FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 42661

FusionGeneSummary for ZDHHC13_MGAT4C

check button Fusion gene summary
Fusion gene informationFusion gene name: ZDHHC13_MGAT4C
Fusion gene ID: 42661
HgeneTgene
Gene symbol

ZDHHC13

MGAT4C

Gene ID

54503

25834

Gene namezinc finger DHHC-type containing 13MGAT4 family member C
SynonymsHIP14L|HIP3RPGNTIVH|HGNT-IV-H
Cytomap

11p15.1

12q21.31-q21.32

Type of geneprotein-codingprotein-coding
Descriptionpalmitoyltransferase ZDHHC13DHHC-13HIP14-related proteinhuntingtin interacting protein HIP3RPhuntingtin-interacting protein 14-related proteinprobable palmitoyltransferase ZDHHC13putative MAPK-activating protein PM03putative NF-kappa-B-activating palpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase CN-acetylglucosaminyltransferase IV homologN-acetylglucosaminyltransferase IVcN-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVcUDP-N-acetylglucosamine: al
Modification date2018052220180522
UniProtAcc

Q8IUH4

Q9UBM8

Ensembl transtripts involved in fusion geneENST00000446113, ENST00000399351, 
ENST00000532812, 		ENST00000549405, 
ENST00000393205, ENST00000332156, 
ENST00000604798, ENST00000552808, 
ENST00000548651, ENST00000552435, 
ENST00000602941, 
Fusion gene scores* DoF score1 X 1 X 1=110 X 8 X 3=240
# samples 18
** MAII scorelog2(1/1*10)=3.32192809488736log2(8/240*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZDHHC13 [Title/Abstract] AND MGAT4C [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A3LT-01AZDHHC13chr11

19174231

+MGAT4Cchr12

86405680

-
TCGALDSARCTCGA-DX-A3LT-01AZDHHC13chr11

19174231

+MGAT4Cchr12

86383330

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000446113ENST00000549405ZDHHC13chr11

