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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42627

FusionGeneSummary for ZCCHC17_FABP3

check button Fusion gene summary
Fusion gene informationFusion gene name: ZCCHC17_FABP3
Fusion gene ID: 42627
HgeneTgene
Gene symbol

ZCCHC17

FABP3

Gene ID

51538

2170

Gene namezinc finger CCHC-type containing 17fatty acid binding protein 3
SynonymsHSPC251|PS1D|pNO40FABP11|H-FABP|M-FABP|MDGI|O-FABP
Cytomap

1p35.2

1p35.2

Type of geneprotein-codingprotein-coding
Descriptionnucleolar protein of 40 kDanucleolar protein 40pnn-interacting nucleolar proteinputative S1 RNA binding domain proteinzinc finger CCHC domain-containing protein 17zinc finger, CCHC domain containing 17fatty acid-binding protein, heartfatty acid binding protein 11fatty acid binding protein 3, muscle and heartheart-type fatty acid-binding proteinmammary-derived growth inhibitormuscle fatty acid-binding protein
Modification date2018052220180527
UniProtAcc

Q9NP64

P05413

Ensembl transtripts involved in fusion geneENST00000344147, ENST00000479629, 
ENST00000373714, ENST00000546109, 
ENST00000422613, 		ENST00000373713, 
ENST00000497275, 
Fusion gene scores* DoF score7 X 6 X 4=1681 X 1 X 1=1
# samples 71
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: ZCCHC17 [Title/Abstract] AND FABP3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVGBMTCGA-14-0786-01BZCCHC17chr1

31792013

+FABP3chr1

31842404

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000344147ENST00000373713ZCCHC17chr1

31792013

+FABP3chr1

31842404

-
5CDS-5UTRENST00000344147ENST00000497275ZCCHC17chr1

31792013

+FABP3chr1

31842404

-
3UTR-3CDSENST00000479629ENST00000373713ZCCHC17chr1

31792013

+FABP3chr1

31842404

-
3UTR-5UTRENST00000479629ENST00000497275ZCCHC17chr1

31792013

+FABP3chr1

31842404

-
In-frameENST00000373714ENST00000373713ZCCHC17chr1

31792013

+FABP3chr1

31842404

-
5CDS-5UTRENST00000373714ENST00000497275ZCCHC17chr1

31792013

+FABP3chr1

31842404

-
In-frameENST00000546109ENST00000373713ZCCHC17chr1

31792013

+FABP3chr1

31842404

-
5CDS-5UTRENST00000546109ENST00000497275ZCCHC17chr1

31792013

+FABP3chr1

31842404

-
In-frameENST00000422613ENST00000373713ZCCHC17chr1

31792013

+FABP3chr1

31842404

-
5CDS-5UTRENST00000422613ENST00000497275ZCCHC17chr1

31792013

+FABP3chr1

31842404

-

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FusionProtFeatures for ZCCHC17_FABP3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZCCHC17

Q9NP64

FABP3

P05413

FABP are thought to play a role in the intracellulartransport of long-chain fatty acids and their acyl-CoA esters.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZCCHC17chr1:31792013chr1:31842404ENST00000344147+38110_11341242Compositional biasNote=Poly-Arg
HgeneZCCHC17chr1:31792013chr1:31842404ENST00000344147+38161_16741242Compositional biasNote=Poly-Glu
HgeneZCCHC17chr1:31792013chr1:31842404ENST00000344147+38185_24041242Compositional biasNote=Lys-rich
HgeneZCCHC17chr1:31792013chr1:31842404ENST00000373714+38110_11341242Compositional biasNote=Poly-Arg
HgeneZCCHC17chr1:31792013chr1:31842404ENST00000373714+38161_16741242Compositional biasNote=Poly-Glu
HgeneZCCHC17chr1:31792013chr1:31842404ENST00000373714+38185_24041242Compositional biasNote=Lys-rich
HgeneZCCHC17chr1:31792013chr1:31842404ENST00000344147+3816_8841242DomainS1 motif
HgeneZCCHC17chr1:31792013chr1:31842404ENST00000373714+3816_8841242DomainS1 motif
HgeneZCCHC17chr1:31792013chr1:31842404ENST00000344147+38131_14841242Zinc fingerCCHC-type
HgeneZCCHC17chr1:31792013chr1:31842404ENST00000373714+38131_14841242Zinc fingerCCHC-type


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FusionGeneSequence for ZCCHC17_FABP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZCCHC17_FABP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZCCHC17SDCBP2, PNN, CACNA1A, APP, JMJD6, HECW2, KDM1A, SUV39H1, SDCBP, ZDHHC17, ZBTB38, SRPK2, PFKFB2, SAP30, PTTG1, ZMYND8, LAP3, ING3, KIAA1598, CSNK2A2, H2AFY2, SSFA2, CDX1, NOS1AP, HIST1H1T, CSNK2A1, NKAP, ZNF512, MECP2, RNPS1, FTL, BPIFB1, MDK, RRP8, RBM4, IGJ, KNOP1, SRRM2, ZC3H14, IGHA1, POF1BFABP3TNNI3K, PLK1, NUP62, KIAA1598, NTRK1, HINT1, SOD1, TAGLN, TAGLN2, FKBP1A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZCCHC17_FABP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZCCHC17_FABP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneFABP3C0026848Myopathy1CTD_human
TgeneFABP3C0027540Necrosis1CTD_human
TgeneFABP3C0036341Schizophrenia1PSYGENET