542713, | |
| Fusion gene scores | * DoF score | 5 X 3 X 4=60 | 11 X 11 X 7=847 |
| # samples | 5 | 17 | |
| ** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(17/847*10)=-2.3168272231945 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ZDHHC14 [Title/Abstract] AND FKBP5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ZDHHC14 | GO:0018345 | protein palmitoylation | 23034182 |
| Tgene | FKBP5 | GO:0061077 | chaperone-mediated protein folding | 11350175 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | MESO | TCGA-TS-A7P1-01A | ZDHHC14 | chr6 | 157803298 | + | FKBP5 | chr6 | 35688325 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000414563 | ENST00000539068 | ZDHHC14 | chr6 | 157803298 | + | FKBP5 | chr6 | 35688325 | - |
| 5CDS-5UTR | ENST00000414563 | ENST00000536438 | ZDHHC14 | chr6 | 157803298 | + | FKBP5 | chr6 | 35688325 | - |
| 5CDS-intron | ENST00000414563 | ENST00000357266 | ZDHHC14 | chr6 | 157803298 | + | FKBP5 | chr6 | 35688325 | - |
| 5CDS-intron | ENST00000414563 | ENST00000540787 | ZDHHC14 | chr6 | 157803298 | + | FKBP5 | chr6 | 35688325 | - |
| 5CDS-intron | ENST00000414563 | ENST00000542713 | ZDHHC14 | chr6 | 157803298 | + | FKBP5 | chr6 | 35688325 | - |
| 5CDS-intron | ENST00000359775 | ENST00000539068 | ZDHHC14 | chr6 | 157803298 | + | FKBP5 | chr6 | 35688325 | - |
| 5CDS-5UTR | ENST00000359775 | ENST00000536438 | ZDHHC14 | chr6 | 157803298 | + | FKBP5 | chr6 | 35688325 | - |
| 5CDS-intron | ENST00000359775 | ENST00000357266 | ZDHHC14 | chr6 | 157803298 | + | FKBP5 | chr6 | 35688325 | - |
| 5CDS-intron | ENST00000359775 | ENST00000540787 | ZDHHC14 | chr6 | 157803298 | + | FKBP5 | chr6 | 35688325 | - |
| 5CDS-intron | ENST00000359775 | ENST00000542713 | ZDHHC14 | chr6 | 157803298 | + | FKBP5 | chr6 | 35688325 | - |
| intron-intron | ENST00000341375 | ENST00000539068 | ZDHHC14 | chr6 | 157803298 | + | FKBP5 | chr6 | 35688325 | - |
| intron-5UTR | ENST00000341375 | ENST00000536438 | ZDHHC14 | chr6 | 157803298 | + | FKBP5 | chr6 | 35688325 | - |
| intron-intron | ENST00000341375 | ENST00000357266 | ZDHHC14 | chr6 | 157803298 | + | FKBP5 | chr6 | 35688325 | - |
| intron-intron | ENST00000341375 | ENST00000540787 | ZDHHC14 | chr6 | 157803298 | + | FKBP5 | chr6 | 35688325 | - |
| intron-intron | ENST00000341375 | ENST00000542713 | ZDHHC14 | chr6 | 157803298 | + | FKBP5 | chr6 | 35688325 | - |
Top |
FusionProtFeatures for ZDHHC14_FKBP5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZDHHC14 | FKBP5 |
| Immunophilin protein with PPIase and co-chaperoneactivities. Component of unligated steroid receptorsheterocomplexes through interaction with heat-shock protein 90(HSP90). Plays a role in the intracellular trafficking ofheterooligomeric forms of steroid hormone receptors maintainingthe complex into the cytoplasm when unliganded. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for ZDHHC14_FKBP5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for ZDHHC14_FKBP5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ZDHHC14 | ELAVL1, TRIM25 | FKBP5 | MAP3K1, IKBKE, ESR1, FES, HSF1, PGR, HSP90AA1, USP49, PHLPP1, CDK9, STK11, STIP1, IKBKB, RIPK3, AKT1, NR3C1, NR3C2, AR, HSPA4, PTGES3, LRRK1, MAGEA11, APP, CLK3, CDK15, MAGED2, MCM3, MCM5, MGEA5, OGFR, TPM3, TRAP1, USP7, PRKAA1, AGO1, AHSA1, CDC37, CDC37L1, SUGT1, NUDCD3, HSP90AB1, ILK, NUDC, AGO2, CACYBP, CHUK, AURKB, ARAF, GLMN, TTC4, CHORDC1, LRRC40, IKBKG, KIAA1279, ANKMY2, EGLN1, HGH1, MCMBP, PDCD2, CDK4, CDK11A, TUBA1A, PNPLA2, DNAJB6, C14orf80, CXorf57, PYGL, MCM4, HSF4, IRS4, LIMK2, SGK2, TSSK6, ULK3, AGO3, MOS, PSKH2, PIPOX, SGK1, CDKL1, CDKL4, AURKC, CDK18, CDK7, CDK13, CDK3, RPS6KB2, DUT, TLE3, NTRK1, XRCC3, TINF2, FBXW7, DUSP2, DUSP8, AMACR, MAP3K6, PRKACB, AKT3, PDIK1L, STK35, NEK11, ABHD15, WDR90, CDK6, ATG7, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for ZDHHC14_FKBP5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for ZDHHC14_FKBP5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | FKBP5 | C0005586 | Bipolar Disorder | 5 | PSYGENET |
| Tgene | FKBP5 | C0011570 | Mental Depression | 5 | PSYGENET |
| Tgene | FKBP5 | C0011581 | Depressive disorder | 5 | PSYGENET |
| Tgene | FKBP5 | C0041696 | Unipolar Depression | 5 | PSYGENET |
| Tgene | FKBP5 | C0525045 | Mood Disorders | 5 | PSYGENET |
| Tgene | FKBP5 | C1269683 | Major Depressive Disorder | 5 | CTD_human;PSYGENET |
| Tgene | FKBP5 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
| Tgene | FKBP5 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
| Tgene | FKBP5 | C0014175 | Endometriosis | 1 | CTD_human |
| Tgene | FKBP5 | C0021290 | Neonatal disorder | 1 | CTD_human |
| Tgene | FKBP5 | C0033975 | Psychotic Disorders | 1 | PSYGENET |
| Tgene | FKBP5 | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
| Tgene | FKBP5 | C0525041 | Neurobehavioral Manifestations | 1 | CTD_human |
| Tgene | FKBP5 | C2362914 | clinical depression | 1 | PSYGENET |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|