19174231

+MGAT4Cchr12

86405680

-
5CDS-intronENST00000446113ENST00000393205ZDHHC13chr11

19174231

+MGAT4Cchr12

86405680

-
5CDS-5UTRENST00000446113ENST00000332156ZDHHC13chr11

19174231

+MGAT4Cchr12

86405680

-
5CDS-5UTRENST00000446113ENST00000604798ZDHHC13chr11

19174231

+MGAT4Cchr12

86405680

-
5CDS-intronENST00000446113ENST00000552808ZDHHC13chr11

19174231

+MGAT4Cchr12

86405680

-
5CDS-intronENST00000446113ENST00000548651ZDHHC13chr11

19174231

+MGAT4Cchr12

86405680

-
5CDS-intronENST00000446113ENST00000552435ZDHHC13chr11

19174231

+MGAT4Cchr12

86405680

-
5CDS-intronENST00000446113ENST00000602941ZDHHC13chr11

19174231

+MGAT4Cchr12

86405680

-
5CDS-intronENST00000399351ENST00000549405ZDHHC13chr11

19174231

+MGAT4Cchr12

86405680

-
5CDS-intronENST00000399351ENST00000393205ZDHHC13chr11

19174231

+MGAT4Cchr12

86405680

-
5CDS-5UTRENST00000399351ENST00000332156ZDHHC13chr11

19174231

+MGAT4Cchr12

86405680

-
5CDS-5UTRENST00000399351ENST00000604798ZDHHC13chr11

19174231

+MGAT4Cchr12

86405680

-
5CDS-intronENST00000399351ENST00000552808ZDHHC13chr11

19174231

+MGAT4Cchr12

86405680

-
5CDS-intronENST00000399351ENST00000548651ZDHHC13chr11

19174231

+MGAT4Cchr12

86405680

-
5CDS-intronENST00000399351ENST00000552435ZDHHC13chr11

19174231

+MGAT4Cchr12

86405680

-
5CDS-intronENST00000399351ENST00000602941ZDHHC13chr11

19174231

+MGAT4Cchr12

86405680

-
3UTR-intronENST00000532812ENST00000549405ZDHHC13chr11

19174231

+MGAT4Cchr12

86405680

-
3UTR-intronENST00000532812ENST00000393205ZDHHC13chr11

19174231

+MGAT4Cchr12

86405680

-
3UTR-5UTRENST00000532812ENST00000332156ZDHHC13chr11

19174231

+MGAT4Cchr12

86405680

-
3UTR-5UTRENST00000532812ENST00000604798ZDHHC13chr11

19174231

+MGAT4Cchr12

86405680

-
3UTR-intronENST00000532812ENST00000552808ZDHHC13chr11

19174231

+MGAT4Cchr12

86405680

-
3UTR-intronENST00000532812ENST00000548651ZDHHC13chr11

19174231

+MGAT4Cchr12

86405680

-
3UTR-intronENST00000532812ENST00000552435ZDHHC13chr11

19174231

+MGAT4Cchr12

86405680

-
3UTR-intronENST00000532812ENST00000602941ZDHHC13chr11

19174231

+MGAT4Cchr12

86405680

-
5CDS-5UTRENST00000446113ENST00000549405ZDHHC13chr11

19174231

+MGAT4Cchr12

86383330

-
5CDS-5UTRENST00000446113ENST00000393205ZDHHC13chr11

19174231

+MGAT4Cchr12

86383330

-
5CDS-5UTRENST00000446113ENST00000332156ZDHHC13chr11

19174231

+MGAT4Cchr12

86383330

-
5CDS-5UTRENST00000446113ENST00000604798ZDHHC13chr11

19174231

+MGAT4Cchr12

86383330

-
5CDS-5UTRENST00000446113ENST00000552808ZDHHC13chr11

19174231

+MGAT4Cchr12

86383330

-
5CDS-5UTRENST00000446113ENST00000548651ZDHHC13chr11

19174231

+MGAT4Cchr12

86383330

-
5CDS-5UTRENST00000446113ENST00000552435ZDHHC13chr11

19174231

+MGAT4Cchr12

86383330

-
5CDS-intronENST00000446113ENST00000602941ZDHHC13chr11

19174231

+MGAT4Cchr12

86383330

-
5CDS-5UTRENST00000399351ENST00000549405ZDHHC13chr11

19174231

+MGAT4Cchr12

86383330

-
5CDS-5UTRENST00000399351ENST00000393205ZDHHC13chr11

19174231

+MGAT4Cchr12

86383330

-
5CDS-5UTRENST00000399351ENST00000332156ZDHHC13chr11

19174231

+MGAT4Cchr12

86383330

-
5CDS-5UTRENST00000399351ENST00000604798ZDHHC13chr11

19174231

+MGAT4Cchr12

86383330

-
5CDS-5UTRENST00000399351ENST00000552808ZDHHC13chr11

19174231

+MGAT4Cchr12

86383330

-
5CDS-5UTRENST00000399351ENST00000548651ZDHHC13chr11

19174231

+MGAT4Cchr12

86383330

-
5CDS-5UTRENST00000399351ENST00000552435ZDHHC13chr11

19174231

+MGAT4Cchr12

86383330

-
5CDS-intronENST00000399351ENST00000602941ZDHHC13chr11

19174231

+MGAT4Cchr12

86383330

-
3UTR-5UTRENST00000532812ENST00000549405ZDHHC13chr11

19174231

+MGAT4Cchr12

86383330

-
3UTR-5UTRENST00000532812ENST00000393205ZDHHC13chr11

19174231

+MGAT4Cchr12

86383330

-
3UTR-5UTRENST00000532812ENST00000332156ZDHHC13chr11

19174231

+MGAT4Cchr12

86383330

-
3UTR-5UTRENST00000532812ENST00000604798ZDHHC13chr11

19174231

+MGAT4Cchr12

86383330

-
3UTR-5UTRENST00000532812ENST00000552808ZDHHC13chr11

19174231

+MGAT4Cchr12

86383330

-
3UTR-5UTRENST00000532812ENST00000548651ZDHHC13chr11

19174231

+MGAT4Cchr12

86383330

-
3UTR-5UTRENST00000532812ENST00000552435ZDHHC13chr11

19174231

+MGAT4Cchr12

86383330

-
3UTR-intronENST00000532812ENST00000602941ZDHHC13chr11

19174231

+MGAT4Cchr12

86383330

-

Top

FusionProtFeatures for ZDHHC13_MGAT4C


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZDHHC13

Q8IUH4

MGAT4C

Q9UBM8

Palmitoyltransferase for HTT and GAD2. May play a rolein Mg(2+) transport. {ECO:0000250|UniProtKB:Q9CWU2}. Glycosyltransferase that participates in the transfer ofN-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structureof N-linked glycans. Essential for the production of tri- andtetra-antennary N-linked sugar chains (By similarity). Does notcatalyze the transfer of GlcNAc to the Manalpha1-6 arm to formGlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity).{ECO:0000250, ECO:0000269|PubMed:10962001}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ZDHHC13_MGAT4C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ZDHHC13_MGAT4C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZDHHC13SPINT2, WBP1, C3AR1, MRAP2, CD83, IPPKMGAT4CGAL, METRN, PCSK1N, HTRA1, HAPLN3, ITGA2, DSE, NMU, GLT8D2, GALNT12, KIAA0319L, TMEM132A, GXYLT2, GYLTL1B, B4GALT6, LRP5, EXTL2, B4GALT5, CNTNAP3, SPCS2, CSGALNACT2, MAN2A2, LDLR, TOR1B, FRAS1, LRP6, PLXNA1, CLSTN1, CHSY3, MAN2A1, SPCS1, PCDH20, ATF6, PBXIP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ZDHHC13_MGAT4C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ZDHHC13_MGAT4C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneZDHHC13C0002170Alopecia1CTD_human
HgeneZDHHC13C0002726Amyloidosis1CTD_human
HgeneZDHHC13C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneZDHHC13C0029456Osteoporosis1CTD_human